Gene

KWMTBOMO01564

Annotation

PREDICTED:_insulin_receptor_substrate_1-B?_partial_[Bombyx_mori]

Location

Bomo_Chr3(+):14003170-14025423      View in EpiBrowser

Full name

Insulin receptor substrate 1-B       + More
Insulin receptor substrate 1      

Alternative Name

XIRS-L'
pp185

Location in the cell

Nuclear   Reliability : 4.117

CDS

ATGAGGCGGCATGAGTACGGCATGACTTCCATGCCCTGCGTACCTGCGGAAGGGCGTGCGGGAGCTATGTCGGGGGCGGGCGCGGGCGCCGTGGTGCGCCAGGGCCACCTGCGTAAGTTAAAAAATATGAAGAAGAAATACTTTGTGTTGCGCGCGGAGACCGCAGACTGTTCGGCACGTCTTGAGTATTACGAATCTGAGAAGAAATTTCGAGCTAGTGCGGCCCCAAAGCGCGTGCTGCCTCTCAAGAGCTGTTACAACATTACTCGGAGGCTGGACCTCAAGCAAAAGCACGTGATCGCCCTGTTCACACGAGAGGAGCAATTCTGCGTTGTTGCAGAAAACGAGCAGGAGTTACACGCCTGGCTCTCAGCCATTCTCAAACAGCATCGTTCAGACGACGCCAGTACCGAACCTCTGCTACCCATACAACGCGTCTGGCAAGTTACCGTTCAAAAGAAAGGACTTGGCGCCTCTAAGAACATCCAGGGTCTATACAACCTCTGTCTTACGGACAAGACTCTAACTCTGGTCAAGATCAAGAGTCACAACAACGTTATCAGCGATCTAGGGATACCCGAGCGAGTGGAGTATTCCCTAAAGAATATTAGAAGGTGCGGGGATTCAGAGTGCTTCTTCTACATGGAAGTCGGAAGGCAGACTACGACGGGAGCCGGCGAACTTTGGATGCTCTGCGACGATTCGAACATAGCGCAGAGCATGCACTCTACTATACTACTAGCGATGCGAGACTGCGCGAAAGAGACAGAGCACGAGCGCGACCACATCGTCATGCACAAGAACTACGAGGGCTCCAACACGCTGCCGACCAGACGACAGACGTACTCCGACGGCAAGGGTCGAGCCGGCCTCACCAACGGTAAGGGCATCTATAGACGCGTCGACTCTGATAATGTCAGTGAATTGGTATTGTACTATTCACCGACCTGTGACCGGCTTATTCTTTCAGCATACCTACTTTATTTTCCGAATTAA

Protein

MRRHEYGMTSMPCVPAEGRAGAMSGAGAGAVVRQGHLRKLKNMKKKYFVLRAETADCSARLEYYESEKKFRASAAPKRVLPLKSCYNITRRLDLKQKHVIALFTREEQFCVVAENEQELHAWLSAILKQHRSDDASTEPLLPIQRVWQVTVQKKGLGASKNIQGLYNLCLTDKTLTLVKIKSHNNVISDLGIPERVEYSLKNIRRCGDSECFFYMEVGRQTTTGAGELWMLCDDSNIAQSMHSTILLAMRDCAKETEHERDHIVMHKNYEGSNTLPTRRQTYSDGKGRAGLTNGKGIYRRVDSDNVSELVLYYSPTCDRLILSAYLLYFPN

Description

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Subunit

Interacts with the NPXY motif of tyrosine-phosphorylated igf1r and insr via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit at a low level in vitro prior to phosphorylation. Binding is greatly enhanced following tyrosine phosphorylation by insr and probably occurs via the phosphorylated YXXM motifs (By similarity).
Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF, FER and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (PubMed:1380456). Interacts with ROCK1 (PubMed:11739394). Interacts (via PH domain) with PHIP (PubMed:11018022). Interacts with GRB2 (PubMed:8491186). Interacts with ALK (By similarity). Interacts with EIF2AK2/PKR (By similarity). Interacts with GKAP1 (PubMed:25586176). Interacts with DGKZ in the absence of insulin; insulin stimulation decreases this interaction (PubMed:27739494). Found in a ternary complex with DGKZ and PIP5K1A in the absence of insulin stimulation (By similarity).
Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF and PIK3CA (PubMed:15197263). Interacts (via PH domain) with PHIP (PubMed:11018022). Interacts with FER (PubMed:11006284). Interacts with ALK (By similarity). Interacts with EIF2AK2/PKR (PubMed:22948222). Interacts with GKAP1 (PubMed:25586176). Interacts with DGKZ in the absence of insulin; insulin stimulation decreases this interaction (PubMed:27739494). Found in a ternary complex with DGKZ and PIP5K1A in the absence of insulin stimulation (PubMed:27739494).

