Gene

KWMTBOMO01484  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009047

Annotation

Brasiliensin_[Operophtera_brumata]

Location

Bomo_Chr3(+):12218050-12219811      View in EpiBrowser

Full name

Serine protease inhibitor dipetalogastin      

Location in the cell

Extracellular   Reliability : 4.775

CDS

ATGTTACTAGCAGCCACGCAGGTGATTGCAACACTTGCATATCCACCAAGCTGTGCGTGCTATAGAAACCAGCGACCAGTGTGCGGAACTGATGGGAAAACATACAACAACGAGTGCCTGCTCGACTGTGCCACCAGAGATGATCCCGGTCTAAGGGTCAGATATCAAGGACCCTGCTCGGAAGGAAACGTCGGCTTCCCCGCGTGCCACTGCGACTACGACCTCAACCAGGTGTGCGGTAGCGACAACCACACGTACGACAACGCTTGCCTGTTGAACTGCGCCGCAGCCACGAACCCAGGCCTTAGCATTTTGTACTCGGGCCTTTGCGCAGACGAAGTCAAAATCGTGGACGGCCCCAGCAAATACCCTTCGTGCACGTGCACGCGCGAGATGAAGCCGGTCTGCGGCAGTGACGGTATCACGTACAACAACGACTGCCTCTTAAACTGTGCCACAATCAATGACTCCAGACTCGGCATCGAATACTACGGGCCTTGCGCTGATAAGGTTATAGTCGTCGACCCTGGGACGCAAGGGGACTACCACGGAATACGACCCCTGTAA

Protein

MLLAATQVIATLAYPPSCACYRNQRPVCGTDGKTYNNECLLDCATRDDPGLRVRYQGPCSEGNVGFPACHCDYDLNQVCGSDNHTYDNACLLNCAAATNPGLSILYSGLCADEVKIVDGPSKYPSCTCTREMKPVCGSDGITYNNDCLLNCATINDSRLGIEYYGPCADKVIVVDPGTQGDYHGIRPL

Description

Thrombin inhibitor. Prevents blood clotting to allow insect to feed on blood. Also functions as an inhibitor of trypsin and plasmin.

Similarity

Belongs to the peptidase S1 family.
Belongs to the histidine acid phosphatase family.

Keywords

3D-structure   Direct protein sequencing   Disulfide bond   Protease inhibitor   Repeat   Secreted   Serine protease inhibitor  

Feature

chain  Serine protease inhibitor dipetalogastin

Uniprot

H9JHP9   A0A0L7KLP1   A0A2A4J4J0   A0A2H1WCW0   A0A1E1WG88   A0A1E1W067   + More
A0A212FFK4   A0A194RMR3   A0A194Q478   Q95P16   A0A0V0GC63   O96790   Q2PQ60   I4DRW4   A7YIH7   A0A224XKS1   D6MTG6   R4G5Q7   G7Z060   A0A2G8KK52   A0A2D4CG12   R4G522   A0A224XI26   A0A2A9MJ26   A7SCV8   R4FKP5   A0A328C1Z1   A0A0V0GCM8   A0A098LWJ0   S4PXB4   R4FNV8   W4GSW3   Q6V4H5   A0A0V0GDE0   Q26057   A0A212EWW4   A0A091Q4T4   K1PRF2   A7S1Y8   A0A2G8JI72   E9FU53   F0VGR8   A0A2D4BTP3   A0A212EWY3   A0A0P4VS39   A0A194AP66   A0A1V9ZNY3   A0A094N0Q6   R4G460   A0A2D4BU67   W4GQI0   A0A091V5K6   K1PUN3   A0A2D4BTW8   A0A2D4C1L9   W4G8P9   A0A2G8L288   A0A074T8B7   A0A3N0ZC33   A0A093IY93   B9QB87   A0A086JPK6   A0A2T6IGH7   A0A086K892   T0QWG7   A0A2G8YD87   A0A142F4W5   A0A151HM21   T0SB17   A0A139XS16   S8F474   A0A345J9N2   A0A086K707   A0A086M8P5   A0A086QDX3   A0A086QRH2   S7UY75   H6TBL5   A0A098LY09   A0A0L7LAI0   A0A150GYM8   A0A2D4BTR7   A0A150GX40   A0A093HJ74   A0A091IR23   A0A091U4N7   A0A329RKD5   A0A087VM52   A0A0A7CMZ8   A0A091TRL1   A0A093ISF4   A0A397A7V7   D8U187   A0A0S4TEL4   R4FPE5   R4G8Z5   A0A2H1X0K7   D8VNJ7   A0A2D4BEB9   A0A397DN89  

