Gene

KWMTBOMO01436  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008925

Annotation

cytidine_deaminase_[Bombyx_mori]

Location

Bomo_Chr3(+):10728420-10729802      View in EpiBrowser

Full name

Cytidine deaminase      

Alternative Name

Cytidine aminohydrolase

Location in the cell

Extracellular   Reliability : 1.801 PlasmaMembrane   Reliability : 1.519

CDS

ATGAAACAATATCTAATCAAAGATCGTTTAACTGTAATCAGTTGGTCGCTGACCGCACTGGGAACCGCGCGCACCAACACGACAGAGACAAACGCACGCACAATGGATAATTTTCAAATCGTGGACTTTAATTCTCTGGATGAGACTGTTCAGAATCTGTTGATGGAAGCTGTCAAAATTAGGAAACGGGCCTATTGTCCTTATTCCAATTTTTCTGTTGGTGCCGCTATACTTACCGAAGAAGATTCGAGAATGTACGCCGGATGCAACATTGAGAACTCCACTTTGACACCATCGATGTGCGCAGAGAGGTCGGCTGTTGCGAAGGCTGTCTGTGACGGTTACACGAAATTTAAATGTGTGGCTATAGTAGCCCATCAAAGAGAATTCACTGCGCCCTGCGGGGTATGTCGGCAGACCCTCAACGAGTTCTGTAGTTCGGACGGTGACATCGAAATCTACTTGAGCAGGCCGACAATGGATACCGTTCTATGTACTAAACTATCACATCTTCTACCTCTTTCGTTCGTGAGTTTTAAAAAGGATAGTGTCATTACGTAA

Protein

MKQYLIKDRLTVISWSLTALGTARTNTTETNARTMDNFQIVDFNSLDETVQNLLMEAVKIRKRAYCPYSNFSVGAAILTEEDSRMYAGCNIENSTLTPSMCAERSAVAKAVCDGYTKFKCVAIVAHQREFTAPCGVCRQTLNEFCSSDGDIEIYLSRPTMDTVLCTKLSHLLPLSFVSFKKDSVIT

Description

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Catalytic Activity

2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)
cytidine + H(+) + H2O = NH4(+) + uridine

Cofactor

Zn(2+)

Similarity

Belongs to the cytidine and deoxycytidylate deaminase family.

Uniprot

Q2F6C1   H9JHC8   A0A212F6S8   A0A0L7LGE0   A0A2H1WUZ4   A0A194RLE4   + More
A0A2A4JT63   A0A194Q2S9   I4DKB1   A0A2W1BZ01   B0W5Q5   A0A023EF61   A0A1Q3FQC4   A0A182G0Q0   A0A1W4WR91   A0A1B0GIX4   T1GY70   Q0IF52   A0A084VPJ4   A0A1B0CYS1   A0A1Y9HAN9   W5JCW6   A0A2M4C229   A0A2M4AXP5   A0A2M3ZCE3   A0A2M4C247   A0A182S563   A0A1L8DXQ1   B3N723   B4Q6B9   B3MPH8   A0A1W4UVE9   A0A182VIZ4   A0A182TIX9   Q7QG43   B4HYG7   A0A336K927   A0A182SW81   A0A182F569   Q9VLR2   A0A1Q3FQJ1   A0A1Y1K3B1   B4NWF6   A0A1Q3FQF6   A0A1Q3FEN4   A0A0M4DZV4   A0A1J1J056   Q29MM0   T1GD71   U5EW02   A0A1A9X489   B4G916   A0A182X0F2   V5H064   A0A182IE66   A0A336MIW9   A0A2A3ELP2   V9IC06   A0A1I8N9E3   A0A0K8V860   A0A2P8XR46   T1HQR7   B4HYG6   A0A0A1WX51   A0A1B0BSH7   A0A1A9VH19   A0A3B0JHK9   B4KGX1   B4NWF5   B4Q6B8   B4LUB4   A0A0L7QUL0   A0A034W4Q3   A0A0K8TSJ5   A0A1B6E3S1   D3TQE5   A0A1A9YGQ2   W8BNF1   Q9VLR3   A0A1B0ACE6   Q29ML9   B4G917   B4KGX2   A0A1W4V8Q0   B3MPH7   A0A3B0K488   A0A3L8DDN2   A0A0M3QT31   A0A1A9VGT2   A0A1B0FJT5   A0A158NVW6   B3N722   A0A0L0BPH3   T1GD69   D6WXL4   A0A1M5XL62   A0A0V0G579   A0A182NEH1   A0A0L0BWI4  

