Gene

KWMTBOMO01503  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009106

Annotation

glutathione_S-transferase_sigma_1_[Bombyx_mori]

Location

Bomo_Chr3(-):12561491-12566399      View in EpiBrowser

Full name

Glutathione S-transferase 2       + More
Glutathione S-transferase      

Alternative Name

GST class-sigma
Major allergen Bla g 5

Location in the cell

Cytoplasmic   Reliability : 3.153

CDS

ATGCCTAAGGTTGTGTACCATTACTTCGCTTGCAAGGCTCTCGGGGAGAGCGGCCGTATGCTGCTCGCCTACGGAGGCCAGGACTTCGAAGACCACCGCGTGCTCTCCGCTGACTGGCCTGACTTCAAGCCAAAGACTCCGTTCGGTCAGATGCCAGTATTAGTGATCGACGGCAAGCAGTACGCTCAGAGCACCGCCATCTGCAGGTACCTCGGCCGCAAGTACGGGCTCGCCGGGGCCAATGACGAGGAGGCCTTCGAGATCGACCAGAACGTGGAGTTCCTGCACGATATTCGCGCCAAAGCGGCCGCTGTATACTACGAAGCTGATGAGGAGTTAAAAGCAAAAAAACACGAGGACTTTTCGAAGAACGTATACCCTGATATGTTGAAGAAGTTGAACTCGATAGTTGAAGCGAACAAAGGTCACATTGCTGCCGGAAAGCTGACATGGGGTGATTTCGTGTTCACCAGCATGTTTGACTACCTGAAGACCATGCTTCAAATACCTGATCTGGAAGTGCAATATCCTGCTTTCAAGAAAGTCTTGCAATCCGTCCTGACACAGCCCAAAGTGAAGGCTTTCTTAGATTTGGGAAGGCCATACGAATTTGAATTTTAA

Protein

MPKVVYHYFACKALGESGRMLLAYGGQDFEDHRVLSADWPDFKPKTPFGQMPVLVIDGKQYAQSTAICRYLGRKYGLAGANDEEAFEIDQNVEFLHDIRAKAAAVYYEADEELKAKKHEDFSKNVYPDMLKKLNSIVEANKGHIAAGKLTWGDFVFTSMFDYLKTMLQIPDLEVQYPAFKKVLQSVLTQPKVKAFLDLGRPYEFEF

Catalytic Activity

glutathione + RX = a halide anion + an S-substituted glutathione + H(+)

Subunit

Homodimer.

Similarity

Belongs to the GST superfamily.
Belongs to the GST superfamily. Sigma family.

Keywords

Transferase   3D-structure   Allergen   Direct protein sequencing  

Feature

chain  Glutathione S-transferase 2

Uniprot

Q7Z1E3   H9JHV8   Q5CCJ4   A0A2L1CF21   S4PA35   A0A0A7KLG0   + More
A0A3G1ZLD3   A0A1P8L0T1   A0A1W6I4L5   A0A075X8Y1   A0A165G1C4   A0A2R4N9Y3   A0A0K8TV03   D3YEX2   C6ZJZ8   A0A3G1ZLD1   A0A2H1VZ98   D3JYQ6   F6KX43   I4DJV2   O76783   A0A0N0PBF2   A0A194Q450   Q6F436   S4NSB8   P46429   H9NAT8   A0A0N1ICL7   A0A3G1ZLD0   A0A2A4J6M7   F6KX42   F6KX44   A0A194Q8Q4   A0A3G1ZLC8   A0A0K8TUE8   A0A2H1WRZ9   A0A2A4J0N1   D7S006   D7S007   B2BNZ2   A0A194Q2M0   A0A2H1WRQ5   D7S008   A0A1P8L0T6   I4DL77   D7S004   I4DMZ0   A0A0K8T4L2   Q4ACU7   D7S005   A0A212FJP1   A0A0K8TUF1   A0A2A4J778   A0A1P8L0V1   I4DL78   A0A212FJP7   A0A212FJR7   A0A2H1VVM4   A0A2H1W020   A0A0D3M5T8   A0A194Q461   A0A194RRD8   A0A0N0PBF3   A0A0K8TUG2   A0A194Q378   A0A2A4J5X4   A0A0N1PH59   A0A2P8ZI29   A0A0C9QT46   G8XWV7   A0A0J7KF28   O18598   A0A232F7Z6   A0A077D6F7   A9XFW9   A0A2U9K4C4   A0A2P0XJ18   F4YUJ0   A0A0L7RGV6   V9Q487   A0A2A3E292   V9IJF3   Q16P79   A0A1J1I2E5   A0A067RMR4   A0A0K8TUF3   E2AX16   A0A023EME7   A0A182H3T8   G9C5D7   A0A336MNI5   A0A1L8E4S0   A0A1W4XE39   E2C1V1   M9VAC6   A8CWB8   T1IG50   A0A2J7R389   A0A0A9YG93   A0A2C9GW59  