Pubmed

19121390    26227816    22118469    26354079    12213235    22683792    + More
10561601    10702701    12051857    16469426    22651552    17575982    20206694    29023486    17615350    25305551    23622113    19071220    8055907    22992520    21292972    25875305    27129103    25527045    26738725    25480939    22200638    27102219    20616280    19616577    20170735   

EMBL

BABH01029603    JTDY01008993    KOB64228.1    NWSH01003404    PCG66360.1    ODYU01007827    + More
SOQ50919.1    GDQN01005051    JAT86003.1    GDQN01010676    JAT80378.1    AGBW02008805    OWR52525.1    KQ459989    KPJ18620.1    KQ459562    KPI99814.1    AF360846    AAK57342.1    GECL01000703    JAP05421.1    AJ131524    CAA10384.1    DQ309461    ABC33721.1    AK405300    BAM20654.1    DQ915949    ABI96910.1    GFTR01003340    JAW13086.1    GQ466491    ADF97836.1    GAHY01000320    JAA77190.1    FJ429307    ACR43430.1    MRZV01000525    PIK48379.1    BBXB01000383    GAY05161.1    GAHY01000271    JAA77239.1    GFTR01004289    JAW12137.1    NWUJ01000001    PFH37975.1    DS469625    EDO38471.1    GAHY01002394    JAA75116.1    QHKO01000010    RAL20443.1    GECL01000467    JAP05657.1    GBQY01000020    JAC94837.1    GAIX01005333    JAA87227.1    GAHY01000413    JAA77097.1    KI913123    ETV81988.1    AY351957    AAQ22771.1    GECL01000246    JAP05878.1    X79512    CAA56043.1    AGBW02011879    OWR45992.1    KK655510    KFQ04649.1    JH817900    EKC18990.1    DS469566    EDO42283.1    MRZV01001902    PIK35441.1    GL732524    EFX89486.1    FR823389    LN714482    CBZ52912.1    CEL66894.1    BBXB01000071    GAX97727.1    GAX97730.1    OWR45993.1    GDKW01003736    JAI52859.1    GELH01000260    GELH01000259    JAS04013.1    JNBR01000045    OQR99694.1    KL262421    KFZ60301.1    GAHY01001071    JAA76439.1    GAX97702.1    ETV81995.1    KL410715    KFQ98606.1    JH819052    EKC22649.1    GAX97734.1    BBXB01000110    GAX99509.1    KI913140    ETV75338.1    MRZV01000251    PIK54376.1    KL544029    KEP66340.1    RJVU01000233    ROL55538.1    KK598246    KFW04567.1    LN714497    AAYL02000145    CEL74369.1    ESS32012.1    AHZU02001279    KFG34074.1    AFHV02003173    PUA84448.1    AEYH02002314    KFG40610.1    JH767132    EQC42564.1    AGQR02000160    PIM05228.1    KT901291    AMQ67844.1    AHZP02000549    KYK70386.1    EQC42563.1    AGQS02005168    KYF41586.1    KE138830    EPT29462.1    MF773969    AXH21510.1    AEYI02001212    KFG40175.1    AFYV02000360    KFG65263.1    AEYJ02000356    KFH10805.1    AEXC02000972    KFH15204.1    AAQM03000090    EPR62761.1    HQ833562    AEW24506.1    GBQY01000006    JAC94851.1    JTDY01001944    KOB72482.1    LSYV01000006    KXZ54430.1    GAX97733.1    KXZ54431.1    KK390833    KFV54618.1    KK500720    KFP09860.1    KK414184    KFQ84825.1    MJFZ01000928    RAW24156.1    KL498401    KFO13694.1    KM038374    AIG55835.1    KK483758    KFQ61306.1    KFW04568.1    QUSZ01007694    RHY01819.1    GL378350    EFJ46514.1    LN877950    CUV05794.1    GAHY01000208    JAA77302.1    GAHY01000112    JAA77398.1    ODYU01012498    SOQ58841.1    GU062746    ADI96221.1    BBXB01000004    GAX92693.1    QUTA01006480    QUTB01008068    QUTD01004491    QUTC01002195    QUTE01024262    QUTF01021138    RHY10993.1    RHY43607.1    RHY67771.1    RHY74923.1    RHY78880.1    RHY94126.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000053240    UP000053268    + More
UP000230750    UP000054177    UP000224006    UP000001593    UP000249169    UP000019040    UP000005408    UP000000305    UP000243579    UP000053283    UP000027470    UP000002226    UP000030762    UP000001529    UP000005641    UP000075714    UP000053119    UP000251314    UP000001058   

