SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01428  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA008956
Annotation
PREDICTED:_protein_lin-54_homolog_[Bombyx_mori]
Full name
Protein lin-54 homolog      
Alternative Name
CXC domain-containing protein 1
Location in the cell
Extracellular   Reliability : 1.808 Nuclear   Reliability : 2.241
 

Sequence

CDS
ATGGGTGAGAATGCGGATAGTATGGACAACAGCACAGGAAATAACGTCGAACACCCGCTAATTGTGATACCGAATTTCCAACATGAGGAGTATGACGACAGGGAAATTGTATACGAGCAAGACATCAAGACGTCTATCAACATGCACGAGTCCAAAACACTGGTTGAGTTAGAACCCGAAATAGTATACTCACCACCGAAAACGTCGCCTTCACCCGATAACGACGTGGGGGCCACGGAACTAGGTCTTCGGCCAAGGAAGGCGTGTAATTGTACAAAGTCTCAGTGCCTCAAGTTGTACTGCGACTGTTTCGCGAACGGGGAGTTTTGCAATCAATGCAACTGCAATAATTGTCATAATAATTTAGAAAATGAAGCGTTAAGGCAGAAAGCCATCAGGGCGTGCTTAGAGAGGAATCCTAATGCGTTTAGGCCGAAAATCGGGAAAGCAAAAATCGGCGGGCCGGACATCATAAGGCGGCATAACAAGGGCTGCAACTGTAAACGAAGTGGATGCCTCAAGAATTATTGTGAATGTTACGAGGCGAAGATAGCGTGTACGGCGATGTGTAAGTGCGTGGGGTGTCGCAACGTGCAGGAGTTGGTGGAGCGGCGCCGCGACATGCGCCTCCGCACGCAGGACAGCGACTCGACCTTCCGCCCGGCCCTGCTGGGGCAGCCCAAACATCCGTGCACGTTCATGACGATGGAGGTGATCGAGGCCGTGTGCCAGTGTCTGGTGGCCGCCGCCGTGGAGCGACGGGACGACTCTCCGCGTGACGCGCCCCGTGACTCGCCGCGTGACGCGCCCCGTGACGCGCTCGGAGACGTGCTTGAAGAGTTCGCGCGCTGTCTGCACGAGATCATCGGGGCTTCGCATCACGACTCCTTGCTGCTCGATGTGGGACAAACGTGA
Protein
MGENADSMDNSTGNNVEHPLIVIPNFQHEEYDDREIVYEQDIKTSINMHESKTLVELEPEIVYSPPKTSPSPDNDVGATELGLRPRKACNCTKSQCLKLYCDCFANGEFCNQCNCNNCHNNLENEALRQKAIRACLERNPNAFRPKIGKAKIGGPDIIRRHNKGCNCKRSGCLKNYCECYEAKIACTAMCKCVGCRNVQELVERRRDMRLRTQDSDSTFRPALLGQPKHPCTFMTMEVIEAVCQCLVAAAVERRDDSPRDAPRDSPRDAPRDALGDVLEEFARCLHEIIGASHHDSLLLDVGQT

Summary

Description
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
Subunit
Component of the DREAM complex.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).
Similarity
Belongs to the lin-54 family.
Keywords
Activator   Cell cycle   Complete proteome   DNA-binding   Metal-binding   Nucleus   Reference proteome   Repressor   Transcription   Transcription regulation   Zinc   3D-structure   Acetylation   Alternative splicing   Isopeptide bond   Phosphoprotein   Ubl conjugation  
Feature
chain  Protein lin-54 homolog
splice variant  In isoform 4.
EMBL
BABH01012496    BABH01012497    BABH01012498    BABH01012499    BABH01012500    BABH01012501    + More
ODYU01008542    SOQ52233.1    NWSH01005367    PCG64270.1    PCG64271.1    KZ149902    PZC78457.1    AGBW02014011    OWR42398.1    KQ459562    KPI99863.1    NNAY01002410    OXU21343.1    GBYB01003013    JAG72780.1    KZ288285    PBC29496.1    GL448558    EFN84203.1    JW868809    AFP01327.1    KQ434787    KZC05293.1    KQ764772    OAD54388.1    GL438137    EFN69485.1    KQ435811    KOX72918.1    KK107921    EZA47220.1    QOIP01000001    RLU26383.1    KQ414620    KOC67673.1    KQ981200    KYN45000.1    KQ979038    KYN23470.1    KQ982691    KYQ52066.1    GL888378    EGI62007.1    ADTU01005778    ADTU01005779    KQ977141    KYN05374.1    KQ976738    KYM75671.1    GACK01007073    JAA57961.1    KK852699    KDR18211.1    GEFM01006409    JAP69387.1    GEGO01003634    JAR91770.1    GEDV01008348    JAP80209.1    GFPF01010995    MAA22141.1    GEGO01003618    JAR91786.1    GAMS01008833    GAMR01006045    GAMP01007927    GAMP01007925    JAB14303.1    JAB27887.1    JAB44828.1    GL767121    EFZ14059.1    AAKN02033474    BC122957    GAMT01008540    GAMR01006044    GAMP01007926    JAB03321.1    JAB27888.1    JAB44829.1    GFAC01000449    JAT98739.1    AEFK01211986    AEFK01211987    AEFK01211988    AEFK01211989    HAAF01011477    CCP83301.1    AAGW02022763    AAGW02022764    AAGW02022765    AAGW02022766    AB111889    AK292769    BX640657    BX640966    AC021105    BC109277    BC109278    JH882267    ELR50096.1    GEZM01007623    JAV95039.1    GEBF01001005    JAO02628.1    CABD030031704    CABD030031705    CABD030031706    CABD030031707    CABD030031708    CABD030031709    AQIA01054600    AQIA01054601    AQIA01054602    NDHI03003433    PNJ52437.1    PNJ52438.1    PNJ52439.1    GABF01009362    GABE01010855    NBAG03000215    JAA12783.1    JAA33884.1    PNI83050.1    PNI83051.1    PNI83052.1    CR858600    CR859347    GABZ01005503    JAA48022.1    ADFV01030343    ADFV01030344    ADFV01030345    ADFV01030346    ADFV01030347    ADFV01030348    ADFV01030349    ADFV01030350    ADFV01030351    JSUE03033425    JSUE03033426    GEBQ01008280    JAT31697.1    GG666580    EEN52478.1    JU327731    AFE71487.1   
Pfam
PF03638   TCR        + More
PF01145   Band_7
PF00856   SET
Interpro
IPR033467   Tesmin/TSO1-like_CXC        + More
IPR001107   Band_7       
IPR033294   Erlin1/2       
IPR005172   CRC       
IPR028307   Lin-54_fam       
IPR001214   SET_dom       
PDB
5FD3     E-value=1.49069e-34,     Score=365

Ontologies

Topology

Subcellular location
Nucleus  
Length:
304
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00872
Exp number, first 60 AAs:
0
Total prob of N-in:
0.03385
outside
1  -  304
 
 

Population Genetic Test Statistics

Pi
26.563682
Theta
223.147364
Tajima's D
0.842123
CLR
0.011396
CSRT
0.618419079046048
Interpretation
Uncertain
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