Gene

KWMTBOMO01692  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006116

Annotation

Adenylate_kinase_isoenzyme_5_[Papilio_xuthus]

Location

Bomo_Chr4(+):1667099-1669991      View in EpiBrowser

Full name

Adenylate kinase isoenzyme 1       + More
Adenylate kinase      

Alternative Name

ATP-AMP transphosphorylase 1
ATP:AMP phosphotransferase
Adenylate monophosphate kinase
Myokinase
ATP-AMP transphosphorylase

Location in the cell

Nuclear   Reliability : 4.108

CDS

ATGCTATCGCAGCCCGAGGCGAAAGGCTTCATCCTGGTCGGCTTCCCCAGGAACTCTCGGATGTCAGATATATTCAGTAGACAAGTAAAATGGCCAGAGAAAGTCGTGGCGCTCGAAGTTGACAATGAAGTGGCCGCTGCAAGGTTACAGAACAAACTATCGGAACTGGGCAGGCCGGAGTCGGAGATTAACGCGGCTCGTCAAATAATCAGGGATGCCGCGCATAAAGTCAAAAACGTTCAGAAGAGATTTGCTCGACACGTGGTCACGGTCGACAGTACCGACAACCGTACCGCTTTAGCTTCAACGCTCAAAGAGATCTTGTCGGATACCATGGAGAAGAATAAGCGACCGGTTTCGCCAGAGCCCCGGCCCCCGTCAACGGTCTCGGCGCCCGCCGTCCTGCCCCCCAGTGCGGAAGTTCAACCTACACCAGACACAGCTGACGAAGGAAACAAATGA

Protein

MLSQPEAKGFILVGFPRNSRMSDIFSRQVKWPEKVVALEVDNEVAAARLQNKLSELGRPESEINAARQIIRDAAHKVKNVQKRFARHVVTVDSTDNRTALASTLKEILSDTMEKNKRPVSPEPRPPSTVSAPAVLPPSAEVQPTPDTADEGNK

Description

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Catalytic Activity

AMP + ATP = 2 ADP
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family.
Belongs to the adenylate kinase family. AK1 subfamily.

Uniprot

H9J9C4   A0A2A4K9Z4   A0A2A4KAH3   A0A2W1BH14   A0A194Q0J6   A0A194RBF9   + More
A0A212EJ37   A0A2H1VQ46   A0A0L7LGQ9   A0A3B1JT29   A0A3B1K0S7   Q56A38   A0A2D0PN27   A0A2D0PLB0   A0A3B4D6Z8   H3BAZ9   A0A1W5AGY6   A0A0L7QRD1   A0A0P7V906   W5U822   A0A2D0R9R7   A0A195EUX6   A0A195B996   A0A158NPJ6   A0A1S3QSY0   A0A3P9KA63   A0A3P9HKT3   H2LDW5   A0A310SBB7   A0A3B3IK72   M0R7U1   A0A1L8GF89   F6QTI0   A0A1H1T3L2   G3PW52   A0A3B3CR70  

EC Number

2.7.4.3
2.7.4.6

Pubmed

19121390    28756777    26354079    22118469    26227816    25329095    + More
23594743    9215903    23127152    21347285    17554307    15057822    15632090    22673903    27762356    19892987    29451363   

EMBL

BABH01004466    NWSH01000011    PCG80899.1    PCG80898.1    KZ150052    PZC74389.1    + More
KQ459584    KPI98519.1    KQ460644    KPJ13236.1    AGBW02014536    OWR41497.1    ODYU01003780    SOQ42965.1    JTDY01001197    KOB74569.1    AL845516    BC092184    AAH92184.1    AFYH01046137    KQ414782    KOC61182.1    JARO02002931    KPP71566.1    JT407726    AHH38098.1    KQ981965    KYN31684.1    KQ976542    KYM81113.1    ADTU01022493    KQ772519    OAD52443.1    AABR07013807    AABR07013808    AABR07013809    AABR07013810    AABR07013811    CH473952    EDL82507.1    CM004473    OCT82539.1    LT629741    SDS54822.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000018467    UP000000437    UP000221080    UP000261440    UP000008672    UP000192224    UP000053825    UP000034805    UP000078541    UP000078540    UP000005205    UP000087266    UP000265180    UP000265200    UP000001038    UP000002494    UP000186698    UP000002281    UP000198536    UP000007635    UP000261560   

PRIDE

H9J9C4    M0R7U1   

Pfam

PF05920   Homeobox_KN

Interpro

IPR001356   Homeobox_dom        + More
IPR000850   Adenylat/UMP-CMP_kin       
IPR027417   P-loop_NTPase       
IPR008422   Homeobox_KN_domain       
IPR009057   Homeobox-like_sf       
IPR033690   Adenylat_kinase_CS       
IPR028582   AK1       
IPR006267   AK1/5       

SUPFAM

SSF46689   SSF46689        + More
SSF52540   SSF52540       

CDD

cd00086  homeodomain
cd01428  ADK

ProteinModelPortal

H9J9C4   A0A2A4K9Z4   A0A2A4KAH3   A0A2W1BH14   A0A194Q0J6   A0A194RBF9   + More
A0A212EJ37   A0A2H1VQ46   A0A0L7LGQ9   A0A3B1JT29   A0A3B1K0S7   Q56A38   A0A2D0PN27   A0A2D0PLB0   A0A3B4D6Z8   H3BAZ9   A0A1W5AGY6   A0A0L7QRD1   A0A0P7V906   W5U822   A0A2D0R9R7   A0A195EUX6   A0A195B996   A0A158NPJ6   A0A1S3QSY0   A0A3P9KA63   A0A3P9HKT3   H2LDW5   A0A310SBB7   A0A3B3IK72   M0R7U1   A0A1L8GF89   F6QTI0   A0A1H1T3L2   G3PW52   A0A3B3CR70  

PDB

1DVR     E-value=0.0851959,     Score=77

KEGG

101736237    K00939 adenylate kinase [EC:2.7.4.3] | (RefSeq) adenylate kinase isoenzyme 1-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0019205   GO:0003677   GO:0006139   GO:0006355   GO:0005524   GO:0016301   GO:0006172   GO:0009142   GO:0004550   GO:0046033   GO:0046034   GO:0005737   GO:0004017   GO:0060271   GO:0005829   GO:0005815   GO:0044209  

PANTHER

PTHR23359  

Subcellular location

Nucleus  
Cytoplasm  

Length:

153

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04600

outside

1  -  153

 

 

Pi

387.839977

Theta

182.117997

Tajima's D

3.412063

CLR

0.753218

CSRT

0.991050447477626

Interpretation

Uncertain