Gene

KWMTBOMO01664  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006105

Annotation

PREDICTED:_anaphase-promoting_complex_subunit_13-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr4(+):1140410-1141691      View in EpiBrowser

Full name

Anaphase-promoting complex subunit 13      

Alternative Name

Cyclosome subunit 13

Location in the cell

Nuclear   Reliability : 2.713

CDS

ATGGACAGTAAGTGTCGCCGTAACGGTCGCCTAATAGACATAGTTGATGAGGACTGGCGTGCGGAACAACTTCCTCACGAGGACATTCAAGTTCCGCTGGATGAGCTCCCGGACCCCGAGGCAGACAGCGCCGACTCTCATCTCACTCTAAAAGAGCAGAGCATGCGTTGGCAGGAGAATTTCCCTGAACCAGCGAGCAGTAATCAAAACTAG

Protein

MDSKCRRNGRLIDIVDEDWRAEQLPHEDIQVPLDELPDPEADSADSHLTLKEQSMRWQENFPEPASSNQN

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).

Subunit

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

Similarity

Belongs to the APC13 family.

Keywords

Cell cycle   Cell division   Complete proteome   Mitosis   Nucleus   Reference proteome   Ubl conjugation pathway  

Feature

chain  Anaphase-promoting complex subunit 13

Uniprot

H9J9B3   S4PHD2   A0A212EGU5   A0A194PZN4   A0A0L7KXH9   A0A0L7KUM8   + More
A0A2A3EQZ0   A0A088AF80   A0A224Y328   A0A069DNR7   A0A023FA82   A0A0V0GDT8   A0A2P8YVU8   A0A154P1T5   A0A067QVD4   A0A0P4VP53   R4G309   A0A139WH34   A0A310S9R7   E2BKZ3   A0A2M4AY03   A0A151IKA6   A0A195EEQ7   F4W9W8   A0A195EY46   A0A158NZI5   A0A151WKR5   A0A182XEV2   A0A182UK85   A0A182HNX8   A0A2M3ZCW0   W5JRS3   A0A0J7KQC2   E2A4Q6   Q7PQ30   A0A2M4C550   A0A026WAL0   A0A0L7QYQ3   A0A1I8PIM1   A0A182QYI4   A0A182MLP5   A0A182RKW0   A0A0K8R6K0   B7Q8J4   A0A2J7QCQ4   A0A182P8S8   A0A182K7W3   K7JCE8   A0A1I8N725   A0A336LCX2   A0A182G703   Q5RBV4   A0A2L2YHC5   A0A182WK22   A0A2J7RD63   U4UPW5   A0A232EDF1   A0A087U180   D3TRJ1   A0A0C9RZU1   A0A1B0FP98   H3AY45   N6TUI7   A0A226NCN8   A0A1L8DCU8   A0A091KF47   B5G2E5   A0A0A0ANS5   A0A093I9H5   A0A093CP24   A0A093ERQ3   A0A091HUA8   A0A091UW42   A0A091WL26   A0A087V753   A0A091LLC4   A0A091MLG3   A0A093DNA7   A0A091KA51   A0A091TG81   A0A2I0LUR1   A0A093R7P2   A0A093GNC1   A0A094KGE7   A0A093J3S4   A0A093H1N3   A0A091QD37   A0A087RD33   R0JW70   B5G2E3   A0A1U7RN24   A0A093R9D4   A0A091EI49   G1QBV4   A0A1S2ZMX8   S7PDV3   A0A1D5PVV7   I3N837   G3SST0   U6CR27  

Pubmed

19121390    23622113    22118469    26354079    26227816    26334808    + More
25474469    29403074    24845553    27129103    18362917    19820115    20798317    21719571    21347285    20920257    23761445    12364791    24508170    30249741    20075255    25315136    26483478    26561354    23537049    28648823    20353571    26131772    9215903    17018643    23371554    21993624    15592404   

