Gene

KWMTBOMO01603  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008818

Annotation

alkaline_phosphatase_[Bombyx_mori]

Location

Bomo_Chr3(+):15173081-15175686      View in EpiBrowser

Full name

Alkaline phosphatase       + More
Membrane-bound alkaline phosphatase      

Location in the cell

Cytoplasmic   Reliability : 2.9

CDS

ATGTCTACATGGTGGTTAGTTGTGGTGGCGGCGGCGGCGGCGGCGGGGCTGGTGAGGGCCGAGGACCGCTACCACCCGGAGCGGCTCGCGGCGGGCGAGGCCAGCGCGGCCACGAGGAGCGCCGCCGAGTCCGAGGCGAGCTTCTGGGTGCGGGAGGCGCAGGAAGCTATCGAGAGACGCGAGCGAGAGGGGGCGGGCGCGAAGCAAGCAGCCGGCCATGCCAAGAACGTGGTCATGTTCCTCGGAGACGGCATGTCCGTGCCCACGCTGGCCGCCGCCCGCACGCTGCTGGGACAGCGACGGGGACAGACGGGAGAAGAGGCTAGCTTGCACTTTGAACAATTCCCCACTCTCGGTCTTGCGAAGACCTACTGCGTGAACGCTCAAGTCCCGGACTCGTCGTGCACGGCGACGGCATACCTGTGCGGCGTGAAGGCCAACCAAGGCACCCTCGGAGTGACGGCCGCCGTGCCGAGGCACGACTGCGAGGCTTCCACCGACGTCACCAAGCGGGTGCAGTCCATCGCCGAGTGGGCACTGGCTGACGGGAGAGATGTCGGTATAGTGACGACCACTCGCATCACGCATGCCTCTCCGGCGGGCGCTTTCGCCAAGGTCGCCAACAGGAACTGGGAGAATGATAACGACGTGAAACAAGAAGGCCACGACGTCAACCGCTGTCCGGACATCGCTCACCAGCTGATCAAGATGGCGCCAGGAAACAAATTTAAAGTGATCTTTGGCGGAGGAAGACGAGAATTTTTACCGACAACCCAAGTCGATGAAGAGGGCACCCGAGGTCTAAGAACAGACGGCCGCAATCTGATCGAAGAATGGCAGAACGATAAGGAGTCGCAGAAAGTGAGCTACAAGTATCTGTGGAATCGACAGGAACTTTTGAAACTGGCCTCATCTCCGCCCGACTACCTGCTCGGACTGTTCGAGGGCAGTCACTTGCAGTACCATCTCGAGGGAGATGAGAGCACGGAGCCAACCCTCGCCGAGCTAACAGACGTTGCCATCCGCGTGCTGAGTCGCAACGAGCGCGGTTTCTTCTTGTTCGTGGAGGGAGGGCGCATCGACCACGCGCATCACGACAACTACGCGCACCTCGCGCTCGATGAGACCATTGAGATGGATCGGGCCGTGAAAGTGGCCACAGACGCACTCAAGGAGGACGAGTCCTTGGTGGTAGTGACTGCTGACCACACCCACGTCATGTCGTTCAACGGGTACTCACCGCGAGGAACGGACGTGCTCGGAACGGTGCGGAGTTTGGACAGCAACAGAATGCCTTTCATGGTGCTCTCGTACACCAACGGACCCGGAGCAAGGATCCAGCAGAACGGCGTTCGACCCGACGTAACGACCGACGCCAACTTCGGTGCACTGCGCTGGAGGACGCACACGGACGTCCCGCTGGACTCGGAGACGCACGGCGGAGATGACGTCACGGTGTTCGCATGGGGTGTGCACCACTGGATGTTCTCTGGTCTGTACGAGCAGACGCACGTGCCACACCGCATGGCGTGGGCAGCCTGCATGGGCCCGGGCCGCCACGTCTGCGTCTCGGCTGCCACTGTGCCCACTGCGGCGCTGCTTTCTCTCTTGCTCGCCGCCTTCATCACCTTGCGGCATCAATGCTTTCTCTAA

Protein

MSTWWLVVVAAAAAAGLVRAEDRYHPERLAAGEASAATRSAAESEASFWVREAQEAIERREREGAGAKQAAGHAKNVVMFLGDGMSVPTLAAARTLLGQRRGQTGEEASLHFEQFPTLGLAKTYCVNAQVPDSSCTATAYLCGVKANQGTLGVTAAVPRHDCEASTDVTKRVQSIAEWALADGRDVGIVTTTRITHASPAGAFAKVANRNWENDNDVKQEGHDVNRCPDIAHQLIKMAPGNKFKVIFGGGRREFLPTTQVDEEGTRGLRTDGRNLIEEWQNDKESQKVSYKYLWNRQELLKLASSPPDYLLGLFEGSHLQYHLEGDESTEPTLAELTDVAIRVLSRNERGFFLFVEGGRIDHAHHDNYAHLALDETIEMDRAVKVATDALKEDESLVVVTADHTHVMSFNGYSPRGTDVLGTVRSLDSNRMPFMVLSYTNGPGARIQQNGVRPDVTTDANFGALRWRTHTDVPLDSETHGGDDVTVFAWGVHHWMFSGLYEQTHVPHRMAWAACMGPGRHVCVSAATVPTAALLSLLLAAFITLRHQCFL

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate

Cofactor

Mg(2+)
Zn(2+)

Similarity

Belongs to the alkaline phosphatase family.

