Gene
KWMTBOMO01684
Pre Gene Modal
BGIBMGA006114
Annotation
PREDICTED:_methyltransferase-like_protein_13_[Papilio_machaon]
Full name
eEF1A lysine and N-terminal methyltransferase homolog
Location in the cell
Extracellular Reliability : 2.563
Sequence
CDS
ATGAATTTACTACCGAGAAGTCACAAAGAATTCAGCGAAAAAGATTATTGGAACAAATTCTTCAGAAAACGGGGAAATAAAGCATTCGAATGGTACGGCGAATATTTAGAACTATGCGGTCAGTTAAACAAATATATAAAAACTAAAGATTCAATACTGATCACTGGCTGTGGTAATTCAAGTTTGAGCGCGGACCTATACGATGTTGGATATGTAAATATAACAAATGTGGATGTCTCGGAAGTTGTTATTAAACAAATGAAAAACGTAAACAAAGCCAGAACCAATATGAAGTTTATGTGCATGGATGCTACGAGAATGTCTTTTGAAGATGAAGCGTTTAATGTTGTGTTAGATAAAGGTACTCTTGACGCCCTAATGCCGGATGCTACAGAAGAAACAAATGCCATTATAGATAAATATTTTTCTGAAATCAAAAGAGTTTTAAAACTCGGAGGACGCTTTGTTTGCATATCACTCTTACAGAGTCACATACTTGCCAAGTTAATGGAAGGGTTTTGTGAGAAGTCATGGATGTTCCGTGTTGTAAGATGTCACGAGGCCGAAGAGAAGAATGCGGAGAATTCTGATGGCCCAACTTTACCGGTATTCGTGGTGATTGCAACTAAGTTCAAAGAAATGCCTCAATTACTAATAGAAGTATGTATGGCTGGTGAAAAAATGGTGCGTGTTCAGACTCCTAAACATCTGCAGGAGCACATAAAGTCAGCTCAGGACACAGCATTCATCACCAATGGACTTGGCAAAACGAAACTAGATGATAATGATGAGGTCAGCTTGGATCTATACCAGCCTGATGAAAATACACCACGCTACACATTGTATGTGGTGGATCAGAGATCTTCTCAAACAATAAATAAATATGCAGTTTTCATAGTACCGCAAGGCAGAGAGTCCGAGTGGCTGTTCGGCACGGCAGCAGGGCGCCGCCAGCTCCAGGACTCGGCCCGGTTCGGTCGGCTCGTGGTGGCCGTGCTCAGACGAGGCCACCACTACTCCAGTCTCGACGCCGTCAAAGAGGAACTAGCGCATTCAGCCAAGATGCTCATACCGAATGGATTCAGCGGACAGATACCATTCTTGTCGATAGGCAGCGACGTGGGGCGTCGGGTGAAGGTTCACGAGGGCTCATCGAAGCTGTCCGGGGACTACGTCGTGGAGGACGTCGACGTGGAAGGACACACCCACAGGCGACTAGTGTTCCTCGACAATCAGTTTCTGGTTCAGTCGGAGGCCAGACTCAGACCTGTTAAAAGAAAAAACAAAACGAAATTTGTCATAGACTACGGGCACATATCTCTGTACCATTCCTTCATGTGCGTGGGAGTGCAGCTGTGCAAGTCCAGCCACGTCGCGGTCCTTGGGCTCGGCGGGGGTAGTCTCTGTATGTTCCTGAGGAGATGCAGGGAGGACCTCAACGTGACCGCCGTGGAGCTGGACCCCGCGATGCTTGAGGTCGCCACACAACACTTCGACTTGAAACTGGATGATAAACTGCGGGTTTTAGTCAAGGACGGATTGGATTTCTTGGCGGAGGAAGCTGTTTCTGGACACAAATATGGTGCAGTACTGTTCGACATGGACAGCAAGGATCGCACGCTCGGCCTCTCGTGTCCTCCCAAACAGTTCCTAGAGGATAAAGTACTCGAAGAAGTTCACAGTATTCTTGACGACGATGGGCATTTCATCCTAAATCTGGTGTGCCGCGATGTTGAACTCCAAGCCTCGATGCTCCTAACCCTTAAGAGACACTTCAAGCATCTAGTGTCGGTGAAACTGTACGAGGAAGTGAACGAAATAATTTTCGCTACAAACAGCAGAAAGCCGTACGAGAACGACGCTCTGGAAACAGCTGTGAGGTCGTTGAACTCGGCGGCGAGAAGTCAAAATTTAGTGAACGTCAAATGCGTTGATATAAAAGATTTTTTGCAATCCATTAATATTATTTCGTAG
