Gene

KWMTBOMO01625

Pre Gene Modal

BGIBMGA006093

Annotation

PREDICTED:_kelch-like_protein_diablo_[Papilio_xuthus]

Location

Bomo_Chr4(+):489802-499214      View in EpiBrowser

Full name

Kelch-like protein diablo      

Location in the cell

Extracellular   Reliability : 1.205 Lysosomal   Reliability : 1.232

CDS

ATGGGTGAGGGCGGATCCCCAGGTGGCGCGCGGCTGTCCCACACCTCGGAGAAACATCCGCGCGCCATACTCGGCGAACTCTCCGCACTGCGACGTCATCGTGAGCTATGCGATGTCGTGCTCAACGTTGCTAACAGGAAACTCTTTGCTCACAGAGTAATCCTATCAGCATGCAGCCCGTACTTCCGAGCGATGTTCACTGGGGAACTGGCCGAGTCTCGCGCCACCGAAGTCACGATCCGGGACGTGGACGAGCAGGCCATGGAGCAGCTCGTGGAGTTCTGCTACACCGCGCACATCGTCGTCGAGGAGAGTAACGTGCAGGCCCTGCTCCCGGCTGCGTGCCTGCTGCAGCTGCAAGAGATCCAGGACGTGTGCTGCGAGTTCCTCAAGCGTCAGCTGGACTGCTCCAACTGCCTCGGCATCAGAGCCTTCGCCGACACCCACTCGTGTCGGGAACTGCTCCGGATCGCCGATAAATTCACACAACAGAACTTCCCAGAGGTGATGGAGAGTGAAGAGTTCTTACTGCTGCCCGCCTCGCAGCTGATCGACATCGTGTCCTCGGACGAGCTGAACGTTCGCTCGGAGGAGCAGACTTTCCAGGCCGTCATGTCCTGGGTCAAGTACAACGTGGCCGAGCGGCGGCAGCACCTGGCGCAGGTGCTCCAGCACGTCCGACTGCCGCTGCTGAGTCCCAAGTTCCTGGTGGGCACCGTCTCCTCGGAGCTGCTGATCCGCTCCGACGACGCCTGCCGCGACCTGCTGGACGAGGCCAAGAACTACCTGCTGCTGCCGCAGGAGCGTCCGCTCATGCAGGGACCTAGGACTCGGCCCAGGAAGCCTACCAGGCGTGGCGAGGTGCTGTTCGCGGTGGGCGGCTGGTGCTCCGGGGACGCCATCGCGTCGGTGGAGCGGTTCGACCCGCAGAGCGGCGAGTGGAAGATGGTGGCGCCCATGTCCAAGCGGCGCTGCGGCGTGGGCGTGGCCGTGCTGCACGACCTGCTGTACGCAGTGGGCGGCCACGACGGACAGAGCTACCTCAACAGCATCGAGCGGTACGACCCGCAGACCAACCAGTGGTGCGGCGCCGTCGCGCCCACGTCGTCGTGCCGCACGTCCGTGGGCGTGGCCGTGCTGGAGGGCGCGCTGTACGCCGTGGGCGGGCAGGACGGCGTCCAGTGCCTCAACCACGTCGAGCGGTACGACCCCAAGGAGAACCGCTGGACCAAGGTCGCGCCCATGACCACGCGGCGTCTGGGCGTCGCCGTGGCAGTGCTGGGCGGACATCTGTACGCCGTGGGCGGCTCCGACGGGCAGGCGCCGCTCAACACCGTAGAGCGGTACGACCCGCGGCACAACAAGTGGACGCCCGTGGCCCCCATGTCCACCAGGAGGAAGCACCTGGGCTGCGCCGTGTTCGACGGGCAGATCTACGCCGTGGGGGGCCGGGACGACTGCACCGAGCTGTCCTCCGCCGAACGGTACGAGCCCAGCACGGACTCGTGGGCGCCCGTGGTGGCCATGACGTCGCGCCGGTCGGGCGTGGGGCTCGCCGTGGTCAACTCGCAGCTCTACGCCGTCGGGGGCTTCGACGGGACCGCCTACCTCAAGTCCATCGAGGTGTTCGATCCGGAATCGAACCAGTGGCGGCTGTGCGGCGCCATGAACTACCGGCGGCTCGGCGGCGGCGTCGGCGTCATGCGCTCGCCGCACCACGACACGCACTACATCTGGAACCGAAAAGATTCAGTGGTGTAA