EC Number

3.5.4.5

Pubmed

19121390    22118469    26227816    26354079    22651552    28756777    + More
24945155    26483478    17510324    24438588    20920257    23761445    17994087    22936249    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28004739    17550304    15632085    25315136    29403074    25830018    25348373    26369729    20353571    24495485    30249741    21347285    26108605    18362917    19820115   

EMBL

DQ311151    ABD36096.1    BABH01012487    AGBW02009978    OWR49428.1    JTDY01001304    + More
KOB74251.1    ODYU01010861    SOQ56224.1    KQ459989    KPJ18653.1    NWSH01000622    PCG75227.1    KQ459562    KPI99851.1    AK401729    BAM18351.1    KZ149902    PZC78467.1    DS231844    EDS35708.1    GAPW01005585    JAC08013.1    GFDL01005250    JAV29795.1    JXUM01037133    KQ561118    KXJ79649.1    AJWK01017757    CAQQ02388194    CH477394    EAT41887.1    ATLV01015007    KE524999    KFB39888.1    AJVK01020378    AXCN02000858    ADMH02001881    ETN60674.1    GGFJ01010226    MBW59367.1    GGFK01012233    MBW45554.1    GGFM01005463    MBW26214.1    GGFJ01010224    MBW59365.1    GFDF01002863    JAV11221.1    CH954177    EDV59319.1    CM000361    CM002910    EDX04195.1    KMY88983.1    CH902620    EDV31274.1    AAAB01008839    EAA05898.3    CH480818    EDW52097.1    UFQS01000127    UFQT01000127    SSX00148.1    SSX20528.1    AE014134    AY070601    AAF52622.1    AAL48072.1    GFDL01005198    JAV29847.1    GEZM01094102    JAV55932.1    CM000157    EDW88473.1    GFDL01005206    JAV29839.1    GFDL01009036    JAV26009.1    CP012523    ALC38204.1    CVRI01000063    CRL04798.1    CH379060    EAL33673.1    CAQQ02038991    GANO01003181    JAB56690.1    CH479180    EDW28846.1    GALX01002258    JAB66208.1    APCN01004570    UFQT01000637    SSX25998.1    KZ288215    PBC32627.1    JR039344    AEY58648.1    GDHF01017185    JAI35129.1    PYGN01001493    PSN34483.1    ACPB03023227    EDW52096.1    GBXI01010875    GBXI01009204    JAD03417.1    JAD05088.1    JXJN01019711    OUUW01000004    SPP79782.1    CH933807    EDW11171.1    EDW88472.1    EDX04194.1    KMY88981.1    CH940649    EDW64100.1    KQ414735    KOC62254.1    GAKP01009675    JAC49277.1    GDAI01000256    JAI17347.1    GEDC01026337    GEDC01004749    JAS10961.1    JAS32549.1    CCAG010011916    EZ423647    ADD19923.1    GAMC01011649    JAB94906.1    BT011046    AAF52621.1    AAR31117.1    EAL33674.1    EDW28847.1    EDW11172.1    EDV31273.1    SPP79781.1    QOIP01000009    RLU18406.1    ALC38203.1    CCAG010010559    ADTU01027562    ADTU01027563    EDV59318.1    JRES01001567    KNC21990.1    CAQQ02038989    CAQQ02038990    KQ971362    EFA08865.1    FQXM01000031    SHI00486.1    GECL01002920    JAP03204.1    JRES01001243    KNC24366.1   

Proteomes

UP000005204    UP000007151    UP000037510    UP000053240    UP000218220    UP000053268    + More
UP000002320    UP000069940    UP000249989    UP000192223    UP000092461    UP000015102    UP000008820    UP000030765    UP000092462    UP000075886    UP000000673    UP000075900    UP000008711    UP000000304    UP000007801    UP000192221    UP000075903    UP000075902    UP000007062    UP000001292    UP000075901    UP000069272    UP000000803    UP000002282    UP000092553    UP000183832    UP000001819    UP000091820    UP000008744    UP000076407    UP000075840    UP000242457    UP000095301    UP000245037    UP000015103    UP000092460    UP000078200    UP000268350    UP000009192    UP000008792    UP000053825    UP000092444    UP000092443    UP000092445    UP000279307    UP000005205    UP000037069    UP000007266    UP000184447    UP000075884   

