Gene

KWMTBOMO01506  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009057

Annotation

PREDICTED:_mitochondrial_2-oxoglutarate/malate_carrier_protein_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr3(+):12575780-12585814      View in EpiBrowser

Full name

Mitochondrial 2-oxoglutarate/malate carrier protein      

Alternative Name

Mitochondrial solute carrier 1

Location in the cell

Mitochondrial   Reliability : 1.202 PlasmaMembrane   Reliability : 1.789

CDS

ATGGCTCAATCATCCGCCGCGCCGCCGAAAGAGCGTTATATACCAAATGGATTGAAGTTCGCGTTTGGTGGCCTTGCAGGAATGGCGGCGACGTGCGTTGTCCAGCCTTTAGATTTGATCAAGACAAGAATGCAATTGAGCGGCAGCGGGAAGAGCTCCTTCGCTGTGGCCGGGGAAATCGTTGCGAAGGAAGGCTTCTTCTCATTGTACGCTGGGCTGTCAGCTGGCTTACTGAGACAAGCAACGTACACGACCACGCGGCTCGGAGTCTATAGCTGGCTCTTCGACGCTTACAGAGAACGCAACGCTGGTGCCAACCCTGGCTTCGGCACGAAGACCATGCTGGGCGTGGCCGCCGGGTCCATTGGCGCGTTCGTCGGCACTCCGGCTGAAGTGGCCCTCATACGGATGACGGCTGACGGACGCCTGCCCCAGGAGCAGAGGAGGAATTACAAGAACGTTGCTGACGCGCTGATCAGGATAGTGCGCGAGGAGGGCGTGCTGAAGCTGTGGCGCGGCGCCACTCCCACGGTGGGACGCGCCATGGTGGTGAACGCGGCGCAGCTGAGCACGTACTCGCAGGCGCGGGAGGCGCTCGCGGGCCGCGTGCCCGACGGCGTGGCGCTGCACTTCTGCGCGTCCATGGTGTCCGGGCTGGTCACGACCATCGCCTCGATGCCCGTCGACATCATTAAGACCAGAATCCAAAACGCGGCAAAAGGTCAAAGTCAGCTGTCGGTAGTGACCTCCCTGCTGCGGAACGAGGGCGTCCTGTCGCTGTGGAAGGGCTTCCTGCCGTACTACGCGCGCCTCGGGCCCCACACCGTGCTCACCTTCATATTCCTGGAGCAAATGAACACGGCCTACTTCAAATACACGTAA

Protein

MAQSSAAPPKERYIPNGLKFAFGGLAGMAATCVVQPLDLIKTRMQLSGSGKSSFAVAGEIVAKEGFFSLYAGLSAGLLRQATYTTTRLGVYSWLFDAYRERNAGANPGFGTKTMLGVAAGSIGAFVGTPAEVALIRMTADGRLPQEQRRNYKNVADALIRIVREEGVLKLWRGATPTVGRAMVVNAAQLSTYSQAREALAGRVPDGVALHFCASMVSGLVTTIASMPVDIIKTRIQNAAKGQSQLSVVTSLLRNEGVLSLWKGFLPYYARLGPHTVLTFIFLEQMNTAYFKYT

Description

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Furthermore, plays a role in the oxidative stress response regulating endogenous levels of reactive oxygen species (ROS) (PubMed:21884719). Involved in the regulation of lin-35/Rb-mediated apoptosis in the germline (PubMed:21448454).

Subunit

Interacts with ant-1.1 and ced-9.

Similarity

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Complete proteome   Membrane   Mitochondrion   Mitochondrion inner membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Mitochondrial 2-oxoglutarate/malate carrier protein

Uniprot

A0A212FJM8   H9JHQ9   A0A2A4K8S6   A0A194Q369   A0A0N1I5X0   A0A1E1WDH8   + More
A0A2H1W0R8   F1LA07   A0A158NTU4   A0A023F2S3   A0A067RW26   A0A224XT43   D6WWN2   N6SSJ1   A0A026WWR7   E1ZYK3   A0A0N4UW82   A0A226EMX4   A0A016V9Q4   T1ID30   K7IWI6   A0A1D2NJ56   A0A1I7Z927   A8X3W6   A0A0N5ATW8   A0A2A2LLF1   A0A368H9A8   J3JX22   N6UTE6   E3MDF6   V4ADF3   A0A2T7PPY7   A0A1B6FLT0   A0A2G5VDD4   A0A0A9ZE86   A0A0D6M3R5   G0N4R5   A0A1I7TG61   A0A1Y1MUL3   A0A1B6C210   A0A1B6LUY1   A0A0B6ZTU3   A0A0N5BRH2   A0A1B6HR07   A0A1I8FUA2   A0A2C9JGJ0   E9HM84   A0A0N4UII4   A0A260YV41   A0A0P5VFM0   A0A3P8Z0V7   A0A0H5SJP7   A0A2G9UFH4   A0A0P5U5E4   A0A2H2I3Z9   A0A1I8ESI2   A0A0P5R8F7   A0A0P5A0S5   P90992   A0A0P4ZG35   F4WJ41   A0A0N5A0L2   A0A195CTU4   F7A7B1   V9KY37   A0A131XZJ5   A0A0P6JCJ9   A0A224YTK8   A0A131YVN0   A0A0K8RQW4   A0A2C9JGK6   F1R319   G1SER3   A0A0R3RSL3   Q6IQ89   A0A1A6HJX8   A0A151JRF5   A0A0B8RT73   A0A287AN76   A0A2Y9DKF4   B5XGL4   A0A131XK54   A0A383YUU4   A0A023GKK9   G7NI38   A0A2K6D105   A0A2K6A3Q9   A0A096P2I5   A0A2K5NI87   G7PT97   H9ZE83   L5JXG6   A0A044RAP0   A0A182DZN8   T1EDN5   D3PGY6   A0A3B3RSA7   A0A1S3WAU8   A0A1E1XU10   A0A0D9RKI6  

