Gene

KWMTBOMO01658  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006047

Annotation

PREDICTED:_calcium_channel_flower_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr4(-):1054281-1064929      View in EpiBrowser

Full name

Calcium channel flower       + More
Autophagy-related protein 3      

Location in the cell

Nuclear   Reliability : 2.747

CDS

ATGTCGTTAACGGACAAGATATCGATGCTCATGTCGCGTCCGGGGGGTGACAATGCCCAGAAAGATGACGTTCCTACTTGGATGCGATATGCTGGACGGGGTCTTGGAACAGTTGGCAGCTTCATCGCCATCTTCTTTGGTCTCTTCAACTGCTTGGGCATTCTAACCTTGGACGTGCCGTGCCTGATCGCGGGCATATGGCAGATGCTTGCTGGTTTCATTGTCATAGTATGCGAGGCTCCCTGCTGCTGTTTCTTCATCGACTACGTGGGGACCTTGAGCCAGAAAATGGAGACCAGACCTTATTGGAACAAGGCCGCTATGTATCTTGGACTGGCCGTGCCTCCGTTTTTCCTTTGCTTCTTCAGTTTCAGTACGTGGTTGGGTAGCGGACTGATATTCGCCACCGGGATCATATACGGAATGATGGCGCTCGGCAAAAAAGCGTCAATAGAGGACATGCGGTCGTCGGCGGCCAATCTGGAGGCGGGCGTGGGGCCAACAACCGCGCCCCGAGCAACCCTCGTTACCAACGAGCAGCCCGTCAGCTTCACCGGCACGCCTGTCACCAAGTGA

Protein

MSLTDKISMLMSRPGGDNAQKDDVPTWMRYAGRGLGTVGSFIAIFFGLFNCLGILTLDVPCLIAGIWQMLAGFIVIVCEAPCCCFFIDYVGTLSQKMETRPYWNKAAMYLGLAVPPFFLCFFSFSTWLGSGLIFATGIIYGMMALGKKASIEDMRSSAANLEAGVGPTTAPRATLVTNEQPVSFTGTPVTK

Description

A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis. Required in the nervous system and necessary in photoreceptor cells (By similarity).
A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis. Isoform A and isoform B are mainly required in the nervous system and necessary in photoreceptor cells.

Subunit

Homomultimer.
Homomultimer; Isoform B.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Belongs to the calcium channel flower family.
Belongs to the ATG3 family.
Belongs to the tetraspanin (TM4SF) family.

Keywords

Calcium   Calcium channel   Calcium transport   Cell junction   Complete proteome   Cytoplasmic vesicle   Endocytosis   Ion channel   Ion transport   Membrane   Reference proteome   Synapse   Transmembrane   Transmembrane helix   Transport   Alternative splicing  

Feature

chain  Calcium channel flower
splice variant  In isoform C.

Uniprot

H9J955   A0A194PZM8   A0A1E1WH15   A0A2A4JVY1   S4PFF6   A0A2H1WRF6   + More
A0A194R7P6   A0A310SD89   A0A0L7R4Q2   A0A0T6AX73   A0A2A3E0W8   A0A1Y1M821   A0A067RNN1   A0A0N0U7H4   A0A026VT25   F4W5W0   E9IJF1   V5GYY9   A0A154P600   A0A158P2U4   A0A2J7RF42   A0A2A3E244   V9IK87   A0A088ADA6   U5EYA5   D6WJ36   A0A0J7N6C2   A0A0C9RCB6   A0A2W1BL35   A0A3L8DS08   A0A1L8DEZ4   A0A1B0CJL6   N6T4S6   A0A195DFH9   A0A195BPM4   A0A182MXU1   A0A069DQG0   A0A224XY48   A0A023EIN2   Q17MR0   A0A0K8TQQ4   A0A182Y5Y6   A0A182G9K9   A0A0P4W0X5   E0VVH2   A0A2M4C0F0   E2AI05   A0A023F010   A0A1B6GRP1   Q7QGH6   A0A182Q7L2   A0A195C2E2   T1E7N1   A0A2M3ZKK9   A0A2M4AMR1   A0A182UV36   A0A182WEU8   A0A0V0G7P7   A0A182MHX3   A0A195EYK5   T1HDB7   A0A182LP65   A0A182U8J1   A0A182HNB2   A0A182XC14   A0A0A9X349   E2BZ86   A0A182RD38   W5J8H2   A0A087ZIR7   A0A1Q3FY30   Q17MQ9   B3M9W1   Q17MQ8   A0A1W7R5A9   A0A1W4WHP6   A0A0M3QWB9   A0A1Q3G3K1   A0A182FBI5   A0A232EN66   B4J043   A0A1W4VNR7   A0A3B0KIX6   A0A0A1XQP6   A0A212EZ16   A0A1B6FQY0   Q95T12   A0A182JIK1   A0A2M4AQT0   A0A1B6CZ35   A0A0J9ULS9   B4QLP9   A0A0R3P864   B4GRI8   B4PD01   A0A0A9WJ01   A0A1A9V4E8   A0A182PKW0   D3TQ18   B3NDM7  

