Gene

KWMTBOMO01508

Pre Gene Modal

BGIBMGA009058

Annotation

PREDICTED:_mitochondrial_2-oxoglutarate/malate_carrier_protein-like_[Bombyx_mori]

Location

Bomo_Chr3(+):12594400-12595711      View in EpiBrowser

Full name

Mitochondrial 2-oxoglutarate/malate carrier protein      

Alternative Name

Mitochondrial solute carrier 1

Location in the cell

Mitochondrial   Reliability : 2.904

CDS

ATGCCAAGTGAGAAGCGAACTCGCAGGGCGTTACAAGAAAACAAAGTGGCTAAAGGTTTGGAGTTGCATTTCTACACGTCGATGATATCAAGCTTCATCGCAGCCGTCATCTCGTTGCCGATAGATCACATTAAAACTAGATACCAAGTTAGAAGTGATTGTGTAACACAGAAGGAAATTTTGGCGGACACAAGGAGGAATAGGGGCATATTTGGTTTGTGGAGAGGATTCACACCGTACTATTTGCGGATGGCTTTTCACACCTTCATCACTTTCTATCTGTTGGAGCAGTTTTTCGAGATGTACCAGAAATGGGAAGAGCACGAGAGAAAACTTAGATGA

Protein

MPSEKRTRRALQENKVAKGLELHFYTSMISSFIAAVISLPIDHIKTRYQVRSDCVTQKEILADTRRNRGIFGLWRGFTPYYLRMAFHTFITFYLLEQFFEMYQKWEEHERKLR

Description

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Furthermore, plays a role in the oxidative stress response regulating endogenous levels of reactive oxygen species (ROS) (PubMed:21884719). Involved in the regulation of lin-35/Rb-mediated apoptosis in the germline (PubMed:21448454).

Subunit

Interacts with ant-1.1 and ced-9.

Similarity

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Complete proteome   Membrane   Mitochondrion   Mitochondrion inner membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Mitochondrial 2-oxoglutarate/malate carrier protein

Uniprot

H9JHR0   A0A2A4K8C6   A0A2H1X0C9   A0A1E1WDH8   T1GU60   A0A194Q369   + More
A0A212FJM8   H9JHQ9   A0A3M7SG43   A0A0L7KTD4   A0A2A4K8S6   A9UVK8   A0A1B0D6E3   K1QEP2   J3JX22   N6UTE6   A0A0M4END4   A0A1W4UDE2   A0A0N1PFN1   B4R056   B4HZB4   A0A0B6ZTU3   A0A368G0A5   A0A1A9WWE1   A0A0N1I5X0   A0A224XT43   A0A1I8CT06   E3MDF6   A0A261C984   A0A0C2FD48   A0A0B1T8X6   A0A368GG42   A0A023F2S3   A0A1A9VT52   D3TM51   A0A1B0AGI0   U5ETU0   B4PPN7   A0A2C9JGJ0   A0A2C9JGK6   B4NBI5   A0A212FEP3   G0N4R5   A0A1B0G164   B4JGU0   A0A016SLW3   B4GPL3   A0A2H2I3Z9   Q29BV6   A0A1A9XTI1   A0A1B0BU17   A0A260YV41   A0A3B0KB41   A0A336LSN2   A0A0N5A0L2   A8X3W6   A0A1D1VD82   T1K0P8   B4M5M9   A0A3P8Z2I8   A0A3P8Z0V7   B5XGL4   B5X7D7   A0A1I7TG61   A0A2G5VDD4   A0A0A9ZE86   H3FSQ0   Q9VAJ9   A0A1I7VCR9   A0A183K6Z7   A0A0C2FUV1   A0A2G9UFH4   A0A0R3PL51   A0A0C9QNG3   A0A1I7VCR1   A0A2T7PPY7   A0A146LWC5   A0A0N5BGR6   A0A0K0E5C3   A0A044RAP0   A0A182DZN8   A0A0K8W9E6   A0A0D2WN72   B3P5G0   A0A0P4VKJ2   A0A1B6HL19   A0A0L0CED9   P90992   A0A090LRC9   A0A2R7WBC7   A0A1B0C9N0   A0A034W7Q0   G7YJP1   A0A1B6FLT0   A0A1L8DZR7   D2VWP2   A0A1L8E012   A0A1I7Z927   T1ID30   A0A183P611  

