Gene

KWMTBOMO01533

Pre Gene Modal

BGIBMGA009071

Annotation

PREDICTED:_phosphatidylinositol_3?4?5-trisphosphate_3-phosphatase_and_dual-specificity_protein_phosphatase_PTEN_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr3(+):12976989-13040873      View in EpiBrowser

Full name

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN      

Alternative Name

Phosphatase and tensin homolog

Location in the cell

Nuclear   Reliability : 2.484

CDS

ATGGGTGTTTGCGTGAGCTGCCGGCGCCGAGAGCGGAAGATCCCAGAAAAGCGGTCGGTGCCGGGAGTGGTTGGGCCCGCTAAGGGCGCGGCGGCGGAGCTGCTGCCCAGGCCAGTGAATCGCTTTACAGCCATGGCAAACTCCATGTCAAATATCAAGATGACCAACCCGATAAAGAATATGGTCAGCAAGCGCAGGATACGCTACACCAAGCACGGATTCAACCTGGACTTAGCCTATATCACAGACAGGCTGATAGCGATGGGTTTCCCGGCCGAGAAATTGGAAGGAGTATACAGGAATCACATAGACGAAGTGTATAGGTTTTTAGAGACAATGCACAAGGATCACTACAAGATATACAACTTGTGCTCCGAGAGGACATACGACCCGAGCAAGTTTCATAAGAGGGTGGAGAGATATGCGTTCGAAGACCACACCCCGCCCCACATGGAGCTGATACAGCCATTCTGCGAGAACGTGCACAGTTGGCTCAGTGCGGATACAAGGAACGTTGCCGTCGTACATTGTAAAGCGGGGAAAGGTCGGACCGGTACAATGGTCTGTTGTTATTTGTTATACAGCGGGGACCAGCCTAATGCAGACGAAGCGCTCAAGTTCTACGGCAGGAAGAGAACTCTAGATGAAAAGGGCGTGACGATACCGTCGCAGCGGCGCTACGTGGAGTACTACGGGGCGCTGCTGCGGTCGGGCGTGGCGTACCGGGCGGGCGCGGCGCGCGTGCAGGTCCGCGAGCTGCGCATGTCGCCGCCGCCCGCCGCCCACGTGCCCGCCGCCGCCGCGCCGCCCGACCTCGTGCTGTGCCAGGCCGACCCGCACGCCGACCCGCACAGCGAACACAACGTGCTCGTGCTCAAGACGCCGCCCGGATGCGTGGATGTGCAGCGAGACGAGAACAGCATCCGCATCTGCCTGACGCAGTGCACGCCGCTGTTCGGCGACATCAGGGTGGACGTCTACAACAAACCGAAGATGAAGATGCGCAAAGAGAAGCTGTTTCATTTCTGGTTCAACACGTTCTTCGTTACGGCCGAAGTCGGAGCCCAAAGAATACCGCCATTACCTGACAGTCCGGACCTGGAGACGTACAAGCTGACCCTGAACAAGTGGCAGCTGGACGACGCCCACAAGGACAAGCAACACAAACATTACAGCCCCGACTTCAAGGTTGAGCTGATAGTGGAGAAGGTGCCGGATTCGTCGACGTACAGACCGGCGTGCGACCGCACCAGGTCACCGACCTCCTCGTCCTCCTCCTCCGGCTCCGTCGGCTCCGACCCCGAGACGGACGGGAACTGGGACTCTGGGACGGTGTGCGAGCGCGTCGGCCATTACCGGCAGCTGTCCCCCGACCACACGTGA

Protein

MGVCVSCRRRERKIPEKRSVPGVVGPAKGAAAELLPRPVNRFTAMANSMSNIKMTNPIKNMVSKRRIRYTKHGFNLDLAYITDRLIAMGFPAEKLEGVYRNHIDEVYRFLETMHKDHYKIYNLCSERTYDPSKFHKRVERYAFEDHTPPHMELIQPFCENVHSWLSADTRNVAVVHCKAGKGRTGTMVCCYLLYSGDQPNADEALKFYGRKRTLDEKGVTIPSQRRYVEYYGALLRSGVAYRAGAARVQVRELRMSPPPAAHVPAAAAPPDLVLCQADPHADPHSEHNVLVLKTPPGCVDVQRDENSIRICLTQCTPLFGDIRVDVYNKPKMKMRKEKLFHFWFNTFFVTAEVGAQRIPPLPDSPDLETYKLTLNKWQLDDAHKDKQHKHYSPDFKVELIVEKVPDSSTYRPACDRTRSPTSSSSSSGSVGSDPETDGNWDSGTVCERVGHYRQLSPDHT

Description

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase.