Protein
MNLLPRSHKEFSEKDYWNKFFRKRGNKAFEWYGEYLELCGQLNKYIKTKDSILITGCGNSSLSADLYDVGYVNITNVDVSEVVIKQMKNVNKARTNMKFMCMDATRMSFEDEAFNVVLDKGTLDALMPDATEETNAIIDKYFSEIKRVLKLGGRFVCISLLQSHILAKLMEGFCEKSWMFRVVRCHEAEEKNAENSDGPTLPVFVVIATKFKEMPQLLIEVCMAGEKMVRVQTPKHLQEHIKSAQDTAFITNGLGKTKLDDNDEVSLDLYQPDENTPRYTLYVVDQRSSQTINKYAVFIVPQGRESEWLFGTAAGRRQLQDSARFGRLVVAVLRRGHHYSSLDAVKEELAHSAKMLIPNGFSGQIPFLSIGSDVGRRVKVHEGSSKLSGDYVVEDVDVEGHTHRRLVFLDNQFLVQSEARLRPVKRKNKTKFVIDYGHISLYHSFMCVGVQLCKSSHVAVLGLGGGSLCMFLRRCREDLNVTAVELDPAMLEVATQHFDLKLDDKLRVLVKDGLDFLAEEAVSGHKYGAVLFDMDSKDRTLGLSCPPKQFLEDKVLEEVHSILDDDGHFILNLVCRDVELQASMLLTLKRHFKHLVSVKLYEEVNEIIFATNSRKPYENDALETAVRSLNSAARSQNLVNVKCVDIKDFLQSINIIS
Summary
Description
Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus.
Catalytic Activity
L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine
N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine
Similarity
Belongs to the methyltransferase superfamily.
Keywords
Complete proteome
Methyltransferase
Multifunctional enzyme
Reference proteome
Transferase
Feature
chain eEF1A lysine and N-terminal methyltransferase homolog
Uniprot
H9J9C2
A0A2A4K9K3
A0A2W1BL47
A0A2H1WN99
A0A194R6F2
A0A194PZQ0
+ More
A0A212EJ53 A0A0L7L998 A0A2J7QFN2 A0A067REE3 A0A1Q3EZJ4 B0W8S4 A0A182JB81 A0A0L0CCY4 A0A182F2C1 A0A1I8NT36 W5JER9 A0A1I8MCI7 A0A0M3QUA8 B4MVJ8 A0A182Q043 A0A0Q9X0Q2 A0A182NUU0 A0A182Y5I0 B4KIZ5 Q17IW3 A0A154P7E7 A0A0K8VZG9 A0A182M3C0 A0A2M4BGL1 A0A2M4BGG8 B4LV98 A0A2M4BGG6 A0A151X879 A0A232F9G6 K7J3U0 A0A182WHF9 A0A2M4BGH2 Q7Q4L4 A0A034WKN7 A0A182P663 A0A182IBY5 W8C287 A0A182RRL7 A0A182TNK6 A0A182VBC3 A0A3B0K3M3 A0A182JXL9 A0A1W4UVV4 B4P430 M9PDA6 A0A0L7QR77 A0A182X143 A0A3B0JH74 B3MJT8 B4JAI9 A0A084VL35 A0A1Y1LZE3 B4Q3G0 B3NLZ5 D6WJR4 F4W732 Q9VIK9 E2BQP6 A0A2J7QFQ2 B4G750 A0A195F642 A0A195C3T6 A0A195DB25 Q29LW1 A0A195AY04 A0A1A9YH75 A0A1B0C3Z1 A0A158NM11 A0A1A9VI24 A0A1B0G2R0 A0A1B0A403 B4IFE3 A0A0M9A8N3 A0A1A9WM16 A0A1J1IG13 A0A0C9QWK3 A0A1B0CKW4 A0A2A3EN53 E1ZW85 A0A088AAP0 A0A2J7QFM8 A0A1B3PDN5 A0A1B6E9X9 A0A3L8E6M4 R4WT10 A0A069DZF7 A0A0V0G7B1 A0A023FAC4 T1HPJ7 A0A1B3PDA5 A0A1B6FY48 U4UGX3 N6T4Y7