EMBL

BABH01004417    GAIX01000509    JAA92051.1    AGBW02015019    OWR40704.1    KQ459584    + More
KPI98498.1    JTDY01004718    KOB67840.1    JTDY01005705    KOB66719.1    KZ288199    PBC33636.1    GFTR01000906    JAW15520.1    GBGD01003657    JAC85232.1    GBBI01000798    JAC17914.1    GECL01000260    JAP05864.1    PYGN01000332    PSN48374.1    KQ434803    KZC05909.1    KK852976    KDR13050.1    GDKW01002472    JAI54123.1    ACPB03020263    GAHY01002106    JAA75404.1    KQ971343    KYB27308.1    KQ767877    OAD53281.1    GL448858    EFN83647.1    GGFK01012352    MBW45673.1    KQ977234    KYN04703.1    KQ979039    KYN23334.1    GL888033    EGI69104.1    KQ981909    KYN33205.1    ADTU01000887    KQ983012    KYQ48371.1    APCN01002811    GGFM01005636    MBW26387.1    ADMH02000362    ETN66831.1    LBMM01004382    KMQ92481.1    GL436716    EFN71590.1    AAAB01008900    EAA09386.5    GGFJ01011289    MBW60430.1    KK107321    QOIP01000002    EZA52696.1    RLU25393.1    KQ414688    KOC63708.1    AXCN02001020    AXCM01001015    GADI01007021    JAA66787.1    ABJB010972031    DS884446    EEC15166.1    NEVH01016057    PNF26369.1    AAZX01003377    UFQS01002630    UFQT01002630    SSX14405.1    SSX33815.1    JXUM01149326    KQ570750    KXJ68307.1    CR858529    IAAA01022778    LAA07509.1    NEVH01005296    PNF38774.1    KI209939    ERL96114.1    NNAY01006739    OXU16364.1    KK117683    KFM71119.1    EZ424043    ADD20319.1    GBZX01002961    JAG89779.1    CCAG010016647    AFYH01050644    APGK01054147    APGK01054148    KB741247    ENN72041.1    MCFN01000098    OXB65288.1    GFDF01009793    JAV04291.1    KK739026    KFP38078.1    DQ216086    ACH45456.1    KL872353    KGL95213.1    KK589767    KFV99369.1    KL463494    KFV14699.1    KK612369    KFV46875.1    KL217789    KFO98727.1    KL410274    KFQ95189.1    KK735750    KFR15613.1    KL482444    KFO08445.1    KL328484    KFP57144.1    KK829451    KFP75327.1    KL227546    KFV03540.1    KK502098    KFP20631.1    KK451973    KFQ74098.1    AKCR02000089    PKK21165.1    KL225058    KFW67059.1    KK367895    KFV42015.1    KL349003    KFZ57640.1    KK569593    KFW06522.1    KL205870    KFV75576.1    KK659809    KFQ07434.1    KL226300    KFM11387.1    KB743085    EOB01507.1    DQ216084    DQ216085    ACH45454.1    KL435359    KFW92697.1    KK718435    KFO56327.1    AAPE02006101    KE161960    EPQ06097.1    AADN05000527    AGTP01046508    HAAF01000217    CCP72043.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000037510    UP000242457    UP000005203    + More
UP000245037    UP000076502    UP000027135    UP000015103    UP000007266    UP000008237    UP000078542    UP000078492    UP000007755    UP000078541    UP000005205    UP000075809    UP000076407    UP000075902    UP000075840    UP000000673    UP000036403    UP000000311    UP000007062    UP000053097    UP000279307    UP000053825    UP000095300    UP000075886    UP000075883    UP000075900    UP000001555    UP000235965    UP000075885    UP000075881    UP000002358    UP000095301    UP000069940    UP000249989    UP000001595    UP000075920    UP000030742    UP000215335    UP000054359    UP000092444    UP000008672    UP000019118    UP000198323    UP000053858    UP000054308    UP000053283    UP000053605    UP000053119    UP000053872    UP000054081    UP000053584    UP000053286    UP000189705    UP000052976    UP000001074    UP000079721    UP000000539    UP000005215    UP000007646   