Protein

MGEGGSPGGARLSHTSEKHPRAILGELSALRRHRELCDVVLNVANRKLFAHRVILSACSPYFRAMFTGELAESRATEVTIRDVDEQAMEQLVEFCYTAHIVVEESNVQALLPAACLLQLQEIQDVCCEFLKRQLDCSNCLGIRAFADTHSCRELLRIADKFTQQNFPEVMESEEFLLLPASQLIDIVSSDELNVRSEEQTFQAVMSWVKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVSSELLIRSDDACRDLLDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQSGEWKMVAPMSKRRCGVGVAVLHDLLYAVGGHDGQSYLNSIERYDPQTNQWCGAVAPTSSCRTSVGVAVLEGALYAVGGQDGVQCLNHVERYDPKENRWTKVAPMTTRRLGVAVAVLGGHLYAVGGSDGQAPLNTVERYDPRHNKWTPVAPMSTRRKHLGCAVFDGQIYAVGGRDDCTELSSAERYEPSTDSWAPVVAMTSRRSGVGLAVVNSQLYAVGGFDGTAYLKSIEVFDPESNQWRLCGAMNYRRLGGGVGVMRSPHHDTHYIWNRKDSVV

Description

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth (By similarity).
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.

Keywords

Actin-binding   Complete proteome   Kelch repeat   Reference proteome   Repeat   Ubl conjugation pathway   Phosphoprotein  

Feature

chain  Kelch-like protein diablo

Uniprot

H9J9A1   A0A212F7Y2   A0A2A4K823   A0A2W1BX11   A0A2H1VFF1   W5J897   + More
Q16RL8   A0A146KZV2   A0A1A9Y0X7   A0A1B0B6W7   A0A1A9W745   A0A2M4AEL0   A0A2M4BIR6   A0A0K8U4L8   A0A195F637   A0A158NLX1   A0A0A1WSQ3   M9PFL3   A0A1W4W686   A0A0C9RKS8   A0A1Y1KE61   A0A336LST5   A0A0C9R0D6   A0A0J9RW76   A0A182X7R8   A0A182MXQ1   A0A182WEQ6   A0A182HN73   A0A1L8DMN9   A0A195DB30   K7J3U8   A0A1B0CL92   A0A151X803   A0A1W4VB51   F4W735   E2A5N0   A0A0Q9XPU5   E9JBX9   A0A088AAP2   A0A1B0F0A0   A0A0N1IU24   A0A1I8Q6X6   A0A1I8N3N7   A0A154PMY4   A0A224X981   A0A0L7QR81   A0A067REC6   A0A182FBI1   A0A1W4WHX5   A0A1A9V3U5   A0A1B6D573   A0A182RAP5   A0A0N7Z9C2   A0A182UVU6   A0A1Q3G3J6   B0WWP2   W8BP65   A0A182PUL3   A0A1B0G8K6   A0A182LVF7   A0A195C1X6   A0A2M3ZHH3   A0A182UFW4   U5EMM9   A0A2J7RF21   A0A0R1DYG0   B4PD06   B4HIK1   Q9VUU5   A0A3B0KMK6   A0A2J7RF25   A0A0M4E9P4   A0A0Q5UK10   B3NDN0   B3M9V8   B4GRJ2   A0A0J9RVU5   B4QLQ2   A0A182IXM2   D6WNA5   A0A0R3P3S1   Q2M0J9   B4L0G9   B4J045   A0A0Q9WJY0   A0A1W4VMU2   B4LIG6   Q7QGL0   B4MXW3   A0A2A3EMJ6   A0A182Y623   A0A182QA14   A0A182LP13   A0A1S4H734   A0A182SAU3   A0A0P6E7W0   A0A3L8E441   A0A0P5ZBA5   E9FR39   A0A0P5DZD4  

