Gene

KWMTBOMO01430  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008922

Annotation

putative_cop9_complex_subunit_[Danaus_plexippus]

Location

Bomo_Chr3(+):10659990-10666859      View in EpiBrowser

Full name

COP9 signalosome complex subunit 4      

Location in the cell

Cytoplasmic   Reliability : 2.053

CDS

ATGCCCGTCAATTTGCAAAGTGTTCGCCAGTACTTAAGCGAGTTGAGAAATTCGGGTGGTTTGCATAAAGATCAAGCTGAAAAGTATCGCAATGTTCTTATGGAGATACTAAAAAGTACAGAACAAGAATTATCAGAGTCATTGAAAGCATTCATAGAAGCGATTGTTAATGAAAATGTGAGCCTAGTGATTTCAAGGCAACTCTTGACAGATGTGAGCACACACTTAGCACTGCTGGCTGATAATGTTTCACAGGAGGTTTCCCACTTTGCACTTGATGTTATACAACCCAGAGTTATTTCATTTGAAGAACAGGTGGCCAGTATCAGACAGCACTTAGCAGATATCTACGAGCGAAATCAAAACTGGAAGGAAGCTGCTAATGTTTTAGTTGGAATACCATTGGAAACTGGACAGAAACAATATTCAGTTGATTACAAACTGGAAACGTACCTAAAGATAGCCAGACTGTACCTTGAAGTGGACGATCCGGTGCAAGCTGAGGCATTCGTCAACAGAGCCTCATTGCTACAGGCCGAAACAACCAACGAGCAACTGCAGATATATTACAAAGTTTGCTATGCAAGAGTTTTAGATTATAGAAGGAAATTCATCGAAGCGGCTCAAAGGTACAATGAATTGTCATATCGTAACATTATCCACGAGGACGAGCGGATGACGTGCCTCAGGAATGCCCTTATATGCACCGTGTTGGCATCTGCTGGACAACAGAGATCCAGAATGCTAGCAACATTGTTCAAAGATGAGCGGTGCCAACAGCTGCCGGCGTATTCTATTCTAGAGAAAATGTATTTAGATCGTATAATTCGACGGTCAGAATTGCAGGAGTTCGAATCCCTCATGCAGACACATCAAAAGGCGACCACACCCGACGGGTCTACGATCCTCGACCGAGCGGTTTTCGAACACAATCTGCTGTCAGCGAGCAAGCTCTACAACAATATAACATTCGAAGAATTAGGTGCGCTACTAGAAACGCCGCCGGCTAAAGCGGAACGAATAGCGAGCCACATGATCAGCGAGGGTCGCATGAACGGGTACATCGACCAGATCAGCTCCATTGTACATTTTGAAACTCGAGAAATATTGCCTCAATGGGACAAACAAATACAAAGCTTATGTTATCAAGTAAATAGTCTGATTGAGAAGATAGCTTCCGCAGAACCAGAGTGGATGGCCAAAGTCGTGGAGGAAGAAATGATTCAATAA

Protein

MPVNLQSVRQYLSELRNSGGLHKDQAEKYRNVLMEILKSTEQELSESLKAFIEAIVNENVSLVISRQLLTDVSTHLALLADNVSQEVSHFALDVIQPRVISFEEQVASIRQHLADIYERNQNWKEAANVLVGIPLETGQKQYSVDYKLETYLKIARLYLEVDDPVQAEAFVNRASLLQAETTNEQLQIYYKVCYARVLDYRRKFIEAAQRYNELSYRNIIHEDERMTCLRNALICTVLASAGQQRSRMLATLFKDERCQQLPAYSILEKMYLDRIIRRSELQEFESLMQTHQKATTPDGSTILDRAVFEHNLLSASKLYNNITFEELGALLETPPAKAERIASHMISEGRMNGYIDQISSIVHFETREILPQWDKQIQSLCYQVNSLIEKIASAEPEWMAKVVEEEMIQ

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).

Subunit

Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.

Similarity

Belongs to the CSN4 family.

Keywords

Cell junction   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Nucleus   Reference proteome   Signalosome   Synapse  