A0A212EJ53 A0A0L7L998 A0A2J7QFN2 A0A067REE3 A0A1Q3EZJ4 B0W8S4 A0A182JB81 A0A0L0CCY4 A0A182F2C1 A0A1I8NT36 W5JER9 A0A1I8MCI7 A0A0M3QUA8 B4MVJ8 A0A182Q043 A0A0Q9X0Q2 A0A182NUU0 A0A182Y5I0 B4KIZ5 Q17IW3 A0A154P7E7 A0A0K8VZG9 A0A182M3C0 A0A2M4BGL1 A0A2M4BGG8 B4LV98 A0A2M4BGG6 A0A151X879 A0A232F9G6 K7J3U0 A0A182WHF9 A0A2M4BGH2 Q7Q4L4 A0A034WKN7 A0A182P663 A0A182IBY5 W8C287 A0A182RRL7 A0A182TNK6 A0A182VBC3 A0A3B0K3M3 A0A182JXL9 A0A1W4UVV4 B4P430 M9PDA6 A0A0L7QR77 A0A182X143 A0A3B0JH74 B3MJT8 B4JAI9 A0A084VL35 A0A1Y1LZE3 B4Q3G0 B3NLZ5 D6WJR4 F4W732 Q9VIK9 E2BQP6 A0A2J7QFQ2 B4G750 A0A195F642 A0A195C3T6 A0A195DB25 Q29LW1 A0A195AY04 A0A1A9YH75 A0A1B0C3Z1 A0A158NM11 A0A1A9VI24 A0A1B0G2R0 A0A1B0A403 B4IFE3 A0A0M9A8N3 A0A1A9WM16 A0A1J1IG13 A0A0C9QWK3 A0A1B0CKW4 A0A2A3EN53 E1ZW85 A0A088AAP0 A0A2J7QFM8 A0A1B3PDN5 A0A1B6E9X9 A0A3L8E6M4 R4WT10 A0A069DZF7 A0A0V0G7B1 A0A023FAC4 T1HPJ7 A0A1B3PDA5 A0A1B6FY48 U4UGX3 N6T4Y7
Pubmed
19121390
28756777
26354079
22118469
26227816
24845553
+ More
26108605 20920257 23761445 25315136 17994087 25244985 17510324 28648823 20075255 12364791 14747013 17210077 25348373 24495485 17550304 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 24438588 28004739 22936249 18362917 19820115 21719571 12537569 20798317 15632085 21347285 30249741 23691247 26334808 25474469 23537049
26108605 20920257 23761445 25315136 17994087 25244985 17510324 28648823 20075255 12364791 14747013 17210077 25348373 24495485 17550304 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 24438588 28004739 22936249 18362917 19820115 21719571 12537569 20798317 15632085 21347285 30249741 23691247 26334808 25474469 23537049
EMBL
BABH01004457
NWSH01000011
PCG80911.1
KZ150052
PZC74395.1
ODYU01009823
+ More
SOQ54508.1 KQ460644 KPJ13242.1 KQ459584 KPI98513.1 AGBW02014536 OWR41490.1 JTDY01002109 KOB72088.1 NEVH01014856 PNF27400.1 KK852514 KDR22226.1 GFDL01014323 JAV20722.1 DS231860 EDS39303.1 JRES01000539 KNC30298.1 ADMH02001716 ETN61319.1 CP012523 ALC40309.1 CH963857 EDW75718.1 AXCN02000745 KRF98299.1 CH933807 EDW13508.1 CH477236 EAT46630.1 KQ434830 KZC07792.1 GDHF01008006 JAI44308.1 AXCM01007175 GGFJ01002992 MBW52133.1 GGFJ01002991 MBW52132.1 CH940649 EDW64358.1 GGFJ01002993 MBW52134.1 KQ982431 KYQ56488.1 NNAY01000665 OXU27110.1 GGFJ01003014 MBW52155.1 AAAB01008964 EAA12896.2 GAKP01004020 