Gene

KWMTBOMO01379  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008984

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_dihydrolipoyllysine-residue_acetyltransferase_component_of_pyruvate_dehydrogenase_complex?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr3(-):9327071-9331750      View in EpiBrowser

Full name

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex       + More
Acetyltransferase component of pyruvate dehydrogenase complex      

Location in the cell

Mitochondrial   Reliability : 1.73

CDS

ATGAAAGAAACTGGGAAAAAGTTTACTTTAATTTGCAAACCAAATATACCATCTTCAGGGCAAGGTACGGGTCTATACGGGTCATTGAAGAGCGGTGACCTGTCAGGAGCGGCAGCGGCAGGACCAGCGGCTCCGGCCTCCGCCCCCTCCGCACCAGCCCCCGCCCCAGCCCCCGGCGCCACCTTTGTGGACCTGCCGCTGTCCGGCATGAGGGAGACCATCGCCAAGAGGCTGACGGCCGCTAAACAAAGCATCCCGCACTACCAGCTCAGTGTCACCGTCAACGTCGAGAAAACCCTCGCCATGAGGAAGCTGGTTAACGAGAGGCTAGCCAGTGAAAAGGCTGATGTTAAGGTTTCAGTGAACGACTTCATCATTAAAGCCGTGGCGGCTGCCTGCAAGCGCGTGCCTACAGTCAACTCACATTGGATGGAGTCTTTCATAAGACAATTCTCCAACGTAGACGTGAGTGTGGCCGTGGCGACTCCGACCGGCCTCATCACGCCGATCCTGCACAACGCTGACTCCCGGGGCATCATCGACCTCTCGAAGAACATGAAGCAATTGGCGCAGAAAGCCAAGGACGGTAAACTTCAACCTCAAGAGTACCAGGGCGGTACTGTCACGGTATCGAACCTAGGAATGTACGGTATTACGATGTTCAACGCCATCATCAATCCCCCCCAGTCGTTCATTATAGCTTGCGGCGGCGTACAAGAACTGGTCATTCCAGACCAAAGTGAACCAAACGGCTTCCGAACAGCCAAGTTCGTCACGTTCACAGCGTCGGCCGACCACAGGGTGGTGGACGGAGCGATCGGCGCTCAATGGATGAAAGTATTCAAGGAGAACCTCGAAGATCCCGCCAACATCATTTTATAA

Protein

MKETGKKFTLICKPNIPSSGQGTGLYGSLKSGDLSGAAAAGPAAPASAPSAPAPAPAPGATFVDLPLSGMRETIAKRLTAAKQSIPHYQLSVTVNVEKTLAMRKLVNERLASEKADVKVSVNDFIIKAVAAACKRVPTVNSHWMESFIRQFSNVDVSVAVATPTGLITPILHNADSRGIIDLSKNMKQLAQKAKDGKLQPQEYQGGTVTVSNLGMYGITMFNAIINPPQSFIIACGGVQELVIPDQSEPNGFRTAKFVTFTASADHRVVDGAIGAQWMKVFKENLEDPANIIL

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA

Cofactor

(R)-lipoate

Similarity

Belongs to the 2-oxoacid dehydrogenase family.

Uniprot

A0A2A4KAE0   A0A2W1BG23   A0A1V0M894   A0A2H1W3Q8   A0A194PUD8   A0A088M9A0   + More
A0A212FDQ0   A0A1L8D6A7   A0A1B2M4X8   Q7Q3P5   A0A1S4GXJ9   J3JXP5   U4URN8   N6STW7   V5GQ93   A0A182F1I7   A0A182QR24   B0XAP0   T1KH17   A0A182NTK2   A0A1J1HZ22   A0A182JXT6   A0A182G2E7   W5J269   A0A1W4XN45   A0A2M4A9I5   A0A2M4A9K5   A0A023EUG5   A0A2M4AA31   A0A2M3ZGV3   T1DJC1   N6T0V1   A0A1Y1L9L5   A0A084WH81   A0A182GTC7   A0A182LZV0   A0A182RJA2   A0A2M4CTQ6   A0A2M4A9D0   A0A2M4CTU8   Q17DA3   A0A182W7H1   A0A182PD10   A0A182WT37   A0A182UTY1   A0A182XZV3   A0A182L1Y4   A0A182TNG9   A0A182HV34   V5SK35   A0A0K8TSU4   A0A1Q3FG88   A0A1Q3FFZ5   A0A1Q3FG58   A0A088A189   A0A1W4XNZ5   A0A1I8P5P1   A0A182J8Z0   A0A2H8TIE9   U5EWN9   A0A1Y1L9G8   A0A1B6JEI9   A0A2S2NPV8   A0A0L7R5P6   J9JMC9   E2A0R2   T1PHM3   T1EFC1   A0A087TQ98   A0A151JNS3   A0A1Q3FG90   A0A1B6KFX3   V4B766   A0A0L0BX35   A0A182S802   F4WR18   A0A2S2PWE6   A0A2T7PGH2   A0A0J7KUZ8   B4KKB2   A0A1S3HD15   A0A151I6C4   A0A1B6LAD7   A0A3L8D4J0   A0A1I8P5J7   W8AW83   A0A034VAS4   A0A0K8UUS3   A0A2A3ENK6   V9IDS4   A0A0A1WRU6   A0A0M3QTF5   A0A195C3E5   A0A0T6AW78   A0A3M7Q7S0   A0A158NHM2   A0A151X0E8   A0A0N0BJZ3   E2BNA7  

