Gene

KWMTBOMO01569

Pre Gene Modal

BGIBMGA008840

Annotation

PREDICTED:_toll-like_receptor_4_[Bombyx_mori]

Location

Bomo_Chr3(-):14086353-14092379      View in EpiBrowser

Location in the cell

Nuclear   Reliability : 2.545

CDS

ATGGATATGCTCCTAGTACATTGTCTTTGGCTGCTGCTTTACAACGTCCACATCAGTCGCGGCGACCTGATCGAAGTTTACAAAGAATTGTCCCACACGATTCTGTACCCGCAAGAGAAGAGTGATGACCTGCCCGTGGAACTAGGCCAGGACGACTATTCGGGCTGCATCTGCCGGGCCAGCAAACAGAATGGGGTCGTGGTCTGCTTCGGGAATTACGAGTGCCGAATGTTCCCTAAGATCAAAGTGAAATGCGAATTTCTCAGAGTCAGAACAACAGTCATAACGAATATAAGAAAAGGACACTTGGATTCATTATACTTTTTAAAAGTGCTGGAAATAGAAGCCAATCATCAACTAAGACACATAGAGGCAGGAGTGTTTAAGAACCTTACGAGTTTACAACAGTTGTCTATATCATACAACACGCACTTACATTCTATTGATGAACATACATTTATCGGACTAGTGAATCTACGCAATTTAACACTAGTCAACAATGGGTTCACTAATATACTCGCCATTACACCAGCTTTCAAGCCTAGTATTCTCCCGGCTCTCAGAGGTCTTGACATCTCAGAAAATGCCTTCGAAATTATACCAGAAGACGCTTTCGTACCAATGAAAGGTACAACGCTTATGAAACTTGATCTGAATCTGTGTAGATTGGATTTTATACATCCGAAGAGTTTTCTTCCATTGAAGAATCTACGAGAACTGCATATAGGCGAAAATGACTTGAACTCAACTTTAATTGGAGATTTTCTTTTGAAAATGAAAGACGAAAGAATTTATCTAATGTATTTGGATCTATCAGGAATGGGGTTCAGAAAAAACCCACCGCGCGACTTGATGGAAATAATAGCTGAAACCAGTGTGAGAAGATTAATTTTATCACATAATCAATTTGAGTTTATCGATGATGATTCGTTCCCTAAAATGGAGAATATAGAATTGATGGATCTTAGGAAAGTTTTGGCAATGCAGATTGGTTCCAATGCATTCAATCCACATAAATTTCCGAACCTGAAACTGCTTTTACTAAGCGGAAACAATTTACCTGGATTACACAAGGCACCCTTCTCAGATCAACTCCTCTTTTTAGATTTATCTGATAACAAAGGTAGTCCAACGAATCCTATGTATTACGAGATTGATAGAAACACTTTTGTCCAAAGCAAGGAACTTAAAATACTAAATTTAGCTTTTAATAGAATCAGAGCTATCTTCGAGTACACGTTTCGTGGCTTGGAAAATCTACAGATCCTGAGTATGGAGAACGGCACCTTGTATCACATTGGTGATAAAAGTTTCAAGCCATTAAAACGATTAGAAATGTTAAATTTAGCCAACAATCCCTTGGAACAAAATGAGAATTTGACAAGTTCCATGTTTGATGGATTAAATGACTTAAAAATTTTGATTCTAGAAAACTGTGGAATAAAGAGATTTTATGATGATGATAACATATTCGAGATGATGCCAAACCTGACCCATCTTGTGCTTAGAAATAACCAATTGTACTATATATCAGCAGAGACGTTGAAGCCGTTAAAATTACTAAAGGTATTAGATCTATCCGAGAATCTCTTTGTTTCGTGGTGGCAACCATTGTTCCTTGCCTCTGGCGTTAAGCCGATCACTCTGAATCTAAAGAACAACAAACTATCACATTTTTCAATGAGTATGATACAAGACATAAGTTATTTGTTAGAAAATAATGGTAATTCAAGAATAGAAATAGAGTTAATGGATAACATTTTTATATGTGATTGCAGTTCGATGTATAAAATGTATAGTTGGTTACAAGCGAACGGTAGCGAGGTTCTTAGAAAGTTTATTCAGAGTTCCAAATTCCAATGCAGCAGTCCGGATATTTGGGAAGATAAGAGGGTAGCTGATTACTTATCTTCAATAAAAACGTTGCGATGCCTGATGACAGAGAAAATGACAAACATAATGTATTTAGTTTGGACTGCACCATCGCTAGTAGCTGTAGCACTGATCTTATTTATAATAGTTTTTATCTTTAAATTTAAGACGTACATTCGCTATTGGATGTTTTTAGCTAAACTGGCTTTAGGGCGGAATTTCAGGAGAAAGTCTGGAAAGCATGTAGAGACAAAGGATTACAAGTATGATGCTTTTATATCTTACTGCAGTGAAGATAGAGATTTTGTCGTCCATATGATTAACAATTTAGAACTGGAACCACCATTCCTGAAGCTATGCGTTTACGAACGAGATTTTGATATAGGATCTTTCATATCAGAAGCAGTATTAAAAAGTGTGAACGAAAGTAAATACGTAATTTTAGTTATAAGTAATGGGTTTGCTAAATCCCAATGGTGCAGATGGGAGACCCAATTGGCGGAGTACCACCGAATTTTTTTAGAAGATGGTACCTCCTATGATCCTTTAGTTTTAGTTAGAATAGGCGATGTACAAAATAAATATCTGACGACAACATTGAAATACTTGTTGAAAACCAAAATTTATCACACGTGGGACGAAAATAATCAAGATGAGTTTTGGAAGAAATTAAGAAATGTACTGACACGGAAGATATAA