Pubmed

19121390    26354079    23622113    28004739    24845553    24508170    + More
21719571    21282665    21347285    18362917    19820115    28756777    30249741    23537049    26334808    24945155    17510324    26369729    25244985    26483478    27129103    20566863    20798317    25474469    12364791    14747013    17210077    20966253    25401762    26823975    20920257    17994087    28648823    25830018    22118469    10731132    12537572    12537569    19737521    22936249    15632085    23185243    20353571   

EMBL

BABH01004402    KQ459584    KPI98493.1    GDQN01004903    JAT86151.1    NWSH01000576    + More
PCG75550.1    GAIX01006610    JAA85950.1    ODYU01010496    SOQ55643.1    KQ460644    KPJ13260.1    KQ762903    OAD55294.1    KQ414657    KOC65845.1    LJIG01022598    KRT79722.1    KZ288467    PBC25403.1    GEZM01038240    JAV81701.1    KK852514    KDR22200.1    KQ435698    KOX80744.1    KK108116    EZA46892.1    GL887695    EGI70436.1    GL763766    EFZ19301.1    GALX01001364    JAB67102.1    KQ434823    KZC07297.1    ADTU01007483    NEVH01004414    PNF39437.1    PBC25402.1    JR049712    AEY61047.1    GANO01000482    JAB59389.1    KQ971342    EFA03876.1    LBMM01009288    KMQ88245.1    GBYB01005950    JAG75717.1    KZ150105    PZC73440.1    QOIP01000005    RLU23096.1    GFDF01009052    JAV05032.1    AJWK01014723    AJWK01014724    APGK01044152    KB741020    KB631628    ENN75139.1    ERL84853.1    KQ980903    KYN11638.1    KQ976432    KYM87447.1    GBGD01002998    JAC85891.1    GFTR01003293    JAW13133.1    GAPW01004300    JAC09298.1    CH477204    EAT47962.1    GDAI01000919    JAI16684.1    JXUM01049369    JXUM01049370    JXUM01049371    KQ561601    KXJ78031.1    GDKW01000050    JAI56545.1    DS235811    EEB17378.1    GGFJ01009317    MBW58458.1    GL439621    EFN66913.1    GBBI01003865    JAC14847.1    GECZ01019535    GECZ01004663    JAS50234.1    JAS65106.1    AAAB01008834    EAA05716.4    AXCN02002117    KQ978344    KYM94992.1    GAMD01002887    JAA98703.1    GGFM01008313    MBW29064.1    GGFK01008716    MBW42037.1    GECL01002104    JAP04020.1    AXCM01005743    KQ981905    KYN33375.1    ACPB03015513    ACPB03015514    ACPB03015515    APCN01001900    GBHO01029175    GBRD01011351    GDHC01017176    JAG14429.1    JAG54473.1    JAQ01453.1    GL451577    EFN78992.1    ADMH02002103    ETN59089.1    GGFL01004627    MBW68805.1    GFDL01002575    JAV32470.1    EAT47963.1    CH902618    EDV40152.1    EAT47964.1    GEHC01001277    JAV46368.1    CP012525    ALC43873.1    GFDL01000660    JAV34385.1    NNAY01003207    OXU19790.1    CH916366    EDV97836.1    OUUW01000009    SPP85041.1    GBXI01000976    JAD13316.1    AGBW02011391    OWR46736.1    GECZ01018114    GECZ01017171    JAS51655.1    JAS52598.1    AE014296    AY060385    AAL25424.1    AAN11767.1    GGFK01009637    MBW42958.1    GEDC01026658    GEDC01026102    GEDC01018673    GEDC01002784    JAS10640.1    JAS11196.1    JAS18625.1    JAS34514.1    CM002912    KMY99825.1    CM000363    EDX10598.1    CH379069    KRT07766.1    KRT07767.1    CH479188    EDW40373.1    CM000159    EDW94933.1    GBHO01038769    GDHC01000405    JAG04835.1    JAQ18224.1    EZ423520    ADD19796.1    CH954178    EDV52160.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000053825    UP000242457    + More
UP000027135    UP000053105    UP000053097    UP000007755    UP000076502    UP000005205    UP000235965    UP000005203    UP000007266    UP000036403    UP000279307    UP000092461    UP000019118    UP000030742    UP000078492    UP000078540    UP000075884    UP000008820    UP000076408    UP000069940    UP000249989    UP000009046    UP000000311    UP000007062    UP000075886    UP000078542    UP000075903    UP000075920    UP000075883    UP000078541    UP000015103    UP000075882    UP000075902    UP000075840    UP000076407    UP000008237    UP000075900    UP000000673    UP000007801    UP000192223    UP000092553    UP000069272    UP000215335    UP000001070    UP000192221    UP000268350    UP000007151    UP000000803    UP000075880    UP000000304    UP000001819    UP000008744    UP000002282    UP000078200    UP000075885    UP000008711   

