Gene

KWMTBOMO01384

Pre Gene Modal

BGIBMGA008904

Annotation

PREDICTED:_polypeptide_N-acetylgalactosaminyltransferase_5_[Amyelois_transitella]

Location

Bomo_Chr3(+):9364991-9381208      View in EpiBrowser

Full name

Polypeptide N-acetylgalactosaminyltransferase       + More
Eukaryotic translation initiation factor 3 subunit K      
Polypeptide N-acetylgalactosaminyltransferase 5      

Alternative Name

Protein-UDP acetylgalactosaminyltransferase
eIF-3 p25
Protein-UDP acetylgalactosaminyltransferase 5
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5

Location in the cell

Cytoplasmic   Reliability : 1.097 Mitochondrial   Reliability : 1.431

CDS

ATGAAACACCTGGGAAAGAAGCTGGAAGATTACATAAAGACATTGCCCGTTTCGACTCGCCTCTTCCGTACAGAGAAACGTTCCGGTCTCATCAGGGCTCGTCTGCTCGGAGCCAAACATGTACTCGGTGACGTCATCACCTTCTTGGACGCACATTGTGAATGTACAGAGGGGTGGTTGGAGCCACTGCTGGCGCGCATCGTGGAAGACAGAGCGACGGTCGTGTGTCCGATCATAGACGTTATATCGGATACGACATTCGAATACATTCAGGCTTCCGACATGACGTGGGGCGGCTTCAACTGGAAACTTAACTTTAGATGGTATCGCGTTCCCGAACGCGAGATGTCACGACGCGGAGGGGACCGTACAGCGCCACTTCGTACCCCGACCATGGCGGGCGGACTCTTCGCCATCGACAAGGAATACTTCTATAAAATCGGTTCTTACGACGAAGGCATGGACATTTGGGGCGGCGAGAACCTTGAGATGAGCTTTAGGGTGTGGCAGTGCGGCGGGCGGCTCGAGATCGTGCCGTGCTCGCACGTGGGCCACGTGTTCCGCGACAAGTCCCCGTACTCGTTCCCGGGCGGCGTTCAGAACGTTGTGTTGCACAACGCGGCCCGCGTCGCCGAAGTCTGGATGGACGAGTGGGGAGATTTCTATTACGCCATGAATCCAGGTGCGTTGAACGTCCCGGTCGGTGACGTCAGCGAGAGGAAAGCTTTAAGAGAACGTCTCAAGTGCAAGAGCTTCAGGTGGTACCTCGAGAACATCTACCCCGAGAGTCAAATGCCTCTCGAGTACTATTACCTTGGAGAGATTCGTAACGCGGAAACATCGAACTGTTTGGACACCCTCGGCGGCAAGGCTGGCCAGCCGCTCGGCATGGGCTACTGTCACGGAATGGGAGGCAACCAGGTGTTTGCTTACACGAAACGCAAGCAAGTAATGTCGGACGACAACTGTTTGGATGCGGCGCATCCGCGTGGACCCATCAAGCTGATCCGGTGTCACGGCATGAGGGGCAACCAGGAGTGGATATACGACACCAAGACGCGGACAATAAAGCACACGAACACGGGCATGTGTCTCGACAAGCCGGACGCGTCGGACGTGTGGAAGCCGGTGCTGCGGGCCTGCGACAAGTCCCGGGGACAGCAGTGGCTGATGCAGGTCGACTTCAAGTGGCAGGCCAGGCGGAACCAGAACAGCTAG

Protein

MKHLGKKLEDYIKTLPVSTRLFRTEKRSGLIRARLLGAKHVLGDVITFLDAHCECTEGWLEPLLARIVEDRATVVCPIIDVISDTTFEYIQASDMTWGGFNWKLNFRWYRVPEREMSRRGGDRTAPLRTPTMAGGLFAIDKEYFYKIGSYDEGMDIWGGENLEMSFRVWQCGGRLEIVPCSHVGHVFRDKSPYSFPGGVQNVVLHNAARVAEVWMDEWGDFYYAMNPGALNVPVGDVSERKALRERLKCKSFRWYLENIYPESQMPLEYYYLGEIRNAETSNCLDTLGGKAGQPLGMGYCHGMGGNQVFAYTKRKQVMSDDNCLDAAHPRGPIKLIRCHGMRGNQEWIYDTKTRTIKHTNTGMCLDKPDASDVWKPVLRACDKSRGQQWLMQVDFKWQARRNQNS

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Catalytic Activity

L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP

Cofactor

Mn(2+)

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

Similarity

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Belongs to the eIF-3 subunit K family.

