Gene

KWMTBOMO01604  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014304

Annotation

alkaline_phosphatase_[Bombyx_mandarina]

Location

Bomo_Chr3(+):15188801-15191295      View in EpiBrowser

Full name

Alkaline phosphatase       + More
Membrane-bound alkaline phosphatase      

Location in the cell

PlasmaMembrane   Reliability : 2.634

CDS

ATGGTGCGTTTGTTGACACTCCTCTCGCTGCTCGCCGCCGGCTCCTGCGGCCGTCGATATGGATTAGATAAGGACGGTTACCACCGGGATGACGTGGGGTCGAGGCGCTCCCTGCAGACGCCCTCAACGCCGGCCCCCGAGCTGGAGTCGGAGTACTGGTCGCGCGACGCCCAGAGTGAGCTGGGGGAGCGCGCCTGGTACGACGGCAGCAGCGGGTACGCGCGGAACGTCGTCATGTTCCTCGGAGACGGCATGTCCGTGGCCACACTCACGGCCGCCCGCACGCTGCTCGGCCAGCGCCGGGGACAGACTGGAGAGGAGTCCCGATTGTCTTTCGAACATTTTCCAACTGTCGGACTTTCTAAGACCTACTGCCTAGACGCCCAGGTAGCGGACTCGGCTTGCTCGGCCTCCGCCTACCTGTGCGGTGCAAAGGCTAACCTGGGCACCATCGGTGTGTCGGGACACGTGGCGCGACACCACTGTACTGCGGCCACCGACGCTGCACACCAGCTCGCCTCCATCGCCTCCTGGGCTCTCGACGCCGACAGGGACGCCGGGATCGTGACCACCACCCGCGTCACGCACGCCTCGCCGGCCGGAGCGTACGCCCACACCGCCGACCGGAACTGGGAGAGCGACGGTGACGTTACCGCCGGCTGCAGCGGCCACGCTCAGCTGGACATCGCGCAGCAACTCGTCCACGCGCGTCCCGGGAAAGACTTCAAGGTTATTTTGGGAGGCGGAAGAAGAGAGTTCCTACCCAACACTATGACGGACGAAGAGGGCAGTAGAGGAAGAAGATACGATGGGCGAAATCTGATCTCAGAGTGGCTCACTGAGAAGGACAGTCGCGGCGTCACGCACGAATACGTGTGGAACAGACAACAGCTGATGGAGGTCTCCGAAGAGTTGCCAGAGTACCTGCTGGGACTATTCGAACCGAGTCACTTACAATATCATATGGAGGCAAACCATACCATGGAGCCGACCCTGGCCGAGCTCACGGAAGTGGCGATCAAATCGTTGAGTCGCAACAAGGAAGGATTCTTCTTGTTTGTCGAGGGAGGCAGGATCGACCACGCGCACCACGAGAACTTGGCCCACCTCGCTCTCGACGAGACCATCGAACTAAGCGCGGCGGTGGAGAAAGCACGGGAGCTGCTCTCGGAGCAGGATTCATTAATCGTAGTGACGGCGGACCACGCTCACGTCATGTCCATCAGCGGGTACACACAGCGCGGCGGGGACATCCTCGGCCCCTCGGACGCGCTGGGCGACGACGGCATCCCCTACATGACGCTCTCGTATGGCAACGGTCCCGGGTACCGCGAGCCGAGGGGCGGGCAGCGCGTCGACCCGACACGACAAGATTACCGAGGGTCAGAGTACGTGTACCCGGCCGCAGTGCCGCTGGACTCGGAGACTCACGGCGGAGACGACGTGGCGGTATTCGCCTGGGGGCCTCACCACGCCCTCTTCTCTGGCCTCTACGAGCAGAGTCACATCCCGCATCGCATGGCGTACGCAGCATGCATCGGTCCCGGCAAGCACGCTTGCCAACATTCACCACATTCAACTACTTAA

Protein

MVRLLTLLSLLAAGSCGRRYGLDKDGYHRDDVGSRRSLQTPSTPAPELESEYWSRDAQSELGERAWYDGSSGYARNVVMFLGDGMSVATLTAARTLLGQRRGQTGEESRLSFEHFPTVGLSKTYCLDAQVADSACSASAYLCGAKANLGTIGVSGHVARHHCTAATDAAHQLASIASWALDADRDAGIVTTTRVTHASPAGAYAHTADRNWESDGDVTAGCSGHAQLDIAQQLVHARPGKDFKVILGGGRREFLPNTMTDEEGSRGRRYDGRNLISEWLTEKDSRGVTHEYVWNRQQLMEVSEELPEYLLGLFEPSHLQYHMEANHTMEPTLAELTEVAIKSLSRNKEGFFLFVEGGRIDHAHHENLAHLALDETIELSAAVEKARELLSEQDSLIVVTADHAHVMSISGYTQRGGDILGPSDALGDDGIPYMTLSYGNGPGYREPRGGQRVDPTRQDYRGSEYVYPAAVPLDSETHGGDDVAVFAWGPHHALFSGLYEQSHIPHRMAYAACIGPGKHACQHSPHSTT

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate

Cofactor

Mg(2+)
Zn(2+)

Similarity

Belongs to the alkaline phosphatase family.

