Gene

KWMTBOMO01489  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009049

Annotation

PREDICTED:_Niemann-Pick_C1_protein_[Bombyx_mori]

Location

Bomo_Chr3(+):12288740-12306900      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.586

CDS

ATGCCCCTTGCGATCTCTTCAATGAAAGCGATGTTCGATATATTCTGCTGTCTGCGGGGCACCAAAACAGACCTGGCAGAACAAGGTGAAGGAGCATTGTACAACCTGTTTCAACATTTCTATGTACCTTTCCTGATGAAGAGGGAAGTCAGAGCCTCAGTCATGATTATATTCTTTGCTTGGCTCTGCTCGTCTGTTGCTGTAGCGCCTCACATCGACATCGGACTAGACCAAGAGCTGTCTATGCCCCACGACAGTTTCCAGTTGAAGTACTTCCAGCATCTGAACCGCTACCTGAACATCGGTCCGCCGGTCTACTTTGTGCTCACGGACGCCGAGACGGACGCCAAGCTGAACTACTCCACCCCCGACGTGCAGAACTTGCTGTGCGGCTCGAGGTTCTGTAGACCCGACAGTCTCGCCATGCAGATATACGCTGCGTCCCGCAGCCCGGCCGACACGTACATCGCGGCTCCAGCCAACTCTTGGCTCGACGACTTCTTCGACTGGTCTGTCTCACCGGAGTGCTGCTTCTACTTCCAGTCCAACAACAGCTTCTGTCCCAGCGACACTCAACCCGACGATTGTGCCGCTTGCAACATAAAGTTGGTGCAGCCGGAAGAGCGTCCCAGCCCGCAGGACTTCAGCACGTACCTGCCGTACTTCCTGCAGGACAACCCGTCGAGCCGCTGCGTCAAGGGAGGCCACGCGGCCTACTCGCACGCCGTCAACCTGCGCTCGCACAGCCAGAACACCACCGGGATCGGCGCCACCTACTACCAGAGCTACCACACGGTCCTGCGCAGCAGCTCGGACTACTACGGCAGCCTGCGGGCGGCGCGCGCGCTGGCGGGCTCGCTCACGGAGACGCTCAACGCGCACCTCCGCGACCTGGGACACTCCGCCACCGTCAACGTCTTCCCCTACTCGGTCTTCTACGTCTTCTACGAGCAGTACCTCACCATGTGGTCCGACACCCTCAAGAGCATGGGCATCTCCGTGCTCTCCATATTCTTCGTCACCTTCGTGCTCATGGGCTTCGATCTCTTCTCGGCTCTTGTAGTCGTAGTGACCATCACTATGATTGTTGTTAATCTCGGCGGCCTCATGTACTGGTGGGGCATCAGTTTGAATGCAGTCTCGCTTGTAAATTTGGTGATGGCGGTGGGCATATCGGTGGAGTTCTGCTCGCACCTGGTGCACTCGTTCAGCGTGTCGGCGGGGCGCGGGCGCGGGGAGCGCGCGGCGGACGCGCTGCTGCGCATGGGCTCGTCCGTGCTGTCCGGCATCACGCTCACCAAGTTCGGCGGCATCATCGTGCTCGCCACGGCCAAGAGCCAGATCTTCCAGGTGTTCTACTTCCGGATGTACCTCGGGATTGTGCTGTTCGGTGCGGCCCACGGACTCGTATTCCTGCCGGTTATGCTCAGCTATATCGGTTCGCCGGTTAACAAACAGAAGCTGGCCAACCAGAGGCGGCGCGGCAACGAGACGACGGTCGCCGAAAGTTCGCTCACACGAGTACATCTGTAA

