Gene

KWMTBOMO01346  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009000

Annotation

PREDICTED:_succinate_dehydrogenase_[ubiquinone]_flavoprotein_subunit?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr3(-):8378598-8397526      View in EpiBrowser

Full name

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial       + More
Succinate dehydrogenase (quinone)      

Alternative Name

Flavoprotein subunit of complex II
Succinyl coenzyme A synthetase flavoprotein subunit

Location in the cell

Mitochondrial   Reliability : 2.997

CDS

ATGAGTGCATTAATGAAAGCGGCAGTTTCCCGCAGTCCTGCGTCACTGGCATCATACTTATATAGAAATATTCACGTGGCTGCTTCTGGTGCTACTTCTAAAGATGCTTCAGTTACAACAAATATGACTAAAGCATACACAGTAATTGACCACAAACATGATGCATTAGTTATTGGGGCTGGTGGAGCAGGACTTCGAGCAGCCTTTGGTCTTGTCCAAGAAGGATTTAAAACTGCTGTCGTAACTAAGTTGTTCCCTACAAGATCACATACTGTTGCTGCACAGGGTGGAATTAATGCTGCTTTGGGAAACATGGAGGAAGACAGTTGGCTCTGGCATATGTATGACACAGTTAAAGGTTCCGACTGGCTTGGAGATCAGGATGCCATTCACTACATGACTAAAGAAGCGCCTCATGCAGTAATCGAACTGGACAACTACGGAATGCCATTCTCCCGCACCCCGGAGGGAAAGATTTACCAGAGGGCCTTCGGAGGACAGTCTCTCAAGTTCGGAAAGGGAGGACAAGCTCATAGATGCTGCGCCGTAGCTGACAGAACCGGGCACTCCCTCCTTCACACGCTGTACGGCCAATCACTCCGCTACGACTGCGAATACTTCATCGAGTATTTCGCTCTCGATTTGCTAATGGAAGACGGAGTCTGCAAGGGATGCATCGCCATCAATCTCGAAGACGGAACACTGCACAGGTTCCAAGCGAAGAATACGATCTTGGCCACGGGAGGCACCGGCCGCTCATACTTCAGTTGCACGTCGGCGCACACCTGCACAGGGGACGGCACCGCCATGGCCGCTCGAGTCGGTCTGCAGAACGAGGATATGGAGTTTGTGCAGTTCCATCCAACTGGTATCTACGGCGCCGGTTGCCTGATGACCGAGGGTTGTCGTGGCGAGGGCGGCTTCCTGGTCAACTCGAAGGGCGAACGGTTCATGGAACGTTACGCGCCCGTCGCCAAGGACCTGGCCAGTCGAGACGTGGTCTCGCGTGCTATGACGGTTGAAATTATGGAAGGTCGCGGTTGCGGCCCGGAGAAGGACCACGTTCACCTACAGTTGCACCACCTGCCTCCCGAACAACTGAAGCAGCGTCTGCCTGGCATCTCGGAGACGGCCATGATCTTCGCTGGGGTCGACGTCACTAAGGAACCCATTCCTGTGCTACCGACAGTGCACTATAATATGGGTGGTACTCCCACCAATTTCCGCGGGGAGGTGATCACGCACCGTGGCGGCGCGGACCGCGTGGTGGCGGGGCTGCTGGCGGCGGGCGAGGCGTCGTGCGCCAGCGTGCACGGCGCCAACCGGCTGGGCGCCAACTCGCTGCTGGACATCGTGGTGTTCGGCCGCGCCTGCGCACTCACCGTGGCCGACACGGCGCGCCCCGGGGACCCGCAGCCGCCGCTCGCGCCCACAACGGGCGAGGCGAGCATTGCCAACTTGGACAGCATCAGATACGCCAATGGTTCGATCTCTACAGCCGACCTTAGACTTAGAATGCAAAAATGCATGCAGAAGAATGCCGCCGTCTTTAGACAGAAGAGCACCTTGGAGGAAGGTCAACGTCAAATTCACGAGATCTACAAGCAGATAAAAGACGTGAAGGTGTCCGACCGGTCCTTGATCTGGAACAGTGATCTAGTGGAGACGCTGGAGCTTCAGAATCTTCTCATCAACTCGGTACAGATCGTGGAGGGAGCACTGGCGCGGGAGGAGTCGCGCGGAGCCCACGCCCGAGAGGACTTCAAGACCAGACGCGACGAGTACGACTACTCTAAACCTCTCGAGGGACAGAGTAAGTTGCCGTTCGAGCAGCACTGGAGGAAGCACACGCTCGCCGAGACGGACCCCGCGACCGGCGACACGCGCCTCACCTACCGCCCCGTCATCGACCGCACGCTCGACGCCGCCGAGTGCAGCACCGTGCCGCCCGTCATCCGCACCTACTAG

