Gene

KWMTBOMO01376  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008986

Annotation

integrin_beta-nu_precursor_[Bombyx_mori]

Location

Bomo_Chr3(-):9298232-9318900      View in EpiBrowser

Full name

Integrin beta       + More
Integrin beta-nu      

Location in the cell

Extracellular   Reliability : 2.852

CDS

ATGTACGATTATACGTTGTGTAAATTGTTAGTGTTTTCAGTTATTATAATATACACGTGCGGTCAAGTTCAAGAAAAACTGCTCAACAAGCTAGTGTGCATCGAGCATGAAGAGTGCGGTGCGTGTTTGTCGGCTGCTTCGCACTGTCGATGGTGTGCAGACCCTTACTTCAGTCACGCTGCTCCCAGGTGCAACGACGACGAAAGTTTGGTGTCTACGGGATGCAGTCAAGCTATGATACAACGACCAGAGAAACCTATATGGGTTGTGGCCGAGAATAGTTCCTTACAAGACATGCAACCGGACAGTGAAGAGTCCGTAGTACAGATCCAGCCTCAAAGGATCAAATTATCGTTGAAACCACGTGAAACAAAAAAAATTAAGTTCGTATACCGGCCAGCGAAGAATTACCCTCTAGATCTCTACTACCTGATGGACTTGACCTGGTCAATGAAGGACGACAAGGAAACACTGGTTTCCTTAAGGGATGACTTGCCTATTCTGTTAAAGAATTTAACTGACAATTTTAGGCTCGGTTTTGGTAGTTTTGCTGATAAACCAATCATGCCATTCATCAACGTGGATGATAGAAGAAAATCAAACCCATGTGCTGTTGAGGAAGAAGCTTGCGAGGCAACATACAGCTACAAACACCATTTATCTCTTACTAATGAGGTAAGCGATTTTATCAAGAAAGTAAACACGAGTTCAGTGACTGCAAATCTGGATAACGCCGAGGCCCAATTAGATGCCCTCATGCAGGTCTTGACTTGCGGCGAGAAGATCGGATGGTCGACGAAAAGCAGAAAGATCGTAATTCTCTCTTCAGATGGACTGTTGCATATTGCTGGCGACGGAAGGATAGGGGGAGCAGCATTAAAGAACGATGAAAATTGCCATCTGGATGACAACGGCTACTATAACAAGGCGGACACCTACGATTATCCATCTATTGCTCAAATCTTTAGATTACTTGATAAGTATAAGGTTAACGTTATATTTGCTGTAACCGAAAGTGTTAAGGATCATTACGATAGTCTACACGAACTTTTAAAAGATTTCACGTACGTAGCTAAATTGGAAAGTGACAGTTCCAACATTCTAAAGCTCGTCAAAACGGGATACGAAGACATCGTCAGCGTTGTCGATTTTGAGGACAATGCAAGCTCGGGCCCGGCTAAGGTTCGGTACTTCTCTGATTGTGGAGTGAAAGGAGGGTCGCTTGTCGAGACGACGCGATGTACCGGAGTCGAATACGGCATGACCCTCAATTACGAGGCGCACATCACTCTCGATGCTTGTTCGGAATTTAAAACTTCGAGTCAGACGATTCGCATTTCCGAAAGTCAACTTGGACAGGACTCGCTCACTCTCGATGTGGAATTACAATGTGGATGCAAATGCGAAGGCGATTCGCAGAAAGATCTGTCCCTGACGTGCCCAGTCAATTCTCACCTCGTGTGCGGTGTTTGTCAGTGTAATAAAGGCTGGTCCGGACCAGACTGTGACTGTTCAATAAGCGACGAGGAAGCATCTGCGGAACTAATGGCTCAATGTCGAGAGCCGAACTCGACGCGGACTCTCGCCTGTTCCGGCGCCGGAGACTGCATCTGCGGGAGGTGCGACTGCGACCGTGGCTACAACGGAAAATATTGCCAGTGCAAGTCGTGTGAAACTAGTCCAGAAAACGGTATCGAATGTGGCGGTGTGGGTCGCGGCGTGTGTGTTTGTGGACAATGTGCGTGTGTCGACGGCTGGGGCGGACCTTCCTGTGACTGCACCACCGTATTGGATTCGTGTATTGCACCGGGAGACGAAAAACTTTGTTCCGGACATGGAGACTGTGTTTGTGGTCAGTGTCAGTGTTCCGCCTCTGATCAGAGCAGCGGCTCCGTATACTCAGGCACGTTTTGCGAGACATGTGCAACCTGTGAGAATCCGCTATGCGCAAACGCGGAACCCTGCGTTTCTTGTCATCTCAACAGCAGTTGTACGGATATATGTACGATTGGCAGCGTCAACTACACAGTCCATGACAGAATGAGCGAAACTGGGTCCGTAAGCGCGGAAGATATCACCTGTATCCTTCGCATAGAGGAGAACTCACTTGAATGCGAATACAAATACACTTACAACGCGGTCAGACAGTCCATAGTCGCCATGGAGATTGCGCTCCGTTCTAAAGACTGCTTCCAGCCGACCAGCGCAAAGATCATGACCAGCGCTTTCGTCATCATAGCCTGCGTGATAGCGGCAGGGCTTCTAATTATCTTAGCCATAAAGAGCGCTCAGATCGTTTCAGACAGGCGAGCATACGCGAAATTCGTTAAAGAAGCACAGGAGAGTCGAAAGAATATGCAAGAACTGAACCCGTTGTATAAATCTCCTATAACAGAGTTTAAGCTGCCGGATTCGTTCCCTAGAGATAAGAATGATTAA