Protein

MPLAISSMKAMFDIFCCLRGTKTDLAEQGEGALYNLFQHFYVPFLMKREVRASVMIIFFAWLCSSVAVAPHIDIGLDQELSMPHDSFQLKYFQHLNRYLNIGPPVYFVLTDAETDAKLNYSTPDVQNLLCGSRFCRPDSLAMQIYAASRSPADTYIAAPANSWLDDFFDWSVSPECCFYFQSNNSFCPSDTQPDDCAACNIKLVQPEERPSPQDFSTYLPYFLQDNPSSRCVKGGHAAYSHAVNLRSHSQNTTGIGATYYQSYHTVLRSSSDYYGSLRAARALAGSLTETLNAHLRDLGHSATVNVFPYSVFYVFYEQYLTMWSDTLKSMGISVLSIFFVTFVLMGFDLFSALVVVVTITMIVVNLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSAGRGRGERAADALLRMGSSVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQKLANQRRRGNETTVAESSLTRVHL

Uniprot

H9JHQ1   A0A1E1W315   A0A1E1WF36   A0A2A4JEW0   A0A2A4JDF8   S4NIY9   + More
A0A194Q389   A0A2H1WD18   A0A1B0CML6   A0A182JVT3   A0A182RCT9   A0A1L8DK92   A0A1L8DJW6   A0A182W717   A0A182WU12   A0A182VKU5   A0A182HUM5   Q7Q409   A0A232F5K7   A0A1S4GY27   W4VRS2   A0A182Y098   A0A212ETH3   E2C5L5   A0A067RJQ3   A0A0J7L4X3   A0A0C9QGJ1   A0A1Q3FAF1   A0A1Q3FAB2   A0A1Q3FEC4   A0A1Q3FDN5   V9IBI8   A0A1Q3FDU7   A0A1Q3FDK5   A0A1A9Y128   A0A182NUF5   A0A0N0BJK7   A0A084W877   Q17FP9   A0A182PPK3   A0A1A9WHG4   A0A1L8DK46   A0A151JV85   A0A1L8DXZ7   A0A1S4F4D2   V5GP54   A0A1A9UD14   A0A1B0C3R6   E2AJ59   B0WCU9   A0A182GSW8   A0A182UD69   A0A182MUA8   A0A2M4A071   A0A2M3ZZS0   A0A0A1WH39   A0A151JN89   A0A0A1WIT2   A0A069DY01   A0A195BJN6   A0A2M4DNX4   A0A2M3ZZG3   D2CG00   A0A2M4DP08   A0A182L1G0   A0A2M4A2E5   A0A0L7LNY8   A0A2M3ZZX1   A0A139WDV5   A0A182S643   A0A2M4B9J8   W8B0I9   W8AQJ5   A0A026WXJ1   A0A2M4B9I5   A0A224X9R7   A0A0K8W2V5   E9J1S5   U4UCF2   A0A336LHM5   A0A336LKH8   N6TS49   A0A0K8VI49   B5DSD6   A0A1I8PCF8   A0A2M3YYS3   A0A0K8WJE9   A0A0K8V6W5   A0A1S4GY52   A0A0P8Y4I3   A0A3B0JHC0   B3N938   A0A1I8MBW9   A0A151I7K5   B3MPM8   A0A2M3YYE1   A0A154PRE1   A0A1J1IL33   A0A087ZWG1   A0A1B6H0T0  

Pubmed

19121390    23622113    26354079    12364791    28648823    25244985    + More
22118469    20798317    24845553    24438588    17510324    26483478    25830018    26334808    18362917    19820115    20966253    26227816    24495485    24508170    30249741    21282665    23537049    15632085    17994087    25315136    18057021   