JAC54932.1 APCN01000761 GAMC01000613 JAC05943.1 OUUW01000004 SPP79631.1 CM000158 EDW90540.1 AE014134 AGB93169.1 KQ414784 KOC61130.1 SPP79632.1 CH902620 EDV31427.1 CH916368 EDW02775.1 ATLV01014403 KE524970 KFB38679.1 GEZM01048840 JAV76357.1 CM000361 CM002910 EDX05641.1 KMY91186.1 CH954179 EDV54531.1 KQ971343 EFA04484.1 GL887802 EGI70022.1 AY061160 GL449798 EFN81965.1 PNF27398.1 CH479180 EDW29249.1 KQ981805 KYN35642.1 KQ978344 KYM94841.1 KQ981042 KYN10088.1 CH379060 KQ976716 KYM76824.1 JXJN01025195 ADTU01002211 CCAG010024026 CH480833 EDW46365.1 KQ435711 KOX79477.1 CVRI01000049 CRK99147.1 GBYB01008119 JAG77886.1 AJWK01016677 KZ288210 PBC32924.1 GL434776 EFN74594.1 PNF27395.1 KU660032 AOG17830.1 GEDC01009170 GEDC01006784 GEDC01002567 JAS28128.1 JAS30514.1 JAS34731.1 QOIP01000001 RLU27619.1 AK417862 BAN21077.1 GBGD01000720 JAC88169.1 GECL01002480 JAP03644.1 GBBI01000352 JAC18360.1 ACPB03001465 KU659908 AOG17707.1 GECZ01014665 JAS55104.1 KB632152 ERL89145.1 APGK01043868 KB741018 ENN75224.1
SOQ54508.1 KQ460644 KPJ13242.1 KQ459584 KPI98513.1 AGBW02014536 OWR41490.1 JTDY01002109 KOB72088.1 NEVH01014856 PNF27400.1 KK852514 KDR22226.1 GFDL01014323 JAV20722.1 DS231860 EDS39303.1 JRES01000539 KNC30298.1 ADMH02001716 ETN61319.1 CP012523 ALC40309.1 CH963857 EDW75718.1 AXCN02000745 KRF98299.1 CH933807 EDW13508.1 CH477236 EAT46630.1 KQ434830 KZC07792.1 GDHF01008006 JAI44308.1 AXCM01007175 GGFJ01002992 MBW52133.1 GGFJ01002991 MBW52132.1 CH940649 EDW64358.1 GGFJ01002993 MBW52134.1 KQ982431 KYQ56488.1 NNAY01000665 OXU27110.1 GGFJ01003014 MBW52155.1 AAAB01008964 EAA12896.2 GAKP01004020 JAC54932.1 APCN01000761 GAMC01000613 JAC05943.1 OUUW01000004 SPP79631.1 CM000158 EDW90540.1 AE014134 AGB93169.1 KQ414784 KOC61130.1 SPP79632.1 CH902620 EDV31427.1 CH916368 EDW02775.1 ATLV01014403 KE524970 KFB38679.1 GEZM01048840 JAV76357.1 CM000361 CM002910 EDX05641.1 KMY91186.1 CH954179 EDV54531.1 KQ971343 EFA04484.1 GL887802 EGI70022.1 AY061160 GL449798 EFN81965.1 PNF27398.1 CH479180 EDW29249.1 KQ981805 KYN35642.1 KQ978344 KYM94841.1 KQ981042 KYN10088.1 CH379060 KQ976716 KYM76824.1 JXJN01025195 ADTU01002211 CCAG010024026 CH480833 EDW46365.1 KQ435711 KOX79477.1 CVRI01000049 CRK99147.1 GBYB01008119 JAG77886.1 