Gene

KWMTBOMO01641

Pre Gene Modal

BGIBMGA006099

Annotation

Na?K-ATPase_beta-subunit_[Bombyx_mori]

Location

Bomo_Chr4(+):840032-846432      View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit beta-2      

Alternative Name

Protein nervana 2
Sodium/potassium-dependent ATPase subunit beta-2

Location in the cell

Nuclear   Reliability : 2.842

CDS

ATGACGGTTAAGAAACGAACATCCGACCTGACGAGCTTAGAGCGATTCAACATGTACTACAGGGAGAAGGAACCACCTCTAACCAGATCTCAAAAAGTGAAACGGTTCATCTGGAACCCGAAGACCAGGCAGTTCTGTGGAAGAACAGGATCTAGTTGGTCAAAAATAGCATTGTTCTATTTTATCTTCTACTCCGCACTCGCCATCCTAGTCGCTATCTGCATGTGGACGTTCCTCCAGCTTTTGGATGCTAGGCAACCGAAATGGCAGCTCGAGAGGAGCATCATTGGCACTAACCCAGGGCTGGGCTTCAGGCCAACGCCTCCGGAGGTCGCCAGCAGTGTCATCTGGTACAAGGGAAATGACCCGGGTAGCCAACAGTTCTGGGTTAAAAAGCTATCCACCTTCTTAGCTGCGTACAAGCGCGATGGCAAAAAAGCTGGTGCGGGCCAGAACATCCACAACTGTGACTTCAAGCTTCCTCCTCCGGCTGGGAAAGTCTGCGATGTAGACATCAGCGCGTGGGGACCTTGCGTGCAGGACAACTATTTCGGCTACCACAAATCGACACCCTGCATCTTCCTGAAGCTAAATAAGATCTACGGTTGGAGGCCCAAGTTCTACAACAGCTCTGACAATCTACCCAAAGACATGCCGGAAGACTTGAAGGAGCACATCAGGAACATGACGGCGTATGATAAGAACTACCTAAACATGGTTTGGGTTTCCTGCCAAGGCGAGAACCCAGCTGATCGCGAGAACATTGGTCCCATACAGTACCTACCTCACCGAGGCTTCCCGGGATACTACTTCCCCTACACCAACCAAGAAGGATACCTGAGCCCTCTTGTAGCTGTGCACTTGCAGAGACCTAAGACTGGCATGTTAATCAACATTGAATGTCGTGCCTGGGCGAACAACATCAAGTATGAGAGACTTGAAGCCATGGGCTCTGTACACATCGAGATGTTGATCGAGTAG

Protein

MTVKKRTSDLTSLERFNMYYREKEPPLTRSQKVKRFIWNPKTRQFCGRTGSSWSKIALFYFIFYSALAILVAICMWTFLQLLDARQPKWQLERSIIGTNPGLGFRPTPPEVASSVIWYKGNDPGSQQFWVKKLSTFLAAYKRDGKKAGAGQNIHNCDFKLPPPAGKVCDVDISAWGPCVQDNYFGYHKSTPCIFLKLNKIYGWRPKFYNSSDNLPKDMPEDLKEHIRNMTAYDKNYLNMVWVSCQGENPADRENIGPIQYLPHRGFPGYYFPYTNQEGYLSPLVAVHLQRPKTGMLINIECRAWANNIKYERLEAMGSVHIEMLIE

Description

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Similarity

Belongs to the X(+)/potassium ATPases subunit beta family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion transport   Membrane   Potassium   Potassium transport   Reference proteome   Signal-anchor   Sodium   Sodium transport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium-transporting ATPase subunit beta-2
splice variant  In isoform 2.1.

