SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01604  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA014304
Annotation
alkaline_phosphatase_[Bombyx_mandarina]
Full name
Alkaline phosphatase       + More
Membrane-bound alkaline phosphatase      
Location in the cell
PlasmaMembrane   Reliability : 2.634
 

Sequence

CDS
ATGGTGCGTTTGTTGACACTCCTCTCGCTGCTCGCCGCCGGCTCCTGCGGCCGTCGATATGGATTAGATAAGGACGGTTACCACCGGGATGACGTGGGGTCGAGGCGCTCCCTGCAGACGCCCTCAACGCCGGCCCCCGAGCTGGAGTCGGAGTACTGGTCGCGCGACGCCCAGAGTGAGCTGGGGGAGCGCGCCTGGTACGACGGCAGCAGCGGGTACGCGCGGAACGTCGTCATGTTCCTCGGAGACGGCATGTCCGTGGCCACACTCACGGCCGCCCGCACGCTGCTCGGCCAGCGCCGGGGACAGACTGGAGAGGAGTCCCGATTGTCTTTCGAACATTTTCCAACTGTCGGACTTTCTAAGACCTACTGCCTAGACGCCCAGGTAGCGGACTCGGCTTGCTCGGCCTCCGCCTACCTGTGCGGTGCAAAGGCTAACCTGGGCACCATCGGTGTGTCGGGACACGTGGCGCGACACCACTGTACTGCGGCCACCGACGCTGCACACCAGCTCGCCTCCATCGCCTCCTGGGCTCTCGACGCCGACAGGGACGCCGGGATCGTGACCACCACCCGCGTCACGCACGCCTCGCCGGCCGGAGCGTACGCCCACACCGCCGACCGGAACTGGGAGAGCGACGGTGACGTTACCGCCGGCTGCAGCGGCCACGCTCAGCTGGACATCGCGCAGCAACTCGTCCACGCGCGTCCCGGGAAAGACTTCAAGGTTATTTTGGGAGGCGGAAGAAGAGAGTTCCTACCCAACACTATGACGGACGAAGAGGGCAGTAGAGGAAGAAGATACGATGGGCGAAATCTGATCTCAGAGTGGCTCACTGAGAAGGACAGTCGCGGCGTCACGCACGAATACGTGTGGAACAGACAACAGCTGATGGAGGTCTCCGAAGAGTTGCCAGAGTACCTGCTGGGACTATTCGAACCGAGTCACTTACAATATCATATGGAGGCAAACCATACCATGGAGCCGACCCTGGCCGAGCTCACGGAAGTGGCGATCAAATCGTTGAGTCGCAACAAGGAAGGATTCTTCTTGTTTGTCGAGGGAGGCAGGATCGACCACGCGCACCACGAGAACTTGGCCCACCTCGCTCTCGACGAGACCATCGAACTAAGCGCGGCGGTGGAGAAAGCACGGGAGCTGCTCTCGGAGCAGGATTCATTAATCGTAGTGACGGCGGACCACGCTCACGTCATGTCCATCAGCGGGTACACACAGCGCGGCGGGGACATCCTCGGCCCCTCGGACGCGCTGGGCGACGACGGCATCCCCTACATGACGCTCTCGTATGGCAACGGTCCCGGGTACCGCGAGCCGAGGGGCGGGCAGCGCGTCGACCCGACACGACAAGATTACCGAGGGTCAGAGTACGTGTACCCGGCCGCAGTGCCGCTGGACTCGGAGACTCACGGCGGAGACGACGTGGCGGTATTCGCCTGGGGGCCTCACCACGCCCTCTTCTCTGGCCTCTACGAGCAGAGTCACATCCCGCATCGCATGGCGTACGCAGCATGCATCGGTCCCGGCAAGCACGCTTGCCAACATTCACCACATTCAACTACTTAA
Protein
MVRLLTLLSLLAAGSCGRRYGLDKDGYHRDDVGSRRSLQTPSTPAPELESEYWSRDAQSELGERAWYDGSSGYARNVVMFLGDGMSVATLTAARTLLGQRRGQTGEESRLSFEHFPTVGLSKTYCLDAQVADSACSASAYLCGAKANLGTIGVSGHVARHHCTAATDAAHQLASIASWALDADRDAGIVTTTRVTHASPAGAYAHTADRNWESDGDVTAGCSGHAQLDIAQQLVHARPGKDFKVILGGGRREFLPNTMTDEEGSRGRRYDGRNLISEWLTEKDSRGVTHEYVWNRQQLMEVSEELPEYLLGLFEPSHLQYHMEANHTMEPTLAELTEVAIKSLSRNKEGFFLFVEGGRIDHAHHENLAHLALDETIELSAAVEKARELLSEQDSLIVVTADHAHVMSISGYTQRGGDILGPSDALGDDGIPYMTLSYGNGPGYREPRGGQRVDPTRQDYRGSEYVYPAAVPLDSETHGGDDVAVFAWGPHHALFSGLYEQSHIPHRMAYAACIGPGKHACQHSPHSTT

