Gene

KWMTBOMO01597  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008824

Annotation

alkaline_phosphatase_[Bombyx_mandarina]

Location

Bomo_Chr3(-):15063734-15066470      View in EpiBrowser

Full name

Alkaline phosphatase       + More
Membrane-bound alkaline phosphatase      

Location in the cell

Mitochondrial   Reliability : 0.878

CDS

ATGTCTACATGGTGGTTAGTTGTGGCGGTGGTGGCGGCGGCGGTGCTGGTAACGGCCGAGGACCGCTACCACCCGGAGTGGCTCGCAGCTCGCGAGGCCGGCGCAGCCACGAGGAGGGCCGCCGAGTCCGAGGCAAGCTTCTGGGTGCGGGAGGCGCAGGAAGCCATCGAGAGACGCGAGCGAGAGGGGGCGGGCGCGAAGCAAGCAGCCGGCCATGCCAAGAACGTGGTCATGTTCCTCGGAGACGGCATGTCCGTGCCCACGCTGGCCGCCGCGCGCACGCTGCTGGGACAGCGACGCGGACAGACAGGAGAAGAGGCTAGCTTGCACTTTGAACAATTCCCCACTCTCGGTCTTGCGAAGACCTACTGCGTGGACGCTCAAGTCCCGGACTCGTCATGCACGGCGACGGCATACCTGTGCGGCGTGAAGGCCAATCATGGCACCCTCGGAGTGACGGCCGCCGTTTCTCGGCGTGACTGCGAGGCTTCCAACGACGTCACCAAGCGGGTGCAGTCCATCGCCGAGTGGGCGCTGGCTGACGGGAGAGATGTTGGTATAGTGACAACCACTCGCGTCACGCATGCCTCTCCGGCGGGCACTTTCGCCAAGGTCGCCAACAGGAACTGGGAGAATGATAACGACGTGAAACAAGAAGGCCACGACGTCAACCGCTGTCCAGACATCGCTCACCAGCTGATCAAGATGGCGCCAGGAAACAAATTTAAAGTGATCTTTGGCGGAGGAAGACGAGAATTTTTACCGACAACCCAAGTCGATGAAGAGGGCACCCGAGGTCTAAGAACAGACGGCCGCAATCTGATCGAAGAATGGCAGAACGATAAGGATTCGCAGAATGTGAGCTACAAGTATCTGTGGAATCAACAGGAACTTTTGGAACTGGGTTCGTCTCCGCCCGACTACCTGCTCGGACTGTTCGAGGGCAGTCACTTGCAGTACCATCTCGAGGGAGATGAGAGCACCGAGCCAACCCTCGCCGAGCTAACAGACGTTGCCATCCGCGTGCTGAGTCGCAACGAGCGCGGTTTCTTCTTGTTCGTGGAGGGAGGGCGCATCGACCACGCGCATCACGACAACTACGCGCACCTCGCGCTCGATGAGACCATTGAGATGGATCGGGCCGTGAAAGTGGCCACAGACACACTCAAAGAGGACGAGTCCTTGGTGGTAGTGACTGCTGACCACACCCACGTCATGTCGTTCAACGGGTACTCACCGCGAGGAATGGACGTGCTCGGGGCGGTGCAAATGTTGGACAGAAGCAGGGTTCCCTTCATGGTGCTCTCGTATACCAACGGACCTGGAGCAAGGATCCAGCAGAATGGCGTTCGACCCGACGTGACGACTGACGCCAACTTCGGTGCGCTGCGCTGGAGGACGCACACGGACGTCCCGCTGAACTCGGAGACGCACGGCGGAGATGACGTCACGGTGTTCGCATGGGGCGTGCACCACTGGATGTTCTCTGGTCTGTACGAGCAGACGCACGTGCCACACCGCATGGCGTGGGCAGCCTGCATGGGCCCGGGTCGCCACGTCTGCGTCTCGGCTGCCACTGCACCCACTGCGGCGCTGCTTTCTGTCTTGCTCGCCGCCTTCATCACCTTGCGGCATCAATGCTTTCTCTAA

Protein

MSTWWLVVAVVAAAVLVTAEDRYHPEWLAAREAGAATRRAAESEASFWVREAQEAIERREREGAGAKQAAGHAKNVVMFLGDGMSVPTLAAARTLLGQRRGQTGEEASLHFEQFPTLGLAKTYCVDAQVPDSSCTATAYLCGVKANHGTLGVTAAVSRRDCEASNDVTKRVQSIAEWALADGRDVGIVTTTRVTHASPAGTFAKVANRNWENDNDVKQEGHDVNRCPDIAHQLIKMAPGNKFKVIFGGGRREFLPTTQVDEEGTRGLRTDGRNLIEEWQNDKDSQNVSYKYLWNQQELLELGSSPPDYLLGLFEGSHLQYHLEGDESTEPTLAELTDVAIRVLSRNERGFFLFVEGGRIDHAHHDNYAHLALDETIEMDRAVKVATDTLKEDESLVVVTADHTHVMSFNGYSPRGMDVLGAVQMLDRSRVPFMVLSYTNGPGARIQQNGVRPDVTTDANFGALRWRTHTDVPLNSETHGGDDVTVFAWGVHHWMFSGLYEQTHVPHRMAWAACMGPGRHVCVSAATAPTAALLSVLLAAFITLRHQCFL

Catalytic Activity

a phosphate monoester + H2O = an alcohol + phosphate

Cofactor

Mg(2+)
Zn(2+)

Similarity

Belongs to the alkaline phosphatase family.