Keywords

Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Magnesium   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Zinc  

Feature

chain  Alkaline phosphatase
propeptide  Removed in mature form

Uniprot

H9JH21   B2ZZX0   B2ZZW7   P29523   B2ZZX1   B2ZZW5   + More
B2ZZW3   A5A746   C6L8N8   H9JH27   A0A2H5CLG8   A0A2H1VQS9   A0A0U1ZJ21   A0A2A4J355   G3GBT4   A0A194Q2F4   C3U1W0   I6MML5   A0A194R254   A0A1B0RHM8   A0A2W1BHB3   B4Z1D7   M4M3L4   B4X983   C3U1W2   I0E1Y2   A0A2H1WA01   C3U1V9   A0A194R1W7   A0A0U2WPZ0   B4Z1D6   A0A0U1ZEC3   A0A1B0RHM5   C3U1W1   R4I4D0   A0A194Q8I8   A0A0U2WZB7   A0A194R2N2   A0A109P4P6   A0A0U1ZEU5   A0A212F875   R4I4E9   A0A212F895   G1JT78   I6PF06   C6L8N9   Q7KXT0   A0A2W1BI04   H9JXN7   B2ZZW4   B2ZZW8   B2ZZX2   I6PI83   O96056   A0A2H5CLJ8   A5A747   A0A194Q2C7   A0A0U2IR33   A0A2A4J4Q0   A0A2W1BMI5   A0A2H1VP42   A0A194R7D1   A0A2H1WF77   A0A2J7PHL4   A0A067QRJ2   A0A067QT98   U5EGZ8   E0VEB3   A0A182JP07   A0A3G1LC34   A0A182I2X2   Q7QJ58   A0A182KQV2   A0A182VAE3   A0A182WZ34   A0A182JL64   C0JBW1   A0A182THI0   A0A182MT69   A0A182RTZ7   A0A0P6JST2   Q16WV8   A0A2L1IQA2   A0A1S4FLA4   A0A1B0CIG9   A0A182XYI9   A0A084VQQ6   A0A2J7PHK8   A0A182SLH6   A0A182WJL0   A0A1Q3EV69   B0W3S9   A0A182QLW3   A0A1Q3EV65   A0A182P207   A0A1J1ID93   A0A182NKM7   A0A1B6DLR4   W5JSA4  

EC Number

3.1.3.1

Pubmed

19121390    1756175    14508679    21840855    26354079    28756777    + More
20170658    26637593    22118469    10196735    24845553    20566863    12364791    14747013    17210077    20966253    26999592    17510324    29415259    25244985    24438588    20920257    23761445   

EMBL

BABH01037520    AB379676    BAG41975.1    AB379674    BAG41972.1    D90454    + More
AB055428    AB379677    BAG41976.1    AB379673    BAG41970.1    AB379672    BAG41968.1    AB270698    BAF62124.1    AB516292    BAH95821.1    BABH01037533    BABH01037534    KY912924    AUH25165.1    ODYU01003612    SOQ42594.1    KM048197    AJW76724.1    NWSH01003359    PCG66485.1    JF825967    AEG79734.1    KQ459562    KPI99721.1    FJ416471    ACP39713.1    HQ110096    AEL23233.1    KQ460870    KPJ11777.1    KM360183    AKH49599.1    KZ150047    PZC74489.1    EU729323    ACF40807.1    JQ747498    AGG36455.1    EF531619    ABR88230.1    FJ416473    ACP39715.1    JQ365182    AFH96950.1    ODYU01007279    SOQ49911.1    FJ416470    ACP39712.1    KPJ11778.1    KT276297    ALS30424.1    EU729322    ACF40806.1    KM048195    AJW76722.1    KM360191    AKH49607.1    FJ416472    ACP39714.1    JN687589    AFJ04290.1    KPI99720.1    KT276303    ALS30430.1    KPJ11779.1    KP420013    ALK86921.1    KM048196    AJW76723.1    AGBW02009775    OWR49944.1    JN687588    AFJ04289.1    OWR49943.1    JN392445    AEM43806.1    JF979061    AFI81421.1    AB516293    BAH95822.1    BAB62746.2    BAG41971.1    PZC74488.1    BABH01044837    BAG41969.1    BAG41973.1    BAG41977.1    JF979062    AFI81420.1    AB013386    BAA34926.1    KY912922    AUH25163.1    BAF62125.1    KPI99722.1    KT276304    ALS30431.1    PCG66484.1    PZC74487.1    SOQ42593.1    KPJ11776.1    ODYU01008153    SOQ51522.1    NEVH01025135    PNF15822.1    KK853042    KDR12134.1    KDR12135.1    GANO01003229    JAB56642.1    DS235088    EEB11719.1    KY922835    AUF74484.1    APCN01000188    AAAB01008807    EAA03918.4    FJ175380    ACN29682.1    AXCM01001173    GDUN01000056    JAN95863.1    CH477553    EAT39089.1    MF741672    AVD96955.1    AJWK01013324    ATLV01015292    KE525006    KFB40300.1    PNF15827.1    GFDL01015845    JAV19200.1    DS231833    EDS32226.1    AXCN02000551    GFDL01015846    JAV19199.1    CVRI01000047    CRK98187.1    GEDC01020887    GEDC01010675    GEDC01009792    JAS16411.1    JAS26623.1    JAS27506.1    ADMH02000578    ETN65800.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000235965    + More
UP000027135    UP000009046    UP000075881    UP000075840    UP000007062    UP000075882    UP000075903    UP000076407    UP000075880    UP000075902    UP000075883    UP000075900    UP000008820    UP000092461    UP000076408    UP000030765    UP000075901    UP000075920    UP000002320    UP000075886    UP000075885    UP000183832    UP000075884    UP000000673   