Catalytic Activity

H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate

Similarity

Belongs to the PTEN phosphatase protein family.

Uniprot

A0A1U9VYP0   A0A385KP72   A0A194Q425   A0A212EQA5   A0A2A4JC56   A0A2J7PXJ8   + More
A0A2J7PXI9   A0A2J7PXJ5   A0A1B6IPR6   A0A1B6I2P7   A0A1B6E296   A0A1B6HBA5   A0A1B6FF62   A0A1W4W8J9   A0A1W4WJU2   A0A026W202   T1IEZ7   A0A3L8DNZ8   A0A1W4WK32   E2B2C4   K7J3F7   C5IX04   C5IX06   A0A2A3EHP8   A0A088AW82   A0A310SNU5   A0A195B6F6   A0A158NH16   A0A151J1Z4   C5IX05   A0A195D1D6   A0A1Y1NNP8   A0A1Y1NIW4   A0A1Y1NMX4   A0A0C9QNZ4   A0A232FEW7   A0A195FPW0   A0A0C9REB5   A0A224XCD3   A0A1L8DKY8   A0A0C9RAI0   A0A023F2V6   A0A067R4W3   A0A0V0GEQ0   V5I9N9   V5G6Z5   A0A139WCR0   U5EGU8   D6WV93   E9IMQ7   V5GVX9   A0A0A9Z3S5   A0A0A9ZDM8   A0A146KZH4   A0A0A9WR37   A0A0A9ZDN1   E2AJE6   A0A0J7KUV5   A0A336LPS5   R7UIY8   A0A336LL10   A0A3Q0IHJ6   C3Y027   A0A0M5L082   A0A1B0GFE4   A0A2S2PGK5   J9JVA7   A0A0T6B671   A0A182YYW0   A0A2H8TZB0   A0A1A9WHF5   A0A2S2QLC3   A0A1I8MDR5   W8BRK9   A0A1B0AH81   A0A1B0C653   A0A1A9Y710   A0A1A9UD18   A0A1S3IBE2   A0A1I8NP83   A0A1W4USY4   A0A147AZ98   F7EQJ0   A0A1W4W8K1   A0A0A1X1W9   I0BWL0   L8HXB3   W5PXK2   A0A0K8VMJ7   A1Z072   A1Z068   A0A1S2ZKK5   I3MU41   A0A2K6EIG7  

EC Number

3.1.3.16
3.1.3.48
3.1.3.67

Pubmed

26893349    26354079    22118469    24508170    30249741    20798317    + More
20075255    21347285    28004739    28648823    25474469    24845553    18362917    19820115    21282665    25401762    26823975    23254933    18563158    15562597    25315136    24495485    17495919    25830018    22751099    20809919    17433073   