Keywords

Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Magnesium   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Zinc  

Feature

chain  Alkaline phosphatase
propeptide  Removed in mature form

Uniprot

B2ZZW8   B2ZZW4   Q7KXT0   C6L8N9   A5A747   B2ZZX2   + More
H9JXN7   O96056   A0A0U2IR33   A0A2H1VP42   A0A2W1BMI5   A0A194Q2C7   A0A2A4J4Q0   A0A2H5CLJ8   I6PI83   A0A212F875   A0A194R1W7   I0E1Y2   A0A194R7D1   A0A194Q2F4   A0A2A4J355   A0A194R254   A0A2W1BHB3   C3U1V9   A0A2H5CLG8   A0A2H1WA01   G3GBT4   A0A0U1ZEU5   A0A109P4P6   B4Z1D7   C3U1W0   I6MML5   C3U1W1   A0A1B0RHM8   A0A0U1ZEC3   B4X983   B4Z1D6   A0A1B0RHM5   A0A0U2WPZ0   A0A2H1VQS9   A0A194Q8I8   C3U1W2   R4I4D0   G1JT78   A0A0U2WZB7   A0A0U1ZJ21   A0A194R2N2   M4M3L4   H9JH21   B2ZZX0   B2ZZW7   B2ZZX1   R4I4E9   P29523   A5A746   B2ZZW3   C6L8N8   H9JH27   B2ZZW5   A0A212F895   I6PF06   A0A2J7PHL4   A0A067QRJ2   A0A2W1BI04   A0A182JP07   A0A067QT98   A0A3G1LC34   A0A2L1IQA2   A0A1S4FLA4   A0A2H1WF77   A0A1Q3EV69   Q16WV8   A0A0P6JST2   A0A1Q3EV65   B0W3S9   C0JBW1   U5EGZ8   A0A182I2X2   Q7QJ58   A0A182WZ34   W8DT07   A0A182XYI9   A0A182KQV2   A0A182VAE3   A0A182SLH6   A0A182THI0   A0A182MT69   A0A182RTZ7   E0VEB3   A0A182JL64   A0A182QLW3   A0A182WJL0   A0A212FHB6   H9JK21   A0A0U1ZF85   A0A182NKM7   A0A182P207   A0A1J1ID93   A0A2H1V6P7   A0A1B0CIG9  

EC Number

3.1.3.1

Pubmed

14508679    19121390    10196735    26637593    28756777    26354079    + More
22118469    21840855    20170658    1756175    24845553    29415259    17510324    26999592    12364791    14747013    17210077    25875245    25244985    20966253    20566863   

EMBL

AB379674    BAG41973.1    AB379672    BAG41969.1    AB055428    AB379673    + More
BAB62746.2    BAG41971.1    AB516293    BAH95822.1    AB270698    BAF62125.1    AB379677    BAG41977.1    BABH01044837    AB013386    BAA34926.1    KT276304    ALS30431.1    ODYU01003612    SOQ42593.1    KZ150047    PZC74487.1    KQ459562    KPI99722.1    NWSH01003359    PCG66484.1    KY912922    AUH25163.1    JF979062    AFI81420.1    AGBW02009775    OWR49944.1    KQ460870    KPJ11778.1    JQ365182    AFH96950.1    KPJ11776.1    KPI99721.1    PCG66485.1    KPJ11777.1    PZC74489.1    FJ416470    ACP39712.1    KY912924    AUH25165.1    ODYU01007279    SOQ49911.1    JF825967    AEG79734.1    KM048196    AJW76723.1    KP420013    ALK86921.1    EU729323    ACF40807.1    FJ416471    ACP39713.1    HQ110096    AEL23233.1    FJ416472    ACP39714.1    KM360183    AKH49599.1    KM048195    AJW76722.1    EF531619    ABR88230.1    EU729322    ACF40806.1    KM360191    AKH49607.1    KT276297    ALS30424.1    SOQ42594.1    KPI99720.1    FJ416473    ACP39715.1    JN687589    AFJ04290.1    JN392445    AEM43806.1    KT276303    ALS30430.1    KM048197    AJW76724.1    KPJ11779.1    JQ747498    AGG36455.1    BABH01037520    AB379676    BAG41975.1    BAG41972.1    BAG41976.1    JN687588    AFJ04289.1    D90454    BAF62124.1    BAG41968.1    AB516292    BAH95821.1    BABH01037533    BABH01037534    BAG41970.1    OWR49943.1    JF979061    AFI81421.1    NEVH01025135    PNF15822.1    KK853042    KDR12134.1    PZC74488.1    KDR12135.1    KY922835    AUF74484.1    MF741672    AVD96955.1    ODYU01008153    SOQ51522.1    GFDL01015845    JAV19200.1    CH477553    EAT39089.1    GDUN01000056    JAN95863.1    GFDL01015846    JAV19199.1    DS231833    EDS32226.1    FJ175380    ACN29682.1    GANO01003229    JAB56642.1    APCN01000188    AAAB01008807    EAA03918.4    KC841472    AHF20243.2    AXCM01001173    DS235088    EEB11719.1    AXCN02000551    AGBW02008519    OWR53113.1    BABH01026539    BABH01026540    KM048198    AJW76725.1    CVRI01000047    CRK98187.1    ODYU01000769    SOQ36062.1    AJWK01013324   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000053240    UP000235965    + More
UP000027135    UP000075881    UP000008820    UP000002320    UP000075840    UP000007062    UP000076407    UP000076408    UP000075882    UP000075903    UP000075901    UP000075902    UP000075883    UP000075900    UP000009046    UP000075880    UP000075886    UP000075920    UP000075884    UP000075885    UP000183832    UP000092461   