EC Number

2.3.1.-
2.3.1.12

Pubmed

28756777    28349297    26354079    26385554    22118469    12364791    + More
22516182    23537049    26483478    20920257    23761445    24945155    28004739    24438588    17510324    25244985    20966253    26369729    20798317    25315136    23254933    26108605    21719571    17994087    30249741    24495485    25348373    25830018    30375419    21347285   

EMBL

NWSH01000002    PCG81049.1    KZ150259    PZC71766.1    KU755489    ARD71199.1    + More
ODYU01006134    SOQ47721.1    KQ459591    KPI96937.1    KJ579231    AIN34707.1    AGBW02009016    OWR51854.1    GEYN01000148    JAV01981.1    KX447600    AOA60267.1    AAAB01008964    EAA12479.4    BT128015    AEE62977.1    KB632196    KI208006    KI210251    ERL89984.1    ERL95772.1    ERL96213.1    APGK01056782    KB741277    ENN71124.1    GALX01002147    JAB66319.1    AXCN02000795    DS232592    EDS43829.1    CAEY01000073    CVRI01000037    CRK93277.1    JXUM01000238    KQ560103    KXJ84541.1    ADMH02002204    ETN57831.1    GGFK01004126    MBW37447.1    GGFK01004138    MBW37459.1    GAPW01001027    JAC12571.1    GGFK01004332    MBW37653.1    GGFM01007023    MBW27774.1    GAMD01001551    JAB00040.1    ENN71123.1    GEZM01061825    JAV70304.1    ATLV01023795    KE525346    KFB49575.1    JXUM01017943    JXUM01017944    KQ560496    KXJ82125.1    AXCM01003126    GGFL01004522    MBW68700.1    GGFK01004021    MBW37342.1    GGFL01004521    MBW68699.1    CH477298    EAT44326.1    APCN01002491    KF647627    AHB50489.1    GDAI01000159    JAI17444.1    GFDL01008478    JAV26567.1    GFDL01008567    JAV26478.1    GFDL01008508    JAV26537.1    GFXV01002089    MBW13894.1    GANO01002877    JAB56994.1    GEZM01061826    JAV70303.1    GECU01010178    JAS97528.1    GGMR01006565    MBY19184.1    KQ414652    KOC66086.1    ABLF02038190    GL435626    EFN72965.1    KA647388    AFP62017.1    AMQM01004049    KB096411    ESO05083.1    KK116279    KFM67287.1    KQ978812    KYN28161.1    GFDL01008476    JAV26569.1    GEBQ01029615    JAT10362.1    KB200027    ESP03381.1    JRES01001205    KNC24613.1    GL888282    EGI63357.1    GGMS01000662    MBY69865.1    PZQS01000004    PVD32536.1    LBMM01003014    KMQ94069.1    CH933807    EDW12643.1    KQ976397    KYM92806.1    GEBQ01019295    JAT20682.1    QOIP01000013    RLU15412.1    GAMC01017577    JAB88978.1    GAKP01020313    GAKP01020310    GAKP01020305    GAKP01020302    GAKP01020299    GAKP01020296    JAC38653.1    GDHF01021860    GDHF01011005    JAI30454.1    JAI41309.1    KZ288215    PBC32719.1    JR039717    AEY58812.1    GBXI01012966    GBXI01001659    JAD01326.1    JAD12633.1    CP012523    ALC38823.1    KQ978350    KYM94711.1    LJIG01022674    KRT79313.1    REGN01007114    RNA07234.1    ADTU01016019    KQ982617    KYQ53821.1    KQ435710    KOX79834.1    GL449385    EFN82869.1   

