Gene

KWMTBOMO01505

Pre Gene Modal

BGIBMGA009056

Annotation

PREDICTED:_melanoma-associated_antigen_G1-like_[Papilio_machaon]

Location

Bomo_Chr3(+):12572260-12574382      View in EpiBrowser

Full name

Non-structural maintenance of chromosomes element 3 homolog      

Alternative Name

MAGE-G1 antigen
Necdin-like protein 2
Hepatocellular carcinoma-associated protein 4
Melanoma-associated antigen G1

Location in the cell

Nuclear   Reliability : 2.679

CDS

ATGAGTAGGCAATCACAAACAGAATCCACAAGACTGTTCGATAACTCTGTAAGACAATGTGTAAGGTATGTGTTTTGTCGCGAAGCTGATAAAATACCCATAAAACGATCTGAGATATTGGAGCAAATTGCGCCCGAATATAGGAAAAAATCGAAAAATGTTTTAGTTGAAGTTGAAAAAGAATTAAAACGGGTGTACGGATATAAACTTGTAGAAATAAAAGATAAAGATAAAATCCTATACATTGTTGTGCTGGATGAAGCATGTGAATCTCCACCTTCGAGAACAACAGACCTACTACAGAAGAGGATATTGTCGGGGGCTCTTACACATATCTTTATGTCAGGAAGACCAGTCAAAGAAGATGATATGTGGAGTTTCCTAGATAAATCTGGTTTACTCGCAGAAGATAACATTTCTGGAAGAAAATTACTAACACAGCAATTTACAAAACAGTTGTACCTTTCATATTCAAAGATGGGGGAAGGTGAACTAGCTAGGTACACATTTGACTGGGGTCCAAGAGCTAATCATGAATTGCCCAAGAAGTTCATACTGCAAAAAGTTGCAGTAGCATTTGGTACAGATCCAGCATGTTGGTCGGAACAATACAAAAGAACACTGCAATAA

Protein

MSRQSQTESTRLFDNSVRQCVRYVFCREADKIPIKRSEILEQIAPEYRKKSKNVLVEVEKELKRVYGYKLVEIKDKDKILYIVVLDEACESPPSRTTDLLQKRILSGALTHIFMSGRPVKEDDMWSFLDKSGLLAEDNISGRKLLTQQFTKQLYLSYSKMGEGELARYTFDWGPRANHELPKKFILQKVAVAFGTDPACWSEQYKRTLQ

Description

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116).
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).

Subunit

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Interacts with PJA1 (By similarity). Interacts with E2F1 (via C-terminus) (PubMed:14593116). Interacts with NGFR (via C-terminus) (PubMed:14593116). Interacts with NSMCE1. Interacts with NSMCE4. Interacts with SMC6. Interacts with EID3 (By similarity).
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer (PubMed:18086888). Interacts with PJA1 (PubMed:20864041). Interacts with E2F1 (via C-terminus) (By similarity). Interacts with NGFR (via C-terminus) (By similarity). Interacts with NSMCE1 (PubMed:18086888, PubMed:21364888, PubMed:20864041, PubMed:27427983). Interacts with NSMCE4 (PubMed:20864041, PubMed:27427983). Interacts with SMC6 (PubMed:18086888). Interacts with EID3 (PubMed:21364888).

Similarity

Belongs to the GST superfamily.

Keywords

Chromosome   Complete proteome   Cytoplasm   DNA damage   DNA recombination   DNA repair   Growth regulation   Nucleus   Phosphoprotein   Reference proteome   Telomere   Tumor antigen   Ubl conjugation pathway   3D-structure   Disease mutation  

Feature

chain  Non-structural maintenance of chromosomes element 3 homolog
sequence variant  In LICS; creates novel endoproteolytic cleavage sites compared to wild-type; loss of interaction with NSMCE4; loss of interaction with NSMCE1; dbSNP:rs886037827.

