Gene

KWMTBOMO01638  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006063

Annotation

PREDICTED:_sodium/potassium-transporting_ATPase_subunit_beta-2-like_[Papilio_machaon]

Location

Bomo_Chr4(-):799150-806431      View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit beta-2      

Alternative Name

Protein nervana 2
Sodium/potassium-dependent ATPase subunit beta-2

Location in the cell

Extracellular   Reliability : 1.33 PlasmaMembrane   Reliability : 1.104

CDS

ATGTACATCAAACAACTGATCCCATTATGCCCGAGCAAGCGAGGCACCCCATCCCAAGACCTCACAATGCCTCACATTCTGCGTTCTATCTCTCAACCACACGGACGTGCTAGCTTTGGGGTACTAACAAGTCAAGTTCAATCTCTTATAATGGGTATGGAAAAACGCACCGTGAAAATAATTATCGCCGTAGCTGTCACCGTGATCGTCATTGCTACAATCCTTGGACTGCTGTTGGGTCTGCTGCTACCGCAACGCTATGTTGAGCTGGAGGTGTGGCCTCGATCTGAGGAGTTCAACTATTATCAACCGATGATCCATTTCACGCCGAGTGACGCCGGCAGCTGGCATCCTTGGTACCGACGCATCAGTGAATTCCTTAAAGTCTACGAGACTTCTGTTCCCGATAATCCACCTCGAGCTCCATGCACCATTCACAACCAGCGCGACATGATCATCCGTTCCGACTCCTGCAGCGTGGCCATGAAAGTATGGGCTCCTTGCACAGCTGATCATTTTTATGGCTACCCCGATGGCAGACCGTGCGTGTTCTTACGGTTATCTCACGTTCATTACTGGGTTCCGCATCCTTACAACATCACCTCACCTCTGCCGATCCCGCAGGAGATGCCACAAAACCTACAGTTCATGATGCGTCAATTCCCTGCTGATAAATACGGCGACACGATCTGGGTGAGCTGCGAAGGTGAGTTCACGGCTGACAAGGAGAACATCGGGCCTGTCCACATCGTGCCCATGTTGTTGCCTCCAGGCTTCCCGACGCACCGCCTCCACACCGCCGATAAGATCCCTTATGCCACCAGGAACCTACCTGATCCAGTGCCCGGGCCACTTGTCGCCGTTTACTTCGAGAATCCCAGACGTGGAGTGGTAGTGAACGTGGAATGTCGTATCTGGTCGCGTGATATTATCTACAGCCCTTCTAGCCGCGTCGGAAGGGCCCGTTTTGAGTTGCTAGTACAGTGA

Protein

MYIKQLIPLCPSKRGTPSQDLTMPHILRSISQPHGRASFGVLTSQVQSLIMGMEKRTVKIIIAVAVTVIVIATILGLLLGLLLPQRYVELEVWPRSEEFNYYQPMIHFTPSDAGSWHPWYRRISEFLKVYETSVPDNPPRAPCTIHNQRDMIIRSDSCSVAMKVWAPCTADHFYGYPDGRPCVFLRLSHVHYWVPHPYNITSPLPIPQEMPQNLQFMMRQFPADKYGDTIWVSCEGEFTADKENIGPVHIVPMLLPPGFPTHRLHTADKIPYATRNLPDPVPGPLVAVYFENPRRGVVVNVECRIWSRDIIYSPSSRVGRARFELLVQ

Description

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Similarity

Belongs to the LAMP family.
Belongs to the X(+)/potassium ATPases subunit beta family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion transport   Membrane   Potassium   Potassium transport   Reference proteome   Signal-anchor   Sodium   Sodium transport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium-transporting ATPase subunit beta-2
splice variant  In isoform 2.1.