Proteomes

UP000218220    UP000053268    UP000007151    UP000007062    UP000030742    UP000019118    + More
UP000069272    UP000075886    UP000002320    UP000015104    UP000075884    UP000183832    UP000075881    UP000069940    UP000249989    UP000000673    UP000192223    UP000030765    UP000075883    UP000075900    UP000008820    UP000075920    UP000075885    UP000076407    UP000075903    UP000076408    UP000075882    UP000075902    UP000075840    UP000005203    UP000095300    UP000075880    UP000053825    UP000007819    UP000000311    UP000095301    UP000015101    UP000054359    UP000078492    UP000030746    UP000037069    UP000075901    UP000007755    UP000245119    UP000036403    UP000009192    UP000085678    UP000078540    UP000279307    UP000242457    UP000092553    UP000078542    UP000276133    UP000005205    UP000075809    UP000053105    UP000008237   

Pfam

PF00364   Biotin_lipoyl        + More
PF00198   2-oxoacid_dh
PF02817   E3_binding

Interpro

IPR023213   CAT-like_dom_sf        + More
IPR006257   LAT1       
IPR000089   Biotin_lipoyl       
IPR003016   2-oxoA_DH_lipoyl-BS       
IPR011053   Single_hybrid_motif       
IPR001078   2-oxoacid_DH_actylTfrase       
IPR036625   E3-bd_dom_sf       
IPR004167   PSBD       

SUPFAM

SSF51230   SSF51230        + More
SSF47005   SSF47005       

Gene 3D

3.30.559.10     4.10.320.10    

ProteinModelPortal

A0A2A4KAE0   A0A2W1BG23   A0A1V0M894   A0A2H1W3Q8   A0A194PUD8   A0A088M9A0   + More
A0A212FDQ0   A0A1L8D6A7   A0A1B2M4X8   Q7Q3P5   A0A1S4GXJ9   J3JXP5   U4URN8   N6STW7   V5GQ93   A0A182F1I7   A0A182QR24   B0XAP0   T1KH17   A0A182NTK2   A0A1J1HZ22   A0A182JXT6   A0A182G2E7   W5J269   A0A1W4XN45   A0A2M4A9I5   A0A2M4A9K5   A0A023EUG5   A0A2M4AA31   A0A2M3ZGV3   T1DJC1   N6T0V1   A0A1Y1L9L5   A0A084WH81   A0A182GTC7   A0A182LZV0   A0A182RJA2   A0A2M4CTQ6   A0A2M4A9D0   A0A2M4CTU8   Q17DA3   A0A182W7H1   A0A182PD10   A0A182WT37   A0A182UTY1   A0A182XZV3   A0A182L1Y4   A0A182TNG9   A0A182HV34   V5SK35   A0A0K8TSU4   A0A1Q3FG88   A0A1Q3FFZ5   A0A1Q3FG58   A0A088A189   A0A1W4XNZ5   A0A1I8P5P1   A0A182J8Z0   A0A2H8TIE9   U5EWN9   A0A1Y1L9G8   A0A1B6JEI9   A0A2S2NPV8   A0A0L7R5P6   J9JMC9   E2A0R2   T1PHM3   T1EFC1   A0A087TQ98   A0A151JNS3   A0A1Q3FG90   A0A1B6KFX3   V4B766   A0A0L0BX35   A0A182S802   F4WR18   A0A2S2PWE6   A0A2T7PGH2   A0A0J7KUZ8   B4KKB2   A0A1S3HD15   A0A151I6C4   A0A1B6LAD7   A0A3L8D4J0   A0A1I8P5J7   W8AW83   A0A034VAS4   A0A0K8UUS3   A0A2A3ENK6   V9IDS4   A0A0A1WRU6   A0A0M3QTF5   A0A195C3E5   A0A0T6AW78   A0A3M7Q7S0   A0A158NHM2   A0A151X0E8   A0A0N0BJZ3   E2BNA7  

PDB

6H55     E-value=1.29951e-63,     Score=615

KEGG

101744429    K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] | (Ref

GO

GO:0045254   GO:0004742   GO:0006090   GO:0016746   GO:0016021   GO:0005759   GO:0007625   GO:0008152   GO:0015074   GO:0004553   GO:0003677   GO:0004518   GO:0003824   GO:0006334   GO:0003779  

Subcellular location

Mitochondrion matrix  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.36994

Exp number, first 60 AAs:

0.00105

Total prob of N-in:

0.05387

outside

1  -  293

 

 

Pi

187.284962

Theta

142.104694

Tajima's D

-0.565409

CLR

14.709954

CSRT

0.224088795560222

Interpretation

Uncertain