EMBL

KX792108    AQY15761.1    MG657022    AXZ96482.1    KQ459562    KPI99764.1    + More
AGBW02013278    OWR43665.1    NWSH01001919    PCG69677.1    NEVH01020856    PNF21052.1    PNF21051.1    PNF21053.1    GECU01018813    JAS88893.1    GECU01026571    JAS81135.1    GEDC01031216    GEDC01025579    GEDC01021541    GEDC01008224    GEDC01005281    JAS06082.1    JAS11719.1    JAS15757.1    JAS29074.1    JAS32017.1    GECU01035776    GECU01003138    JAS71930.1    JAT04569.1    GECZ01020942    JAS48827.1    KK107487    EZA50068.1    ACPB03007378    QOIP01000006    RLU22170.1    GL445130    EFN90161.1    FJ969918    ACR55735.1    FJ969920    ACR55737.1    KZ288256    PBC30531.1    KQ761783    OAD57012.1    KQ976574    KYM80091.1    ADTU01015432    KQ980447    KYN16012.1    FJ969919    ACR55736.1    KQ976973    KYN06661.1    GEZM01001533    JAV97697.1    GEZM01001531    JAV97699.1    GEZM01001534    JAV97696.1    GBYB01005269    JAG75036.1    NNAY01000310    OXU29306.1    KQ981387    KYN41969.1    GBYB01005268    GBYB01005271    JAG75035.1    JAG75038.1    GFTR01006379    JAW10047.1    GFDF01006941    JAV07143.1    GBYB01005270    JAG75037.1    GBBI01003174    JAC15538.1    KK852699    KDR18177.1    GECL01000386    JAP05738.1    GALX01002605    JAB65861.1    GALX01002606    JAB65860.1    KQ971363    KYB25713.1    GANO01003297    JAB56574.1    EFA07760.2    GL764255    EFZ18116.1    GALX01002604    JAB65862.1    GBHO01003683    GBHO01003682    GBRD01017941    GBRD01017940    GDHC01000972    JAG39921.1    JAG39922.1    JAG47886.1    JAQ17657.1    GBHO01003684    GBHO01003681    JAG39920.1    JAG39923.1    GDHC01017440    JAQ01189.1    GBHO01033718    GBHO01033717    GBHO01021857    GBHO01003686    JAG09886.1    JAG09887.1    JAG21747.1    JAG39918.1    GBHO01003685    GBHO01003679    GBRD01017939    GBRD01017938    GDHC01010648    GDHC01004693    JAG39919.1    JAG39925.1    JAG47888.1    JAQ07981.1    JAQ13936.1    GL439972    EFN66467.1    LBMM01003020    KMQ94063.1    UFQT01000037    SSX18397.1    AMQN01007375    KB300556    ELU06519.1    SSX18395.1    GG666477    EEN66393.1    KR075846    ALE20565.1    CCAG010014184    GGMR01015950    MBY28569.1    ABLF02006459    LJIG01009534    KRT82888.1    GFXV01007772    MBW19577.1    GGMS01009344    MBY78547.1    GAMC01004773    JAC01783.1    JXJN01026447    GCES01002440    JAR83883.1    GBXI01008993    JAD05299.1    JQ326290    AFH66808.1    JH882713    ELR48481.1    AMGL01063172    AMGL01063173    AMGL01063174    GDHF01012210    JAI40104.1    EF153770    ABM21568.1    EF153766    ABM21564.1    AGTP01101032    AGTP01101033   

Proteomes

UP000053268    UP000007151    UP000218220    UP000235965    UP000192223    UP000053097    + More
UP000015103    UP000279307    UP000008237    UP000002358    UP000242457    UP000005203    UP000078540    UP000005205    UP000078492    UP000078542    UP000215335    UP000078541    UP000027135    UP000007266    UP000000311    UP000036403    UP000014760    UP000079169    UP000001554    UP000092444    UP000007819    UP000076420    UP000091820    UP000095301    UP000092445    UP000092460    UP000092443    UP000078200    UP000085678    UP000095300    UP000192221    UP000265000    UP000002280    UP000002356    UP000079721    UP000005215    UP000233160   

Pfam

PF10409   PTEN_C2        + More
PF00782   DSPc

Interpro

IPR029021   Prot-tyrosine_phosphatase-like        + More
IPR003595   Tyr_Pase_cat       
IPR016130   Tyr_Pase_AS       
IPR014020   Tensin_C2-dom       
IPR029023   Tensin_phosphatase       
IPR000340   Dual-sp_phosphatase_cat-dom       
IPR017361   Bifunc_PIno_P3_Pase/Pase_PTEN       