Keywords

Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Magnesium   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal   Zinc  

Feature

chain  Alkaline phosphatase
propeptide  Removed in mature form

Uniprot

H9JH27   B2ZZW3   P29523   B2ZZW7   B2ZZX1   H9JH21   + More
B2ZZX0   B2ZZW5   A5A746   C6L8N8   A0A2H5CLG8   A0A2H1VQS9   A0A2A4J355   A0A0U1ZJ21   A0A1B0RHM8   G3GBT4   A0A2W1BHB3   C3U1W0   B4Z1D7   I6MML5   B4X983   C3U1W2   M4M3L4   A0A194Q2F4   C3U1V9   B4Z1D6   A0A194R254   A0A2H1WA01   A0A1B0RHM5   I0E1Y2   C3U1W1   A0A194R1W7   A0A194Q8I8   A0A194R2N2   A0A0U1ZEC3   A0A0U2WPZ0   A0A109P4P6   A0A0U1ZEU5   R4I4D0   A0A0U2WZB7   A0A212F875   R4I4E9   G1JT78   A0A212F895   I6PF06   A0A2H5CLJ8   C6L8N9   Q7KXT0   B2ZZW4   B2ZZW8   H9JXN7   B2ZZX2   I6PI83   A0A2W1BI04   O96056   A5A747   A0A194Q2C7   A0A0U2IR33   A0A2W1BMI5   A0A2A4J4Q0   A0A2H1VP42   A0A194R7D1   A0A2H1WF77   A0A2J7PHL4   A0A067QRJ2   A0A067QT98   A0A182JP07   E0VEB3   U5EGZ8   Q7QJ58   A0A182MT69   A0A182I2X2   A0A182RTZ7   A0A182WZ34   A0A182KQV2   A0A182VAE3   A0A182JL64   A0A0P6JST2   Q16WV8   A0A182THI0   A0A182XYI9   A0A084VQQ6   A0A182SLH6   A0A182WJL0   A0A1S4FLA4   C0JBW1   A0A3G1LC34   A0A2L1IQA2   A0A182QLW3   A0A1B0CIG9   A0A182NKM7   A0A1B6DLR4   A0A2J7PHK8   A0A1Q3EV69   A0A1J1ID93   A0A182P207   A0A1Q3EV65   B0W3S9   W5JSA4  

EC Number

3.1.3.1

Pubmed

19121390    1756175    14508679    21840855    28756777    20170658    + More
26354079    26637593    22118469    10196735    24845553    20566863    12364791    14747013    17210077    20966253    26999592    17510324    25244985    24438588    29415259    20920257    23761445   

EMBL

BABH01037533    BABH01037534    AB379672    BAG41968.1    D90454    AB055428    + More
AB379674    BAG41972.1    AB379677    BAG41976.1    BABH01037520    AB379676    BAG41975.1    AB379673    BAG41970.1    AB270698    BAF62124.1    AB516292    BAH95821.1    KY912924    AUH25165.1    ODYU01003612    SOQ42594.1    NWSH01003359    PCG66485.1    KM048197    AJW76724.1    KM360183    AKH49599.1    JF825967    AEG79734.1    KZ150047    PZC74489.1    FJ416471    ACP39713.1    EU729323    ACF40807.1    HQ110096    AEL23233.1    EF531619    ABR88230.1    FJ416473    ACP39715.1    JQ747498    AGG36455.1    KQ459562    KPI99721.1    FJ416470    ACP39712.1    EU729322    ACF40806.1    KQ460870    KPJ11777.1    ODYU01007279    SOQ49911.1    KM360191    AKH49607.1    JQ365182    AFH96950.1    FJ416472    ACP39714.1    KPJ11778.1    KPI99720.1    KPJ11779.1    KM048195    AJW76722.1    KT276297    ALS30424.1    KP420013    ALK86921.1    KM048196    AJW76723.1    JN687589    AFJ04290.1    KT276303    ALS30430.1    AGBW02009775    OWR49944.1    JN687588    AFJ04289.1    JN392445    AEM43806.1    OWR49943.1    JF979061    AFI81421.1    KY912922    AUH25163.1    AB516293    BAH95822.1    BAB62746.2    BAG41971.1    BAG41969.1    BAG41973.1    BABH01044837    BAG41977.1    JF979062    AFI81420.1    PZC74488.1    AB013386    BAA34926.1    BAF62125.1    KPI99722.1    KT276304    ALS30431.1    PZC74487.1    PCG66484.1    SOQ42593.1    KPJ11776.1    ODYU01008153    SOQ51522.1    NEVH01025135    PNF15822.1    KK853042    KDR12134.1    KDR12135.1    DS235088    EEB11719.1    GANO01003229    JAB56642.1    AAAB01008807    EAA03918.4    AXCM01001173    APCN01000188    GDUN01000056    JAN95863.1    CH477553    EAT39089.1    ATLV01015292    KE525006    KFB40300.1    FJ175380    ACN29682.1    KY922835    AUF74484.1    MF741672    AVD96955.1    AXCN02000551    AJWK01013324    GEDC01020887    GEDC01010675    GEDC01009792    JAS16411.1    JAS26623.1    JAS27506.1    PNF15827.1    GFDL01015845    JAV19200.1    CVRI01000047    CRK98187.1    GFDL01015846    JAV19199.1    DS231833    EDS32226.1    ADMH02000578    ETN65800.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000235965    + More
UP000027135    UP000075881    UP000009046    UP000007062    UP000075883    UP000075840    UP000075900    UP000076407    UP000075882    UP000075903    UP000075880    UP000008820    UP000075902    UP000076408    UP000030765    UP000075901    UP000075920    UP000075886    UP000092461    UP000075884    UP000183832    UP000075885    UP000002320    UP000000673   

