SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01525  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA009063
Annotation
PREDICTED:_uncharacterized_protein_LOC106138821_[Amyelois_transitella]
Full name
Protein quiver      
Alternative Name
Protein sleepless
Location in the cell
Extracellular   Reliability : 4.068
 

Sequence

CDS
ATGGCGTACTTTTTCGTTTTCGCGGCTTTGTGCGGTTTTGTGGAGCAAGGCCAAGCAATCGTCTGCTACCAATGCAACAGTCACAACGACTCCCGATGCATCATGGAGGACCTGCCGGACACGCTGCGGCAGCCGTGCAAGTCCACTGACACAATGTGCAGGAAGATCAGCCAGGTCGTGGAGTTCGAGATGAACGGCATGCCCCCGGATAACAGAGTCATCAGAGGGTGCGGGTGGGATGAAAGCAACTACAAGGGCCGTTGCTACCAGCGATCAGGGTTCGGCGGAAGACAAGAGGTCTGCTCGTGCCTGACCGACGGCTGCAACTCAGCGTCGTTACCAGTTATGGGAACAACAGTGATGCTCCTCACGCTAGCACTCCTGAAGTTCTAG
Protein
MAYFFVFAALCGFVEQGQAIVCYQCNSHNDSRCIMEDLPDTLRQPCKSTDTMCRKISQVVEFEMNGMPPDNRVIRGCGWDESNYKGRCYQRSGFGGRQEVCSCLTDGCNSASLPVMGTTVMLLTLALLKF

Summary

Description
Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.
Similarity
Belongs to the quiver family.
Feature
chain  Protein quiver
EMBL
BABH01029550    ODYU01004819    SOQ45093.1    AGBW02014682    OWR41192.1    AK401470    + More
BAM18092.1    NWSH01001836    PCG69954.1    KQ459562    KPI99770.1    KQ435819    KOX72511.1    GECZ01012130    JAS57639.1    KZ288365    PBC26841.1    JR040721    JR040722    AEY59260.1    AEY59261.1    GEBQ01007544    JAT32433.1    GANO01005006    JAB54865.1    GECU01018063    JAS89643.1    GEDC01008093    JAS29205.1    GL452364    EFN77331.1    GDJX01023554    JAT44382.1    KQ978231    KYM96146.1    KK852699    KDR18175.1    KQ976529    KYM81741.1    AXCN02000765    GGFK01010398    MBW43719.1    GGFK01010421    MBW43742.1    ADTU01020810    GL888334    EGI62568.1    GGFJ01010418    MBW59559.1    GGFJ01010440    MBW59581.1    AAAB01008964    EAA12565.4    KK108051    EZA46965.1    APCN01002471    QOIP01000001    RLU26985.1    GGFL01006051    MBW70229.1    GBRD01003542    GDHC01001065    JAG62279.1    JAQ17564.1    KQ982721    KYQ51644.1    GAMD01002536    JAA99054.1    GGFF01000093    MBW20560.1    GBHO01029707    JAG13897.1    CVRI01000055    CRL01109.1    ADMH02002111    ETN58883.1    GL434781    EFN74541.1    SOQ45092.1    AXCM01002772    PCG69953.1    KC741139    AGM32963.1    KQ981940    KYN32727.1    KQ979147    KYN22440.1    GEMB01004104    JAR99158.1    GFDF01010881    JAV03203.1    GFTR01002390    JAW14036.1    KQ461175    KPJ07813.1    GFDF01010883    JAV03201.1    GFDF01011225    JAV02859.1    GAPW01005708    JAC07890.1    GFDF01010880    JAV03204.1    GECL01000139    JAP05985.1    GFDF01010882    JAV03202.1    GDKW01003192    JAI53403.1    KB632196    ERL89976.1    CH477651    EAT37771.1    ATLV01021400    KE525317    KFB46455.1    KK854375    PTY15211.1    APGK01056778    KB741277    ENN71115.1    GAPW01005707    JAC07891.1    DS232641    EDS44324.1    GGMS01002707    MBY71910.1    JXUM01071693    JXUM01071694    KQ562679    KXJ75336.1    ABLF02036162    ABLF02036172    AK341094    BAH71566.1    GBYB01008298    JAG78065.1    GFDL01005000    JAV30045.1    GFDF01011731    JAV02353.1    CH916368    EDW04069.1    ATLV01021399    KFB46454.1    GEHC01001089    JAV46556.1    CH902620    EDV31256.1    CH933807    EDW11478.1    CH963920    EDW78036.1    GALA01000623    JAA94229.1    GALA01001383    JAA93469.1    GEZM01097287    JAV54294.1    DS235816    EEB17548.1    KX950846    ARU12056.1    JRES01000536    KNC30367.1    CCAG010006162    CH940649    EDW64803.1   
Pfam
PF00439   Bromodomain        + More
PF17064   QVR
Interpro
IPR001487   Bromodomain        + More
IPR036427   Bromodomain-like_sf       
IPR031424   QVR       
SUPFAM
SSF47370   SSF47370       
Gene 3D

Ontologies

Topology

Subcellular location
Cell membrane  
SignalP
Position:   1 - 19,         Likelihood:  0.997040
 
 
Length:
130
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.46758
Exp number, first 60 AAs:
0.38646
Total prob of N-in:
0.05552
outside
1  -  130
 
 

Population Genetic Test Statistics

Pi
215.81586
Theta
168.933244
Tajima's D
0.621828
CLR
0.031991
CSRT
0.554322283885806
Interpretation
Possibly Positive selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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