EMBL

BABH01029600    BABH01029601    BABH01029602    GDQN01010904    GDQN01009686    JAT80150.1    + More
JAT81368.1    GDQN01005456    JAT85598.1    NWSH01001793    PCG70124.1    PCG70125.1    GAIX01013884    JAA78676.1    KQ459562    KPI99808.1    ODYU01007827    SOQ50927.1    AJWK01018887    AJWK01018888    AJWK01018889    AJWK01018890    GFDF01007330    JAV06754.1    GFDF01007331    JAV06753.1    APCN01002466    AAAB01008964    EAA12360.4    NNAY01000911    OXU25955.1    GANO01000231    JAB59640.1    AGBW02012571    OWR44805.1    GL452770    EFN76828.1    KK852428    KDR24042.1    LBMM01000596    KMQ97997.1    GBYB01002584    JAG72351.1    GFDL01010528    JAV24517.1    GFDL01010521    JAV24524.1    GFDL01009138    JAV25907.1    GFDL01009355    JAV25690.1    JR037260    AEY57664.1    GFDL01009318    JAV25727.1    GFDL01009411    JAV25634.1    KQ435713    KOX79311.1    ATLV01021379    ATLV01021380    ATLV01021381    ATLV01021382    KE525317    KFB46421.1    CH477269    EAT45375.1    GFDF01007339    JAV06745.1    KQ981703    KYN37448.1    GFDF01002747    JAV11337.1    GALX01005084    JAB63382.1    JXJN01025092    GL439967    EFN66499.1    DS231890    EDS43825.1    JXUM01017416    JXUM01017417    JXUM01017418    KQ560483    KXJ82189.1    AXCM01006422    GGFK01000824    MBW34145.1    GGFK01000743    MBW34064.1    GBXI01016090    GBXI01000437    JAC98201.1    JAD13855.1    KQ978858    KYN27920.1    GBXI01015530    JAC98761.1    GBGD01000124    JAC88765.1    KQ976453    KYM85401.1    GGFL01015095    MBW79273.1    GGFK01000622    MBW33943.1    KQ971357    EFA11848.2    GGFL01015083    MBW79261.1    GGFK01001580    MBW34901.1    JTDY01000425    KOB77248.1    GGFK01000728    MBW34049.1    KYB26045.1    GGFJ01000541    MBW49682.1    GAMC01019805    GAMC01019804    GAMC01019803    JAB86751.1    GAMC01019808    GAMC01019807    GAMC01019806    JAB86748.1    KK107078    QOIP01000011    EZA60461.1    RLU17131.1    GGFJ01000573    MBW49714.1    GFTR01008772    JAW07654.1    GDHF01006925    JAI45389.1    GL767674    EFZ13188.1    KB632196    ERL89983.1    UFQT01000004    SSX17240.1    SSX17241.1    APGK01056781    KB741277    ENN71121.1    GDHF01013777    JAI38537.1    CH475491    EDY70961.2    GGFM01000655    MBW21406.1    GDHF01012848    GDHF01001051    JAI39466.1    JAI51263.1    GDHF01020819    GDHF01017640    JAI31495.1    JAI34674.1    CH902620    KPU73871.1    OUUW01000006    SPP81585.1    CH954177    EDV58473.2    KQ978411    KYM94111.1    EDV32276.1    KPU73872.1    KPU73873.1    KPU73874.1    KPU73875.1    GGFM01000497    MBW21248.1    KQ435078    KZC14443.1    CVRI01000055    CRL00931.1    GECZ01001485    JAS68284.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000092461    UP000075881    UP000075900    + More
UP000075920    UP000076407    UP000075903    UP000075840    UP000007062    UP000215335    UP000076408    UP000007151    UP000008237    UP000027135    UP000036403    UP000092443    UP000075884    UP000053105    UP000030765    UP000008820    UP000075885    UP000091820    UP000078541    UP000078200    UP000092460    UP000000311    UP000002320    UP000069940    UP000249989    UP000075902    UP000075883    UP000078492    UP000078540    UP000007266    UP000075882    UP000037510    UP000075901    UP000053097    UP000279307    UP000030742    UP000019118    UP000001819    UP000095300    UP000007801    UP000268350    UP000008711    UP000095301    UP000078542    UP000076502    UP000183832    UP000005203   

PRIDE

H9JHQ1   

Pfam

PF12349   Sterol-sensing        + More
PF16414   NPC1_N
PF02460   Patched
PF03129   HGTP_anticodon