Keywords

Alternative splicing   Complete proteome   Disulfide bond   Glycoprotein   Glycosyltransferase   Golgi apparatus   Lectin   Manganese   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Polypeptide N-acetylgalactosaminyltransferase
splice variant  In isoform B.

Uniprot

A0A2A4K9S6   D6WVN2   A0A0T6BBG3   A0A1Y1NCE0   A0A067RJP5   A0A2J7RBV9   + More
A0A069DVS4   A0A1B6BW91   A0A023F5E7   A0A224XLV8   A0A0P4VU64   A0A1J1ILF5   A0A2H8U044   A0A2A3ECZ4   A0A2S2QI64   J9JLD8   K7J3H1   B0WLK6   A0A154PJ57   A0A0K8VJU9   A0A034VZY2   A0A1Q3F100   A0A0N0BC90   A0A195D3X8   A0A1I8PFH5   A0A1I8N431   A0A1Q3F0J8   A0A2S2NUP5   A0A195BR02   A0A0A1X6T4   A0A195DIZ8   A0A158NQJ6   A0A151XAW4   Q0IE85   A0A146LCQ1   A0A0A9Z0W6   F4WKB1   A0A0J7KWC3   E2BM83   W8BGX1   T1GSB1   Q7Q8I5   A0A182YQI4   A0A1S4GYR0   A0A182KN87   A0A182F6A5   A0A182Q6N9   A0A182IL88   A0A0M4E8C9   E0VKN8   B4KGT0   A0A084WFY1   A0A0L7R8E6   A0A0Q9WYQ5   E1ZXG2   B4LUF2   U5ELA3   B4G8M8   Q29MW2   B4JAT3   A0A0N8NZB4   A0A1W4UVP4   A0A3B0JPF7   B4I1D1   A0A0J9QX07   A0A0R1DMM4   Q6WV17   A0A1J1IJI8   B3N4S7   A0A182TW23   E9HLY2   A0A2S2N6P9   A0A1I8PFR7   A0A0P5BWM2   A0A0P5Z058   A0A1I8N438   A0A1S4GZG0   A0A0N8BND7   A0A0P5KFM2   A0A0P4YNL2   A0A1L8E279   A0A2M3Z1K7   A0A2M4CS93   A0A2M4A5H3   A0A2M4BGJ7   A0A0P5B813   A0A0N7ZSZ4   A0A195ERL9   A0A3L8E443   T1DG70   A0A0Q9XAP7   B4MU14   A0A0Q9WKK0   A0A0P4VRH7   A0A087UME6   A0A0R3NS93   B3MPA0   A0A1W4UVZ0   Q6WV17-2   A0A0J9QW36  

EC Number

2.4.1.-
2.4.1.41

Pubmed

18362917    19820115    28004739    24845553    26334808    25474469    + More
27129103    20075255    25348373    25315136    25830018    21347285    17510324    26823975    25401762    21719571    20798317    24495485    12364791    25244985    20966253    20566863    17994087    24438588    15632085    18057021    22936249    17550304    10731132    12537572    12537569    12829714    16251381    21292972    30249741    24330624   

EMBL

NWSH01000002    PCG81045.1    KQ971357    EFA08271.1    LJIG01002272    KRT84668.1    + More
GEZM01010699    JAV93896.1    KK852639    KDR19630.1    NEVH01005890    PNF38298.1    GBGD01000879    JAC88010.1    GEDC01031747    GEDC01000495    JAS05551.1    JAS36803.1    GBBI01002354    JAC16358.1    GFTR01007427    JAW08999.1    GDKW01000397    JAI56198.1    CVRI01000054    CRL00396.1    GFXV01007725    MBW19530.1    KZ288300    PBC28891.1    GGMS01008211    MBY77414.1    ABLF02017877    DS231987    EDS30536.1    KQ434936    KZC11889.1    GDHF01013167    GDHF01012091    JAI39147.1    JAI40223.1    GAKP01010093    GAKP01010092    GAKP01010091    JAC48861.1    GFDL01013815    JAV21230.1    KQ435922    KOX68612.1    KQ976885    KYN07551.1    GFDL01013962    JAV21083.1    GGMR01008169    MBY20788.1    KQ976419    KYM89313.1    GBXI01016735    GBXI01014375    GBXI01007258    JAC97556.1    JAC99916.1    JAD07034.1    KQ980824    KYN12479.1    ADTU01023353    KQ982335    KYQ57505.1    CH478001    EAT34493.1    GDHC01014303    GDHC01012638    GDHC01000315    JAQ04326.1    JAQ05991.1    JAQ18314.1    GBHO01006098    GBHO01000992    JAG37506.1    JAG42612.1    GL888199    EGI65335.1    LBMM01002437    KMQ94832.1    GL449158    EFN83209.1    GAMC01008573    JAB97982.1    CAQQ02038961    CAQQ02038962    CAQQ02038963    CAQQ02038964    CAQQ02038965    AAAB01008944    EAA10180.4    AXCN02000712    CP012523    ALC38238.1    DS235250    EEB13944.1    CH933807    EDW11130.1    ATLV01023410    ATLV01023411    KE525343    KFB49125.1    KQ414632    KOC67145.1    CH963852    KRF98280.1    GL435038    EFN74139.1    CH940649    EDW64138.2    GANO01001491    JAB58380.1    CH479180    EDW28708.1    CH379060    EAL33581.1    CH916368    EDW03891.1    CH902620    KPU73852.1    OUUW01000006    SPP82242.1    CH480820    EDW54338.1    CM002910    KMY88254.1    CM000157    KRJ97741.1    AE014134    AY060338    AY268066    CRL00395.1    CH954177    EDV57829.1    GL732682    EFX67256.1    GGMR01000129    MBY12748.1    GDIP01179421    JAJ43981.1    GDIP01052051    JAM51664.1    GDIQ01160763    LRGB01002674    JAK90962.1    KZS06591.1    GDIQ01186049    JAK65676.1    GDIP01235132    JAI88269.1    GFDF01001310    JAV12774.1    GGFM01001633    MBW22384.1    GGFL01003971    MBW68149.1    GGFK01002684    MBW36005.1    GGFJ01003011    MBW52152.1    GDIP01193284    JAJ30118.1    GDIP01215585    JAJ07817.1    KQ982021    KYN30547.1    QOIP01000001    RLU27396.1    GALA01000292    JAA94560.1    KRG02538.1    EDW75603.2    KRF81438.1    GDRN01104804    JAI57854.1    KK120552    KFM78535.1    KRT03963.1    EDV32219.2    KMY88253.1   

Proteomes

UP000218220    UP000007266    UP000027135    UP000235965    UP000183832    UP000242457    + More
UP000007819    UP000002358    UP000002320    UP000076502    UP000053105    UP000078542    UP000095300    UP000095301    UP000078540    UP000078492    UP000005205    UP000075809    UP000008820    UP000007755    UP000036403    UP000008237    UP000015102    UP000007062    UP000076408    UP000075882    UP000069272    UP000075886    UP000075880    UP000092553    UP000009046    UP000009192    UP000030765    UP000053825    UP000007798    UP000000311    UP000008792    UP000008744    UP000001819    UP000001070    UP000007801    UP000192221    UP000268350    UP000001292    UP000002282    UP000000803    UP000008711    UP000075902    UP000000305    UP000076858    UP000078541    UP000279307    UP000054359   

PRIDE

Q6WV17   

Pfam

PF00535   Glycos_transf_2        + More
PF00652   Ricin_B_lectin
PF10075   CSN8_PSD8_EIF3K
PF08711   Med26
PF01096   TFIIS_C
PF07500   TFIIS_M

Interpro

IPR001173   Glyco_trans_2-like        + More
IPR029044   Nucleotide-diphossugar_trans       
IPR000772   Ricin_B_lectin       
IPR035992   Ricin_B-like_lectins       
IPR017923   TFIIS_N       
IPR033464   CSN8_PSD8_EIF3K       
IPR006289   TFSII       
IPR003617   TFIIS/CRSP70_N_sub       
IPR003618   TFIIS_cen_dom       
IPR016020   Transl_init_fac_sub12_N_euk       
IPR036575   TFIIS_cen_dom_sf       
IPR001222   Znf_TFIIS       
IPR009374   eIF3k       
IPR000717   PCI_dom       
IPR016024   ARM-type_fold       
IPR035441   TFIIS/LEDGF_dom_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR036390   WH_DNA-bd_sf       

SUPFAM

SSF50370   SSF50370        + More
SSF53448   SSF53448       
SSF47676   SSF47676       
SSF48371   SSF48371       
SSF46942   SSF46942       
SSF46785   SSF46785       

Gene 3D

3.90.550.10     1.10.10.10     1.10.472.30     1.20.930.10     1.25.40.250    

CDD

cd00161  RICIN

ProteinModelPortal

A0A2A4K9S6   D6WVN2   A0A0T6BBG3   A0A1Y1NCE0   A0A067RJP5   A0A2J7RBV9   + More
A0A069DVS4   A0A1B6BW91   A0A023F5E7   A0A224XLV8   A0A0P4VU64   A0A1J1ILF5   A0A2H8U044   A0A2A3ECZ4   A0A2S2QI64   J9JLD8   K7J3H1   B0WLK6   A0A154PJ57   A0A0K8VJU9   A0A034VZY2   A0A1Q3F100   A0A0N0BC90   A0A195D3X8   A0A1I8PFH5   A0A1I8N431   A0A1Q3F0J8   A0A2S2NUP5   A0A195BR02   A0A0A1X6T4   A0A195DIZ8   A0A158NQJ6   A0A151XAW4   Q0IE85   A0A146LCQ1   A0A0A9Z0W6   F4WKB1   A0A0J7KWC3   E2BM83   W8BGX1   T1GSB1   Q7Q8I5   A0A182YQI4   A0A1S4GYR0   A0A182KN87   A0A182F6A5   A0A182Q6N9   A0A182IL88   A0A0M4E8C9   E0VKN8   B4KGT0   A0A084WFY1   A0A0L7R8E6   A0A0Q9WYQ5   E1ZXG2   B4LUF2   U5ELA3   B4G8M8   Q29MW2   B4JAT3   A0A0N8NZB4   A0A1W4UVP4   A0A3B0JPF7   B4I1D1   A0A0J9QX07   A0A0R1DMM4   Q6WV17   A0A1J1IJI8   B3N4S7   A0A182TW23   E9HLY2   A0A2S2N6P9   A0A1I8PFR7   A0A0P5BWM2   A0A0P5Z058   A0A1I8N438   A0A1S4GZG0   A0A0N8BND7   A0A0P5KFM2   A0A0P4YNL2   A0A1L8E279   A0A2M3Z1K7   A0A2M4CS93   A0A2M4A5H3   A0A2M4BGJ7   A0A0P5B813   A0A0N7ZSZ4   A0A195ERL9   A0A3L8E443   T1DG70   A0A0Q9XAP7   B4MU14   A0A0Q9WKK0   A0A0P4VRH7   A0A087UME6   A0A0R3NS93   B3MPA0   A0A1W4UVZ0   Q6WV17-2   A0A0J9QW36  

PDB

1XHB     E-value=1.04062e-153,     Score=1394

KEGG

101744145    K00710 polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41] | (RefSeq) polypeptide N-acetylga

PATHWAY

00512    Mucin type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006486   GO:0016757   GO:0030246   GO:0016021   GO:0000139   GO:0005794   GO:0001732   GO:0005634   GO:0005852   GO:0003743   GO:0043022   GO:0006355   GO:0016282   GO:0006446   GO:0006351   GO:0008270   GO:0033290   GO:0009312   GO:0004653   GO:0005795   GO:0012505   GO:0046872  

Subcellular location

Golgi apparatus membrane  
Cytoplasm  
Nucleus  

Length:

405

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0099

Exp number, first 60 AAs:

0.00267

Total prob of N-in:

0.01124

outside

1  -  405

 

 

Pi

193.10288

Theta

175.231302

Tajima's D

-1.3092

CLR

1.739046

CSRT

0.0888955552222389

Interpretation

Uncertain