Gene

KWMTBOMO01593

Pre Gene Modal

BGIBMGA008827

Annotation

serine_protease_inhibitor_20_precursor_[Bombyx_mori]

Location

Bomo_Chr3(-):14767040-14770728      View in EpiBrowser

Full name

Alaserpin       + More
Serine protease inhibitor 3/4      
Antichymotrypsin-2      
Antitrypsin      

Alternative Name

Serpin-1
Antichymotrypsin II

Location in the cell

Nuclear   Reliability : 3.858

CDS

ATGGAATATTACTACAGTTTCGTCACGATTGTGTTCCCGCTGCTAAGCGCATTGGGTCAGCTGGCCTTGTTCTCGGAAAAGAAAAACGAACAAAAGCTTCTTGATCTTCTAGAATTGGATAATAAGGAACAGATACGTAGAATATTTCCGTATATACGAGAGGAGTACTTCAGTGAAGACCTTGTAGCTTCACCGAAATTCGACCTGAAAGTTTACACTGACGACGACAACAAGCTGTGTCCCGCTTTCAAAAAGTCATACAAAAAGACCTTTGGTGGTGAGACCGGGGAGGTAGACTACAGTGAACCCGAAGAAGCTGCTGAAGAAATCAACGATTATGTAAAAAGTCAAGGCACAGGTGGCTTCAAAGACCTCGTTTCAAGTCGAAAAATAGAGGACAAGGATGGACTGAATTTTATAGGCACCTACGAGCTAAGTTTTAAATTTGACGATAGATTCGTTTTCACGAGCAGCAAAGTGGTGAAGTTCAAAACCGGTAAGACTGTTACAATCATTCCCGGGGCGGCCGGGGAAGGTATCATCAAATATGCCGACGTTAAATCTATAAACGCCAAGGTTATAGAAATTCTGGCTAGAGGTGGAGAATACTCGTATGTCGTAGTTCTTCCAAACAAAGTTGATGGACTGAAAGAGGTACTGAAGAAATTCACAGATCCTGAAGTTTTCAGACAAGCCATAGACCAAGGGAAAAACGTTTGTGCCAAACTATTAGTTCCCAGCCGAGAAGTGATCAGTAAGGTGGATTTAGCAAACTCTCTCCAACAGTTCCGTTTTGATGAAGCCGATTCCTTTATCGTGATAACATTGAGAGAAGAAATATTCAACAGATGGGAACCAAATGAAACCGGAACCTTCTTGCAGTGA

Protein

MEYYYSFVTIVFPLLSALGQLALFSEKKNEQKLLDLLELDNKEQIRRIFPYIREEYFSEDLVASPKFDLKVYTDDDNKLCPAFKKSYKKTFGGETGEVDYSEPEEAAEEINDYVKSQGTGGFKDLVSSRKIEDKDGLNFIGTYELSFKFDDRFVFTSSKVVKFKTGKTVTIIPGAAGEGIIKYADVKSINAKVIEILARGGEYSYVVVLPNKVDGLKEVLKKFTDPEVFRQAIDQGKNVCAKLLVPSREVISKVDLANSLQQFRFDEADSFIVITLREEIFNRWEPNETGTFLQ

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

3D-structure   Alternative splicing   Glycoprotein   Protease inhibitor   Secreted   Serine protease inhibitor   Signal   Direct protein sequencing   Complete proteome   Reference proteome  

Feature

chain  Alaserpin
splice variant  In isoform 2.

Uniprot

H9JH30   C0J8G9   C0J8H3   C0J8G4   C0J8G6   H9JH34   + More
H9JH33   C0J8H9   C0J8H4   C0J8H2   C0J8G8   H9J5E5   A0A3G1T1Q1   H9J5E6   A0A3G1T1R3   F5B4G8   G9F9J2   B4XHA0   H9JH29   B4XHA1   B4XH99   B4XH98   A0A385XRR7   G9F9J3   A0A385XRT7   Q25499   Q25494   Q25501   Q25495   A0A2H1VE36   Q25497   P14754   Q25526   Q25492   Q25491   Q25493   Q25498   Q25496   Q25500   Q5MGH0   D9HQ60   A0A1L7B975   K4P392   D9HQA1   G9D4T8   A0A0L7LMC8   B0FZ64   B0FZ60   B0FZ62   B0FZ63   B0FZ66   B0FZ68   B0FZ65   B0FZ67   B0FZ61   Q8IS84   Q8IS85   Q8IS86   C5I794   C5I795   A3KEZ8   Q60FS0   A3KEZ7   B2X122   P80034   C7ASM2   P22922   C7ASM3   C7ASM4   A0A0M4K7J2   A0A212FD15  

Pubmed

19121390    19150649    19524698    30237077    8910411    2463253    + More
8276850    14728663    10368276    16023793    18342903    20375075    21967427    26227816    19481148    1761030    2277028    1368515    21104446    22118469   