Interpro

IPR000731   SSD        + More
IPR003392   Ptc/Disp       
IPR032190   NPC1_N       
IPR004765   NPC1-like       
IPR020846   MFS_dom       
IPR036621   Anticodon-bd_dom_sf       
IPR004154   Anticodon-bd       

Gene 3D

3.40.50.800    

CDD

cd06174  MFS

ProteinModelPortal

H9JHQ1   A0A1E1W315   A0A1E1WF36   A0A2A4JEW0   A0A2A4JDF8   S4NIY9   + More
A0A194Q389   A0A2H1WD18   A0A1B0CML6   A0A182JVT3   A0A182RCT9   A0A1L8DK92   A0A1L8DJW6   A0A182W717   A0A182WU12   A0A182VKU5   A0A182HUM5   Q7Q409   A0A232F5K7   A0A1S4GY27   W4VRS2   A0A182Y098   A0A212ETH3   E2C5L5   A0A067RJQ3   A0A0J7L4X3   A0A0C9QGJ1   A0A1Q3FAF1   A0A1Q3FAB2   A0A1Q3FEC4   A0A1Q3FDN5   V9IBI8   A0A1Q3FDU7   A0A1Q3FDK5   A0A1A9Y128   A0A182NUF5   A0A0N0BJK7   A0A084W877   Q17FP9   A0A182PPK3   A0A1A9WHG4   A0A1L8DK46   A0A151JV85   A0A1L8DXZ7   A0A1S4F4D2   V5GP54   A0A1A9UD14   A0A1B0C3R6   E2AJ59   B0WCU9   A0A182GSW8   A0A182UD69   A0A182MUA8   A0A2M4A071   A0A2M3ZZS0   A0A0A1WH39   A0A151JN89   A0A0A1WIT2   A0A069DY01   A0A195BJN6   A0A2M4DNX4   A0A2M3ZZG3   D2CG00   A0A2M4DP08   A0A182L1G0   A0A2M4A2E5   A0A0L7LNY8   A0A2M3ZZX1   A0A139WDV5   A0A182S643   A0A2M4B9J8   W8B0I9   W8AQJ5   A0A026WXJ1   A0A2M4B9I5   A0A224X9R7   A0A0K8W2V5   E9J1S5   U4UCF2   A0A336LHM5   A0A336LKH8   N6TS49   A0A0K8VI49   B5DSD6   A0A1I8PCF8   A0A2M3YYS3   A0A0K8WJE9   A0A0K8V6W5   A0A1S4GY52   A0A0P8Y4I3   A0A3B0JHC0   B3N938   A0A1I8MBW9   A0A151I7K5   B3MPM8   A0A2M3YYE1   A0A154PRE1   A0A1J1IL33   A0A087ZWG1   A0A1B6H0T0  

PDB

5U74     E-value=6.59967e-121,     Score=1112

KEGG

101742149    K12385 Niemann-Pick C1 protein | (RefSeq) Niemann-Pick C1 protein

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005319   GO:0007591   GO:0016125   GO:0032374   GO:0007291   GO:0045456   GO:0005515   GO:0051287   GO:0004930   GO:0006420   GO:0004812   GO:0006418   GO:0006334   GO:0003779  

Length:

510

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

131.31679

Exp number, first 60 AAs:

7.66742

Total prob of N-in:

0.64878

inside

1  -  49

TMhelix

50  -  72

outside

73  -  328

TMhelix

329  -  346

inside

347  -  352

TMhelix

353  -  375

outside

376  -  378

TMhelix

379  -  401

inside

402  -  421

TMhelix

422  -  444

outside

445  -  458

TMhelix

459  -  481

inside

482  -  510

 

 

Pi

238.192607

Theta

175.834574

Tajima's D

1.086191

CLR

0.143573

CSRT

0.67901604919754

Interpretation

Uncertain