Uniprot

H9J971   A0A2A4K1H6   A0A2W1CP79   A0A2H1VZX0   A0A2W1BWL9   A0A194R6I6   + More
A0A194PYS3   A0A212F3E7   K7IVU1   A0A232ETF2   A0A212F3C9   A0A0L7LDP8   A0A1A9W5H2   A0A1B0ATI7   A0A1A9XQN8   A0A1A9VF43   A0A2H1VU14   W8ALM6   A0A1B0FFL4   W8AQQ7   A0A1I8Q9N6   A0A1I8Q9T2   A0A0N0U489   K7IVU0   A0A034VMN5   A0A0L0BL02   A0A2A4K154   A0A2W1BL15   A0A194RBK0   A0A232F5D8   A0A1A9ZFE8   T1E275   A0A034VNN3   T1E8B1   A0A182F246   A0A182QDC3   A0A034VPI2   A0A310SHK5   A0A2M4CTN4   H9J970   A0A0K8W790   E0W229   U5EXA6   A0A2M4A6M2   A0A182IDW3   Q7PK91   A0A2M4CLL9   E2AJ49   A0A0A1XLF2   T1PK16   A0A0C9RLC5   A0A1I8NAQ9   A0A0A1XIS6   U5EVF5   T1P7P0   A0A2M3Z0F1   A0A2M4BUW5   A0A182V944   A0A0L7QPH5   B4P009   A0A0R1DR04   A0A0J9QX06   A0A0J9THC4   A0A194PYR3   E2C794   A0A182GXN1   B4HXY0   A0A182Y5L6   A0A0J7L1W9   A0A0Q9X198   A0A154PEL0   A0A023EPB7   A0A195BKU6   Q16RY8   B4N1F6   A0A1Q3FYT7   A0A336MCH0   A0A1Q3FYQ3   Q24048-2   Q1RL12   A4V0B5   Q24048   A0A336M5T7   A0A2S2PDY7   A0A151X0X1   A0A1W4UQD7   F4WKT6   A0A195CN73   A0A1W4UNJ0   B3N5X3   A0A0Q5WAH7   A0A336LVH5   A0A0N8NZ69   B3MKP9   E9J1Q5  

Pubmed

19121390    28756777    26354079    22118469    20075255    28648823    + More
26227816    24495485    25348373    26108605    24330624    20566863    12364791    14747013    17210077    20798317    25830018    25315136    17994087    17550304    22936249    26483478    25244985    24945155    17510324    7777518    10731132    12537572    12537569    7540667    9648860    17893096    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21719571    18057021    21282665   

EMBL

BABH01004373    BABH01004374    NWSH01000323    PCG77482.1    NHMN01024311    PZC87404.1    + More
ODYU01005489    SOQ46390.1    KZ149934    PZC77200.1    KQ460644    KPJ13277.1    KQ459584    KPI98476.1    AGBW02010580    OWR48242.1    NNAY01002286    OXU21622.1    OWR48241.1    JTDY01001561    KOB73524.1    JXJN01003333    ODYU01004281    SOQ43982.1    GAMC01019728    JAB86827.1    CCAG010002985    CCAG010002986    GAMC01019727    JAB86828.1    KQ435840    KOX71432.1    GAKP01015258    JAC43694.1    JRES01001704    KNC20746.1    PCG77483.1    KZ150105    PZC73420.1    KPJ13276.1    NNAY01000939    OXU25822.1    GALA01000989    JAA93863.1    GAKP01015261    GAKP01015260    GAKP01015259    JAC43692.1    GAMD01002332    JAA99258.1    AXCN02000751    AXCN02000752    GAKP01015263    GAKP01015262    JAC43690.1    KQ766043    OAD53765.1    GGFL01004447    MBW68625.1    BABH01004375    GDHF01030989    GDHF01028963    GDHF01005372    JAI21325.1    JAI23351.1    JAI46942.1    DS235874    EEB19685.1    GANO01002628    JAB57243.1    GGFK01002957    MBW36278.1    APCN01004534    APCN01004535    AAAB01008980    EAA43463.4    GGFL01001987    MBW66165.1    GL439967    EFN66489.1    GBXI01006452    GBXI01004712    GBXI01002506    JAD07840.1    JAD09580.1    JAD11786.1    KA649142    AFP63771.1    GBYB01007721    JAG77488.1    GBXI01005074    GBXI01003386    JAD09218.1    JAD10906.1    GANO01001901    JAB57970.1    KA644517    KA649141    AFP59146.1    GGFM01001261    MBW22012.1    GGFJ01007600    MBW56741.1    KQ414813    KOC60537.1    CM000157    EDW87836.1    KRJ97426.1    KRJ97427.1    KRJ97425.1    CM002910    KMY88624.1    KMY88626.1    KMY88627.1    KMY88628.1    KMY88625.1    KPI98477.1    GL453340    EFN76207.1    JXUM01095755    KQ564216    KXJ72578.1    CH480818    EDW51910.1    LBMM01001166    KMQ96792.1    CH963920    KRF98806.1    KQ434874    KZC09650.1    GAPW01002763    JAC10835.1    KQ976453    KYM85345.1    CH477692    EAT37221.1    EDW78067.1    GFDL01002339    JAV32706.1    UFQT01000377    SSX23728.1    GFDL01002340    JAV32705.1    U22439    U22440    AE014134    AY060289    BT025048    AAF52439.1    AAX52660.1    ABE73219.1    AAX52659.1    AGB92700.1    SSX23727.1    GGMR01015040    MBY27659.1    KQ982612    KYQ53875.1    GL888206    EGI65178.1    KQ977513    KYN02163.1    CH954177    EDV59132.1    KQS70647.1    UFQT01000215    SSX21830.1    CH902620    KPU73492.1    EDV31580.1    KPU73493.1    KPU73494.1    GL767674    EFZ13266.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000002358    + More
UP000215335    UP000037510    UP000091820    UP000092460    UP000092443    UP000078200    UP000092444    UP000095300    UP000053105    UP000037069    UP000092445    UP000069272    UP000075886    UP000009046    UP000075840    UP000007062    UP000000311    UP000095301    UP000075903    UP000053825    UP000002282    UP000008237    UP000069940    UP000249989    UP000001292    UP000076408    UP000036403    UP000007798    UP000076502    UP000078540    UP000008820    UP000000803    UP000075809    UP000192221    UP000007755    UP000078542    UP000008711    UP000007801   