Pubmed

19121390    26354079    22118469    30375419    26227816    18273011    + More
22992520    22516182    23537049    17994087    26829753    25474469    20353571    17550304    15562597    25730766    15632085    14624247    27649274    25069045    20433749    25401762    26823975    18806794    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25217238    22919073    27129103    26108605    9851916    21884719    21448454    25348373    22023798    20211133    26392177   

EMBL

BABH01029576    NWSH01000043    PCG80319.1    ODYU01012377    SOQ58656.1    GDQN01008576    + More
GDQN01006021    JAT82478.1    JAT85033.1    CAQQ02002331    KQ459562    KPI99788.1    AGBW02008248    OWR53948.1    REGN01001429    RNA34706.1    JTDY01006079    KOB66316.1    PCG80318.1    CH991547    EDQ90600.1    AJVK01025940    JH818292    EKC19976.1    BT127790    AEE62752.1    APGK01017094    APGK01017095    KB739995    KB632192    ENN82037.1    ERL89886.1    CP012526    ALC46188.1    KQ460941    KPJ10586.1    CM000364    EDX14862.1    CH480819    EDW53371.1    HACG01024406    CEK71271.1    JOJR01000533    RCN36699.1    KPJ10583.1    GFTR01004816    JAW11610.1    DS268437    EFO99243.1    NIPN01000024    OZG19051.1    KN776428    KIH44654.1    KN550664    KHJ93664.1    JOJR01000221    RCN41797.1    GBBI01002795    JAC15917.1    EZ422503    ADD18779.1    GANO01002629    JAB57242.1    CM000160    EDW98287.1    CH964232    EDW81149.1    AGBW02008911    OWR52211.1    GL379838    EGT52749.1    CCAG010011180    CH916369    EDV92694.1    JARK01001540    EYB91580.1    CH479186    EDW39096.1    CM000070    EAL26890.2    JXJN01020448    NMWX01000640    OZF77242.1    OUUW01000007    SPP82886.1    UFQT01000092    SSX19589.1    HE600960    CAP27326.1    BDGG01000004    GAU98032.1    CAEY01001145    CH940652    EDW58955.1    BT050183    ACI69984.1    BT046956    ACI66757.1    PDUG01000002    PIC49785.1    GBHO01001953    GBHO01001952    GBHO01001951    GBRD01008205    GBRD01008204    GDHC01019362    JAG41651.1    JAG41652.1    JAG41653.1    JAG57616.1    JAP99266.1    AE014297    AY052135    AAF56907.1    AAK93559.1    UZAK01033982    VDP41493.1    KN749687    KIH50449.1    KZ347087    PIO68472.1    UYYA01003871    VDM57023.1    GBYB01002182    JAG71949.1    JH712230    EFO21996.1    PZQS01000002    PVD35437.1    GDHC01006665    JAQ11964.1    CMVM020000376    UYRW01000136    VDK63566.1    GDHF01004501    JAI47813.1    KE346363    KJE91788.1    CH954182    EDV53210.1    GDKW01003575    JAI53020.1    GECU01032421    JAS75285.1    JRES01000501    KNC30620.1    BX284602    LN609530    CEF70692.1    KK854491    PTY16310.1    AJWK01002497    AJWK01002498    GAKP01008787    JAC50165.1    DF143435    GAA53174.1    GECZ01028964    GECZ01028205    GECZ01018965    GECZ01018611    GECZ01016242    GECZ01007861    JAS40805.1    JAS41564.1    JAS50804.1    JAS51158.1    JAS53527.1    JAS61908.1    GFDF01002094    JAV11990.1    GG738905    EFC38731.1    GFDF01002095    JAV11989.1    ACPB03022134    UZAL01029998    VDP51520.1   