Pubmed

19121390    22118469    28756777    20920257    23761445    17510324    + More
26823975    21347285    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    28004739    22936249    20075255    21719571    20798317    17994087    18057021    21282665    25315136    24845553    27129103    24495485    17550304    16408305    18327897    18362917    19820115    15632085    23185243    12364791    25244985    20966253    30249741    21292972   

EMBL

BABH01004347    AGBW02009824    OWR49833.1    NWSH01000047    PCG80219.1    KZ149934    + More
PZC77216.1    ODYU01002281    SOQ39555.1    ADMH02002103    ETN59095.1    CH477704    EAT37050.1    GDHC01016758    GDHC01002501    JAQ01871.1    JAQ16128.1    JXJN01009256    GGFK01005882    MBW39203.1    GGFJ01003567    MBW52708.1    GDHF01031636    GDHF01031089    GDHF01023387    GDHF01022982    GDHF01013229    GDHF01001251    JAI20678.1    JAI21225.1    JAI28927.1    JAI29332.1    JAI39085.1    JAI51063.1    KQ981805    KYN35637.1    ADTU01002193    GBXI01012752    JAD01540.1    AE014296    AGB94585.1    GBYB01007521    JAG77288.1    GEZM01091177    JAV57057.1    UFQS01000171    UFQT01000171    SSX00706.1    SSX21086.1    GBYB01006401    GBYB01006402    GBYB01006404    JAG76168.1    JAG76169.1    JAG76171.1    CM002912    KMY99832.1    APCN01001877    GFDF01006474    JAV07610.1    KQ981042    KYN10093.1    AJWK01017047    KQ982431    KYQ56493.1    GL887802    EGI70025.1    GL437023    EFN71227.1    CH933809    KRG06513.1    KRG06514.1    GL771642    EFZ09633.1    AJVK01007787    KQ435711    KOX79474.1    KQ434994    KZC13203.1    GFTR01007530    JAW08896.1    KQ414784    KOC61133.1    KK852514    KDR22201.1    GEDC01016446    GEDC01012954    JAS20852.1    JAS24344.1    GDKW01000955    JAI55640.1    GFDL01000667    JAV34378.1    DS232150    EDS36134.1    GAMC01008087    JAB98468.1    CCAG010000259    AXCM01004742    KQ978344    KYM94847.1    GGFM01007243    MBW27994.1    GANO01000954    JAB58917.1    NEVH01004414    PNF39435.1    CM000159    KRK02120.1    EDW94938.1    CH480815    EDW41631.1    AB027612    AF237711    BT010272    AAF49578.1    AAQ23590.1    BAD06413.1    OUUW01000009    SPP85038.1    PNF39436.1    CP012525    ALC43854.1    CH954178    KQS44130.1    EDV52163.1    CH902618    EDV40149.1    CH479188    EDW40377.1    KMY99833.1    CM000363    EDX10601.1    KQ971342    EFA03772.1    CH379069    KRT07769.1    KRT07770.1    EAL30933.2    EDW19138.1    CH916366    EDV97838.1    CH940647    KRF85085.1    EDW70753.1    AAAB01008834    CH963876    EDW76882.1    KZ288210    PBC32927.1    AXCN02001048    GDIQ01080991    JAN13746.1    QOIP01000001    RLU27185.1    GDIP01046201    JAM57514.1    GL732523    EFX90258.1    GDIP01150141    LRGB01000248    JAJ73261.1    KZS20043.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000000673    UP000008820    UP000092443    + More
UP000092460    UP000091820    UP000078541    UP000005205    UP000000803    UP000192223    UP000076407    UP000075884    UP000075920    UP000075840    UP000078492    UP000002358    UP000092461    UP000075809    UP000192221    UP000007755    UP000000311    UP000009192    UP000005203    UP000092462    UP000053105    UP000095300    UP000095301    UP000076502    UP000053825    UP000027135    UP000069272    UP000078200    UP000075900    UP000075903    UP000002320    UP000075885    UP000092444    UP000075883    UP000078542    UP000075902    UP000235965    UP000002282    UP000001292    UP000268350    UP000092553    UP000008711    UP000007801    UP000008744    UP000000304    UP000075880    UP000007266    UP000001819    UP000001070    UP000008792    UP000007062    UP000007798    UP000242457    UP000076408    UP000075886    UP000075882    UP000075901    UP000279307    UP000000305    UP000076858   