Uniprot

H9JHQ8   A0A1E1W4G7   A0A212FJR2   A0A2H1WPK6   A0A2A4K7V2   A0A194Q450   + More
S4P8X2   A0A146NX14   W5NEH9   W5NEI2   K7FXQ8   M7AP72   A0A2U9C2W3   A0A3L8Q7F4   M3ZDG2   A0A2D0SLS7   A0A1A6HYB4   I3KBY9   A0A3B4FDS0   A0A3P8PD01   A0A067RNC7   B5FY58   A0A2S2N4P0   A0A1W4XNS0   A0A2J8RFG8   A0A3P9DMM8   A0A218U7Q5   A0A3P9MZQ2   A0A3P4P4W0   Q9CPR8   A0A0S7I1S1   A0A0D9SEG3   Q6KAQ0   G3I8H2   A0A2R9BEC8   A0A3B3YDU5   A0A087X4Q9   A0A3B3TV35   G7PAL9   F6UA39   K7BRV0   K7AY23   K7DDV0   A0A3P4M186   U3DJR0   I3N673   A0A2R8PBK6   A0A2K5CY64   A0A340XKZ8   A0A2Y9FEC9   A0A2Y9KBK8   Q96MG7   A0A383YXY5   A0A3P8U346   F7CAS5   A0A1U7QZN4   A0A061IFY0   A0A384BU82   L5L1D6   A0A2U3WAX6   A0A384BTF2   A0A2Y9GDM3   A0A2U3XDD6   F6ZSW3   A0A2I4D5X5   A0A2I4AMF6   U6DQD6   D2HY46   A0A3B3RVL0   A0A2U4C6Z1   Q4KM72   A0A1U7SIE0   M3Z8P4   W5L054   F1PB59   A0A341DDF6   A0A2Y9MJD7   A0A2Y9GB05   A0A2U3XFF1   A0A2U3WLI6   G9KCV8   A0A1S2ZM33   A0A2Y9FYP3   A0A3B3DZC6   A0A3B4X4T8   A0A2Y9KB84   A0A1A6FZV6   A0A2Y9LN91   A0A3B5BK72   A0A3B4DEB1   A0A2Y9DDS4   A0A340X8X0   A0A1A8GMN4   A0A3B3RVI7   A0A3B5B3D1   A9JSA2   G3SQM4   S7N3R6   A0A1A6HJ41  

Pubmed

19121390    22118469    26354079    23622113    17381049    23624526    + More
30282656    23542700    23127152    25186727    24845553    17018643    16141072    15489334    11782285    14593116    21183079    21804562    22722832    22002653    25319552    25243066    14702039    18086888    18669648    19413330    21269460    21364888    21406692    23186163    24275569    20864041    27427983    18464734    23929341    29704459    23258410    20010809    29240929    25329095    16341006    23236062    29451363    20431018   

EMBL

BABH01029576    GDQN01009225    JAT81829.1    AGBW02008248    OWR53949.1    ODYU01009735    + More
SOQ54364.1    NWSH01000043    PCG80317.1    KQ459562    KPI99789.1    GAIX01003994    JAA88566.1    GCES01150762    JAQ35560.1    AHAT01031363    AGCU01085766    KB580997    EMP26339.1    CP026253    AWP09996.1    QUSF01003600    RLV63168.1    LZPO01007949    OBS83236.1    AERX01014389    KK852401    KDR24548.1    DQ213805    ACH43969.1    GGMT01000383    MBY12069.1    NDHI03003705    PNJ07267.1    MUZQ01000742    OWK49716.1    CYRY02030947    VCX05313.1    AF319979    AK010294    AK017727    AK018250    AK049759    AK076471    BC034892    BC092289    GBYX01434317    JAO47012.1    AQIB01116503    AK131157    BAD21407.1    JH001505    EGW11769.1    AJFE02034517    AYCK01015936    CM001282    EHH62929.1    JU335479    CM001259    AFE79232.1    EHH27156.1    GABC01008971    GABD01010197    NBAG03000353    JAA02367.1    JAA22903.1    PNI35943.1    GABF01009337    JAA12808.1    GABE01005920    GABE01005919    GABE01005918    JAA38819.1    CYRY02004187    VCW68706.1    GAMS01009510    GAMQ01000835    JAB13626.1    JAB41016.1    AGTP01015839    AF490510    AK056957    BC041166    BC053999    AK074138    AF320911    KE670977    RAZU01000138    ERE80707.1    RLQ70411.1    KB030428    ELK16858.1    HAAF01012923    CCP84746.1    GL193674    EFB17619.1    BC098730    AAH98730.1    AEYP01097082    AAEX03002201    JP014135    AES02733.1    LZPO01108073    OBS59468.1    HAEB01013195    HAEC01003582    SBQ71659.1    AAMC01094780    BC155975    AAI55976.1    KE163054    EPQ10675.1    LZPO01028475    OBS77657.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053268    UP000018468    UP000007267    + More
UP000031443    UP000246464    UP000276834    UP000002852    UP000221080    UP000092124    UP000005207    UP000261460    UP000265100    UP000027135    UP000192224    UP000265160    UP000197619    UP000242638    UP000000589    UP000029965    UP000001075    UP000240080    UP000261480    UP000028760    UP000261500    UP000009130    UP000005215    UP000008225    UP000233020    UP000265300    UP000248484    UP000248482    UP000005640    UP000261681    UP000265080    UP000002279    UP000189706    UP000030759    UP000273346    UP000261680    UP000010552    UP000245340    UP000248481    UP000245341    UP000192220    UP000261540    UP000245320    UP000189704    UP000000715    UP000018467    UP000002254    UP000252040    UP000248483    UP000079721    UP000248480    UP000261560    UP000261360    UP000261400    UP000261440    UP000008143    UP000007646   