Pubmed

22118469    19121390    26354079    21685128    21347285    25474469    + More
24845553    18362917    19820115    23537049    24508170    20798317    25730766    20075255    27289101    26392177    14624247    22516182    23254933    25401762    26823975    28004739    26392545    15562597    21292972    25069045    17885136    26850696    9851916    21884719    21448454    21719571    19892987    24402279    28797301    26830274    23594743    21993624    30723633    20433749    28049606    22002653    25319552    23258410    22919073    29240929    29209593   

EMBL

AGBW02008248    OWR53948.1    BABH01029576    NWSH01000043    PCG80318.1    KQ459562    + More
KPI99788.1    KQ460941    KPJ10583.1    GDQN01008576    GDQN01006021    JAT82478.1    JAT85033.1    ODYU01005633    SOQ46678.1    JI175073    ADY46961.1    ADTU01026158    GBBI01002795    JAC15917.1    KK852428    KDR24074.1    GFTR01004816    JAW11610.1    KQ971361    EFA08739.1    APGK01058767    KB741291    ENN70619.1    KK107079    EZA60141.1    GL435225    EFN73757.1    UXUI01007211    VDD86298.1    LNIX01000003    OXA58630.1    JARK01001350    EYC24399.1    ACPB03022134    LJIJ01000025    ODN05308.1    HE600960    CAP27326.1    LIAE01006613    PAV86980.1    JOJR01000008    RCN52298.1    BT127790    AEE62752.1    APGK01017094    APGK01017095    KB739995    KB632192    ENN82037.1    ERL89886.1    DS268437    EFO99243.1    KB202283    ESO91331.1    PZQS01000002    PVD35437.1    GECZ01028964    GECZ01028205    GECZ01018965    GECZ01018611    GECZ01016242    GECZ01007861    JAS40805.1    JAS41564.1    JAS50804.1    JAS51158.1    JAS53527.1    JAS61908.1    PDUG01000002    PIC49785.1    GBHO01001953    GBHO01001952    GBHO01001951    GBRD01008205    GBRD01008204    GDHC01019362    JAG41651.1    JAG41652.1    JAG41653.1    JAG57616.1    JAP99266.1    KE124806    EPB78779.1    GL379838    EGT52749.1    GEZM01020146    JAV89364.1    GEDC01030043    GEDC01002883    JAS07255.1    JAS34415.1    GEBQ01023988    GEBQ01014140    GEBQ01012514    GEBQ01011530    JAT15989.1    JAT25837.1    JAT27463.1    JAT28447.1    HACG01024406    CEK71271.1    GECU01030596    GECU01024978    GECU01018431    GECU01011511    GECU01007791    JAS77110.1    JAS82728.1    JAS89275.1    JAS96195.1    JAS99915.1    NIVC01002334    NIVC01001299    PAA58771.1    PAA69701.1    GL732685    EFX67149.1    UYYG01001200    VDN60082.1    NMWX01000640    OZF77242.1    GDIP01100557    LRGB01000512    JAM03158.1    KZS18399.1    LN856934    CRZ24036.1    KZ347087    PIO68472.1    GDIP01117746    JAL85968.1    GDIQ01104248    JAL47478.1    GDIP01205595    JAJ17807.1    BX284602    GDIP01213146    JAJ10256.1    GL888181    EGI65811.1    KQ977279    KYN04085.1    JW871629    AFP04147.1    GEFM01003122    JAP72674.1    GDIQ01009242    JAN85495.1    GFPF01009801    MAA20947.1    GEDV01005520    JAP83037.1    GADI01000799    JAA73009.1    CU656043    AAGW02049626    BC071521    AAH71521.1    LZPO01027416    OBS78524.1    KQ978615    KYN29815.1    GBZA01000593    JAG69175.1    AEMK02000082    DQIR01070929    DQIR01084131    DQIR01084132    DQIR01097964    DQIR01099431    DQIR01154767    HDA26405.1    HDA53440.1    BT050183    ACI69984.1    GEFH01000697    JAP67884.1    GBBM01001820    JAC33598.1    CM001268    EHH24405.1    AHZZ02009597    AQIA01026236    CM001291    EHH57614.1    JU336649    JU477445    JV048410    AFE80402.1    AFH34249.1    AFI38481.1    KB031076    ELK03762.1    CMVM020000376    UYRW01000136    VDK63566.1    AMQM01008796    KB095851    ESO11150.1    BT120892    ADD24532.1    GFAA01000682    JAU02753.1    AQIB01137995   