SUPFAM

SSF52799   SSF52799       

Gene 3D

3.90.190.10    

ProteinModelPortal

A0A1U9VYP0   A0A385KP72   A0A194Q425   A0A212EQA5   A0A2A4JC56   A0A2J7PXJ8   + More
A0A2J7PXI9   A0A2J7PXJ5   A0A1B6IPR6   A0A1B6I2P7   A0A1B6E296   A0A1B6HBA5   A0A1B6FF62   A0A1W4W8J9   A0A1W4WJU2   A0A026W202   T1IEZ7   A0A3L8DNZ8   A0A1W4WK32   E2B2C4   K7J3F7   C5IX04   C5IX06   A0A2A3EHP8   A0A088AW82   A0A310SNU5   A0A195B6F6   A0A158NH16   A0A151J1Z4   C5IX05   A0A195D1D6   A0A1Y1NNP8   A0A1Y1NIW4   A0A1Y1NMX4   A0A0C9QNZ4   A0A232FEW7   A0A195FPW0   A0A0C9REB5   A0A224XCD3   A0A1L8DKY8   A0A0C9RAI0   A0A023F2V6   A0A067R4W3   A0A0V0GEQ0   V5I9N9   V5G6Z5   A0A139WCR0   U5EGU8   D6WV93   E9IMQ7   V5GVX9   A0A0A9Z3S5   A0A0A9ZDM8   A0A146KZH4   A0A0A9WR37   A0A0A9ZDN1   E2AJE6   A0A0J7KUV5   A0A336LPS5   R7UIY8   A0A336LL10   A0A3Q0IHJ6   C3Y027   A0A0M5L082   A0A1B0GFE4   A0A2S2PGK5   J9JVA7   A0A0T6B671   A0A182YYW0   A0A2H8TZB0   A0A1A9WHF5   A0A2S2QLC3   A0A1I8MDR5   W8BRK9   A0A1B0AH81   A0A1B0C653   A0A1A9Y710   A0A1A9UD18   A0A1S3IBE2   A0A1I8NP83   A0A1W4USY4   A0A147AZ98   F7EQJ0   A0A1W4W8K1   A0A0A1X1W9   I0BWL0   L8HXB3   W5PXK2   A0A0K8VMJ7   A1Z072   A1Z068   A0A1S2ZKK5   I3MU41   A0A2K6EIG7  

PDB

1D5R     E-value=8.65549e-80,     Score=757

KEGG

101745952    K01110 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphata

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0008138   GO:0004725   GO:0016301   GO:0016314   GO:0051800   GO:0046855   GO:0051717   GO:0046856   GO:0008285   GO:0007399   GO:0016605   GO:0005737   GO:0004438   GO:0019901   GO:0042711   GO:0060736   GO:0008284   GO:0002902   GO:0030165   GO:0005829   GO:0032228   GO:0060997   GO:0033555   GO:0070373   GO:0043066   GO:0004722   GO:0071257   GO:0045736   GO:0060044   GO:0060291   GO:1903690   GO:0021955   GO:0090344   GO:0032286   GO:0060070   GO:0070374   GO:0097107   GO:0051898   GO:0001525   GO:0010719   GO:0051895   GO:0030534   GO:0043491   GO:0060179   GO:0016324   GO:0051091   GO:0050680   GO:2000463   GO:0009898   GO:0090071   GO:0060024   GO:0048738   GO:0043542   GO:0050821   GO:0045475   GO:0007270   GO:0051548   GO:0033032   GO:0035749   GO:0090394   GO:2000808   GO:0007611   GO:0043220   GO:1903984   GO:0060134   GO:0031642   GO:0071456   GO:0043005   GO:0097105   GO:0021542   GO:1990381   GO:0048853   GO:0042802   GO:0035176   GO:0060074   GO:0045792   GO:2000060   GO:0050771   GO:0061002   GO:1904668   GO:0010997   GO:0048681   GO:2000134   GO:1904706   GO:0006470   GO:0005515   GO:0016311   GO:0016791   GO:0006418   GO:0006334   GO:0003779   GO:0016021  

Subcellular location

Cytoplasm  
Nucleus  
PML body  

Length:

460

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.01085

Exp number, first 60 AAs:

0.01366

Total prob of N-in:

0.06955

outside

1  -  460

 

 

Pi

234.838654

Theta

164.798082

Tajima's D

1.294244

CLR

0.339883

CSRT

0.733513324333783

Interpretation

Uncertain