Gene

KWMTBOMO01644  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006057

Annotation

PREDICTED:_sodium/potassium-transporting_ATPase_subunit_beta-2-like_[Papilio_polytes]

Location

Bomo_Chr4(-):889233-896421      View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit beta-2      

Alternative Name

Protein nervana 2
Sodium/potassium-dependent ATPase subunit beta-2

Location in the cell

Cytoplasmic   Reliability : 2.431

CDS

ATGGACACCAAGCCGCCCCGAAAGAGTTTTCAACACAAATTCAGTGATTTTCTGCATAATGATGAGACTGGTACTATTTTAGGTCGCACTCCTGAAAGCTGGTCTAAGATCTTGGTCTTCTATACGATATTCTATGCAGCACTCATAGCTCTGTTTGCAATCTGCATGGTGACATTCCTGCAACAGTTCATTAACCCCCGAGTACCTCGTCTCCAACAGGAGTACAGTGTGATTGGTACAAGTCCAGGCTTGGGCTTCCGACCCCTTCCCGCTGATGTAAGGAGTACACTAATATATTACAAGGGAACAGGATATGAAAGCTATAAATTTTGGGAAGACCAGCTGATTGATTTCTTGTCAGTATACAAGAAGAAAGGGCAGACGGCAGGCACGGGTCAGAATATTTTCAACTGTGACTTTAGGAATCCACCTCCCCCTGGCAAGGTCTGTGACGTAGACATCCGAAGCTGGGATCCTTGCATTGAAGAGAATCACTTCTCCTTCCACAAGTCTTCACCTTGCATCTTCCTGAAGCTTAATAGGATCTACGGCTGGCGGCCCGAGTTCTTCGACGACCTGGCGAGCCTCCCGCGCGACATGCCCGACGACCTGGTCTCCTACATCACGAACGCCACCGCCAACAACCGGGACTATGCCAACATGGTGTGGGTGTCGTGCCAAGGCGAGACCCCGGCCGACAGGGAGATGTTGGGCCCCATCAGCTACCTGCCTTACCCTGGTTTCCCGGGATATTTCTATCCCTACGAAAACGCGGAGGGATATTTGAGTCCGCTCGTGGCCATACATCTTCAATCTCCTAAAACTGGCATAATACTGAACATCGAGTGTCGCGCCTGGGCCAAGAACATCAGGTACGACCGCCGGGAGAAGCTAGGGGTCGTTCACTTCGAGCTTATGCTGGAGTAA

Protein

MDTKPPRKSFQHKFSDFLHNDETGTILGRTPESWSKILVFYTIFYAALIALFAICMVTFLQQFINPRVPRLQQEYSVIGTSPGLGFRPLPADVRSTLIYYKGTGYESYKFWEDQLIDFLSVYKKKGQTAGTGQNIFNCDFRNPPPPGKVCDVDIRSWDPCIEENHFSFHKSSPCIFLKLNRIYGWRPEFFDDLASLPRDMPDDLVSYITNATANNRDYANMVWVSCQGETPADREMLGPISYLPYPGFPGYFYPYENAEGYLSPLVAIHLQSPKTGIILNIECRAWAKNIRYDRREKLGVVHFELMLE

Description

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Similarity

Belongs to the X(+)/potassium ATPases subunit beta family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion transport   Membrane   Potassium   Potassium transport   Reference proteome   Signal-anchor   Sodium   Sodium transport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium-transporting ATPase subunit beta-2
splice variant  In isoform 2.1.

Uniprot

H9J965   A0A2H1V2Z3   A0A2W1BI97   A0A2A4JHJ4   A0A194PYR8   A0A212F3C8   + More
A0A0N1PGD8   A0A0L7KVS8   A0A0L7KZ37   A0A212F3C0   A0A0K2S4T7   A0A0A1XLF2   T1PK16   A0A194Q0F6   T1P7P0   A0A1I8NAQ9   A0A0L0BL02   A0A2H1VT27   A0A034VNN3   W8ALM6   A0A0K8W790   A0A2A4K0R6   U5EXA6   A0A1I8Q9N6   A0A2W1BE21   A0A1I8Q9T2   A0A151X0L1   A0A034VPI2   A0A0A1XIS6   A0A0Q5WAH7   A0A151JW23   A0A0Q9X198   A0A195BJK0   A0A158P3Y8   F4WKT5   A0A151JM32   Q24048-2   Q1RL12   W8AQQ7   E2C795   A0A3L8DD16   A0A0Q9WFY6   A0A0J9QX06   A0A182JE55   A0A2C9H707   Q7Q3B0   A0A0R3NQZ8   E9J1Q7   A0A1W4UNJ0   A0A0R1DR04   J9EAN8   A0A1B0FFL4   B4LRJ7   A0A0Q9XBM1   A0A195CN39   A0A1L8DF34   B4N1F6   A0A0N8NZ69   Q16TR9   A0A023EQW5   A0A3B0JUA9   Q29P10   B4GJW8   A0A154NY27   E2AJ48   A0A182X1I1   B3N5X3   A0A182URH5   A0A182L2K0   A0A1S4GW98   A0A182HDG2   B4JB94   A0A310S7A7   V9IJT5   T1D4D1   A0A2M3Z1Y5   A0A194R6X6   A0A182FNA7   A4V0B5   Q24048   A0A182QHA3   A0A1W4UQD7   A0A088A4D5   A0A2M4AFG7   A0A0J9THC4   B4HXY0   A0A1L8DFI6   A0A026WUE4   B3MKP9   A0A067RA63   A0A2M4BU32   A0A0L7QPX7   T1EB20   B4P009   B4KKY6   A0A3B0JUB9   A0A2M4CPQ7   A0A2M4CPK3   A0A336MCH0   A0A1B6G1H7  