PRIDE

H9JH27    B2ZZW3    P29523    B2ZZW7    B2ZZX1    H9JH21    + More
B2ZZX0    B2ZZW5    A5A746    C6L8N8    C6L8N9    Q7KXT0    B2ZZW4    B2ZZW8    H9JXN7    B2ZZX2    O96056    A5A747   

Pfam

PF00245   Alk_phosphatase

Interpro

IPR001952   Alkaline_phosphatase        + More
IPR018299   Alkaline_phosphatase_AS       
IPR017850   Alkaline_phosphatase_core_sf       

SUPFAM

SSF53649   SSF53649       

Gene 3D

3.40.720.10    

CDD

cd16012  ALP

ProteinModelPortal

H9JH27   B2ZZW3   P29523   B2ZZW7   B2ZZX1   H9JH21   + More
B2ZZX0   B2ZZW5   A5A746   C6L8N8   A0A2H5CLG8   A0A2H1VQS9   A0A2A4J355   A0A0U1ZJ21   A0A1B0RHM8   G3GBT4   A0A2W1BHB3   C3U1W0   B4Z1D7   I6MML5   B4X983   C3U1W2   M4M3L4   A0A194Q2F4   C3U1V9   B4Z1D6   A0A194R254   A0A2H1WA01   A0A1B0RHM5   I0E1Y2   C3U1W1   A0A194R1W7   A0A194Q8I8   A0A194R2N2   A0A0U1ZEC3   A0A0U2WPZ0   A0A109P4P6   A0A0U1ZEU5   R4I4D0   A0A0U2WZB7   A0A212F875   R4I4E9   G1JT78   A0A212F895   I6PF06   A0A2H5CLJ8   C6L8N9   Q7KXT0   B2ZZW4   B2ZZW8   H9JXN7   B2ZZX2   I6PI83   A0A2W1BI04   O96056   A5A747   A0A194Q2C7   A0A0U2IR33   A0A2W1BMI5   A0A2A4J4Q0   A0A2H1VP42   A0A194R7D1   A0A2H1WF77   A0A2J7PHL4   A0A067QRJ2   A0A067QT98   A0A182JP07   E0VEB3   U5EGZ8   Q7QJ58   A0A182MT69   A0A182I2X2   A0A182RTZ7   A0A182WZ34   A0A182KQV2   A0A182VAE3   A0A182JL64   A0A0P6JST2   Q16WV8   A0A182THI0   A0A182XYI9   A0A084VQQ6   A0A182SLH6   A0A182WJL0   A0A1S4FLA4   C0JBW1   A0A3G1LC34   A0A2L1IQA2   A0A182QLW3   A0A1B0CIG9   A0A182NKM7   A0A1B6DLR4   A0A2J7PHK8   A0A1Q3EV69   A0A1J1ID93   A0A182P207   A0A1Q3EV65   B0W3S9   W5JSA4  

PDB

1K7H     E-value=1.46721e-105,     Score=980

KEGG

101737199    K01077 alkaline phosphatase [EC:3.1.3.1] | (RefSeq) membrane-bound alkaline phosphatase-like

PATHWAY

00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004035   GO:0005886   GO:0031225   GO:0046872   GO:0016021   GO:0016791   GO:0008152   GO:0003824   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11596  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.975006

 

 

Length:

549

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

20.10016

Exp number, first 60 AAs:

4.88379

Total prob of N-in:

0.26951

outside

1  -  549

 

 

Pi

200.922621

Theta

154.865456

Tajima's D

1.075417

CLR

0.423991

CSRT

0.67751612419379

Interpretation

Uncertain