EMBL

BABH01037565    EU935621    ACG61183.1    EU935625    ACG61187.1    EU935616    + More
ACG61178.1    EU935618    ACG61180.1    BABH01037571    BABH01037572    BABH01037570    EU935631    ACG61193.1    EU935626    ACG61188.1    EU935624    ACG61186.1    EU935620    ACG61182.1    BABH01039199    MG770320    AXY94922.1    BABH01039200    MG770321    AXY94923.1    HQ615869    ADT63775.1    JN033737    AEW46890.2    EU040209    ABW17157.1    BABH01037558    EU040210    ABW17158.1    EU040208    ABW17156.1    EU040207    ABW17155.1    MG753799    AYC12556.1    JN033738    AEW46891.2    MG753798    AYC12555.1    U58361    AAC47340.1    AAC47332.1    AAC47339.1    AAC47341.1    ODYU01002062    SOQ39103.1    AAC47333.1    M23438    L20792    L20793    AAA29334.1    AAC47338.1    AAC47334.1    AAC47337.1    AAC47342.1    AAC47336.1    AAC47335.1    AY829816    AY829817    AAV91430.1    HM023815    JF777348    ADJ58548.1    AEU11693.1    KY385635    APT69916.1    JX524148    AFV46312.1    HM023856    ADJ58589.2    JF777341    AEU11686.1    JTDY01000556    KOB76688.1    EU368832    ABY68559.1    ABY68563.1    ABY68561.1    ABY68560.1    ABY68557.1    ABY68555.1    ABY68558.1    ABY68556.1    ABY68562.1    AY148485    AAN71634.1    AY148484    AAN71633.1    AY148483    AAN71632.1    FJ763763    ACR56864.1    FJ763764    ACR56865.1    AB295499    BAF48335.1    AB189029    BAD52261.1    AB295498    BAF48334.1    EF584499    ABU62829.1    FJ613793    ACT36272.1    D00738    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613795    ACT36274.1    KR003729    ALD62507.1    AGBW02009121    OWR51607.1   

Proteomes

UP000005204    UP000037510    UP000007151   

PRIDE

H9JH30    C0J8G9    C0J8H3    C0J8G4    C0J8G6    H9JH34    + More
H9JH33    C0J8H9    C0J8H4    C0J8H2    C0J8G8    H9J5E5    H9J5E6    H9JH29    P14754    P80034    P22922    C7ASM3    C7ASM4   

Pfam

PF00079   Serpin        + More
PF01826   TIL

Interpro

IPR036186   Serpin_sf        + More
IPR000215   Serpin_fam       
IPR023796   Serpin_dom       
IPR042178   Serpin_sf_1       
IPR042185   Serpin_sf_2       
IPR023795   Serpin_CS       
IPR002919   TIL_dom       
IPR036084   Ser_inhib-like_sf       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

3.30.497.10     2.30.39.10    

ProteinModelPortal

H9JH30   C0J8G9   C0J8H3   C0J8G4   C0J8G6   H9JH34   + More
H9JH33   C0J8H9   C0J8H4   C0J8H2   C0J8G8   H9J5E5   A0A3G1T1Q1   H9J5E6   A0A3G1T1R3   F5B4G8   G9F9J2   B4XHA0   H9JH29   B4XHA1   B4XH99   B4XH98   A0A385XRR7   G9F9J3   A0A385XRT7   Q25499   Q25494   Q25501   Q25495   A0A2H1VE36   Q25497   P14754   Q25526   Q25492   Q25491   Q25493   Q25498   Q25496   Q25500   Q5MGH0   D9HQ60   A0A1L7B975   K4P392   D9HQA1   G9D4T8   A0A0L7LMC8   B0FZ64   B0FZ60   B0FZ62   B0FZ63   B0FZ66   B0FZ68   B0FZ65   B0FZ67   B0FZ61   Q8IS84   Q8IS85   Q8IS86   C5I794   C5I795   A3KEZ8   Q60FS0   A3KEZ7   B2X122   P80034   C7ASM2   P22922   C7ASM3   C7ASM4   A0A0M4K7J2   A0A212FD15  

PDB

1K9O     E-value=3.15599e-14,     Score=189

KEGG

100272185    no KO assigned | (RefSeq) serpin-20, BmSPN16, SPN16; serine protease inhibitor 20

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617  

PANTHER

PTHR11461  

Subcellular location

  
Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.606647

 

 

Length:

294

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.88688

Exp number, first 60 AAs:

17.88473

Total prob of N-in:

0.79846

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  24

outside

25  -  294

 

 

Pi

315.008297

Theta

207.023008

Tajima's D

1.827767

CLR

20.686834

CSRT

0.855957202139893

Interpretation

Uncertain