Pubmed

19121390    28756777    26354079    22118469    26227816    25830018    + More
25315136    26108605    25348373    24495485    17994087    21347285    21719571    7777518    10731132    12537572    12537569    7540667    9648860    17893096    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20798317    30249741    22936249    12364791    14747013    17210077    15632085    23185243    21282665    17550304    17510324    24945155    20966253    26483478    24330624    24508170    18057021    24845553   

EMBL

BABH01004378    ODYU01000439    SOQ35210.1    KZ150105    PZC73425.1    NWSH01001558    + More
PCG70862.1    KQ459584    KPI98482.1    AGBW02010580    OWR48236.1    KQ458968    KPJ04531.1    JTDY01005126    KOB67343.1    JTDY01004233    KOB68415.1    OWR48239.1    LC029031    BAS22118.1    GBXI01006452    GBXI01004712    GBXI01002506    JAD07840.1    JAD09580.1    JAD11786.1    KA649142    AFP63771.1    KPI98479.1    KA644517    KA649141    AFP59146.1    JRES01001704    KNC20746.1    ODYU01004281    SOQ43980.1    GAKP01015261    GAKP01015260    GAKP01015259    JAC43692.1    GAMC01019728    JAB86827.1    GDHF01030989    GDHF01028963    GDHF01005372    JAI21325.1    JAI23351.1    JAI46942.1    NWSH01000323    PCG77484.1    GANO01002628    JAB57243.1    PZC73422.1    KQ982612    KYQ53877.1    GAKP01015263    GAKP01015262    JAC43690.1    GBXI01005074    GBXI01003386    JAD09218.1    JAD10906.1    CH954177    KQS70647.1    KQ981701    KYN37501.1    CH963920    KRF98806.1    KQ976453    KYM85348.1    ADTU01008623    GL888206    EGI65177.1    KQ978949    KYN27360.1    U22439    U22440    AE014134    AY060289    BT025048    AAF52439.1    AAX52660.1    ABE73219.1    GAMC01019727    JAB86828.1    GL453340    EFN76208.1    QOIP01000009    RLU18375.1    CH940649    KRF81175.1    CM002910    KMY88624.1    KMY88626.1    KMY88627.1    KMY88628.1    AAAB01008964    EAA12801.3    CH379058    KRT03574.1    KRT03575.1    KRT03576.1    GL767674    EFZ13198.1    CM000157    KRJ97425.1    CH477641    EJY57851.1    CCAG010002985    CCAG010002986    EDW63592.1    CH933807    KRG02858.1    KQ977513    KYN02161.1    GFDF01009089    JAV04995.1    EDW78067.1    CH902620    KPU73492.1    EAT37924.1    EAT37926.1    GAPW01002579    JAC11019.1    OUUW01000010    SPP85695.1    EAL34483.1    CH479184    EDW36934.1    KQ434782    KZC04576.1    GL439967    EFN66488.1    EDV59132.1    JXUM01034452    JXUM01034453    JXUM01034454    JXUM01034455    JXUM01034456    KQ561023    KXJ79990.1    CH916368    EDW02899.1    KQ766043    OAD53764.1    JR049281    AEY60917.1    GALA01001003    JAA93849.1    GGFM01001775    MBW22526.1    KQ460644    KPJ13274.1    AAX52659.1    AGB92700.1    AXCN02002071    AXCN02002072    GGFK01006218    MBW39539.1    KMY88625.1    CH480818    EDW51910.1    GFDF01008939    JAV05145.1    KK107119    EZA58729.1    EDV31580.1    KPU73493.1    KPU73494.1    KK852595    KDR20644.1    GGFJ01007372    MBW56513.1    KQ414813    KOC60536.1    GAMD01000463    JAB01128.1    EDW87836.1    KRJ97426.1    KRJ97427.1    EDW11716.1    SPP85694.1    GGFL01003105    MBW67283.1    GGFL01003076    MBW67254.1    UFQT01000377    SSX23728.1    GECZ01013485    JAS56284.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037510    UP000095301    + More
UP000037069    UP000095300    UP000075809    UP000008711    UP000078541    UP000007798    UP000078540    UP000005205    UP000007755    UP000078492    UP000000803    UP000008237    UP000279307    UP000008792    UP000075880    UP000076407    UP000007062    UP000001819    UP000192221    UP000002282    UP000008820    UP000092444    UP000009192    UP000078542    UP000007801    UP000268350    UP000008744    UP000076502    UP000000311    UP000075903    UP000075882    UP000069940    UP000249989    UP000001070    UP000053240    UP000069272    UP000075886    UP000005203    UP000001292    UP000053097    UP000027135    UP000053825   