PRIDE

H9J9B3   

Pfam

PF04900   Fcf1        + More
PF05839   Apc13p
PF01428   zf-AN1
PF00118   Cpn60_TCP1
PF01504   PIP5K
PF01363   FYVE

Interpro

IPR008401   Apc13p        + More
IPR029060   PIN-like_dom_sf       
IPR006984   Fcf1/Utp23       
IPR035896   AN1-like_Znf       
IPR000058   Znf_AN1       
IPR027409   GroEL-like_apical_dom_sf       
IPR000306   Znf_FYVE       
IPR002498   PInositol-4-P-5-kinase_core       
IPR011011   Znf_FYVE_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR017455   Znf_FYVE-rel       
IPR027484   PInositol-4-P-5-kinase_N       
IPR002423   Cpn60/TCP-1       

SUPFAM

SSF88723   SSF88723        + More
SSF118310   SSF118310       
SSF57903   SSF57903       
SSF52029   SSF52029       

Gene 3D

4.10.1110.10     3.30.40.10     3.30.800.10     3.50.7.10    

ProteinModelPortal

H9J9B3   S4PHD2   A0A212EGU5   A0A194PZN4   A0A0L7KXH9   A0A0L7KUM8   + More
A0A2A3EQZ0   A0A088AF80   A0A224Y328   A0A069DNR7   A0A023FA82   A0A0V0GDT8   A0A2P8YVU8   A0A154P1T5   A0A067QVD4   A0A0P4VP53   R4G309   A0A139WH34   A0A310S9R7   E2BKZ3   A0A2M4AY03   A0A151IKA6   A0A195EEQ7   F4W9W8   A0A195EY46   A0A158NZI5   A0A151WKR5   A0A182XEV2   A0A182UK85   A0A182HNX8   A0A2M3ZCW0   W5JRS3   A0A0J7KQC2   E2A4Q6   Q7PQ30   A0A2M4C550   A0A026WAL0   A0A0L7QYQ3   A0A1I8PIM1   A0A182QYI4   A0A182MLP5   A0A182RKW0   A0A0K8R6K0   B7Q8J4   A0A2J7QCQ4   A0A182P8S8   A0A182K7W3   K7JCE8   A0A1I8N725   A0A336LCX2   A0A182G703   Q5RBV4   A0A2L2YHC5   A0A182WK22   A0A2J7RD63   U4UPW5   A0A232EDF1   A0A087U180   D3TRJ1   A0A0C9RZU1   A0A1B0FP98   H3AY45   N6TUI7   A0A226NCN8   A0A1L8DCU8   A0A091KF47   B5G2E5   A0A0A0ANS5   A0A093I9H5   A0A093CP24   A0A093ERQ3   A0A091HUA8   A0A091UW42   A0A091WL26   A0A087V753   A0A091LLC4   A0A091MLG3   A0A093DNA7   A0A091KA51   A0A091TG81   A0A2I0LUR1   A0A093R7P2   A0A093GNC1   A0A094KGE7   A0A093J3S4   A0A093H1N3   A0A091QD37   A0A087RD33   R0JW70   B5G2E3   A0A1U7RN24   A0A093R9D4   A0A091EI49   G1QBV4   A0A1S2ZMX8   S7PDV3   A0A1D5PVV7   I3N837   G3SST0   U6CR27  

PDB

5LCW     E-value=1.76859e-09,     Score=143

KEGG

NA   

GO

GO:0005680   GO:0032040   GO:0008270   GO:0005524   GO:0046872   GO:0016307   GO:0010008   GO:0046854   GO:0000285   GO:0070979   GO:0051301   GO:0007049  

Subcellular location

Nucleus  

Length:

70

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.83602

inside

1  -  70

 

 

Pi

260.476347

Theta

202.812636

Tajima's D

0.903684

CLR

0.002506

CSRT

0.624918754062297

Interpretation

Uncertain