Protein

MYDYTLCKLLVFSVIIIYTCGQVQEKLLNKLVCIEHEECGACLSAASHCRWCADPYFSHAAPRCNDDESLVSTGCSQAMIQRPEKPIWVVAENSSLQDMQPDSEESVVQIQPQRIKLSLKPRETKKIKFVYRPAKNYPLDLYYLMDLTWSMKDDKETLVSLRDDLPILLKNLTDNFRLGFGSFADKPIMPFINVDDRRKSNPCAVEEEACEATYSYKHHLSLTNEVSDFIKKVNTSSVTANLDNAEAQLDALMQVLTCGEKIGWSTKSRKIVILSSDGLLHIAGDGRIGGAALKNDENCHLDDNGYYNKADTYDYPSIAQIFRLLDKYKVNVIFAVTESVKDHYDSLHELLKDFTYVAKLESDSSNILKLVKTGYEDIVSVVDFEDNASSGPAKVRYFSDCGVKGGSLVETTRCTGVEYGMTLNYEAHITLDACSEFKTSSQTIRISESQLGQDSLTLDVELQCGCKCEGDSQKDLSLTCPVNSHLVCGVCQCNKGWSGPDCDCSISDEEASAELMAQCREPNSTRTLACSGAGDCICGRCDCDRGYNGKYCQCKSCETSPENGIECGGVGRGVCVCGQCACVDGWGGPSCDCTTVLDSCIAPGDEKLCSGHGDCVCGQCQCSASDQSSGSVYSGTFCETCATCENPLCANAEPCVSCHLNSSCTDICTIGSVNYTVHDRMSETGSVSAEDITCILRIEENSLECEYKYTYNAVRQSIVAMEIALRSKDCFQPTSAKIMTSAFVIIACVIAAGLLIILAIKSAQIVSDRRAYAKFVKEAQESRKNMQELNPLYKSPITEFKLPDSFPRDKND

Description

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.

Subunit

Heterodimer of an alpha and a beta subunit. Interacts with scb/alpha-PS3.

Similarity

Belongs to the integrin beta chain family.

Keywords

Cell adhesion   Complete proteome   Glycoprotein   Integrin   Membrane   Phagocytosis   Receptor   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Integrin beta

Uniprot

A0A076JUD9   H9JHI8   A0A194RMR4   A0A194PW01   A0A2A4KA02   A0A212FDP2   + More
A0A2H1WGU6   A0A1E1VXT8   A0A0L7L1Q4   A0A2W1B938   A0A1W7R6Y7   A0A1Q3FQ99   A0A1Q3FQF2   A0A336LEA7   A0A336KAI0   A0A1Q3FQA7   A0A182R6X4   A0A182VSW8   A0A3L8D5H4   Q16TB6   A0A1L8DLQ6   A0A1L8DLZ9   A0A1L8DLQ7   B0W9T9   A0A310SFX4   A0A182JW23   Q17K64   E2BNA6   A0A182Q580   A0A182P887   A0A0N0U352   A0A1A9ZPW0   A0A1A9V8Z9   A0A1A9Y5S3   Q7PME7   Q8T5U7   A0A182KJT3   A0A182I0S3   A0A182XM86   A0A1J1HHK0   A0A0L0C681   A0A088A188   W5J9X8   A0A182N8S2   A0A0L7R5I8   A0A2A3ELY3   A0A1W4UI89   A0A182GK62   B4MZU0   A0A1B0DC03   A0A1I8M0W6   B4KL00   A0A1B0DL74   B3MU64   A0A182FMW5   B4JEA5   B4IFJ1   T1P8K2   A0A3B0JIT6   Q29NR4   B4GJH0   A0A3B0K923   A0A0S0WGT1   Q27591   A0A0J9R574   A0A1B0B8X4   B4LUM4   B4P709   B3NKV9   A0A1I8P121   A0A0R1DSU0   A0A1W7RAE7   T1K5U0   V5IFB6   A0A0R3NXK3   A0A026VXQ7   A0A2I9LP51   V5GLP5   A0A1Y3EQP6   A0A1I8P153   A0A0M3QUB4   F0JAH6   A0A2M4BDW1   A0A0A0PEU5   D3K4F4   A0A2M4BDV9   A0A1S4FW80   A0A182Q0X5   A0A182RHJ6   T1GNV7   A0A1I7RZ20   B0WJW0   A0A336M8L1   A0A336MBS4   U5EVW7   A0A0K0ELJ0   T1JH92   A0A0N5D3K5   A0A1B0FKA3  