Feature

chain  COP9 signalosome complex subunit 4

Uniprot

A0A1E1W959   A0A2H1WH71   A0A2W1BTR2   A0A212ELP6   A0A194Q2S5   A0A194RMA6   + More
S4PLU2   A0A2A4IX87   A0A2A4IXY3   A0A2J7R0G0   E2ARX5   A0A0J7KFY9   A0A195BN51   A0A158P021   A0A1Y1N9E8   A0A0L7R9X4   A0A026WNV2   A0A151XJ94   A0A2A3ECM8   A0A088AD77   A0A154P1T1   A0A232ESL5   E9IT22   A0A195CQL6   K7IRV8   A0A1W4W4F2   T1JPH2   A0A1B6FNZ5   A0A1B6CDI1   A0A023EQL0   D6WWM1   Q17K03   A0A0N7Z8U1   R4G4T7   A0A224XR48   A0A0V0G8P5   A0A023F9F6   E0VW05   A0A182X350   A0A084W8T8   A0A131Z1L5   L7MB00   B0W1Q2   A0A182PLM4   A0A224YVQ7   A0A182IPJ2   A0A182VLE7   A0A182KTT1   A0A182TJC9   A0A182HRP2   Q7Q1D8   A0A182KF35   A0A2P8Z6L7   A0A182S5C7   A0A1Q3FE03   A0A182LYN5   A0A182Q245   A0A0K8RCM7   A0A182WGQ9   A0A2M4AQT6   A0A2M4BPN6   W5J4G9   A0A182NC08   A0A182T3H6   A0A182F1W2   A0A023FJM0   A0A182YDJ1   A0A131XAM9   A0A1E1X4B8   A0A023GJP1   G3MNI6   A0A293MUT7   A0A1L8DV74   A0A1B0CTJ0   A0A1A9X3P3   A0A1A9YGZ0   A0A1A9UZ35   A0A1B0ABU4   D3TPN7   J3JTT1   A0A0L0CMN1   E9HRN8   A0A0P4VZC6   A0A336KZ05   A0A0A9X562   W5MXG4   A0A1I8N9B6   A0A0P5SRQ1   A0A3B4BZ28   A0A1W4Z9M3   W5UAB3   A0A0P6I6R1   A0A2M3ZI27   A0A3B3QWZ3   A0A3B1JZK1   G3PSY7   C3YIY6   Q6P0H6   A0A1I8QAN0   A0A060YQY9  

Pubmed

28756777    22118469    26354079    23622113    20798317    21347285    + More
28004739    24508170    30249741    28648823    21282665    20075255    24945155    26483478    18362917    19820115    17510324    27129103    25474469    20566863    24438588    26830274    25576852    28797301    20966253    12364791    14747013    17210077    29403074    20920257    23761445    25244985    28049606    28503490    22216098    20353571    22516182    23537049    26108605    21292972    25401762    26823975    25315136    23127152    29240929    25329095    18563158    24755649   

EMBL

GDQN01007597    JAT83457.1    ODYU01008542    SOQ52232.1    KZ149902    PZC78458.1    + More
AGBW02014011    OWR42397.1    KQ459562    KPI99862.1    KQ459989    KPJ18662.1    GAIX01003855    JAA88705.1    NWSH01005367    PCG64269.1    PCG64268.1    NEVH01008242    PNF34317.1    GL442192    EFN63824.1    LBMM01008068    KMQ89169.1    KQ976440    KYM86609.1    ADTU01005246    GEZM01009520    JAV94541.1    KQ414620    KOC67672.1    KK107139    QOIP01000003    EZA57737.1    RLU24399.1    KQ982074    KYQ60459.1    KZ288285    PBC29495.1    KQ434787    KZC05294.1    NNAY01002410    OXU21341.1    GL765434    EFZ16324.1    KQ977394    KYN03038.1    JH431661    GECZ01017833    JAS51936.1    GEDC01025794    JAS11504.1    JXUM01025937    JXUM01118040    GAPW01001716    KQ566144    KQ560739    JAC11882.1    KXJ70372.1    KXJ81057.1    KQ971361    EFA08119.1    CH477229    EAT46996.1    GDKW01002403    JAI54192.1    ACPB03006224    GAHY01000481    JAA77029.1    GFTR01005977    JAW10449.1    GECL01001720    JAP04404.1    GBBI01000581    JAC18131.1    AAZO01005734    DS235816    EEB17561.1    ATLV01021514    KE525319    KFB46632.1    GEDV01003739    JAP84818.1    GACK01004720    JAA60314.1    DS231823    EDS26603.1    GFPF01006908    MAA18054.1    APCN01001728    AAAB01008980    EAA13836.3    PYGN01000173    PSN52138.1    GFDL01009317    JAV25728.1    AXCM01002732    AXCN02000699    GADI01004886    JAA68922.1    GGFK01009820    MBW43141.1    GGFJ01005905    MBW55046.1    ADMH02002142    ETN58313.1    GBBK01002630    JAC21852.1    GEFH01004622    JAP63959.1    GFAC01005312    JAT93876.1    GBBM01001274    JAC34144.1    JO843437    AEO35054.1    GFWV01019003    MAA43731.1    GFDF01003764    JAV10320.1    AJWK01027683    CCAG010011926    EZ423389    ADD19665.1    APGK01056622    BT126640    KB741277    KB631611    AEE61603.1    ENN71088.1    ERL84659.1    JRES01000182    KNC33541.1    GL732739    EFX65591.1    GDRN01105294    JAI57758.1    UFQS01001261    UFQT01001261    SSX10024.1    SSX29746.1    GBHO01027732    GBRD01014929    GDHC01000114    JAG15872.1    JAG50897.1    JAQ18515.1    AHAT01013372    GDIP01141501    LRGB01000715    JAL62213.1    KZS16426.1    JT408987    AHH38519.1    GDIQ01010473    JAN84264.1    GGFM01007337    MBW28088.1    GG666516    EEN59860.1    BC056527    BC065617    FR916939    CDQ94141.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000218220    UP000235965    UP000000311    + More
UP000036403    UP000078540    UP000005205    UP000053825    UP000053097    UP000279307    UP000075809    UP000242457    UP000005203    UP000076502    UP000215335    UP000078542    UP000002358    UP000192223    UP000069940    UP000249989    UP000007266    UP000008820    UP000015103    UP000009046    UP000076407    UP000030765    UP000002320    UP000075885    UP000075880    UP000075903    UP000075882    UP000075902    UP000075840    UP000007062    UP000075881    UP000245037    UP000075900    UP000075883    UP000075886    UP000075920    UP000000673    UP000075884    UP000075901    UP000069272    UP000076408    UP000092461    UP000091820    UP000092443    UP000078200    UP000092445    UP000092444    UP000019118    UP000030742    UP000037069    UP000000305    UP000018468    UP000095301    UP000076858    UP000261440    UP000192224    UP000221080    UP000261540    UP000018467    UP000007635    UP000001554    UP000000437    UP000095300    UP000193380   