AJWK01016677 KZ288210 PBC32924.1 GL434776 EFN74594.1 PNF27395.1 KU660032 AOG17830.1 GEDC01009170 GEDC01006784 GEDC01002567 JAS28128.1 JAS30514.1 JAS34731.1 QOIP01000001 RLU27619.1 AK417862 BAN21077.1 GBGD01000720 JAC88169.1 GECL01002480 JAP03644.1 GBBI01000352 JAC18360.1 ACPB03001465 KU659908 AOG17707.1 GECZ01014665 JAS55104.1 KB632152 ERL89145.1 APGK01043868 KB741018 ENN75224.1
Proteomes
UP000005204
UP000218220
UP000053240
UP000053268
UP000007151
UP000037510
+ More
UP000235965 UP000027135 UP000002320 UP000075880 UP000037069 UP000069272 UP000095300 UP000000673 UP000095301 UP000092553 UP000007798 UP000075886 UP000075884 UP000076408 UP000009192 UP000008820 UP000076502 UP000075883 UP000008792 UP000075809 UP000215335 UP000002358 UP000075920 UP000007062 UP000075885 UP000075840 UP000075900 UP000075902 UP000075903 UP000268350 UP000075881 UP000192221 UP000002282 UP000000803 UP000053825 UP000076407 UP000007801 UP000001070 UP000030765 UP000000304 UP000008711 UP000007266 UP000007755 UP000008237 UP000008744 UP000078541 UP000078542 UP000078492 UP000001819 UP000078540 UP000092443 UP000092460 UP000005205 UP000078200 UP000092444 UP000092445 UP000001292 UP000053105 UP000091820 UP000183832 UP000092461 UP000242457 UP000000311 UP000005203 UP000279307 UP000015103 UP000030742 UP000019118
UP000235965 UP000027135 UP000002320 UP000075880 UP000037069 UP000069272 UP000095300 UP000000673 UP000095301 UP000092553 UP000007798 UP000075886 UP000075884 UP000076408 UP000009192 UP000008820 UP000076502 UP000075883 UP000008792 UP000075809 UP000215335 UP000002358 UP000075920 UP000007062 UP000075885 UP000075840 UP000075900 UP000075902 UP000075903 UP000268350 UP000075881 UP000192221 UP000002282 UP000000803 UP000053825 UP000076407 UP000007801 UP000001070 UP000030765 UP000000304 UP000008711 UP000007266 UP000007755 UP000008237 UP000008744 UP000078541 UP000078542 UP000078492 UP000001819 UP000078540 UP000092443 UP000092460 UP000005205 UP000078200 UP000092444 UP000092445 UP000001292 UP000053105 UP000091820 UP000183832 UP000092461 UP000242457 UP000000311 UP000005203 UP000279307 UP000015103 UP000030742 UP000019118
Interpro
SUPFAM
SSF53335
SSF53335
ProteinModelPortal
H9J9C2
A0A2A4K9K3
A0A2W1BL47
A0A2H1WN99
A0A194R6F2