Keywords

Phosphoprotein   Repeat   Transducer   3D-structure   Complete proteome   Direct protein sequencing   Reference proteome   Ubl conjugation  

Feature

chain  Insulin receptor substrate 1-B

Uniprot

A0A2R4RM46   A0A212EQY5   A0A0N1PF91   A0A2W1C087   A0A385KNU5   E0VU10   + More
A0A2J7QHN1   A0A1B6DS25   A0A2M4A672   A0A2P0XJ52   A0A060WAN8   A0A2J7QHM4   W5UF94   A0A2D0SWJ3   A0A2D0SWI6   H0ZCS2   P84770   H3D2I1   I3J8S8   F6XDD6   A0A1L8GB03   A0A1L8G4J8   A0A091GEW2   W5U827   A0A151NAL3   A0A151NAM8   A0A3B3V071   E7F4P8   G3V7V7   P35570   A0A3B5KTL8   Q543V3   W5L0U4   P35569   E7F0F4   A0A0P7YIS1   A0A087TYE5   A0A1W4Y7E0   A0A146ZV70   A0A1L2TQP8   A0A1W4Y7Y0   A0A3B4DEN8   A0A3B5KZQ4   A0A3B4D7R1   I3J8S9   H0Z1G2  

Pubmed

22118469    26354079    28756777    20566863    24755649    23127152    + More
20360741    7791763    15496914    25186727    20431018    27762356    22293439    23594743    15057822    15632090    22673903    1648180    2022647    1380456    8491186    7504175    8349691    11018022    11606564    12006586    11739394    25586176    27739494    21551351    10349636    11042159    11076861    11217851    12466851    12040188    16141073    17242355    19468303    21183079    25329095    8167159    8448209    11006284    10749573    11598104    15197263    16098829    22948222    27864748   

EMBL

MF040616    AVZ23638.1    AGBW02013182    OWR43908.1    KQ461158    KPJ08075.1    + More
KZ149928    PZC77483.1    MG657019    AXZ96479.1    DS235777    EEB16866.1    NEVH01013973    PNF28091.1    GEDC01008845    JAS28453.1    GGFK01002983    MBW36304.1    KY763990    AVA30826.1    FR904402    CDQ62264.1    PNF28095.1    JT408393    AHH38327.1    ABQF01030092    AERX01042792    AAMC01065833    CM004474    OCT80906.1    CM004475    OCT78720.1    KL448071    KFO79866.1    JT407733    AHH38103.1    AKHW03003627    KYO33863.1    KYO33864.1    CR854848    CR854907    CT027718    AC103270    CH474004    EDL75502.1    X58375    AC123690    AC137845    AK045317    AK142242    CH466629    BAC32308.1    BAE24991.1    EDL02131.1    L24563    X69722    BX088704    BX322601    CU019646    JARO02005134    KPP67285.1    KK117314    KFM70134.1    GCES01016486    JAR69837.1    KX254609    APE61640.1    ABQF01018607   

Proteomes

UP000007151    UP000053240    UP000009046    UP000235965    UP000193380    UP000221080    + More
UP000007754    UP000007303    UP000005207    UP000008143    UP000186698    UP000053760    UP000050525    UP000261500    UP000000437    UP000002494    UP000005226    UP000000589    UP000018467    UP000034805    UP000054359    UP000192224    UP000265000    UP000261440    UP000261380   

PRIDE

P84770    E7F4P8    P35570    P35569    E7F0F4   

Pfam

PF02174   IRS        + More
PF00169   PH

Interpro

IPR001849   PH_domain        + More
IPR011993   PH-like_dom_sf       
IPR039011   IRS       
IPR002404   IRS_PTB       

Gene 3D

2.30.29.30    

CDD

cd01204  PTB_IRS

ProteinModelPortal

A0A2R4RM46   A0A212EQY5   A0A0N1PF91   A0A2W1C087   A0A385KNU5   E0VU10   + More
A0A2J7QHN1   A0A1B6DS25   A0A2M4A672   A0A2P0XJ52   A0A060WAN8   A0A2J7QHM4   W5UF94   A0A2D0SWJ3   A0A2D0SWI6   H0ZCS2   P84770   H3D2I1   I3J8S8   F6XDD6   A0A1L8GB03   A0A1L8G4J8   A0A091GEW2   W5U827   A0A151NAL3   A0A151NAM8   A0A3B3V071   E7F4P8   G3V7V7   P35570   A0A3B5KTL8   Q543V3   W5L0U4   P35569   E7F0F4   A0A0P7YIS1   A0A087TYE5   A0A1W4Y7E0   A0A146ZV70   A0A1L2TQP8   A0A1W4Y7Y0   A0A3B4DEN8   A0A3B5KZQ4   A0A3B4D7R1   I3J8S9   H0Z1G2  

PDB

1QQG     E-value=2.53138e-52,     Score=518

KEGG

101745072    K16172 insulin receptor substrate 1 | (RefSeq) insulin receptor substrate 1-B

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0008286   GO:0005158   GO:0071456   GO:0032000   GO:0005901   GO:0005070   GO:0046628   GO:0014065   GO:0005829   GO:0048009   GO:0005634   GO:0045725   GO:0005159   GO:0046676   GO:0001784   GO:0046326   GO:0043548   GO:0042169   GO:0043231   GO:0005737   GO:0005886   GO:0046627   GO:0090275   GO:0051291   GO:0043552   GO:0005068   GO:0007568   GO:0005899   GO:0014823   GO:1904385   GO:0043434   GO:0031000   GO:0070094   GO:0005080   GO:0071478   GO:0042327   GO:0019904   GO:0019901   GO:1990416   GO:0071398   GO:0030335   GO:0030879   GO:0010468   GO:0016042   GO:0010907   GO:0043491   GO:0032868   GO:0036064   GO:0034504   GO:0032869   GO:0002053   GO:0003964   GO:0006278   GO:0004190   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779   GO:0016021  

PANTHER

PTHR10614  

Length:

331

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32441

Exp number, first 60 AAs:

0.21296

Total prob of N-in:

0.06774

outside

1  -  331

 

 

Pi

221.451869

Theta

177.338266

Tajima's D

0.568523

CLR

0.220684

CSRT

0.534573271336433

Interpretation

Uncertain