Gene

KWMTBOMO01425  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008956

Annotation

PREDICTED:_erlin-2-like_[Amyelois_transitella]

Location

Bomo_Chr3(-):10619107-10622949      View in EpiBrowser

Full name

Erlin-2      

Alternative Name

Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

Location in the cell

Cytoplasmic   Reliability : 2.514

CDS

ATGGCTGACCAATCTTCTATTTTGGCCATTGTGATTCTGGCTGTAGGGGTCACGGTTCATTTTTCCCTTCATAAAGTAGAAGAAGGACATGTTGGTGTTTATTATCGGGGTGGAGCTTTATTACCAGTTACAAGTCAAGCTGGTTTTCACATGATGATACCACTTCTAACATCATACAAAGCCATTCAGACAACTTTACAAACTGATGAAGTTAAAAATGTGCCTTGTGGCACAAGTGGTGGGGTGTTGATTTATTTTGAAAGAATCGAGGTAGTCAATAAGCTGGACCCACAAAGCGTACTAGATATGGTGCGCAACTTCACAGCTGAATATGACAGGACTCTTATTTTCAATAAAGTGCACCATGAACTGAATCAATTCTGTAGTGCCCATACCTTGCACGAGGTATACATTGATTTGTTTGATCAAATCGACGAGAATTTACGGACAGCATTGCAAAAGGATCTTCATGAAATGGCTCCAGGTTTAAGGGTTCAAGCTGTTCGCGTCACAAAACCAAAAATCCCAGAATCAATCAGGAAAAATTACGAACTTATGGAAGCTGAGAAATCTAAACTACTTATTGCAGCCCAACATCAGAAAGTTGTTGAAAAAGAAGCAGAGACAGCAAGGCGCAAGGCTATAATTGAAGCAGAAAAAGAGGCCCATGTAGCAAAAATACAATATGAACAAAAAATCATGGAGAAGGAATCTCTACAGAAAATTGAACTCATTGAAGACAGTATTCACAAGGCCAAACAACAGACAAAGGCAGAAGCTGACTTTTACCATCTCAAAAAACAGGCTGAAGCCAATAAACTTCTTCTGACGCGGGAATATTTGGAGTTGAAGAAATATGAAGCGCTCTCCAACAATAATAAGATTTACTTTGGAAGTGATATACCCAACATGTTCTTACAAGCAAATGTTGGTGAAAGTGTTCCCATCTTAAAAGGTGTAAAAGTTGAGTGA

Protein

MADQSSILAIVILAVGVTVHFSLHKVEEGHVGVYYRGGALLPVTSQAGFHMMIPLLTSYKAIQTTLQTDEVKNVPCGTSGGVLIYFERIEVVNKLDPQSVLDMVRNFTAEYDRTLIFNKVHHELNQFCSAHTLHEVYIDLFDQIDENLRTALQKDLHEMAPGLRVQAVRVTKPKIPESIRKNYELMEAEKSKLLIAAQHQKVVEKEAETARRKAIIEAEKEAHVAKIQYEQKIMEKESLQKIELIEDSIHKAKQQTKAEADFYHLKKQAEANKLLLTREYLELKKYEALSNNNKIYFGSDIPNMFLQANVGESVPILKGVKVE

Description

Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity).

Similarity

Belongs to the band 7/mec-2 family.

Keywords

Cholesterol metabolism   Complete proteome   Endoplasmic reticulum   Glycoprotein   Lipid metabolism   Membrane   Reference proteome   Signal-anchor   Steroid metabolism   Sterol metabolism   Transmembrane   Transmembrane helix  

Feature

chain  Erlin-2

Uniprot

A0A2H1WGN6   A0A194RRJ4   A0A0L7KT91   A0A194Q8X1   H9JHF9   S4PTB4   + More
A0A212ELQ2   E2ARX9   A0A151XJH8   A0A1B6D714   A0A026WP51   E2BY99   F4X3N4   A0A195BMU5   A0A158P016   A0A0J7K1Y2   A0A232FI32   A0A0M8ZZP7   A0A195CSE5   A0A088AD80   A0A1B6IRA7   A0A1B6FWX8   A0A1B6KKG0   A0A2A3EEQ3   D6WV22   A0A195F2D7   A0A195E091   A0A0L7R9Y2   A0A2J7QGT6   A0A067RGI1   A0A2L2XWE6   A0A0C9QP27   A0A2L2XWN8   A0A0N7Z956   R4G8A1   A0A1W4XBP6   A0A087TX48   A0A069DS77   A0A0V0G762   E0VE91   A0A224XN48   A0A2C9K5A5   A0A131XKZ1   L7M0K9   A0A224YPD4   A0A023F8Q9   A0A224YWX1   A0A023GBN7   A0A293LY48   J9K522   A0A2A4JX15   A0A2R5L6M6   A0A023FT93   A0A023FMP2   A0A1E1XG10   J3JWD9   A0A2H8TYW5   A0A0K8RNW4   D3PHE1   A0A131Y3M3   A0A2B4SLC8   A0A2S2PWE8   C1BVU6   A0A0A9XWC7   C1C0R9   A0A162QF91   A0A1S3HMA2   A0A1Y3B116   A0A1A7WZQ7   A0A1V9XJ01   A0A3P9QEB6   A0A0S7HEJ6   A0A3B3US95   A0A3B3CZH3   A0A3B5QV11   E9G6V1   W5U6W4   V4CN47   A0A3B4GZU4   A0A3P8NWZ6   A0A3P9B5X4   A0A3B3Y8Q2   A0A087XPX8   A0A1A8IXN1   A0A1A8RQG8   A0A1A8KZ06   A0A1A8C4U9   A0A1A8V102   Q28J34   I3JT94   A0A0N8EAV5   W5NE17   A0A1A8G2Y6   A0A2I0U9H2   A0A3B4CDE4   A0A131Z3J0   A0A336LY54   T1FRP1   A0A1W5B1L0   A0A3P8VST5  