PRIDE

H9J965    Q24048    Q1RL12    A4V0B5   

Pfam

PF00287   Na_K-ATPase

Interpro

IPR038702   Na/K_ATPase_sub_beta_sf        + More
IPR000402   Na/K_ATPase_sub_beta       

Gene 3D

2.60.40.1660    

ProteinModelPortal

H9J965   A0A2H1V2Z3   A0A2W1BI97   A0A2A4JHJ4   A0A194PYR8   A0A212F3C8   + More
A0A0N1PGD8   A0A0L7KVS8   A0A0L7KZ37   A0A212F3C0   A0A0K2S4T7   A0A0A1XLF2   T1PK16   A0A194Q0F6   T1P7P0   A0A1I8NAQ9   A0A0L0BL02   A0A2H1VT27   A0A034VNN3   W8ALM6   A0A0K8W790   A0A2A4K0R6   U5EXA6   A0A1I8Q9N6   A0A2W1BE21   A0A1I8Q9T2   A0A151X0L1   A0A034VPI2   A0A0A1XIS6   A0A0Q5WAH7   A0A151JW23   A0A0Q9X198   A0A195BJK0   A0A158P3Y8   F4WKT5   A0A151JM32   Q24048-2   Q1RL12   W8AQQ7   E2C795   A0A3L8DD16   A0A0Q9WFY6   A0A0J9QX06   A0A182JE55   A0A2C9H707   Q7Q3B0   A0A0R3NQZ8   E9J1Q7   A0A1W4UNJ0   A0A0R1DR04   J9EAN8   A0A1B0FFL4   B4LRJ7   A0A0Q9XBM1   A0A195CN39   A0A1L8DF34   B4N1F6   A0A0N8NZ69   Q16TR9   A0A023EQW5   A0A3B0JUA9   Q29P10   B4GJW8   A0A154NY27   E2AJ48   A0A182X1I1   B3N5X3   A0A182URH5   A0A182L2K0   A0A1S4GW98   A0A182HDG2   B4JB94   A0A310S7A7   V9IJT5   T1D4D1   A0A2M3Z1Y5   A0A194R6X6   A0A182FNA7   A4V0B5   Q24048   A0A182QHA3   A0A1W4UQD7   A0A088A4D5   A0A2M4AFG7   A0A0J9THC4   B4HXY0   A0A1L8DFI6   A0A026WUE4   B3MKP9   A0A067RA63   A0A2M4BU32   A0A0L7QPX7   T1EB20   B4P009   B4KKY6   A0A3B0JUB9   A0A2M4CPQ7   A0A2M4CPK3   A0A336MCH0   A0A1B6G1H7  

PDB

4XE5     E-value=2.76989e-10,     Score=155

KEGG

101746152    K01540 sodium/potassium-transporting ATPase subunit beta | (RefSeq) sodium/potassium-transporting AT

GO

GO:0005890   GO:0006813   GO:0006814   GO:0007424   GO:0098655   GO:0006812   GO:0005918   GO:0061343   GO:0005886   GO:0019991   GO:0035151   GO:0030424   GO:0007605   GO:0035159   GO:0060857   GO:0010248   GO:0035158   GO:0005391   GO:0016021   GO:0001671   GO:0030007   GO:0006883   GO:1990573   GO:0036376   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11523  

Subcellular location

Cell membrane  

Length:

308

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.92331

Exp number, first 60 AAs:

22.71192

Total prob of N-in:

0.91293

POSSIBLE N-term signal

sequence

inside

1  -  37

TMhelix

38  -  60

outside

61  -  308

 

 

Pi

28.718179

Theta

49.861286

Tajima's D

-1.862545

CLR

0.307859

CSRT

0.023698815059247

Interpretation

Uncertain