PRIDE

H9J955    B4J043    Q95T12   

Pfam

PF10233   Cg6151-P        + More
PF00225   Kinesin
PF00271   Helicase_C
PF00270   DEAD
PF03987   Autophagy_act_C
PF00651   BTB
PF00335   Tetraspanin
PF03986   Autophagy_N
PF09237   GAGA
PF10381   Autophagy_C

Interpro

IPR019365   TVP18/Ca-channel_flower        + More
IPR036961   Kinesin_motor_dom_sf       
IPR019821   Kinesin_motor_CS       
IPR001752   Kinesin_motor_dom       
IPR027640   Kinesin-like_fam       
IPR027417   P-loop_NTPase       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR019461   Autophagy-rel_prot_3_C       
IPR008952   Tetraspanin_EC2_sf       
IPR007134   Autophagy-rel_prot_3_N       
IPR007135   Autophagy-rel_prot_3       
IPR000210   BTB/POZ_dom       
IPR011333   SKP1/BTB/POZ_sf       
IPR013087   Znf_C2H2_type       
IPR015318   Znf_GAGA-bd_fac       
IPR018499   Tetraspanin/Peripherin       

SUPFAM

SSF52540   SSF52540        + More
SSF54695   SSF54695       
SSF48652   SSF48652       

Gene 3D

3.40.850.10     1.10.1450.10    

CDD

cd00079  HELICc

ProteinModelPortal

H9J955   A0A194PZM8   A0A1E1WH15   A0A2A4JVY1   S4PFF6   A0A2H1WRF6   + More
A0A194R7P6   A0A310SD89   A0A0L7R4Q2   A0A0T6AX73   A0A2A3E0W8   A0A1Y1M821   A0A067RNN1   A0A0N0U7H4   A0A026VT25   F4W5W0   E9IJF1   V5GYY9   A0A154P600   A0A158P2U4   A0A2J7RF42   A0A2A3E244   V9IK87   A0A088ADA6   U5EYA5   D6WJ36   A0A0J7N6C2   A0A0C9RCB6   A0A2W1BL35   A0A3L8DS08   A0A1L8DEZ4   A0A1B0CJL6   N6T4S6   A0A195DFH9   A0A195BPM4   A0A182MXU1   A0A069DQG0   A0A224XY48   A0A023EIN2   Q17MR0   A0A0K8TQQ4   A0A182Y5Y6   A0A182G9K9   A0A0P4W0X5   E0VVH2   A0A2M4C0F0   E2AI05   A0A023F010   A0A1B6GRP1   Q7QGH6   A0A182Q7L2   A0A195C2E2   T1E7N1   A0A2M3ZKK9   A0A2M4AMR1   A0A182UV36   A0A182WEU8   A0A0V0G7P7   A0A182MHX3   A0A195EYK5   T1HDB7   A0A182LP65   A0A182U8J1   A0A182HNB2   A0A182XC14   A0A0A9X349   E2BZ86   A0A182RD38   W5J8H2   A0A087ZIR7   A0A1Q3FY30   Q17MQ9   B3M9W1   Q17MQ8   A0A1W7R5A9   A0A1W4WHP6   A0A0M3QWB9   A0A1Q3G3K1   A0A182FBI5   A0A232EN66   B4J043   A0A1W4VNR7   A0A3B0KIX6   A0A0A1XQP6   A0A212EZ16   A0A1B6FQY0   Q95T12   A0A182JIK1   A0A2M4AQT0   A0A1B6CZ35   A0A0J9ULS9   B4QLP9   A0A0R3P864   B4GRI8   B4PD01   A0A0A9WJ01   A0A1A9V4E8   A0A182PKW0   D3TQ18   B3NDM7  

KEGG

101747044    no KO assigned | (RefSeq) calcium channel flower

GO

GO:0016021   GO:0016192   GO:0008017   GO:0005524   GO:0007018   GO:0003777   GO:0003676   GO:0043525   GO:0150008   GO:0099533   GO:0048488   GO:0150007   GO:0044214   GO:0030285   GO:0005262   GO:0042802   GO:0046530   GO:0030054   GO:0035212   GO:0005737   GO:0015031   GO:0006914   GO:0042981   GO:0070588   GO:0006816   GO:0005886   GO:0019079   GO:0043066   GO:0043154   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR13314   PTHR24115  

Subcellular location

   Upon fusion of the synaptic vesicle with the presynaptic membrane, protein is present in the periactive zones, where endocytosis is known to occur.   With evidence from 1 publications.
Cytoplasm  

Length:

191

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

78.67001

Exp number, first 60 AAs:

22.43114

Total prob of N-in:

0.85334

POSSIBLE N-term signal

sequence

inside

1  -  33

TMhelix

34  -  56

outside

57  -  70

TMhelix

71  -  93

inside

94  -  105

TMhelix

106  -  128

outside

129  -  131

TMhelix

132  -  151

inside

152  -  191

 

 

Pi

165.171363

Theta

156.158753

Tajima's D

-0.626171

CLR

10.40874

CSRT

0.210139493025349

Interpretation

Uncertain