Protein

MDMLLVHCLWLLLYNVHISRGDLIEVYKELSHTILYPQEKSDDLPVELGQDDYSGCICRASKQNGVVVCFGNYECRMFPKIKVKCEFLRVRTTVITNIRKGHLDSLYFLKVLEIEANHQLRHIEAGVFKNLTSLQQLSISYNTHLHSIDEHTFIGLVNLRNLTLVNNGFTNILAITPAFKPSILPALRGLDISENAFEIIPEDAFVPMKGTTLMKLDLNLCRLDFIHPKSFLPLKNLRELHIGENDLNSTLIGDFLLKMKDERIYLMYLDLSGMGFRKNPPRDLMEIIAETSVRRLILSHNQFEFIDDDSFPKMENIELMDLRKVLAMQIGSNAFNPHKFPNLKLLLLSGNNLPGLHKAPFSDQLLFLDLSDNKGSPTNPMYYEIDRNTFVQSKELKILNLAFNRIRAIFEYTFRGLENLQILSMENGTLYHIGDKSFKPLKRLEMLNLANNPLEQNENLTSSMFDGLNDLKILILENCGIKRFYDDDNIFEMMPNLTHLVLRNNQLYYISAETLKPLKLLKVLDLSENLFVSWWQPLFLASGVKPITLNLKNNKLSHFSMSMIQDISYLLENNGNSRIEIELMDNIFICDCSSMYKMYSWLQANGSEVLRKFIQSSKFQCSSPDIWEDKRVADYLSSIKTLRCLMTEKMTNIMYLVWTAPSLVAVALILFIIVFIFKFKTYIRYWMFLAKLALGRNFRRKSGKHVETKDYKYDAFISYCSEDRDFVVHMINNLELEPPFLKLCVYERDFDIGSFISEAVLKSVNESKYVILVISNGFAKSQWCRWETQLAEYHRIFLEDGTSYDPLVLVRIGDVQNKYLTTTLKYLLKTKIYHTWDENNQDEFWKKLRNVLTRKI

Similarity

Belongs to the Toll-like receptor family.

Uniprot

H9JH43   A0A2A4JAB1   A0A2W1BXS4   A0A2H1W6M1   A0A0L7LGF1   A0A194Q8L2   + More
A0A0N1IF49   A0A346RAG4   A0A212FA48   A0A2P8ZI00   A0A2J7RQS3   A0A2J7RQS2   A0A1W4WVW1   A0A139WDW1   A0A2J7RQR5   T1HC46   A0A146LZP2   A0A0P5JJQ3   E9G6W0   A0A0P5IAH1   A0A0P4XKS5   A0A162Q7U5   A0A0P6A7L5   A0A0P5N741   A0A0T6B638   A0A0P6J8S2   A0A0P6GCG8   T1ITN8   A0A147BEG0   A0A0P6C638   A0A0P5CFV9   A0A087UAT7   A0A0N8A8V3   A0A2R3SK02   A0A3B4B2C9   W0ZGY1   W5LS69   T1SBW7   A0A169T826  