PRIDE

Q2F6C1    H9JHC8    Q9VLR2    Q9VLR3   

Pfam

PF00383   dCMP_cyt_deam_1        + More
PF00241   Cofilin_ADF
PF01454   MAGE
PF08211   dCMP_cyt_deam_2
PF13910   DUF4209
PF00787   PX
PF09325   Vps5

Interpro

IPR006262   Cyt_deam_tetra        + More
IPR002125   CMP_dCMP_dom       
IPR016193   Cytidine_deaminase-like       
IPR016192   APOBEC/CMP_deaminase_Zn-bd       
IPR011171   GMF       
IPR029006   ADF-H/Gelsolin-like_dom_sf       
IPR002108   ADF-H       
IPR041899   MAGE_WH2       
IPR041898   MAGE_WH1       
IPR002190   MHD_dom       
IPR025209   DUF4209       
IPR013171   Cyd/dCyd_deaminase_Zn-bd       
IPR027267   AH/BAR_dom_sf       
IPR036871   PX_dom_sf       
IPR015404   Vps5_C       
IPR001683   Phox       

SUPFAM

SSF53927   SSF53927        + More
SSF64268   SSF64268       

Gene 3D

3.40.20.10     1.10.10.1200     1.10.10.1210     1.20.1270.60     3.30.1520.10    

CDD

cd11283  ADF_GMF-beta_like

ProteinModelPortal

Q2F6C1   H9JHC8   A0A212F6S8   A0A0L7LGE0   A0A2H1WUZ4   A0A194RLE4   + More
A0A2A4JT63   A0A194Q2S9   I4DKB1   A0A2W1BZ01   B0W5Q5   A0A023EF61   A0A1Q3FQC4   A0A182G0Q0   A0A1W4WR91   A0A1B0GIX4   T1GY70   Q0IF52   A0A084VPJ4   A0A1B0CYS1   A0A1Y9HAN9   W5JCW6   A0A2M4C229   A0A2M4AXP5   A0A2M3ZCE3   A0A2M4C247   A0A182S563   A0A1L8DXQ1   B3N723   B4Q6B9   B3MPH8   A0A1W4UVE9   A0A182VIZ4   A0A182TIX9   Q7QG43   B4HYG7   A0A336K927   A0A182SW81   A0A182F569   Q9VLR2   A0A1Q3FQJ1   A0A1Y1K3B1   B4NWF6   A0A1Q3FQF6   A0A1Q3FEN4   A0A0M4DZV4   A0A1J1J056   Q29MM0   T1GD71   U5EW02   A0A1A9X489   B4G916   A0A182X0F2   V5H064   A0A182IE66   A0A336MIW9   A0A2A3ELP2   V9IC06   A0A1I8N9E3   A0A0K8V860   A0A2P8XR46   T1HQR7   B4HYG6   A0A0A1WX51   A0A1B0BSH7   A0A1A9VH19   A0A3B0JHK9   B4KGX1   B4NWF5   B4Q6B8   B4LUB4   A0A0L7QUL0   A0A034W4Q3   A0A0K8TSJ5   A0A1B6E3S1   D3TQE5   A0A1A9YGQ2   W8BNF1   Q9VLR3   A0A1B0ACE6   Q29ML9   B4G917   B4KGX2   A0A1W4V8Q0   B3MPH7   A0A3B0K488   A0A3L8DDN2   A0A0M3QT31   A0A1A9VGT2   A0A1B0FJT5   A0A158NVW6   B3N722   A0A0L0BPH3   T1GD69   D6WXL4   A0A1M5XL62   A0A0V0G579   A0A182NEH1   A0A0L0BWI4  

PDB

2FR6     E-value=3.28367e-26,     Score=290

KEGG

692798    K01489 cytidine deaminase [EC:3.5.4.5] | (RefSeq) cytidine deaminase

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004126   GO:0008270   GO:0009972   GO:0005829   GO:0034316   GO:0003779   GO:0071933   GO:0042802   GO:0035091   GO:0003824   GO:0016787   GO:0016491   GO:0016651   GO:0006334   GO:0016021  

PANTHER

PTHR11249  

Length:

186

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03266

Exp number, first 60 AAs:

0.02009

Total prob of N-in:

0.22377

outside

1  -  186

 

 

Pi

274.626979

Theta

237.504142

Tajima's D

0.479074

CLR

0.003402

CSRT

0.505024748762562

Interpretation

Uncertain