PRIDE

H9J9A1    Q16RL8    B0WWP2    Q9VUU5    Q7QGL0   

Pfam

PF01344   Kelch_1        + More
PF00651   BTB
PF07707   BACK

Interpro

IPR011333   SKP1/BTB/POZ_sf        + More
IPR017096   BTB-kelch_protein       
IPR000210   BTB/POZ_dom       
IPR006652   Kelch_1       
IPR015915   Kelch-typ_b-propeller       
IPR011043   Gal_Oxase/kelch_b-propeller       
IPR011705   BACK       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF54695   SSF54695        + More
SSF50965   SSF50965       
SSF117281   SSF117281       

Gene 3D

2.120.10.80    

ProteinModelPortal

H9J9A1   A0A212F7Y2   A0A2A4K823   A0A2W1BX11   A0A2H1VFF1   W5J897   + More
Q16RL8   A0A146KZV2   A0A1A9Y0X7   A0A1B0B6W7   A0A1A9W745   A0A2M4AEL0   A0A2M4BIR6   A0A0K8U4L8   A0A195F637   A0A158NLX1   A0A0A1WSQ3   M9PFL3   A0A1W4W686   A0A0C9RKS8   A0A1Y1KE61   A0A336LST5   A0A0C9R0D6   A0A0J9RW76   A0A182X7R8   A0A182MXQ1   A0A182WEQ6   A0A182HN73   A0A1L8DMN9   A0A195DB30   K7J3U8   A0A1B0CL92   A0A151X803   A0A1W4VB51   F4W735   E2A5N0   A0A0Q9XPU5   E9JBX9   A0A088AAP2   A0A1B0F0A0   A0A0N1IU24   A0A1I8Q6X6   A0A1I8N3N7   A0A154PMY4   A0A224X981   A0A0L7QR81   A0A067REC6   A0A182FBI1   A0A1W4WHX5   A0A1A9V3U5   A0A1B6D573   A0A182RAP5   A0A0N7Z9C2   A0A182UVU6   A0A1Q3G3J6   B0WWP2   W8BP65   A0A182PUL3   A0A1B0G8K6   A0A182LVF7   A0A195C1X6   A0A2M3ZHH3   A0A182UFW4   U5EMM9   A0A2J7RF21   A0A0R1DYG0   B4PD06   B4HIK1   Q9VUU5   A0A3B0KMK6   A0A2J7RF25   A0A0M4E9P4   A0A0Q5UK10   B3NDN0   B3M9V8   B4GRJ2   A0A0J9RVU5   B4QLQ2   A0A182IXM2   D6WNA5   A0A0R3P3S1   Q2M0J9   B4L0G9   B4J045   A0A0Q9WJY0   A0A1W4VMU2   B4LIG6   Q7QGL0   B4MXW3   A0A2A3EMJ6   A0A182Y623   A0A182QA14   A0A182LP13   A0A1S4H734   A0A182SAU3   A0A0P6E7W0   A0A3L8E441   A0A0P5ZBA5   E9FR39   A0A0P5DZD4  

PDB

6GY5     E-value=1.01178e-139,     Score=1275

KEGG

101744566    K10457 kelch-like protein 20 | (RefSeq) kelch-like protein diablo

GO

GO:0016567   GO:0045886   GO:0003779   GO:0003676   GO:0042803   GO:0051865   GO:0005515   GO:0004523   GO:0003824   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0016021  

Length:

586

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02621

Exp number, first 60 AAs:

0.0038

Total prob of N-in:

0.00048

outside

1  -  586

 

 

Pi

52.740922

Theta

176.531162

Tajima's D

-1.497267

CLR

1.602417

CSRT

0.063896805159742

Interpretation

Possibly Positive selection