Pubmed

19121390    28756777    26227816    26354079    29910977    22118469    + More
29403074    18362917    19820115    26823975    21292972    29652888    25463417    24333435    25329095    23969138   

EMBL

BABH01041041    BABH01041042    NWSH01002406    PCG68362.1    KZ149928    PZC77486.1    + More
ODYU01006654    SOQ48687.1    JTDY01001182    KOB74623.1    KQ459562    KPI99745.1    KQ461158    KPJ08072.1    MH243030    AXS59164.1    AGBW02009521    OWR50604.1    PYGN01000051    PSN56123.1    NEVH01000618    PNF43173.1    PNF43175.1    KQ971357    KYB26109.1    PNF43174.1    ACPB03006194    GDHC01005571    JAQ13058.1    GDIQ01202050    JAK49675.1    GL732534    EFX84748.1    GDIQ01239980    JAK11745.1    GDIP01241213    JAI82188.1    LRGB01000389    KZS19436.1    GDIP01046189    JAM57526.1    GDIQ01148760    JAL02966.1    LJIG01009569    KRT82818.1    GDIQ01011162    JAN83575.1    GDIQ01054695    JAN40042.1    JH431493    GEGO01006214    JAR89190.1    GDIP01012917    JAM90798.1    GDIP01186766    JAJ36636.1    KK119042    KFM74476.1    GDIP01171113    JAJ52289.1    MF326514    AVP74315.1    HG794237    CDK37745.1    JX898685    AGS14315.2    LC150775    BAU98393.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053268    UP000053240    UP000007151    + More
UP000245037    UP000235965    UP000192223    UP000007266    UP000015103    UP000000305    UP000076858    UP000054359    UP000261520    UP000018467   

PRIDE

H9JH43   

Pfam

PF13676   TIR_2        + More
PF13855   LRR_8
PF00560   LRR_1
PF01582   TIR
PF13306   LRR_5
PF13516   LRR_6
PF12799   LRR_4

Interpro

IPR035897   Toll_tir_struct_dom_sf        + More
IPR032675   LRR_dom_sf       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR001611   Leu-rich_rpt       
IPR000157   TIR_dom       
IPR026906   LRR_5       
IPR000483   Cys-rich_flank_reg_C       
IPR025875   Leu-rich_rpt_4       

SUPFAM

SSF52200   SSF52200       

Gene 3D

3.40.50.10140     3.80.10.10    

ProteinModelPortal

H9JH43   A0A2A4JAB1   A0A2W1BXS4   A0A2H1W6M1   A0A0L7LGF1   A0A194Q8L2   + More
A0A0N1IF49   A0A346RAG4   A0A212FA48   A0A2P8ZI00   A0A2J7RQS3   A0A2J7RQS2   A0A1W4WVW1   A0A139WDW1   A0A2J7RQR5   T1HC46   A0A146LZP2   A0A0P5JJQ3   E9G6W0   A0A0P5IAH1   A0A0P4XKS5   A0A162Q7U5   A0A0P6A7L5   A0A0P5N741   A0A0T6B638   A0A0P6J8S2   A0A0P6GCG8   T1ITN8   A0A147BEG0   A0A0P6C638   A0A0P5CFV9   A0A087UAT7   A0A0N8A8V3   A0A2R3SK02   A0A3B4B2C9   W0ZGY1   W5LS69   T1SBW7   A0A169T826  

PDB

1FYW     E-value=4.23296e-11,     Score=167

KEGG

101739406    no KO assigned | (RefSeq) toll-like receptor 4

GO

GO:0042116   GO:0004888   GO:0045087   GO:0050829   GO:0034142   GO:0050707   GO:0001875   GO:0002755   GO:0046696   GO:0006954   GO:0005887   GO:0009986   GO:0005886   GO:0002224   GO:0016021   GO:0007165   GO:0009617   GO:0002221   GO:0005515   GO:0006468   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0003779  

SignalP

Position:   1 - 21,         Likelihood:  0.983820

 

 

Length:

856

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.11038

Exp number, first 60 AAs:

0.01968

Total prob of N-in:

0.00222

outside

1  -  654

TMhelix

655  -  677

inside

678  -  856

 

 

Pi

191.29917

Theta

171.980219

Tajima's D

0.370146

CLR

0.456138

CSRT

0.471726413679316

Interpretation

Possibly Positive selection