PRIDE

B2ZZW8    B2ZZW4    Q7KXT0    C6L8N9    A5A747    B2ZZX2    + More
H9JXN7    O96056    H9JH21    B2ZZX0    B2ZZW7    B2ZZX1    P29523    A5A746    B2ZZW3    C6L8N8    H9JH27    B2ZZW5    H9JK21   

Pfam

PF00245   Alk_phosphatase

Interpro

IPR001952   Alkaline_phosphatase        + More
IPR017850   Alkaline_phosphatase_core_sf       
IPR018299   Alkaline_phosphatase_AS       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16012  ALP

ProteinModelPortal

B2ZZW8   B2ZZW4   Q7KXT0   C6L8N9   A5A747   B2ZZX2   + More
H9JXN7   O96056   A0A0U2IR33   A0A2H1VP42   A0A2W1BMI5   A0A194Q2C7   A0A2A4J4Q0   A0A2H5CLJ8   I6PI83   A0A212F875   A0A194R1W7   I0E1Y2   A0A194R7D1   A0A194Q2F4   A0A2A4J355   A0A194R254   A0A2W1BHB3   C3U1V9   A0A2H5CLG8   A0A2H1WA01   G3GBT4   A0A0U1ZEU5   A0A109P4P6   B4Z1D7   C3U1W0   I6MML5   C3U1W1   A0A1B0RHM8   A0A0U1ZEC3   B4X983   B4Z1D6   A0A1B0RHM5   A0A0U2WPZ0   A0A2H1VQS9   A0A194Q8I8   C3U1W2   R4I4D0   G1JT78   A0A0U2WZB7   A0A0U1ZJ21   A0A194R2N2   M4M3L4   H9JH21   B2ZZX0   B2ZZW7   B2ZZX1   R4I4E9   P29523   A5A746   B2ZZW3   C6L8N8   H9JH27   B2ZZW5   A0A212F895   I6PF06   A0A2J7PHL4   A0A067QRJ2   A0A2W1BI04   A0A182JP07   A0A067QT98   A0A3G1LC34   A0A2L1IQA2   A0A1S4FLA4   A0A2H1WF77   A0A1Q3EV69   Q16WV8   A0A0P6JST2   A0A1Q3EV65   B0W3S9   C0JBW1   U5EGZ8   A0A182I2X2   Q7QJ58   A0A182WZ34   W8DT07   A0A182XYI9   A0A182KQV2   A0A182VAE3   A0A182SLH6   A0A182THI0   A0A182MT69   A0A182RTZ7   E0VEB3   A0A182JL64   A0A182QLW3   A0A182WJL0   A0A212FHB6   H9JK21   A0A0U1ZF85   A0A182NKM7   A0A182P207   A0A1J1ID93   A0A2H1V6P7   A0A1B0CIG9  

PDB

1SHQ     E-value=4.48472e-110,     Score=1019

KEGG

692396    K01077 alkaline phosphatase [EC:3.1.3.1] | (RefSeq) Alps, Alp-s, S-alp; soluble alkaline phosphatase

PATHWAY

00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004035   GO:0016791   GO:0016021   GO:0005886   GO:0031225   GO:0046872   GO:0008152   GO:0003824   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11596  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 17,         Likelihood:  0.969066

 

 

Length:

528

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0449400000000001

Exp number, first 60 AAs:

0.00696

Total prob of N-in:

0.00198

outside

1  -  528

 

 

Pi

203.97141

Theta

176.83905

Tajima's D

0.403226

CLR

1.000838

CSRT

0.48267586620669

Interpretation

Uncertain