Pubmed

26354079    26227816    19121390    23622113    22118469    20798317    + More
24508170    30249741    21719571    21347285    28648823    18362917    19820115    24845553    26561354    27129103    26334808    20566863    15562597    28049606    25576852    28797301    25474469    28503490    22516182    23537049    25401762    26823975    26383154    28327890    29451363    23542700    21292972    23127152    23254933    25186727    26830274    24487278   

EMBL

ODYU01008542    SOQ52235.1    KQ459989    KPJ18666.1    JTDY01005901    KOB66498.1    + More
KQ459562    KPI99865.1    BABH01012496    BABH01012497    BABH01012498    BABH01012499    BABH01012500    BABH01012501    GAIX01012333    JAA80227.1    AGBW02014011    OWR42399.1    GL442192    EFN63828.1    KQ982074    KYQ60455.1    GEDC01015852    JAS21446.1    KK107139    QOIP01000003    EZA57733.1    RLU24403.1    GL451420    EFN79378.1    GL888624    EGI58831.1    KQ976440    KYM86606.1    ADTU01005245    LBMM01016798    KMQ84304.1    NNAY01000187    OXU30180.1    KQ435811    KOX72913.1    KQ977394    KYN03034.1    GECU01018279    JAS89427.1    GECZ01015069    GECZ01012010    GECZ01000513    JAS54700.1    JAS57759.1    JAS69256.1    GEBQ01029658    GEBQ01028044    GEBQ01023528    JAT10319.1    JAT11933.1    JAT16449.1    KZ288285    PBC29491.1    KQ971357    EFA08527.1    KQ981856    KYN34546.1    KQ979955    KYN18516.1    KQ414620    KOC67668.1    NEVH01014361    PNF27763.1    KK852699    KDR18219.1    IAAA01002148    LAA00391.1    GBYB01005304    JAG75071.1    IAAA01002147    LAA00388.1    GDKW01001483    JAI55112.1    ACPB03010134    GAHY01001332    JAA76178.1    KK117154    KFM69687.1    GBGD01002099    JAC86790.1    GECL01002188    JAP03936.1    DS235088    EEB11697.1    GFTR01005188    JAW11238.1    GEFH01001706    JAP66875.1    GACK01007474    JAA57560.1    GFPF01007649    MAA18795.1    GBBI01000940    JAC17772.1    GFPF01007647    MAA18793.1    GBBM01004106    JAC31312.1    GFWV01008685    MAA33414.1    ABLF02010954    NWSH01000489    PCG76043.1    GGLE01001003    MBY05129.1    GBBL01002691    JAC24629.1    GBBK01001451    JAC23031.1    GFAC01000968    JAT98220.1    APGK01039000    BT127557    KB740966    KB632186    AEE62519.1    ENN76927.1    ERL89697.1    GFXV01006543    MBW18348.1    GADI01001514    JAA72294.1    BT121047    HACA01007435    ADD37977.1    CDW24796.1    GEFM01002836    JAP72960.1    LSMT01000059    PFX29883.1    GGMS01000578    MBY69781.1    BT078725    ACO13149.1    GBHO01022029    GBRD01004327    GDHC01016958    GDHC01000125    JAG21575.1    JAG61494.1    JAQ01671.1    JAQ18504.1    BT080448    ACO14872.1    LRGB01000337    KZS19642.1    MUJZ01049523    OTF73907.1    HADW01009806    HADX01000443    SBP11206.1    MNPL01010065    OQR73363.1    GBYX01441891    JAO39495.1    GL732533    EFX84809.1    JT405689    AHH37284.1    KB199905    ESP03810.1    AYCK01002059    HAED01015695    SBR02140.1    HAEI01007670    HAEH01018863    SBS08350.1    HAEF01000403    HAEG01014727    SBR37785.1    HADZ01010986    HAEA01009166    SBP74927.1    HADY01020946    HAEJ01012496    SBS52953.1    CR760081    BC158953    AAI58954.1    CAJ82623.1    AERX01006355    GDIP01051363    GDIQ01044828    JAM52352.1    JAN49909.1    AHAT01006095    HAEB01019050    HAEC01004892    SBQ65577.1    KZ505968    PKU42706.1    GEDV01002680    JAP85877.1    UFQS01000292    UFQT01000292    SSX02530.1    SSX22904.1    AMQM01002643    KB095858    ESO10558.1   

