Gene

KWMTBOMO01524

Annotation

PREDICTED:_uncharacterized_protein_LOC106718368_[Papilio_machaon]

Location

Bomo_Chr3(-):12840771-12843718      View in EpiBrowser

Full name

Protein quiver      

Alternative Name

Protein sleepless

Location in the cell

Extracellular   Reliability : 3.937

CDS

ATGGAGTTCCGATTTGTATCATGTATTATCGTCGGTTTTGTTCTACTCCTATTTACCCACAGAAGCGCGGCCGTTAAATGCTTCGAGTGCAATAGCGCCAACAATTCCGCCTGTCTGGATCTGAACCTTCCCAGGATGCACTCCATCGTCCCTGTCGTGGACTGCGGGAAGACCTTGCCTCACGTGTTGAGCAAGCAATTCTTTTGCCGAAAGATCACGCAGACAATTCTCCACCCAGAACAAACGCCAGAGGTCCGAATAACAAGAAGTTGCGGCTGGATCAAACACAAGCGGGCATGTTATACGGCAGACAATAAAGACCATTTAGAGACCGTGTGCCAATGCTTCGGTGATATGTGCAATTCCGCGTCCACAATAACAAACGTCAAAGTTGCGTTTTTGACAGCTACCGTCGCCATATTGACTGTTTGTCGAAATTGGCGGGAACGTAATGTGATTTAA

Protein

MEFRFVSCIIVGFVLLLFTHRSAAVKCFECNSANNSACLDLNLPRMHSIVPVVDCGKTLPHVLSKQFFCRKITQTILHPEQTPEVRITRSCGWIKHKRACYTADNKDHLETVCQCFGDMCNSASTITNVKVAFLTATVAILTVCRNWRERNVI

Description

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

Similarity

Belongs to the quiver family.

Feature

chain  Protein quiver

Uniprot

A0A194QQN6   A0A194Q2K0   A0A2A4JCZ3   A0A2H1VW95   A0A2A4J3C9   A0A2H1X2E0   + More
A0A2H1WLM6   A0A2H1VWH0   A9NQN4   A0A2A4JDV0   A0A212EI56   I4DL76   A0A194QS56   A0A194RC22   A0A194PXY0   A0A0L7KP16   A0A1B6EBK2   A0A1S4FPR5   A0A146L5R6   Q16TE3   T1DH23   A0A2M3YWC0   A0A0A9XZB9   A0A2M4C2S5   A0A2M4C344   A0A2M4ASN4   A0A2M4ASH1   A0A1B6DU84   A0A2M4CY83   A0A0K8ST25   W5J654   A0A182QXG4   A0A182Y078   A0A1W7R7F3   A0A0A9ZFY9   A0A0K8SE02   A0A182V1F2   A0A182UGL4   A0A182WU35   A0A1S4GXB8   A0A182HUP7   Q7Q3Z5   A0A2R7W6A1   U5ES22   B5DIS5   B4G7D9   A0A067RGE3   A0A1B6I5Y0   A0A182SJ17   A0A182M2T4   A0A2A4JEV1   A0A182T4F6   A0A182GLC5   A0A1B6M2H9   A0A1B6G5C7   A0A182JQW8   A0A182J2F7   A0A182RZU7   A0A182Y080   A0A084W8B1   A0A1B6EW33   A0A1B6ID59   A0A146M3T3   A0A1B6HRF6   A0A1Y0F444   A0A182W741   A0A0A9WYG5   A0A182QPV9   A0A3L8E3L0   A0A2R7W7U9   A0A224XNC3   B4JBW7   A0A023EGD7   A0A182W740   A0A194QQM9   D6WX56   A0A3B0K1G2   B0XBL2   A0A3B0JBM2   A0A139WDI4   A0A182PMQ3   A0A1B6M922   A0A1Q3FR88   A0A0K8T9R8   A0A1B6M3F7   B4NWW4   A0A1B6M7B4   A0A0A9WZJ0   A0A2R7W661  

Pubmed

26354079    18854048    22118469    22651552    26227816    26823975    + More
17510324    25401762    20920257    23761445    25244985    12364791    15632085    17994087    24845553    26483478    24438588    30249741    24945155    18362917    19820115    17550304   