Uniprot

A0A0K2S4T7   A0A194Q0F6   A0A2W1BE21   A0A2A4K0R6   A0A2H1VT27   A0A212F3C0   + More
A0A194R6X6   H9J9A7   A0A3L8DD16   A0A151JW23   E9J1Q7   A0A151X0L1   A0A195BJK0   A0A158P3Y8   E2C795   F4WKT5   E2AJ48   A0A026WUE4   A0A195CN39   A0A151JM32   A0A336M5T7   A0A194PYR8   A0A2H1V2Z3   V9IJT5   A0A088A4D5   A0A310S7A7   A0A034VPI2   A0A154NY27   W8AQQ7   A0A0A1XIS6   A0A2C9H707   Q7Q3B0   A0A0L7QPX7   B4LRJ7   Q16TR9   T1D4D1   A0A1L8DFI6   A0A1Q3G4C7   B4JB94   A0A0L0BL02   B4KKY6   T1PK16   A0A232ETF2   K7IVU1   A0A182URH5   A0A182X1I1   A0A2W1BI97   A0A0K8W790   B4N1F6   A0A182L2K0   A0A1S4GW98   A0A1I8Q9N6   A0A034VNN3   E0VS44   W5U5U7   A0A182QHA3   A0A0Q9WFY6   A0A2A4JHJ4   U5EXA6   A0A212F3C8   A0A182JE55   A0A336MCH0   B4P009   A0A0A1XLF2   A4V0B5   Q24048   J9EAN8   W8ALM6   A0A0Q9X198   A0A0J9THC4   B4HXY0   A0A023EQW5   A0A1S4JIQ4   B3N5X3   B3MKP9   A0A2M4CPQ7   A0A1B0FFL4   A0A1W4UQD7   A0A2M3Z1Y5   A0A0Q9XBM1   A0A2M4CPK3   A0A1L8DF34   T1EB20   A0A2M4AFG7   A0A182HDG2   Q24048-2   Q1RL12   A0A182FNA7   A0A0J9QX06   Q29P10   B4GJW8   A0A182XZM8   A0A0R1DR04   A0A067RA63   A0A2M4BU32   A0A1Q3FIL8   A0A1W4UNJ0   A0A0Q5WAH7   A0A0N8NZ69   A0A3B0JUB9  

Pubmed

26354079    28756777    22118469    19121390    30249741    21282665    + More
21347285    20798317    21719571    24508170    25348373    24495485    25830018    12364791    14747013    17210077    17994087    17510324    24330624    26108605    25315136    28648823    20075255    20966253    20566863    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    7777518    12537569    7540667    9648860    17893096    22936249    24945155    18057021    26483478    15632085    25244985    24845553   

EMBL

LC029031    BAS22118.1    KQ459584    KPI98479.1    KZ150105    PZC73422.1    + More
NWSH01000323    PCG77484.1    ODYU01004281    SOQ43980.1    AGBW02010580    OWR48239.1    KQ460644    KPJ13274.1    BABH01004376    BABH01004377    QOIP01000009    RLU18375.1    KQ981701    KYN37501.1    GL767674    EFZ13198.1    KQ982612    KYQ53877.1    KQ976453    KYM85348.1    ADTU01008623    GL453340    EFN76208.1    GL888206    EGI65177.1    GL439967    EFN66488.1    KK107119    EZA58729.1    KQ977513    KYN02161.1    KQ978949    KYN27360.1    UFQT01000377    SSX23727.1    KPI98482.1    ODYU01000439    SOQ35210.1    JR049281    AEY60917.1    KQ766043    OAD53764.1    GAKP01015263    GAKP01015262    JAC43690.1    KQ434782    KZC04576.1    GAMC01019727    JAB86828.1    GBXI01005074    GBXI01003386    JAD09218.1    JAD10906.1    AAAB01008964    EAA12801.3    KQ414813    KOC60536.1    CH940649    EDW63592.1    CH477641    EAT37924.1    EAT37926.1    GALA01001003    JAA93849.1    GFDF01008939    JAV05145.1    GFDL01000429    JAV34616.1    CH916368    EDW02899.1    JRES01001704    KNC20746.1    CH933807    EDW11716.1    KA649142    AFP63771.1    NNAY01002286    OXU21622.1    PZC73425.1    GDHF01030989    GDHF01028963    GDHF01005372    JAI21325.1    JAI23351.1    JAI46942.1    CH963920    EDW78067.1    GAKP01015261    GAKP01015260    GAKP01015259    JAC43692.1    DS235744    EEB16200.1    KF813100    AHH35013.1    AXCN02002071    AXCN02002072    KRF81175.1    NWSH01001558    PCG70862.1    GANO01002628    JAB57243.1    OWR48236.1    SSX23728.1    CM000157    EDW87836.1    KRJ97426.1    KRJ97427.1    GBXI01006452    GBXI01004712    GBXI01002506    JAD07840.1    JAD09580.1    JAD11786.1    AE014134    AAX52659.1    AGB92700.1    U22439    U22440    AY060289    EJY57851.1    GAMC01019728    JAB86827.1    KRF98806.1    CM002910    KMY88625.1    CH480818    EDW51910.1    GAPW01002579    JAC11019.1    CH954177    EDV59132.1    CH902620    EDV31580.1    KPU73493.1    KPU73494.1    GGFL01003105    MBW67283.1    CCAG010002985    CCAG010002986    GGFM01001775    MBW22526.1    KRG02858.1    GGFL01003076    MBW67254.1    GFDF01009089    JAV04995.1    GAMD01000463    JAB01128.1    GGFK01006218    MBW39539.1    JXUM01034452    JXUM01034453    JXUM01034454    JXUM01034455    JXUM01034456    KQ561023    KXJ79990.1    BT025048    AAF52439.1    AAX52660.1    ABE73219.1    KMY88624.1    KMY88626.1    KMY88627.1    KMY88628.1    CH379058    EAL34483.1    CH479184    EDW36934.1    KRJ97425.1    KK852595    KDR20644.1    GGFJ01007372    MBW56513.1    GFDL01007628    JAV27417.1    KQS70647.1    KPU73492.1    OUUW01000010    SPP85694.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000053240    UP000005204    UP000279307    + More
UP000078541    UP000075809    UP000078540    UP000005205    UP000008237    UP000007755    UP000000311    UP000053097    UP000078542    UP000078492    UP000005203    UP000076502    UP000076407    UP000007062    UP000053825    UP000008792    UP000008820    UP000001070    UP000037069    UP000009192    UP000095301    UP000215335    UP000002358    UP000075903    UP000007798    UP000075882    UP000095300    UP000009046    UP000075886    UP000075880    UP000002282    UP000000803    UP000001292    UP000008711    UP000007801    UP000092444    UP000192221    UP000069940    UP000249989    UP000069272    UP000001819    UP000008744    UP000076408    UP000027135    UP000268350   