PRIDE

H9JH21    B2ZZX0    B2ZZW7    P29523    B2ZZX1    B2ZZW5    + More
B2ZZW3    A5A746    C6L8N8    H9JH27    C6L8N9    Q7KXT0    H9JXN7    B2ZZW4    B2ZZW8    B2ZZX2    O96056    A5A747   

Pfam

PF00245   Alk_phosphatase

Interpro

IPR017850   Alkaline_phosphatase_core_sf        + More
IPR001952   Alkaline_phosphatase       
IPR018299   Alkaline_phosphatase_AS       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16012  ALP

ProteinModelPortal

H9JH21   B2ZZX0   B2ZZW7   P29523   B2ZZX1   B2ZZW5   + More
B2ZZW3   A5A746   C6L8N8   H9JH27   A0A2H5CLG8   A0A2H1VQS9   A0A0U1ZJ21   A0A2A4J355   G3GBT4   A0A194Q2F4   C3U1W0   I6MML5   A0A194R254   A0A1B0RHM8   A0A2W1BHB3   B4Z1D7   M4M3L4   B4X983   C3U1W2   I0E1Y2   A0A2H1WA01   C3U1V9   A0A194R1W7   A0A0U2WPZ0   B4Z1D6   A0A0U1ZEC3   A0A1B0RHM5   C3U1W1   R4I4D0   A0A194Q8I8   A0A0U2WZB7   A0A194R2N2   A0A109P4P6   A0A0U1ZEU5   A0A212F875   R4I4E9   A0A212F895   G1JT78   I6PF06   C6L8N9   Q7KXT0   A0A2W1BI04   H9JXN7   B2ZZW4   B2ZZW8   B2ZZX2   I6PI83   O96056   A0A2H5CLJ8   A5A747   A0A194Q2C7   A0A0U2IR33   A0A2A4J4Q0   A0A2W1BMI5   A0A2H1VP42   A0A194R7D1   A0A2H1WF77   A0A2J7PHL4   A0A067QRJ2   A0A067QT98   U5EGZ8   E0VEB3   A0A182JP07   A0A3G1LC34   A0A182I2X2   Q7QJ58   A0A182KQV2   A0A182VAE3   A0A182WZ34   A0A182JL64   C0JBW1   A0A182THI0   A0A182MT69   A0A182RTZ7   A0A0P6JST2   Q16WV8   A0A2L1IQA2   A0A1S4FLA4   A0A1B0CIG9   A0A182XYI9   A0A084VQQ6   A0A2J7PHK8   A0A182SLH6   A0A182WJL0   A0A1Q3EV69   B0W3S9   A0A182QLW3   A0A1Q3EV65   A0A182P207   A0A1J1ID93   A0A182NKM7   A0A1B6DLR4   W5JSA4  

PDB

1K7H     E-value=7.17554e-106,     Score=982

KEGG

693074    K01077 alkaline phosphatase [EC:3.1.3.1] | (RefSeq) Alpm, Alp-m, M-alp; membrane-bound alkaline phos

PATHWAY

00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004035   GO:0016021   GO:0005886   GO:0031225   GO:0046872   GO:0016791   GO:0008152   GO:0003824   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11596  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.933604

 

 

Length:

550

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

19.80393

Exp number, first 60 AAs:

2.17665

Total prob of N-in:

0.09624

outside

1  -  550

 

 

Pi

247.879472

Theta

203.676022

Tajima's D

0.693471

CLR

0.078973

CSRT

0.567421628918554

Interpretation

Uncertain