Pubmed

25064490    19121390    26354079    22118469    26227816    28756777    + More
30249741    17510324    20798317    12364791    14747013    17210077    20966253    26108605    20920257    23761445    26483478    17994087    25315136    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8076521    15469969    18925939    21592968    22547074    23054837    23426364    22936249    17550304    25765539    24508170    29248469    24982879    21909270   

EMBL

KJ511858    AII79417.1    BABH01012588    KQ459989    KPJ18714.1    KQ459591    + More
KPI96939.1    NWSH01000002    PCG81051.1    AGBW02009016    OWR51852.1    ODYU01008576    SOQ52295.1    GDQN01011508    JAT79546.1    JTDY01003666    KOB69184.1    KZ150259    PZC71768.1    GEHC01000731    JAV46914.1    GFDL01005270    JAV29775.1    GFDL01005281    JAV29764.1    UFQS01003657    UFQT01003657    SSX15829.1    SSX35175.1    UFQS01000170    UFQT01000170    SSX00698.1    SSX21078.1    GFDL01005256    JAV29789.1    QOIP01000013    RLU15411.1    CH477653    EAT37755.1    GFDF01006686    JAV07398.1    GFDF01006687    JAV07397.1    GFDF01006688    JAV07396.1    DS231866    EDS40506.1    KQ764881    OAD54370.1    CH477228    EAT47028.1    GL449385    EFN82868.1    AXCN02001862    KQ435908    KOX68994.1    AAAB01008980    EAA13939.2    AF492464    AAM11657.1    APCN01005251    CVRI01000004    CRK87503.1    JRES01000842    KNC27795.1    ADMH02002068    ETN59660.1    KQ414652    KOC66084.1    KZ288215    PBC32717.1    JXUM01013004    KQ560366    KXJ82792.1    CH963920    EDW77875.2    AJVK01030471    AJVK01030472    CH933807    EDW12750.2    AJVK01036185    AJVK01036186    CH902624    EDV33393.2    CH916368    EDW03625.1    CH480833    EDW46413.1    KA644460    AFP59089.1    OUUW01000006    SPP82125.1    CH379058    EAL34580.3    CH479184    EDW36786.1    SPP82126.1    AE014134    ALI30216.1    L13305    BT031252    CM002910    KMY91263.1    JXJN01010098    CH940649    EDW64210.1    CM000158    EDW89978.2    CH954179    EDV54482.1    KRJ98850.1    GFAH01000303    JAV48086.1    CAEY01001590    GANP01008722    JAB75746.1    KRT03680.1    KK107796    EZA47614.1    GFWZ01000163    MBW20153.1    GANP01013203    JAB71265.1    LVZM01008211    OUC45859.1    CP012523    ALC40339.1    BT126018    ADY17717.1    GGFJ01002056    MBW51197.1    KC715739    AHH32890.1    GU370128    ADC35398.1    GGFJ01002095    MBW51236.1    AXCN02002227    CAQQ02145466    CAQQ02145467    DS231965    EDS29490.1    UFQT01000673    SSX26380.1    SSX26379.1    GANO01001694    JAB58177.1    JH432223    UYYF01004515    VDN04972.1    CCAG010009532   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000037510    + More
UP000075900    UP000075920    UP000279307    UP000008820    UP000002320    UP000075881    UP000008237    UP000075886    UP000075885    UP000053105    UP000092445    UP000078200    UP000092443    UP000007062    UP000075882    UP000075840    UP000076407    UP000183832    UP000037069    UP000005203    UP000000673    UP000075884    UP000053825    UP000242457    UP000192221    UP000069940    UP000249989    UP000007798    UP000092462    UP000095301    UP000009192    UP000007801    UP000069272    UP000001070    UP000001292    UP000268350    UP000001819    UP000008744    UP000000803    UP000092460    UP000008792    UP000002282    UP000008711    UP000095300    UP000015104    UP000053097    UP000243006    UP000092553    UP000015102    UP000095284    UP000035681    UP000046394    UP000276776    UP000092444   