Proteomes

UP000053240    UP000037510    UP000053268    UP000005204    UP000007151    UP000000311    + More
UP000075809    UP000053097    UP000279307    UP000008237    UP000007755    UP000078540    UP000005205    UP000036403    UP000215335    UP000053105    UP000078542    UP000005203    UP000242457    UP000007266    UP000078541    UP000078492    UP000053825    UP000235965    UP000027135    UP000015103    UP000192223    UP000054359    UP000009046    UP000076420    UP000007819    UP000218220    UP000019118    UP000030742    UP000225706    UP000076858    UP000085678    UP000192247    UP000242638    UP000261500    UP000261560    UP000002852    UP000000305    UP000221080    UP000030746    UP000261460    UP000265100    UP000265160    UP000261480    UP000028760    UP000008143    UP000005207    UP000018468    UP000261440    UP000015101    UP000192224    UP000265120   

PRIDE

H9JHF9    L7M0K9   

Pfam

PF01145   Band_7        + More
PF03638   TCR
PF08923   MAPKK1_Int

Interpro

IPR001107   Band_7        + More
IPR036013   Band_7/SPFH_dom_sf       
IPR033294   Erlin1/2       
IPR033467   Tesmin/TSO1-like_CXC       
IPR005172   CRC       
IPR015019   LAMTOR3       

SUPFAM

SSF117892   SSF117892       

CDD

cd03406  SPFH_like_u3

ProteinModelPortal

A0A2H1WGN6   A0A194RRJ4   A0A0L7KT91   A0A194Q8X1   H9JHF9   S4PTB4   + More
A0A212ELQ2   E2ARX9   A0A151XJH8   A0A1B6D714   A0A026WP51   E2BY99   F4X3N4   A0A195BMU5   A0A158P016   A0A0J7K1Y2   A0A232FI32   A0A0M8ZZP7   A0A195CSE5   A0A088AD80   A0A1B6IRA7   A0A1B6FWX8   A0A1B6KKG0   A0A2A3EEQ3   D6WV22   A0A195F2D7   A0A195E091   A0A0L7R9Y2   A0A2J7QGT6   A0A067RGI1   A0A2L2XWE6   A0A0C9QP27   A0A2L2XWN8   A0A0N7Z956   R4G8A1   A0A1W4XBP6   A0A087TX48   A0A069DS77   A0A0V0G762   E0VE91   A0A224XN48   A0A2C9K5A5   A0A131XKZ1   L7M0K9   A0A224YPD4   A0A023F8Q9   A0A224YWX1   A0A023GBN7   A0A293LY48   J9K522   A0A2A4JX15   A0A2R5L6M6   A0A023FT93   A0A023FMP2   A0A1E1XG10   J3JWD9   A0A2H8TYW5   A0A0K8RNW4   D3PHE1   A0A131Y3M3   A0A2B4SLC8   A0A2S2PWE8   C1BVU6   A0A0A9XWC7   C1C0R9   A0A162QF91   A0A1S3HMA2   A0A1Y3B116   A0A1A7WZQ7   A0A1V9XJ01   A0A3P9QEB6   A0A0S7HEJ6   A0A3B3US95   A0A3B3CZH3   A0A3B5QV11   E9G6V1   W5U6W4   V4CN47   A0A3B4GZU4   A0A3P8NWZ6   A0A3P9B5X4   A0A3B3Y8Q2   A0A087XPX8   A0A1A8IXN1   A0A1A8RQG8   A0A1A8KZ06   A0A1A8C4U9   A0A1A8V102   Q28J34   I3JT94   A0A0N8EAV5   W5NE17   A0A1A8G2Y6   A0A2I0U9H2   A0A3B4CDE4   A0A131Z3J0   A0A336LY54   T1FRP1   A0A1W5B1L0   A0A3P8VST5  

KEGG

101740340    K23341 erlin | (RefSeq) erlin-2-like

GO

GO:0031625   GO:0005783   GO:0030433   GO:0016021   GO:0032006   GO:0015485   GO:0032933   GO:0005789   GO:0008233   GO:0008203   GO:0016020   GO:0042773   GO:0016491   GO:0016651   GO:0006334   GO:0003779  

PANTHER

PTHR15351  

Subcellular location

Endoplasmic reticulum membrane   Associated with lipid raft-like domains of the endoplasmic reticulum membrane.   With evidence from 1 publications.

Length:

323

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.56066

Exp number, first 60 AAs:

25.52873

Total prob of N-in:

0.61399

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  24

outside

25  -  323

 

 

Pi

232.222

Theta

182.883767

Tajima's D

1.026424

CLR

0.776867

CSRT

0.663116844157792

Interpretation

Uncertain