EC Number

2.5.1.18

Pubmed

20364407    19121390    17284839    23458683    23622113    30319435    + More
26017144    22299369    21605564    22651552    26354079    7742833    18651917    22118469    29403074    9252418    28648823    17703094    29234290    21413139    17510324    24845553    20798317    24945155    26483478    21835214    25480347    28767183    18194529    25401762    26823975   

EMBL

AY297161    DQ862466    AAP50848.1    ABI15775.1    BABH01029576    BABH01029577    + More
KF743058    AB206971    AHC69716.1    BAD91107.1    MF521977    AVC05621.1    GAIX01003429    JAA89131.1    KM433693    AIZ46905.1    MH177606    AYM01178.1    KX229716    APW77577.1    KX500037    ARM39007.1    KF482967    AIH07591.1    KT984985    AMY26653.1    MF503495    AVX32553.1    GCVX01000112    JAI18118.1    GU453917    ADD14027.1    EU912434    ACK75952.1    MH177604    AYM01176.1    ODYU01005380    SOQ46161.1    GU338052    ADC32118.1    HQ667937    AEG75843.1    AK401570    BAM18192.1    AF082570    AAC34097.1    KQ460941    KPJ10581.1    KQ459562    KPI99789.1    AB180454    BAD26698.1    GAIX01014167    JAA78393.1    L32092    JQ236852    AFF27579.1    KPJ10579.1    MH177605    AYM01177.1    NWSH01002798    PCG67519.1    HQ667936    AEG75842.1    HQ667938    AEG75844.1    KPI99790.1    MH177603    AYM01175.1    GCVX01000116    JAI18114.1    ODYU01010552    SOQ55742.1    NWSH01004458    PCG65084.1    HM209429    ADI32890.1    HM209430    ADI32891.1    EF591059    ABU88426.1    KPI99791.1    SOQ55741.1    HM209431    ADI32892.1    KX229717    APW77578.1    AK402045    BAM18667.1    HM209427    ADI32888.1    AK402658    BAM19280.1    GBRD01005353    JAG60468.1    AB223045    BAE16754.1    HM209428    ADI32889.1    AGBW02008248    OWR53951.1    GCVX01000111    JAI18119.1    PCG67518.1    KX229719    APW77580.1    AK402046    BAM18668.1    OWR53952.1    OWR53950.1    ODYU01004709    SOQ44879.1    SOQ46162.1    KJ468619    AIB07720.1    KPI99799.1    KQ459989    KPJ18606.1    KPJ10574.1    GCVX01000113    JAI18117.1    KPI99798.1    PCG67517.1    KPJ10578.1    PYGN01000050    PSN56155.1    GBYB01003772    JAG73539.1    FJ855499    AEV23881.1    LBMM01008228    KMQ89038.1    U92412    NNAY01000776    OXU26573.1    KM099188    AIL29318.1    EF202178    ABP04044.1    MG387112    AWS20692.1    KY661341    AVA17428.1    HM131836    AEB91973.1    KQ414596    KOC69921.1    KF680481    AHC08043.1    KZ288431    PBC25817.1    JR050147    AEY61185.1    CH477792    EAT36155.2    CVRI01000036    CRK93022.1    KK852417    KDR24333.1    GCVX01000123    JAI18107.1    GL443495    EFN62036.1    GAPW01004109    JAC09489.1    JXUM01108106    JXUM01108107    KQ565202    KXJ71233.1    HQ851378    AEV89756.1    UFQS01001264    UFQT01001264    SSX10045.1    SSX29767.1    GFDF01000357    JAV13727.1    GL452008    EFN78063.1    KC161213    KJ913696    MF036029    MF036052    AGJ76541.1    AIL33467.1    AST11608.1    AST11631.1    AJWK01030929    AJWK01030930    EU124611    ABV60329.1    ACPB03002684    NEVH01007822    PNF35302.1    GBHO01013501    GDHC01018636    JAG30103.1    JAP99992.1    AXCN02001759   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000245037    + More
UP000036403    UP000215335    UP000053825    UP000242457    UP000008820    UP000183832    UP000027135    UP000000311    UP000069940    UP000249989    UP000192223    UP000008237    UP000092461    UP000015103    UP000235965    UP000075886   