PRIDE

H9JHI8    Q27591    F0JAH6   

Pfam

PF07974   EGF_2        + More
PF00362   Integrin_beta
PF08725   Integrin_b_cyt
PF17205   PSI_integrin
PF18372   I-EGF_1
PF00106   adh_short
PF07965   Integrin_B_tail

Interpro

IPR036465   vWFA_dom_sf        + More
IPR015812   Integrin_bsu       
IPR014836   Integrin_bsu_cyt_dom       
IPR002369   Integrin_bsu_VWA       
IPR013111   EGF_extracell       
IPR002035   VWF_A       
IPR032695   Integrin_dom_sf       
IPR033760   Integrin_beta_N       
IPR040622   I-EGF_1       
IPR000742   EGF-like_dom       
IPR036349   Integrin_bsu_tail_dom_sf       
IPR002347   SDR_fam       
IPR036291   NAD(P)-bd_dom_sf       
IPR016201   PSI       
IPR012896   Integrin_bsu_tail       

SUPFAM

SSF53300   SSF53300        + More
SSF69179   SSF69179       
SSF69687   SSF69687       
SSF51735   SSF51735       

Gene 3D

3.40.50.410    

ProteinModelPortal

A0A076JUD9   H9JHI8   A0A194RMR4   A0A194PW01   A0A2A4KA02   A0A212FDP2   + More
A0A2H1WGU6   A0A1E1VXT8   A0A0L7L1Q4   A0A2W1B938   A0A1W7R6Y7   A0A1Q3FQ99   A0A1Q3FQF2   A0A336LEA7   A0A336KAI0   A0A1Q3FQA7   A0A182R6X4   A0A182VSW8   A0A3L8D5H4   Q16TB6   A0A1L8DLQ6   A0A1L8DLZ9   A0A1L8DLQ7   B0W9T9   A0A310SFX4   A0A182JW23   Q17K64   E2BNA6   A0A182Q580   A0A182P887   A0A0N0U352   A0A1A9ZPW0   A0A1A9V8Z9   A0A1A9Y5S3   Q7PME7   Q8T5U7   A0A182KJT3   A0A182I0S3   A0A182XM86   A0A1J1HHK0   A0A0L0C681   A0A088A188   W5J9X8   A0A182N8S2   A0A0L7R5I8   A0A2A3ELY3   A0A1W4UI89   A0A182GK62   B4MZU0   A0A1B0DC03   A0A1I8M0W6   B4KL00   A0A1B0DL74   B3MU64   A0A182FMW5   B4JEA5   B4IFJ1   T1P8K2   A0A3B0JIT6   Q29NR4   B4GJH0   A0A3B0K923   A0A0S0WGT1   Q27591   A0A0J9R574   A0A1B0B8X4   B4LUM4   B4P709   B3NKV9   A0A1I8P121   A0A0R1DSU0   A0A1W7RAE7   T1K5U0   V5IFB6   A0A0R3NXK3   A0A026VXQ7   A0A2I9LP51   V5GLP5   A0A1Y3EQP6   A0A1I8P153   A0A0M3QUB4   F0JAH6   A0A2M4BDW1   A0A0A0PEU5   D3K4F4   A0A2M4BDV9   A0A1S4FW80   A0A182Q0X5   A0A182RHJ6   T1GNV7   A0A1I7RZ20   B0WJW0   A0A336M8L1   A0A336MBS4   U5EVW7   A0A0K0ELJ0   T1JH92   A0A0N5D3K5   A0A1B0FKA3  

PDB

4UM8     E-value=3.96406e-85,     Score=805

KEGG

101744815    K05719 integrin beta 1 | (RefSeq) integrin beta-nu

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)
04512    ECM-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0007229   GO:0007155   GO:0005178   GO:0005925   GO:0016477   GO:0008305   GO:0033627   GO:0009986   GO:0007160   GO:0045886   GO:0046982   GO:0035011   GO:0046716   GO:0043277   GO:0016740   GO:0006909   GO:0007157  

PANTHER

PTHR10082  

Subcellular location

Membrane  

SignalP

Position:   1 - 21,         Likelihood:  0.867072

 

 

Length:

812

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.6481

Exp number, first 60 AAs:

1.04842

Total prob of N-in:

0.05703

outside

1  -  737

TMhelix

738  -  760

inside

761  -  812

 

 

Pi

232.533341

Theta

182.568122

Tajima's D

0.630634

CLR

0.303409

CSRT

0.550472476376181

Interpretation

Uncertain