EMBL

KQ461175    KPJ07812.1    KQ459562    KPI99771.1    NWSH01001836    PCG69955.1    + More
ODYU01004819    SOQ45095.1    NWSH01003318    PCG66565.1    ODYU01012968    SOQ59530.1    ODYU01009460    SOQ53917.1    SOQ45096.1    EF083605    ABK22945.1    PCG69956.1    AGBW02014682    OWR41193.1    AK402044    BAM18666.1    KPJ07815.1    KQ460627    KPJ13456.1    KQ459585    KPI98187.1    JTDY01007995    KOB64811.1    GEDC01002044    JAS35254.1    GDHC01014876    JAQ03753.1    CH477651    EAT37773.1    GAMD01002536    JAA99054.1    GGFF01000093    MBW20560.1    GBHO01019396    GBHO01019395    JAG24208.1    JAG24209.1    GGFJ01010418    MBW59559.1    GGFJ01010440    MBW59581.1    GGFK01010421    MBW43742.1    GGFK01010398    MBW43719.1    GEDC01008093    JAS29205.1    GGFL01006051    MBW70229.1    GBRD01009366    JAG56458.1    ADMH02002111    ETN58883.1    AXCN02000765    GEHC01000630    JAV47015.1    GBHO01000140    GDHC01011193    JAG43464.1    JAQ07436.1    GBRD01014309    JAG51517.1    AAAB01008964    APCN01002471    EAA12565.4    KK854375    PTY15212.1    GANO01005006    JAB54865.1    CH379060    EDY70218.1    CH479180    EDW29272.1    KK852699    KDR18174.1    GECU01025374    JAS82332.1    AXCM01002772    PCG69953.1    JXUM01071690    KQ562679    KXJ75334.1    GEBQ01009831    JAT30146.1    GECZ01012130    JAS57639.1    ATLV01021400    KE525317    KFB46455.1    GECZ01027620    JAS42149.1    GECU01030423    GECU01030128    GECU01025081    GECU01022832    GECU01016958    GECU01016104    GECU01010534    GECU01009974    GECU01002747    JAS77283.1    JAS77578.1    JAS82625.1    JAS84874.1    JAS90748.1    JAS91602.1    JAS97172.1    JAS97732.1    JAT04960.1    GDHC01004947    JAQ13682.1    GECU01037545    GECU01031949    GECU01030473    GECU01028717    GECU01024976    GECU01020943    GECU01014029    GECU01006896    JAS70161.1    JAS75757.1    JAS77233.1    JAS78989.1    JAS82730.1    JAS86763.1    JAS93677.1    JAT00811.1    KX950850    ARU12060.1    GBHO01031143    GBRD01007381    JAG12461.1    JAG58440.1    AXCN02000764    QOIP01000001    RLU26985.1    PTY15211.1    GFTR01002430    JAW13996.1    CH916368    EDW04070.1    GAPW01005708    JAC07890.1    KPJ07813.1    KQ971361    EFA08039.1    OUUW01000004    SPP79436.1    DS232641    EDS44324.1    SPP79435.1    KYB25915.1    GEBQ01007544    JAT32433.1    GFDL01005000    JAV30045.1    GBRD01003542    GDHC01001065    JAG62279.1    JAQ17564.1    GEBQ01009512    JAT30465.1    CM000157    EDW88494.1    GEBQ01008194    JAT31783.1    GBHO01029707    JAG13897.1    PTY15213.1   

Proteomes

UP000053240    UP000053268    UP000218220    UP000007151    UP000037510    UP000008820    + More
UP000000673    UP000075886    UP000076408    UP000075903    UP000075902    UP000076407    UP000075840    UP000007062    UP000001819    UP000008744    UP000027135    UP000075901    UP000075883    UP000069940    UP000249989    UP000075881    UP000075880    UP000075900    UP000030765    UP000075920    UP000279307    UP000001070    UP000007266    UP000268350    UP000002320    UP000075885    UP000002282   

Pfam

PF17064   QVR        + More
PF00439   Bromodomain

Interpro

IPR001487   Bromodomain        + More
IPR036427   Bromodomain-like_sf       
IPR031424   QVR       

SUPFAM

SSF47370   SSF47370       

Gene 3D

1.20.920.10    

ProteinModelPortal

A0A194QQN6   A0A194Q2K0   A0A2A4JCZ3   A0A2H1VW95   A0A2A4J3C9   A0A2H1X2E0   + More
A0A2H1WLM6   A0A2H1VWH0   A9NQN4   A0A2A4JDV0   A0A212EI56   I4DL76   A0A194QS56   A0A194RC22   A0A194PXY0   A0A0L7KP16   A0A1B6EBK2   A0A1S4FPR5   A0A146L5R6   Q16TE3   T1DH23   A0A2M3YWC0   A0A0A9XZB9   A0A2M4C2S5   A0A2M4C344   A0A2M4ASN4   A0A2M4ASH1   A0A1B6DU84   A0A2M4CY83   A0A0K8ST25   W5J654   A0A182QXG4   A0A182Y078   A0A1W7R7F3   A0A0A9ZFY9   A0A0K8SE02   A0A182V1F2   A0A182UGL4   A0A182WU35   A0A1S4GXB8   A0A182HUP7   Q7Q3Z5   A0A2R7W6A1   U5ES22   B5DIS5   B4G7D9   A0A067RGE3   A0A1B6I5Y0   A0A182SJ17   A0A182M2T4   A0A2A4JEV1   A0A182T4F6   A0A182GLC5   A0A1B6M2H9   A0A1B6G5C7   A0A182JQW8   A0A182J2F7   A0A182RZU7   A0A182Y080   A0A084W8B1   A0A1B6EW33   A0A1B6ID59   A0A146M3T3   A0A1B6HRF6   A0A1Y0F444   A0A182W741   A0A0A9WYG5   A0A182QPV9   A0A3L8E3L0   A0A2R7W7U9   A0A224XNC3   B4JBW7   A0A023EGD7   A0A182W740   A0A194QQM9   D6WX56   A0A3B0K1G2   B0XBL2   A0A3B0JBM2   A0A139WDI4   A0A182PMQ3   A0A1B6M922   A0A1Q3FR88   A0A0K8T9R8   A0A1B6M3F7   B4NWW4   A0A1B6M7B4   A0A0A9WZJ0   A0A2R7W661  

KEGG

101739816    no KO assigned | (RefSeq) uncharacterized LOC101739816

GO

GO:0016021   GO:0016874   GO:0032222   GO:0031225   GO:1903818   GO:0030431   GO:0034235   GO:0048511   GO:0005886   GO:0045187  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 24,         Likelihood:  0.996619

 

 

Length:

153

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

23.2138

Exp number, first 60 AAs:

13.74993

Total prob of N-in:

0.65485

POSSIBLE N-term signal

sequence

outside

1  -  153

 

 

Pi

167.735796

Theta

140.68552

Tajima's D

0.586651

CLR

0.221345

CSRT

0.538023098845058

Interpretation

Uncertain