Proteomes

UP000005204    UP000218220    UP000015102    UP000053268    UP000007151    UP000276133    + More
UP000037510    UP000001357    UP000092462    UP000005408    UP000019118    UP000030742    UP000092553    UP000192221    UP000053240    UP000000304    UP000001292    UP000252519    UP000091820    UP000095286    UP000008281    UP000216463    UP000078200    UP000092445    UP000002282    UP000076420    UP000007798    UP000008068    UP000092444    UP000001070    UP000024635    UP000008744    UP000005237    UP000001819    UP000092443    UP000092460    UP000216624    UP000268350    UP000038045    UP000008549    UP000186922    UP000015104    UP000008792    UP000265140    UP000087266    UP000095282    UP000230233    UP000005239    UP000000803    UP000095285    UP000050789    UP000050601    UP000267027    UP000245119    UP000046392    UP000035681    UP000024404    UP000077448    UP000271087    UP000008743    UP000008711    UP000037069    UP000001940    UP000035682    UP000092461    UP000006671    UP000095287    UP000015103    UP000050791   

PRIDE

H9JHR0    H9JHQ9    A8X3W6    Q9VAJ9   

Pfam

PF00153   Mito_carr

Interpro

IPR018108   Mitochondrial_sb/sol_carrier        + More
IPR023395   Mt_carrier_dom_sf       
IPR002030   Mit_uncoupling_UCP-like       
IPR002067   Mit_carrier       

SUPFAM

SSF103506   SSF103506       

Gene 3D

1.50.40.10    

ProteinModelPortal

H9JHR0   A0A2A4K8C6   A0A2H1X0C9   A0A1E1WDH8   T1GU60   A0A194Q369   + More
A0A212FJM8   H9JHQ9   A0A3M7SG43   A0A0L7KTD4   A0A2A4K8S6   A9UVK8   A0A1B0D6E3   K1QEP2   J3JX22   N6UTE6   A0A0M4END4   A0A1W4UDE2   A0A0N1PFN1   B4R056   B4HZB4   A0A0B6ZTU3   A0A368G0A5   A0A1A9WWE1   A0A0N1I5X0   A0A224XT43   A0A1I8CT06   E3MDF6   A0A261C984   A0A0C2FD48   A0A0B1T8X6   A0A368GG42   A0A023F2S3   A0A1A9VT52   D3TM51   A0A1B0AGI0   U5ETU0   B4PPN7   A0A2C9JGJ0   A0A2C9JGK6   B4NBI5   A0A212FEP3   G0N4R5   A0A1B0G164   B4JGU0   A0A016SLW3   B4GPL3   A0A2H2I3Z9   Q29BV6   A0A1A9XTI1   A0A1B0BU17   A0A260YV41   A0A3B0KB41   A0A336LSN2   A0A0N5A0L2   A8X3W6   A0A1D1VD82   T1K0P8   B4M5M9   A0A3P8Z2I8   A0A3P8Z0V7   B5XGL4   B5X7D7   A0A1I7TG61   A0A2G5VDD4   A0A0A9ZE86   H3FSQ0   Q9VAJ9   A0A1I7VCR9   A0A183K6Z7   A0A0C2FUV1   A0A2G9UFH4   A0A0R3PL51   A0A0C9QNG3   A0A1I7VCR1   A0A2T7PPY7   A0A146LWC5   A0A0N5BGR6   A0A0K0E5C3   A0A044RAP0   A0A182DZN8   A0A0K8W9E6   A0A0D2WN72   B3P5G0   A0A0P4VKJ2   A0A1B6HL19   A0A0L0CED9   P90992   A0A090LRC9   A0A2R7WBC7   A0A1B0C9N0   A0A034W7Q0   G7YJP1   A0A1B6FLT0   A0A1L8DZR7   D2VWP2   A0A1L8E012   A0A1I7Z927   T1ID30   A0A183P611  

PDB

2LCK     E-value=0.000677369,     Score=95

KEGG

101746937    K15104 solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 | (RefSeq) mitoc

GO

GO:0022857   GO:0016021   GO:0006839   GO:0031966   GO:0015367   GO:0005739   GO:0015743   GO:0015742   GO:0005743  

Subcellular location

Mitochondrion  
Mitochondrion inner membrane  

Length:

113

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

37.95168

Exp number, first 60 AAs:

18.03422

Total prob of N-in:

0.80078

POSSIBLE N-term signal

sequence

inside

1  -  18

TMhelix

19  -  41

outside

42  -  72

TMhelix

73  -  95

inside

96  -  113

 

 

Pi

330.046322

Theta

226.165691

Tajima's D

1.423411

CLR

0

CSRT

0.765911704414779

Interpretation

Uncertain