PRIDE

H9J9A7    A4V0B5    Q24048    Q1RL12   

Pfam

PF00287   Na_K-ATPase

Interpro

IPR000402   Na/K_ATPase_sub_beta        + More
IPR038702   Na/K_ATPase_sub_beta_sf       

Gene 3D

2.60.40.1660    

ProteinModelPortal

A0A0K2S4T7   A0A194Q0F6   A0A2W1BE21   A0A2A4K0R6   A0A2H1VT27   A0A212F3C0   + More
A0A194R6X6   H9J9A7   A0A3L8DD16   A0A151JW23   E9J1Q7   A0A151X0L1   A0A195BJK0   A0A158P3Y8   E2C795   F4WKT5   E2AJ48   A0A026WUE4   A0A195CN39   A0A151JM32   A0A336M5T7   A0A194PYR8   A0A2H1V2Z3   V9IJT5   A0A088A4D5   A0A310S7A7   A0A034VPI2   A0A154NY27   W8AQQ7   A0A0A1XIS6   A0A2C9H707   Q7Q3B0   A0A0L7QPX7   B4LRJ7   Q16TR9   T1D4D1   A0A1L8DFI6   A0A1Q3G4C7   B4JB94   A0A0L0BL02   B4KKY6   T1PK16   A0A232ETF2   K7IVU1   A0A182URH5   A0A182X1I1   A0A2W1BI97   A0A0K8W790   B4N1F6   A0A182L2K0   A0A1S4GW98   A0A1I8Q9N6   A0A034VNN3   E0VS44   W5U5U7   A0A182QHA3   A0A0Q9WFY6   A0A2A4JHJ4   U5EXA6   A0A212F3C8   A0A182JE55   A0A336MCH0   B4P009   A0A0A1XLF2   A4V0B5   Q24048   J9EAN8   W8ALM6   A0A0Q9X198   A0A0J9THC4   B4HXY0   A0A023EQW5   A0A1S4JIQ4   B3N5X3   B3MKP9   A0A2M4CPQ7   A0A1B0FFL4   A0A1W4UQD7   A0A2M3Z1Y5   A0A0Q9XBM1   A0A2M4CPK3   A0A1L8DF34   T1EB20   A0A2M4AFG7   A0A182HDG2   Q24048-2   Q1RL12   A0A182FNA7   A0A0J9QX06   Q29P10   B4GJW8   A0A182XZM8   A0A0R1DR04   A0A067RA63   A0A2M4BU32   A0A1Q3FIL8   A0A1W4UNJ0   A0A0Q5WAH7   A0A0N8NZ69   A0A3B0JUB9  

PDB

4XE5     E-value=6.77949e-29,     Score=316

KEGG

101746632    K01540 sodium/potassium-transporting ATPase subunit beta | (RefSeq) sodium/potassium-transporting AT

GO

GO:0005890   GO:0006814   GO:0006813   GO:0016021   GO:0001671   GO:0030007   GO:0006883   GO:1990573   GO:0010248   GO:0036376   GO:0035158   GO:0060857   GO:0007605   GO:0030424   GO:0061343   GO:0019991   GO:0005391   GO:0005918   GO:0035159   GO:0035151   GO:0005886   GO:0098655   GO:0006812   GO:0007424   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11523  

Subcellular location

Cell membrane  

Length:

326

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.88913

Exp number, first 60 AAs:

4.03857

Total prob of N-in:

0.99121

inside

1  -  56

TMhelix

57  -  79

outside

80  -  326

 

 

Pi

201.236599

Theta

163.043747

Tajima's D

0.706672

CLR

0

CSRT

0.576421178941053

Interpretation

Uncertain