PRIDE

H9J971    H9J970    Q24048    Q1RL12    A4V0B5   

Pfam

PF01299   Lamp        + More
PF00287   Na_K-ATPase

Interpro

IPR000402   Na/K_ATPase_sub_beta        + More
IPR002000   Lysosome-assoc_membr_glycop       
IPR038702   Na/K_ATPase_sub_beta_sf       
IPR018134   LAMP_CS       
IPR036026   Seven-hairpin_glycosidases       

SUPFAM

SSF48225   SSF48225       

Gene 3D

2.60.40.1660    

ProteinModelPortal

H9J971   A0A2A4K1H6   A0A2W1CP79   A0A2H1VZX0   A0A2W1BWL9   A0A194R6I6   + More
A0A194PYS3   A0A212F3E7   K7IVU1   A0A232ETF2   A0A212F3C9   A0A0L7LDP8   A0A1A9W5H2   A0A1B0ATI7   A0A1A9XQN8   A0A1A9VF43   A0A2H1VU14   W8ALM6   A0A1B0FFL4   W8AQQ7   A0A1I8Q9N6   A0A1I8Q9T2   A0A0N0U489   K7IVU0   A0A034VMN5   A0A0L0BL02   A0A2A4K154   A0A2W1BL15   A0A194RBK0   A0A232F5D8   A0A1A9ZFE8   T1E275   A0A034VNN3   T1E8B1   A0A182F246   A0A182QDC3   A0A034VPI2   A0A310SHK5   A0A2M4CTN4   H9J970   A0A0K8W790   E0W229   U5EXA6   A0A2M4A6M2   A0A182IDW3   Q7PK91   A0A2M4CLL9   E2AJ49   A0A0A1XLF2   T1PK16   A0A0C9RLC5   A0A1I8NAQ9   A0A0A1XIS6   U5EVF5   T1P7P0   A0A2M3Z0F1   A0A2M4BUW5   A0A182V944   A0A0L7QPH5   B4P009   A0A0R1DR04   A0A0J9QX06   A0A0J9THC4   A0A194PYR3   E2C794   A0A182GXN1   B4HXY0   A0A182Y5L6   A0A0J7L1W9   A0A0Q9X198   A0A154PEL0   A0A023EPB7   A0A195BKU6   Q16RY8   B4N1F6   A0A1Q3FYT7   A0A336MCH0   A0A1Q3FYQ3   Q24048-2   Q1RL12   A4V0B5   Q24048   A0A336M5T7   A0A2S2PDY7   A0A151X0X1   A0A1W4UQD7   F4WKT6   A0A195CN73   A0A1W4UNJ0   B3N5X3   A0A0Q5WAH7   A0A336LVH5   A0A0N8NZ69   B3MKP9   E9J1Q5  

PDB

3A3Y     E-value=4.88232e-13,     Score=179

KEGG

101745575    K01540 sodium/potassium-transporting ATPase subunit beta | (RefSeq) sodium/potassium-transporting AT

GO

GO:0006814   GO:0006813   GO:0005890   GO:0005509   GO:0004571   GO:0006883   GO:0030007   GO:0001671   GO:0010248   GO:0036376   GO:1990573   GO:0030424   GO:0061343   GO:0019991   GO:0060857   GO:0035158   GO:0007605   GO:0005918   GO:0005391   GO:0007424   GO:0098655   GO:0006812   GO:0005886   GO:0035151   GO:0035159   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779   GO:0016021  

PANTHER

PTHR11506   PTHR11523  

Subcellular location

Membrane  
Cell membrane  

Length:

328

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.72885

Exp number, first 60 AAs:

0.87083

Total prob of N-in:

0.96498

inside

1  -  59

TMhelix

60  -  82

outside

83  -  328

 

 

Pi

273.056085

Theta

154.034583

Tajima's D

2.618257

CLR

0.591899

CSRT

0.957002149892505

Interpretation

Uncertain