PRIDE

H9JHQ8    Q9CPR8    G3I8H2    Q96MG7   

Pfam

PF01454   MAGE        + More
PF02798   GST_N
PF14497   GST_C_3

Interpro

IPR041898   MAGE_WH1        + More
IPR002190   MHD_dom       
IPR037445   MAGE       
IPR041899   MAGE_WH2       
IPR036249   Thioredoxin-like_sf       
IPR036282   Glutathione-S-Trfase_C_sf       
IPR004046   GST_C       
IPR004045   Glutathione_S-Trfase_N       
IPR010987   Glutathione-S-Trfase_C-like       
IPR040079   Glutathione_S-Trfase       

SUPFAM

SSF47616   SSF47616        + More
SSF52833   SSF52833       

Gene 3D

1.10.10.1200     1.10.10.1210    

ProteinModelPortal

H9JHQ8   A0A1E1W4G7   A0A212FJR2   A0A2H1WPK6   A0A2A4K7V2   A0A194Q450   + More
S4P8X2   A0A146NX14   W5NEH9   W5NEI2   K7FXQ8   M7AP72   A0A2U9C2W3   A0A3L8Q7F4   M3ZDG2   A0A2D0SLS7   A0A1A6HYB4   I3KBY9   A0A3B4FDS0   A0A3P8PD01   A0A067RNC7   B5FY58   A0A2S2N4P0   A0A1W4XNS0   A0A2J8RFG8   A0A3P9DMM8   A0A218U7Q5   A0A3P9MZQ2   A0A3P4P4W0   Q9CPR8   A0A0S7I1S1   A0A0D9SEG3   Q6KAQ0   G3I8H2   A0A2R9BEC8   A0A3B3YDU5   A0A087X4Q9   A0A3B3TV35   G7PAL9   F6UA39   K7BRV0   K7AY23   K7DDV0   A0A3P4M186   U3DJR0   I3N673   A0A2R8PBK6   A0A2K5CY64   A0A340XKZ8   A0A2Y9FEC9   A0A2Y9KBK8   Q96MG7   A0A383YXY5   A0A3P8U346   F7CAS5   A0A1U7QZN4   A0A061IFY0   A0A384BU82   L5L1D6   A0A2U3WAX6   A0A384BTF2   A0A2Y9GDM3   A0A2U3XDD6   F6ZSW3   A0A2I4D5X5   A0A2I4AMF6   U6DQD6   D2HY46   A0A3B3RVL0   A0A2U4C6Z1   Q4KM72   A0A1U7SIE0   M3Z8P4   W5L054   F1PB59   A0A341DDF6   A0A2Y9MJD7   A0A2Y9GB05   A0A2U3XFF1   A0A2U3WLI6   G9KCV8   A0A1S2ZM33   A0A2Y9FYP3   A0A3B3DZC6   A0A3B4X4T8   A0A2Y9KB84   A0A1A6FZV6   A0A2Y9LN91   A0A3B5BK72   A0A3B4DEB1   A0A2Y9DDS4   A0A340X8X0   A0A1A8GMN4   A0A3B3RVI7   A0A3B5B3D1   A9JSA2   G3SQM4   S7N3R6   A0A1A6HJ41  

PDB

5WY5     E-value=4.67483e-20,     Score=237

KEGG

101741054    K22823 non-structural maintenance of chromosomes element 3 | (RefSeq) melanoma-associated antigen G1

GO

GO:0016740   GO:0006355   GO:0071478   GO:0046983   GO:0000781   GO:0005737   GO:0005634   GO:0034644   GO:0006310   GO:0072711   GO:0040008   GO:0031398   GO:0030915   GO:0006281   GO:0005654   GO:0070534   GO:0042752   GO:0005768   GO:0034314   GO:0004842   GO:0042147   GO:0005829   GO:0045892   GO:0030904   GO:0051127  

PANTHER

PTHR11736  

Subcellular location

Cytoplasm  
Nucleus  
Chromosome  
Telomere  

Length:

209

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00226

Exp number, first 60 AAs:

0

Total prob of N-in:

0.29836

outside

1  -  209

 

 

Pi

13.407745

Theta

18.147414

Tajima's D

-0.843666

CLR

46.259912

CSRT

0.168291585420729

Interpretation

Uncertain