Summary

Catalytic Activity
a phosphate monoester + H2O = an alcohol + phosphate
Cofactor
Mg(2+)
Zn(2+)
Similarity
Belongs to the alkaline phosphatase family.
Keywords
Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Magnesium   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Zinc  
Feature
chain  Alkaline phosphatase
propeptide  Removed in mature form
EC Number
3.1.3.1
EMBL
AB379674    BAG41973.1    AB379672    BAG41969.1    AB055428    AB379673    + More
BAB62746.2    BAG41971.1    AB516293    BAH95822.1    AB270698    BAF62125.1    AB379677    BAG41977.1    BABH01044837    AB013386    BAA34926.1    KT276304    ALS30431.1    ODYU01003612    SOQ42593.1    KZ150047    PZC74487.1    KQ459562    KPI99722.1    NWSH01003359    PCG66484.1    KY912922    AUH25163.1    JF979062    AFI81420.1    AGBW02009775    OWR49944.1    KQ460870    KPJ11778.1    JQ365182    AFH96950.1    KPJ11776.1    KPI99721.1    PCG66485.1    KPJ11777.1    PZC74489.1    FJ416470    ACP39712.1    KY912924    AUH25165.1    ODYU01007279    SOQ49911.1    JF825967    AEG79734.1    KM048196    AJW76723.1    KP420013    ALK86921.1    EU729323    ACF40807.1    FJ416471    ACP39713.1    HQ110096    AEL23233.1    FJ416472    ACP39714.1    KM360183    AKH49599.1    KM048195    AJW76722.1    EF531619    ABR88230.1    EU729322    ACF40806.1    KM360191    AKH49607.1    KT276297    ALS30424.1    SOQ42594.1    KPI99720.1    FJ416473    ACP39715.1    JN687589    AFJ04290.1    JN392445    AEM43806.1    KT276303    ALS30430.1    KM048197    AJW76724.1    KPJ11779.1    JQ747498    AGG36455.1    BABH01037520    AB379676    BAG41975.1    BAG41972.1    BAG41976.1    JN687588    AFJ04289.1    D90454    BAF62124.1    BAG41968.1    AB516292    BAH95821.1    BABH01037533    BABH01037534    BAG41970.1    OWR49943.1    JF979061    AFI81421.1    NEVH01025135    PNF15822.1    KK853042    KDR12134.1    PZC74488.1    KDR12135.1    KY922835    AUF74484.1    MF741672    AVD96955.1    ODYU01008153    SOQ51522.1    GFDL01015845    JAV19200.1    CH477553    EAT39089.1    GDUN01000056    JAN95863.1    GFDL01015846    JAV19199.1    DS231833    EDS32226.1    FJ175380    ACN29682.1    GANO01003229    JAB56642.1    APCN01000188    AAAB01008807    EAA03918.4    KC841472    AHF20243.2    AXCM01001173    DS235088    EEB11719.1    AXCN02000551    AGBW02008519    OWR53113.1    BABH01026539    BABH01026540    KM048198    AJW76725.1    CVRI01000047    CRK98187.1    ODYU01000769    SOQ36062.1    AJWK01013324   
Pfam
PF00245   Alk_phosphatase
Interpro
IPR001952   Alkaline_phosphatase        + More
IPR017850   Alkaline_phosphatase_core_sf       
IPR018299   Alkaline_phosphatase_AS       
SUPFAM
SSF53649   SSF53649       
Gene 3D
PDB
1SHQ     E-value=4.48472e-110,     Score=1019

Ontologies

Topology

Subcellular location
Cell membrane  
SignalP
Position:   1 - 17,         Likelihood:  0.969066
 
 
Length:
528
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0449400000000001
Exp number, first 60 AAs:
0.00696
Total prob of N-in:
0.00198
outside
1  -  528
 
 

Population Genetic Test Statistics

Pi
203.97141
Theta
176.83905
Tajima's D
0.403226
CLR
1.000838
CSRT
0.48267586620669
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 WIESVIGER 100.00 3e-10
28556443 NLISEWLTEK 100.00 6e-04
28556443 EFLPNTMTDEEGSR 100.00 6e-04
28556443 HHCTAATDAAHQLASIASWALDADR 100.00 0.003
28556443 DFKVILGGGRR 100.00 0.039
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