A0A194PZQ0
+ More
A0A212EJ53 A0A0L7L998 A0A2J7QFN2 A0A067REE3 A0A1Q3EZJ4 B0W8S4 A0A182JB81 A0A0L0CCY4 A0A182F2C1 A0A1I8NT36 W5JER9 A0A1I8MCI7 A0A0M3QUA8 B4MVJ8 A0A182Q043 A0A0Q9X0Q2 A0A182NUU0 A0A182Y5I0 B4KIZ5 Q17IW3 A0A154P7E7 A0A0K8VZG9 A0A182M3C0 A0A2M4BGL1 A0A2M4BGG8 B4LV98 A0A2M4BGG6 A0A151X879 A0A232F9G6 K7J3U0 A0A182WHF9 A0A2M4BGH2 Q7Q4L4 A0A034WKN7 A0A182P663 A0A182IBY5 W8C287 A0A182RRL7 A0A182TNK6 A0A182VBC3 A0A3B0K3M3 A0A182JXL9 A0A1W4UVV4 B4P430 M9PDA6 A0A0L7QR77 A0A182X143 A0A3B0JH74 B3MJT8 B4JAI9 A0A084VL35 A0A1Y1LZE3 B4Q3G0 B3NLZ5 D6WJR4 F4W732 Q9VIK9 E2BQP6 A0A2J7QFQ2 B4G750 A0A195F642 A0A195C3T6 A0A195DB25 Q29LW1 A0A195AY04 A0A1A9YH75 A0A1B0C3Z1 A0A158NM11 A0A1A9VI24 A0A1B0G2R0 A0A1B0A403 B4IFE3 A0A0M9A8N3 A0A1A9WM16 A0A1J1IG13 A0A0C9QWK3 A0A1B0CKW4 A0A2A3EN53 E1ZW85 A0A088AAP0 A0A2J7QFM8 A0A1B3PDN5 A0A1B6E9X9 A0A3L8E6M4 R4WT10 A0A069DZF7 A0A0V0G7B1 A0A023FAC4 T1HPJ7 A0A1B3PDA5 A0A1B6FY48 U4UGX3 N6T4Y7
A0A212EJ53 A0A0L7L998 A0A2J7QFN2 A0A067REE3 A0A1Q3EZJ4 B0W8S4 A0A182JB81 A0A0L0CCY4 A0A182F2C1 A0A1I8NT36 W5JER9 A0A1I8MCI7 A0A0M3QUA8 B4MVJ8 A0A182Q043 A0A0Q9X0Q2 A0A182NUU0 A0A182Y5I0 B4KIZ5 Q17IW3 A0A154P7E7 A0A0K8VZG9 A0A182M3C0 A0A2M4BGL1 A0A2M4BGG8 B4LV98 A0A2M4BGG6 A0A151X879 A0A232F9G6 K7J3U0 A0A182WHF9 A0A2M4BGH2 Q7Q4L4 A0A034WKN7 A0A182P663 A0A182IBY5 W8C287 A0A182RRL7 A0A182TNK6 A0A182VBC3 A0A3B0K3M3 A0A182JXL9 A0A1W4UVV4 B4P430 M9PDA6 A0A0L7QR77 A0A182X143 A0A3B0JH74 B3MJT8 B4JAI9 A0A084VL35 A0A1Y1LZE3 B4Q3G0 B3NLZ5 D6WJR4 F4W732 Q9VIK9 E2BQP6 A0A2J7QFQ2 B4G750 A0A195F642 A0A195C3T6 A0A195DB25 Q29LW1 A0A195AY04 A0A1A9YH75 A0A1B0C3Z1 A0A158NM11 A0A1A9VI24 A0A1B0G2R0 A0A1B0A403 B4IFE3 A0A0M9A8N3 A0A1A9WM16 A0A1J1IG13 A0A0C9QWK3 A0A1B0CKW4 A0A2A3EN53 E1ZW85 A0A088AAP0 A0A2J7QFM8 A0A1B3PDN5 A0A1B6E9X9 A0A3L8E6M4 R4WT10 A0A069DZF7 A0A0V0G7B1 A0A023FAC4 T1HPJ7 A0A1B3PDA5 A0A1B6FY48 U4UGX3 N6T4Y7
PDB
5WCJ
E-value=3.40816e-28,
Score=313
Ontologies
GO
Topology
Length:
657
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.07866
Exp number, first 60 AAs:
0.00039
Total prob of N-in:
0.00149
outside
1 - 657
Population Genetic Test Statistics
Pi
170.889754
Theta
137.736756
Tajima's D
-1.152037
CLR
0.700692
CSRT
0.111944402779861
Interpretation
Uncertain