PRIDE

Q6P0H6   

Pfam

PF01399   PCI        + More
PF18420   CSN4_RPN5_eIF3a
PF01459   Porin_3

Interpro

IPR041406   CSN4_HTH        + More
IPR036388   WH-like_DNA-bd_sf       
IPR036390   WH_DNA-bd_sf       
IPR040134   PSMD12/CSN4       
IPR037754   CSN4       
IPR000717   PCI_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR027246   Porin_Euk/Tom40       
IPR023614   Porin_dom_sf       
IPR001925   Porin_Euk       

SUPFAM

SSF46785   SSF46785       

Gene 3D

1.10.10.10     1.25.40.10     2.40.160.10    

ProteinModelPortal

A0A1E1W959   A0A2H1WH71   A0A2W1BTR2   A0A212ELP6   A0A194Q2S5   A0A194RMA6   + More
S4PLU2   A0A2A4IX87   A0A2A4IXY3   A0A2J7R0G0   E2ARX5   A0A0J7KFY9   A0A195BN51   A0A158P021   A0A1Y1N9E8   A0A0L7R9X4   A0A026WNV2   A0A151XJ94   A0A2A3ECM8   A0A088AD77   A0A154P1T1   A0A232ESL5   E9IT22   A0A195CQL6   K7IRV8   A0A1W4W4F2   T1JPH2   A0A1B6FNZ5   A0A1B6CDI1   A0A023EQL0   D6WWM1   Q17K03   A0A0N7Z8U1   R4G4T7   A0A224XR48   A0A0V0G8P5   A0A023F9F6   E0VW05   A0A182X350   A0A084W8T8   A0A131Z1L5   L7MB00   B0W1Q2   A0A182PLM4   A0A224YVQ7   A0A182IPJ2   A0A182VLE7   A0A182KTT1   A0A182TJC9   A0A182HRP2   Q7Q1D8   A0A182KF35   A0A2P8Z6L7   A0A182S5C7   A0A1Q3FE03   A0A182LYN5   A0A182Q245   A0A0K8RCM7   A0A182WGQ9   A0A2M4AQT6   A0A2M4BPN6   W5J4G9   A0A182NC08   A0A182T3H6   A0A182F1W2   A0A023FJM0   A0A182YDJ1   A0A131XAM9   A0A1E1X4B8   A0A023GJP1   G3MNI6   A0A293MUT7   A0A1L8DV74   A0A1B0CTJ0   A0A1A9X3P3   A0A1A9YGZ0   A0A1A9UZ35   A0A1B0ABU4   D3TPN7   J3JTT1   A0A0L0CMN1   E9HRN8   A0A0P4VZC6   A0A336KZ05   A0A0A9X562   W5MXG4   A0A1I8N9B6   A0A0P5SRQ1   A0A3B4BZ28   A0A1W4Z9M3   W5UAB3   A0A0P6I6R1   A0A2M3ZI27   A0A3B3QWZ3   A0A3B1JZK1   G3PSY7   C3YIY6   Q6P0H6   A0A1I8QAN0   A0A060YQY9  

PDB

4WSN     E-value=2.96132e-161,     Score=1459

KEGG

101740208    K12178 COP9 signalosome complex subunit 4 | (RefSeq) COP9 signalosome complex subunit 4

GO

GO:0005737   GO:0008180   GO:0005829   GO:0006508   GO:0005741   GO:0008308   GO:0030054   GO:0008021   GO:0005515   GO:0030433   GO:0031625   GO:0016020   GO:0042773   GO:0016491   GO:0016651   GO:0006334   GO:0003779   GO:0016021  

PANTHER

PTHR10855   PTHR10855:SF2  

Subcellular location

Cytoplasm  
Nucleus  
Cytoplasmic vesicle  
Secretory vesicle  
Synaptic vesicle  

Length:

409

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00769

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.00888

outside

1  -  409

 

 

Pi

234.795478

Theta

169.952766

Tajima's D

1.371361

CLR

0.045053

CSRT

0.755512224388781

Interpretation

Uncertain