Silkworm Genome Informatics Database

Gene

KWMTBOMO01417

Pre Gene Modal

BGIBMGA008918

Annotation

PREDICTED:_malate_dehydrogenase?_mitochondrial-like_[Papilio_machaon]

Location

Bomo_Chr3(+):10414390-10463739 View in EpiBrowser

Full name

Malate dehydrogenase

Location in the cell

Cytoplasmic Reliability : 1.058 Extracellular Reliability : 1.31 Nuclear Reliability : 1.183

CDS

ATGAATCCATCCACAGTCTTCATTAAATCAAAACATTTATGGTCATGTCTACTCGATGCATATGTACCATTAACGTTTCGGAGTGACGTATTCAACAGATGTTATGCTAAGAAATCTGGTGATGACGAATGTAGAAGAGCATTAGTGGATATTCCACCGGACGTAGACCCGAAATGCCCACAGCCCTGTGAGAGAATAAAAAAGAAAAAACCTGGTTTATTACATAGAATTAAATTGAGGGTCATCGAAGGAGGCACGAATTTCGGAACTCCATTTCGGCGCGTCTCGTGTAAAGAAGAGGAGAAGCTTCCTCCGAAAAAAGTTGATACTGAAACGAAGGCATTGCCGCCACCGTCACGACCGGCAAAGGTGCCTTCAATGCCGGAGACTAGGTCAGGCGTCCAAGTATCGATTCTTGGTGCAGACTCTCCGTTAGGACACTACGTAGCTTTGCTTTTGAAACAATGTCCTTGTATAAAGAAATTGCGTTTGTACGAAGCAAAGCACTGCGAATGTTCGGCATGCAACCGGAATCTTTGTAAAGTCGTGAAAGATCTACAACATATCAACACGAATTGCCTTGTGCAGGCTTTTAGCAGTTCTTGTAACGAATTGGAACGATGTCTACAGAATACAGATATAGTGTTGATGCTTGAAAGCAGTTATCCGAACTTGGACCTATCTTTTGAGAAGAGATTCAATTGTCAAGCGCCCATAGTGAAAAACTACGCCGATGCTATAGCCAACGAATGTCCTAAAGCGTTCATAATAGTTTGCACAACGCCCATTGATTGTATGGTACCATTGATAGCAGAGACGCTGAAAGAAACCGGTTGGTATGATCCTCGAAAGGTGCTCGGTTCTCTGGCTGTACCAGAAATGCGTGCTAGCACGCTCGCTGCAAGGGCCCTGTGTCTTGAACCTCGATATACTAGAGTCCCTATCGTTGGAGGAACTGAAGGCGAATCACTAGTTCCGCTGTTTTCAAAAGCTGTTGAATACTTTGACTTTGCTAAGCATAATGCCCTTATGATGACTGATGCTGTGCGAGGGGCCCAAACTGCTGTTACCAGGACCGATGGAGCTTGTGTTAGAGCTGCCGACCTTAGCGAGGCCCATGCGCTATCTGGTTTAGTAACAAAGGTCGCACATGCTCTCCTCTGTCACGACATCCCAAGAGTTACTGGTTTTGTAGAAACAGATGCCAGTCAAGTCATTTCTCCTGCCAGATATATAGCAAATACTGTAGTAATTGGAGGGAGTGGAGTAGTGAAAAATTTGGGGCTACCCAAGATGACGGATTGGGAAACCACACTTGTTAATTTTGCGTTAATCGAATTGCTCGAAAAGCAGAAAATGGTTGAAGATTGGCATTTTAAATACTGCAGCTCTTCCTGTAGACTGGACGCCTGTCAGTTCCAATTCTTCACTCCGGGGTCTTTCCAAAGATTTGACGACTGTGCTTATGCTAATTTATAG

Protein

MNPSTVFIKSKHLWSCLLDAYVPLTFRSDVFNRCYAKKSGDDECRRALVDIPPDVDPKCPQPCERIKKKKPGLLHRIKLRVIEGGTNFGTPFRRVSCKEEEKLPPKKVDTETKALPPPSRPAKVPSMPETRSGVQVSILGADSPLGHYVALLLKQCPCIKKLRLYEAKHCECSACNRNLCKVVKDLQHINTNCLVQAFSSSCNELERCLQNTDIVLMLESSYPNLDLSFEKRFNCQAPIVKNYADAIANECPKAFIIVCTTPIDCMVPLIAETLKETGWYDPRKVLGSLAVPEMRASTLAARALCLEPRYTRVPIVGGTEGESLVPLFSKAVEYFDFAKHNALMMTDAVRGAQTAVTRTDGACVRAADLSEAHALSGLVTKVAHALLCHDIPRVTGFVETDASQVISPARYIANTVVIGGSGVVKNLGLPKMTDWETTLVNFALIELLEKQKMVEDWHFKYCSSSCRLDACQFQFFTPGSFQRFDDCAYANL

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Similarity

Belongs to the LDH/MDH superfamily.

Uniprot

H9JHC1 A0A2A4JVJ0 A0A194RML9 A0A2A4JWN5 A0A212EP43 A0A0L7LE96 + More
A0A0Q3TNU5 A0A146MJY9

EC Number

1.1.1.37

Pubmed

19121390 26354079 22118469 26227816

EMBL

BABH01012512 BABH01012513 BABH01012514 BABH01012515 NWSH01000489 PCG76045.1 + More
KQ459989 KPJ18674.1 PCG76044.1 AGBW02013528 OWR43265.1 JTDY01001501 KOB73715.1 LMAW01001980 KQK82166.1 GCES01166309 JAQ20013.1

Proteomes

UP000005204 UP000218220 UP000053240 UP000007151 UP000037510 UP000051836 + More

PRIDE

H9JHC1

Pfam

PF00056 Ldh_1_N + More
PF02866 Ldh_1_C

Interpro

IPR001236   Lactate/malate_DH_N        + More
IPR036291   NAD(P)-bd_dom_sf
IPR022383   Lactate/malate_DH_C
IPR015955   Lactate_DH/Glyco_Ohase_4_C
IPR001557   L-lactate/malate_DH
IPR010097   Malate_DH_type1
IPR001252   Malate_DH_AS

SUPFAM

SSF56327 SSF56327 + More
SSF51735 SSF51735

Gene 3D

3.90.110.10

ProteinModelPortal

H9JHC1 A0A2A4JVJ0 A0A194RML9 A0A2A4JWN5 A0A212EP43 A0A0L7LE96 + More
A0A0Q3TNU5 A0A146MJY9

PDB

2DFD E-value=4.02188e-34, Score=363

KEGG

101740981 K00026 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) malate dehydrogenase, mitochondrial-like

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005975 GO:0016616 GO:0030060 GO:0006108 GO:0006099 GO:0019752 GO:0016491 GO:0003824 GO:0005634 GO:0004518 GO:0006334 GO:0003779 GO:0016021 GO:0055114

Length:

492

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04589

Exp number, first 60 AAs:

0.02045

Total prob of N-in:

0.00318

outside

1 - 492

Pi

270.496799

Theta

174.288474

Tajima's D

1.832898

CLR

0.048399

CSRT

0.857157142142893

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics