Gene

KWMTBOMO01380  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008983

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_dihydrolipoyllysine-residue_acetyltransferase_component_of_pyruvate_dehydrogenase_complex?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr3(-):9336370-9339850      View in EpiBrowser

Full name

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex       + More
Acetyltransferase component of pyruvate dehydrogenase complex      

Location in the cell

Nuclear   Reliability : 2.227

CDS

ATGTTGCGAACAATTGTGTTACGGAATCAAATCTTAAGCGATGGTCTTAAGAAAGCTATACGGTCGAACATTACGAGGTGCATTAGTACAGAACTGGCAAAAAGGAAAGTTACGAATAAATTGTTAGAACATGCACAGAACCAGACAGTTCTATCTACACCACAATGGACTGTTCAGATGAGGTATTATTCGAGTCTACCATCACATATAAAGGTCAACCTTCCAGCTCTTTCGCCAACCATGGAGAGTGGTTCAATTGTAAGCTGGGAAAAAAAGGAAGGGGACAAACTTAGTGAAGGCGATCTTCTGTGCGAGATTGAAACTGACAAAGCAACTATGGGCTTTGAGACACCTGAAGAAGGTTACCTGGCCAAAATATTGATTCCGGCCGGTACAAAGGGAGTGCCTGTCGGGAAATTATTGTGCATTATTGTTGGAGATCAGAATGATGTTGCGGCATTCAAAGATTTCAAAGATGACTCATCACCTGCAACACCTCAAAAACCGGCTAGTCAAGATAAAGGTAATTACTAA

Protein

MLRTIVLRNQILSDGLKKAIRSNITRCISTELAKRKVTNKLLEHAQNQTVLSTPQWTVQMRYYSSLPSHIKVNLPALSPTMESGSIVSWEKKEGDKLSEGDLLCEIETDKATMGFETPEEGYLAKILIPAGTKGVPVGKLLCIIVGDQNDVAAFKDFKDDSSPATPQKPASQDKGNY

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA

Cofactor

(R)-lipoate

Similarity

Belongs to the 2-oxoacid dehydrogenase family.

Uniprot

H9JHI5   A0A1V0M894   A0A2W1BG23   A0A2A4KAE0   A0A2H1W3Q8   A0A212FDQ0   + More
A0A194RMF9   A0A194PUD8   A0A0T6AW78   A0A232FP25   A0A1Y1L9G8   A0A1Y1L9L5   A0A1B2M4X8   V5GQ93   A0A2J7Q998   A0A1B0CB93   A0A2P8ZEI8   A0A2A3ENK6   V9IDS4   K7ITB9   D6WXB4   A0A310SBX6   A0A1L8E0Q1   A0A1L8E0Y0   U4URN8   A0A1B0EZF6   A0A0N0BJZ3   N6T0V1   J3JXP5   N6STW7   A0A0L7LHT8   F4WR18   A0A0J7KUZ8   A0A151X0E8   A0A1J1HZ22   A0A3L8D4J0   E2A0R2   A0A0K8TSU4   U5EWN9   A0A084WH81   F0J940   A0A0P8XX56   A0A0P8ZGU3   A0A182J8Z0   A0A1A9WKQ7   A0A195C3E5   A0A1B0AZA2   A0A1S6KZB4   V5SK35   A0A1A9YQZ5   B3MKA8   A0A151JNS3   A0A151JWZ2   Q7Q3P5   B4GJS2   A0A0R3NR10   L7MHC4   A0A3B0K7L2   Q29NY1   A0A023G390   A0A3B0KEJ2   B4JQP6   A0A026VV59   A0A182L1Y4   A0A182TNG9   A0A182HV34   A0A1A9ZVG5   A0A182S802   A0A1B0FLV3   A0A182WT37   A0A1S4GXJ9   A0A182UTY1   A0A182W7H1   D3TLJ8   L7MIF7   A0A1Z5KVQ2   A0A182PD10   A0A182XZV3   A0A182LZV0   A0A224YWJ9   Q17DA3   A0A1I8MFC6   B0XAP0   A0A1W4XNZ5   A0A1W4W8A6   A0A182JXT6   A0A1W4W7F5   B4LS28   A0A1A9V058   A0A0Q9WMY4   A0A1W4VWD0   A0A131YPS5   A0A1I8MFE1   A0A0K8U8E5   T1PHM3   A0A151I6C4   A0A1W4XN45   A0A0Q9X399   A0A2M4A9K5  

EC Number

2.3.1.-
2.3.1.12

Pubmed

19121390    28349297    28756777    22118469    26354079    28648823    + More
28004739    29403074    20075255    18362917    19820115    23537049    22516182    26227816    21719571    30249741    20798317    26369729    24438588    21362191    17994087    24330026    18057021    12364791    15632085    25576852    24508170    20966253    20353571    28528879    25244985    28797301    17510324    25315136    26830274   

EMBL

BABH01012585    BABH01012586    KU755489    ARD71199.1    KZ150259    PZC71766.1    + More
NWSH01000002    PCG81049.1    ODYU01006134    SOQ47721.1    AGBW02009016    OWR51854.1    KQ459989    KPJ18712.1    KQ459591    KPI96937.1    LJIG01022674    KRT79313.1    NNAY01000006    OXU32117.1    GEZM01061826    JAV70303.1    GEZM01061825    JAV70304.1    KX447600    AOA60267.1    GALX01002147    JAB66319.1    NEVH01016943    PNF25153.1    AJWK01004914    PYGN01000079    PSN54919.1    KZ288215    PBC32719.1    JR039717    AEY58812.1    AAZX01008169    KQ971361    EFA08008.1    KQ764881    OAD54368.1    GFDF01001761    JAV12323.1    GFDF01001760    JAV12324.1    KB632196    KI208006    KI210251    ERL89984.1    ERL95772.1    ERL96213.1    AJVK01005896    AJVK01005897    KQ435710    KOX79834.1    APGK01056782    KB741277    ENN71123.1    BT128015    AEE62977.1    ENN71124.1    JTDY01001050    KOB75012.1    GL888282    EGI63357.1    LBMM01003014    KMQ94069.1    KQ982617    KYQ53821.1    CVRI01000037    CRK93277.1    QOIP01000013    RLU15412.1    GL435626    EFN72965.1    GDAI01000159    JAI17444.1    GANO01002877    JAB56994.1    ATLV01023795    KE525346    KFB49575.1    BK007391    DAA34353.1    CH902620    KPU73975.1    KPU73974.1    KQ978350    KYM94711.1    JXJN01006219    KC223161    AQT27064.1    KF647627    AHB50489.1    EDV32492.1    KPU73973.1    KQ978812    KYN28161.1    KQ981627    KYN38981.1    AAAB01008964    EAA12479.4    CH479184    EDW36888.1    CH379058    KRT03598.1    GACK01001448    JAA63586.1    OUUW01000006    SPP82009.1    EAL34512.2    GBBM01006757    JAC28661.1    SPP82008.1    CH916372    EDV99226.1    KK107796    EZA47612.1    APCN01002491    CCAG010002025    EZ422300    ADD18576.1    GACK01001447    JAA63587.1    GFJQ02007793    JAV99176.1    AXCM01003126    GFPF01007198    MAA18344.1    CH477298    EAT44326.1    DS232592    EDS43829.1    CH940649    EDW64714.1    KRF81813.1    GEDV01008015    JAP80542.1    GDHF01029461    JAI22853.1    KA647388    AFP62017.1    KQ976397    KYM92806.1    CH963920    KRF98759.1    GGFK01004138    MBW37459.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000215335    + More
UP000235965    UP000092461    UP000245037    UP000242457    UP000002358    UP000007266    UP000030742    UP000092462    UP000053105    UP000019118    UP000037510    UP000007755    UP000036403    UP000075809    UP000183832    UP000279307    UP000000311    UP000030765    UP000007801    UP000075880    UP000091820    UP000078542    UP000092460    UP000092443    UP000078492    UP000078541    UP000007062    UP000008744    UP000001819    UP000268350    UP000001070    UP000053097    UP000075882    UP000075902    UP000075840    UP000092445    UP000075901    UP000092444    UP000076407    UP000075903    UP000075920    UP000075885    UP000076408    UP000075883    UP000008820    UP000095301    UP000002320    UP000192223    UP000192221    UP000075881    UP000008792    UP000078200    UP000078540    UP000007798   

PRIDE

H9JHI5   

Pfam

PF00364   Biotin_lipoyl        + More
PF00198   2-oxoacid_dh
PF02817   E3_binding
PF02141   DENN
PF03455   dDENN

Interpro

IPR011053   Single_hybrid_motif        + More
IPR023213   CAT-like_dom_sf       
IPR003016   2-oxoA_DH_lipoyl-BS       
IPR000089   Biotin_lipoyl       
IPR001078   2-oxoacid_DH_actylTfrase       
IPR006257   LAT1       
IPR036625   E3-bd_dom_sf       
IPR004167   PSBD       
IPR037516   Tripartite_DENN       
IPR001194   cDENN_dom       
IPR005112   dDENN_dom       

SUPFAM

SSF51230   SSF51230        + More
SSF47005   SSF47005       

Gene 3D

3.30.559.10     4.10.320.10    

ProteinModelPortal

H9JHI5   A0A1V0M894   A0A2W1BG23   A0A2A4KAE0   A0A2H1W3Q8   A0A212FDQ0   + More
A0A194RMF9   A0A194PUD8   A0A0T6AW78   A0A232FP25   A0A1Y1L9G8   A0A1Y1L9L5   A0A1B2M4X8   V5GQ93   A0A2J7Q998   A0A1B0CB93   A0A2P8ZEI8   A0A2A3ENK6   V9IDS4   K7ITB9   D6WXB4   A0A310SBX6   A0A1L8E0Q1   A0A1L8E0Y0   U4URN8   A0A1B0EZF6   A0A0N0BJZ3   N6T0V1   J3JXP5   N6STW7   A0A0L7LHT8   F4WR18   A0A0J7KUZ8   A0A151X0E8   A0A1J1HZ22   A0A3L8D4J0   E2A0R2   A0A0K8TSU4   U5EWN9   A0A084WH81   F0J940   A0A0P8XX56   A0A0P8ZGU3   A0A182J8Z0   A0A1A9WKQ7   A0A195C3E5   A0A1B0AZA2   A0A1S6KZB4   V5SK35   A0A1A9YQZ5   B3MKA8   A0A151JNS3   A0A151JWZ2   Q7Q3P5   B4GJS2   A0A0R3NR10   L7MHC4   A0A3B0K7L2   Q29NY1   A0A023G390   A0A3B0KEJ2   B4JQP6   A0A026VV59   A0A182L1Y4   A0A182TNG9   A0A182HV34   A0A1A9ZVG5   A0A182S802   A0A1B0FLV3   A0A182WT37   A0A1S4GXJ9   A0A182UTY1   A0A182W7H1   D3TLJ8   L7MIF7   A0A1Z5KVQ2   A0A182PD10   A0A182XZV3   A0A182LZV0   A0A224YWJ9   Q17DA3   A0A1I8MFC6   B0XAP0   A0A1W4XNZ5   A0A1W4W8A6   A0A182JXT6   A0A1W4W7F5   B4LS28   A0A1A9V058   A0A0Q9WMY4   A0A1W4VWD0   A0A131YPS5   A0A1I8MFE1   A0A0K8U8E5   T1PHM3   A0A151I6C4   A0A1W4XN45   A0A0Q9X399   A0A2M4A9K5  

PDB

6H55     E-value=6.65327e-31,     Score=330

KEGG

101744429    K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] | (Ref

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004742   GO:0006090   GO:0045254   GO:0016746   GO:0016021   GO:0005759   GO:0016740   GO:0007625  

Subcellular location

Mitochondrion matrix  

Length:

177

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01636

Exp number, first 60 AAs:

0

Total prob of N-in:

0.21697

outside

1  -  177

 

 

Pi

217.987567

Theta

198.282767

Tajima's D

0.210948

CLR

0.323665

CSRT

0.428778561071946

Interpretation

Uncertain