Proteomes

UP000007151    UP000005204    UP000218220    UP000053268    UP000053240    UP000005205    + More
UP000027135    UP000007266    UP000019118    UP000053097    UP000000311    UP000038041    UP000274131    UP000198287    UP000024635    UP000015103    UP000002358    UP000094527    UP000095287    UP000008549    UP000046393    UP000218231    UP000252519    UP000030742    UP000008281    UP000030746    UP000245119    UP000230233    UP000008068    UP000095282    UP000046392    UP000095280    UP000215902    UP000076420    UP000000305    UP000038040    UP000274756    UP000216624    UP000076858    UP000265140    UP000006672    UP000005237    UP000093561    UP000001940    UP000007755    UP000038045    UP000078542    UP000002281    UP000000437    UP000001811    UP000050640    UP000092124    UP000078492    UP000008227    UP000248480    UP000087266    UP000261681    UP000233120    UP000233140    UP000028761    UP000233060    UP000009130    UP000233100    UP000010552    UP000024404    UP000077448    UP000271087    UP000015101    UP000261540    UP000079721    UP000029965   

PRIDE

H9JHQ9    A8X3W6    F1R319   

Pfam

PF00153   Mito_carr        + More
PF01965   DJ-1_PfpI
PF09809   MRP-L27

Interpro

IPR018108   Mitochondrial_sb/sol_carrier        + More
IPR023395   Mt_carrier_dom_sf       
IPR002030   Mit_uncoupling_UCP-like       
IPR006287   DJ-1       
IPR002818   DJ-1/PfpI       
IPR029062   Class_I_gatase-like       
IPR019189   Ribosomal_L27/L41_mit       

SUPFAM

SSF103506   SSF103506        + More
SSF52317   SSF52317       

Gene 3D

1.50.40.10     3.40.50.880    

ProteinModelPortal

A0A212FJM8   H9JHQ9   A0A2A4K8S6   A0A194Q369   A0A0N1I5X0   A0A1E1WDH8   + More
A0A2H1W0R8   F1LA07   A0A158NTU4   A0A023F2S3   A0A067RW26   A0A224XT43   D6WWN2   N6SSJ1   A0A026WWR7   E1ZYK3   A0A0N4UW82   A0A226EMX4   A0A016V9Q4   T1ID30   K7IWI6   A0A1D2NJ56   A0A1I7Z927   A8X3W6   A0A0N5ATW8   A0A2A2LLF1   A0A368H9A8   J3JX22   N6UTE6   E3MDF6   V4ADF3   A0A2T7PPY7   A0A1B6FLT0   A0A2G5VDD4   A0A0A9ZE86   A0A0D6M3R5   G0N4R5   A0A1I7TG61   A0A1Y1MUL3   A0A1B6C210   A0A1B6LUY1   A0A0B6ZTU3   A0A0N5BRH2   A0A1B6HR07   A0A1I8FUA2   A0A2C9JGJ0   E9HM84   A0A0N4UII4   A0A260YV41   A0A0P5VFM0   A0A3P8Z0V7   A0A0H5SJP7   A0A2G9UFH4   A0A0P5U5E4   A0A2H2I3Z9   A0A1I8ESI2   A0A0P5R8F7   A0A0P5A0S5   P90992   A0A0P4ZG35   F4WJ41   A0A0N5A0L2   A0A195CTU4   F7A7B1   V9KY37   A0A131XZJ5   A0A0P6JCJ9   A0A224YTK8   A0A131YVN0   A0A0K8RQW4   A0A2C9JGK6   F1R319   G1SER3   A0A0R3RSL3   Q6IQ89   A0A1A6HJX8   A0A151JRF5   A0A0B8RT73   A0A287AN76   A0A2Y9DKF4   B5XGL4   A0A131XK54   A0A383YUU4   A0A023GKK9   G7NI38   A0A2K6D105   A0A2K6A3Q9   A0A096P2I5   A0A2K5NI87   G7PT97   H9ZE83   L5JXG6   A0A044RAP0   A0A182DZN8   T1EDN5   D3PGY6   A0A3B3RSA7   A0A1S3WAU8   A0A1E1XU10   A0A0D9RKI6  

PDB

2LCK     E-value=2.29133e-35,     Score=371

KEGG

101740913    K15104 solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 | (RefSeq) mitoc

GO

GO:0022857   GO:0016021   GO:0006839   GO:0031966   GO:0015367   GO:0005739   GO:0005743  

Subcellular location

Mitochondrion  
Mitochondrion inner membrane  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

53.4155200000001

Exp number, first 60 AAs:

19.02547

Total prob of N-in:

0.74191

POSSIBLE N-term signal

sequence

outside

1  -  293

 

 

Pi

185.384353

Theta

166.246623

Tajima's D

0.168956

CLR

110.478181

CSRT

0.416929153542323

Interpretation

Uncertain