PRIDE

H9JHP9   

Pfam

PF00050   Kazal_1        + More
PF07648   Kazal_2
PF00293   NUDIX
PF02494   HYR
PF00008   EGF
PF00089   Trypsin
PF00328   His_Phos_2
PF00094   VWD

Interpro

IPR036058   Kazal_dom_sf        + More
IPR002350   Kazal_dom       
IPR020084   NUDIX_hydrolase_CS       
IPR000086   NUDIX_hydrolase_dom       
IPR015797   NUDIX_hydrolase-like_dom_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR013032   EGF-like_CS       
IPR000742   EGF-like_dom       
IPR003410   HYR_dom       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR033116   TRYPSIN_SER       
IPR001239   Prot_inh_Kazal-m       
IPR003645   Fol_N       
IPR029033   His_PPase_superfam       
IPR000560   His_Pase_clade-2       
IPR001846   VWF_type-D       

SUPFAM

SSF100895   SSF100895        + More
SSF55811   SSF55811       
SSF50494   SSF50494       
SSF53254   SSF53254       

Gene 3D

3.40.50.1240    

CDD

cd00190  Tryp_SPc
cd07061  HP_HAP_like

ProteinModelPortal

H9JHP9   A0A0L7KLP1   A0A2A4J4J0   A0A2H1WCW0   A0A1E1WG88   A0A1E1W067   + More
A0A212FFK4   A0A194RMR3   A0A194Q478   Q95P16   A0A0V0GC63   O96790   Q2PQ60   I4DRW4   A7YIH7   A0A224XKS1   D6MTG6   R4G5Q7   G7Z060   A0A2G8KK52   A0A2D4CG12   R4G522   A0A224XI26   A0A2A9MJ26   A7SCV8   R4FKP5   A0A328C1Z1   A0A0V0GCM8   A0A098LWJ0   S4PXB4   R4FNV8   W4GSW3   Q6V4H5   A0A0V0GDE0   Q26057   A0A212EWW4   A0A091Q4T4   K1PRF2   A7S1Y8   A0A2G8JI72   E9FU53   F0VGR8   A0A2D4BTP3   A0A212EWY3   A0A0P4VS39   A0A194AP66   A0A1V9ZNY3   A0A094N0Q6   R4G460   A0A2D4BU67   W4GQI0   A0A091V5K6   K1PUN3   A0A2D4BTW8   A0A2D4C1L9   W4G8P9   A0A2G8L288   A0A074T8B7   A0A3N0ZC33   A0A093IY93   B9QB87   A0A086JPK6   A0A2T6IGH7   A0A086K892   T0QWG7   A0A2G8YD87   A0A142F4W5   A0A151HM21   T0SB17   A0A139XS16   S8F474   A0A345J9N2   A0A086K707   A0A086M8P5   A0A086QDX3   A0A086QRH2   S7UY75   H6TBL5   A0A098LY09   A0A0L7LAI0   A0A150GYM8   A0A2D4BTR7   A0A150GX40   A0A093HJ74   A0A091IR23   A0A091U4N7   A0A329RKD5   A0A087VM52   A0A0A7CMZ8   A0A091TRL1   A0A093ISF4   A0A397A7V7   D8U187   A0A0S4TEL4   R4FPE5   R4G8Z5   A0A2H1X0K7   D8VNJ7   A0A2D4BEB9   A0A397DN89  

PDB

1YU6     E-value=3.26851e-08,     Score=134

KEGG

101742927    no KO assigned | (RefSeq) serine protease inhibitor dipetalogastin

GO

GO:0016021   GO:0008233   GO:0004867   GO:0005576   GO:0050819   GO:0005509   GO:0004252   GO:0005515   GO:0016616   GO:0051287   GO:0004930   GO:0006420   GO:0004812   GO:0006418   GO:0006334   GO:0003779  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.604770

 

 

Length:

188

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02249

Exp number, first 60 AAs:

0.01323

Total prob of N-in:

0.06018

outside

1  -  188

 

 

Pi

59.574607

Theta

124.199635

Tajima's D

-0.498546

CLR

0.218826

CSRT

0.24048797560122

Interpretation

Uncertain