PRIDE

Q7Z1E3    H9JHV8    Q5CCJ4    P46429   

Pfam

PF02798   GST_N        + More
PF14497   GST_C_3
PF01454   MAGE
PF01239   PPTA

Interpro

IPR010987   Glutathione-S-Trfase_C-like        + More
IPR004045   Glutathione_S-Trfase_N       
IPR036282   Glutathione-S-Trfase_C_sf       
IPR036249   Thioredoxin-like_sf       
IPR004046   GST_C       
IPR040079   Glutathione_S-Trfase       
IPR041899   MAGE_WH2       
IPR002190   MHD_dom       
IPR041898   MAGE_WH1       
IPR003080   GST_alpha       
IPR002088   Prenyl_trans_a       

SUPFAM

SSF47616   SSF47616        + More
SSF52833   SSF52833       

Gene 3D

1.10.10.1200     1.10.10.1210    

ProteinModelPortal

Q7Z1E3   H9JHV8   Q5CCJ4   A0A2L1CF21   S4PA35   A0A0A7KLG0   + More
A0A3G1ZLD3   A0A1P8L0T1   A0A1W6I4L5   A0A075X8Y1   A0A165G1C4   A0A2R4N9Y3   A0A0K8TV03   D3YEX2   C6ZJZ8   A0A3G1ZLD1   A0A2H1VZ98   D3JYQ6   F6KX43   I4DJV2   O76783   A0A0N0PBF2   A0A194Q450   Q6F436   S4NSB8   P46429   H9NAT8   A0A0N1ICL7   A0A3G1ZLD0   A0A2A4J6M7   F6KX42   F6KX44   A0A194Q8Q4   A0A3G1ZLC8   A0A0K8TUE8   A0A2H1WRZ9   A0A2A4J0N1   D7S006   D7S007   B2BNZ2   A0A194Q2M0   A0A2H1WRQ5   D7S008   A0A1P8L0T6   I4DL77   D7S004   I4DMZ0   A0A0K8T4L2   Q4ACU7   D7S005   A0A212FJP1   A0A0K8TUF1   A0A2A4J778   A0A1P8L0V1   I4DL78   A0A212FJP7   A0A212FJR7   A0A2H1VVM4   A0A2H1W020   A0A0D3M5T8   A0A194Q461   A0A194RRD8   A0A0N0PBF3   A0A0K8TUG2   A0A194Q378   A0A2A4J5X4   A0A0N1PH59   A0A2P8ZI29   A0A0C9QT46   G8XWV7   A0A0J7KF28   O18598   A0A232F7Z6   A0A077D6F7   A9XFW9   A0A2U9K4C4   A0A2P0XJ18   F4YUJ0   A0A0L7RGV6   V9Q487   A0A2A3E292   V9IJF3   Q16P79   A0A1J1I2E5   A0A067RMR4   A0A0K8TUF3   E2AX16   A0A023EME7   A0A182H3T8   G9C5D7   A0A336MNI5   A0A1L8E4S0   A0A1W4XE39   E2C1V1   M9VAC6   A8CWB8   T1IG50   A0A2J7R389   A0A0A9YG93   A0A2C9GW59  

PDB

3VUR     E-value=1.48503e-76,     Score=724

KEGG

692631    K04097 prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18] | (RefSeq) GSTs

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016740   GO:0004364   GO:0016021   GO:0018342   GO:0008318   GO:0005515   GO:0022857   GO:0006468   GO:0004930   GO:0006420   GO:0004812   GO:0006418   GO:0006334   GO:0003779  

Length:

206

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01602

Exp number, first 60 AAs:

0.00799

Total prob of N-in:

0.07487

outside

1  -  206

 

 

Pi

235.677806

Theta

165.1521

Tajima's D

1.058922

CLR

0.960459

CSRT

0.671816409179541

Interpretation

Uncertain