Protein

MSALMKAAVSRSPASLASYLYRNIHVAASGATSKDASVTTNMTKAYTVIDHKHDALVIGAGGAGLRAAFGLVQEGFKTAVVTKLFPTRSHTVAAQGGINAALGNMEEDSWLWHMYDTVKGSDWLGDQDAIHYMTKEAPHAVIELDNYGMPFSRTPEGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLRYDCEYFIEYFALDLLMEDGVCKGCIAINLEDGTLHRFQAKNTILATGGTGRSYFSCTSAHTCTGDGTAMAARVGLQNEDMEFVQFHPTGIYGAGCLMTEGCRGEGGFLVNSKGERFMERYAPVAKDLASRDVVSRAMTVEIMEGRGCGPEKDHVHLQLHHLPPEQLKQRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGTPTNFRGEVITHRGGADRVVAGLLAAGEASCASVHGANRLGANSLLDIVVFGRACALTVADTARPGDPQPPLAPTTGEASIANLDSIRYANGSISTADLRLRMQKCMQKNAAVFRQKSTLEEGQRQIHEIYKQIKDVKVSDRSLIWNSDLVETLELQNLLINSVQIVEGALAREESRGAHAREDFKTRRDEYDYSKPLEGQSKLPFEQHWRKHTLAETDPATGDTRLTYRPVIDRTLDAAECSTVPPVIRTY

Description

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.

Catalytic Activity

a quinone + succinate = a quinol + fumarate

Cofactor

FAD

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Similarity

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Keywords

Complete proteome   Electron transport   FAD   Flavoprotein   Membrane   Mitochondrion   Mitochondrion inner membrane   Oxidoreductase   Reference proteome   Transit peptide   Transport   Tricarboxylic acid cycle  

Feature

chain  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Uniprot

H9JHK2   A0A2W1BZK9   A0A212FEF5   M9VDW9   A0A1Q3FY45   A0A182KAN5   + More
A0A1Q3FY46   A0A1Q3FY53   A0A1Q3FY78   A0A182LN92   Q7QDV0   A0A182WR96   A0A182MA54   A0A182NDK7   A0A182ULS7   A0A182HX90   A0A084VTQ4   A0A182YLX1   A0A096ZN66   A0A182W3S5   A0A2M4BGH8   A0A182PVF3   A0A182Q1E1   A0A2M3ZFY9   W5JUV9   A0A182RBD4   A0A182FM31   A0A2M4A5Q6   A0A0A9XPU2   A0A182J2T0   A0A2M4A5S3   A0A2J7Q925   A0A182GZD1   A0A1B6JXD6   U5ELV7   R4WJV3   A0A1B0CLP4   B0WFX7   A0A1L8E0S2   A0A0K2UW91   B4MYF9   A0A0M3QV67   T1E1E5   A0A2D1QW02   B4GDN2   E2AMC7   A0A182TQ59   Q292E4   A0A0J7L7M0   A0A1D2MTD8   A0A1B6E5X9   Q16SE4   A0A3B0J5Z3   A0A1I8Q5A7   T1PAV8   A0A0J9RGM7   B3NJU5   B4PBL8   Q94523   A0A0P5KK93   A0A023EV92   A0A1W4WNT7   B4LJP8   A0A0P5D600   A0A1W4VHE0   A0A336LMK4   A0A0P5AIL3   A0A0P5AEN9   A0A0P5Z0V4   B4JW44   D6WVS3   E2B4M1   A0A3Q0IHL7   A0A0P4WYF9   B4KT93   A0A0P5AMF6   A0A023FCI3   A0A1W0X758   A0A0P4WTD1   A0A0L0BSS9   A0A0P5UMW0   A0A0P5SMH2   A0A0P4WMI9   A0A0P5T1B1   K7ITI9   T1IC04   A0A0P5BVR8   A0A026VYM8   A0A0P6BER3   A0A0P5SY40   F4X086   A0A2I0MWU9   A0A0P5T6T1   B3MGG8   A0A1V4J9E3   A0A0P4ZXE5   A0A099ZDT3   A0A093QLW7   A0A218VA71   H0ZD78  

EC Number

1.3.5.1

Pubmed

19121390    28756777    22118469    20966253    12364791    14747013    + More
17210077    24438588    25244985    20920257    23761445    25401762    26823975    26483478    23691247    17994087    18057021    24330624    20798317    15632085    23185243    27289101    17510324    25315136    22936249    17550304    10731132    12537572    12537569    10071211    15693940    18599508    24945155    18362917    19820115    25474469    26108605    20075255    24508170    30249741    21719571    23371554    20360741   

EMBL

BABH01012716    BABH01012717    KZ149894    PZC78885.1    AGBW02008935    OWR52136.1    + More
KC161216    AGJ76544.1    GFDL01002556    JAV32489.1    GFDL01002555    JAV32490.1    GFDL01002551    JAV32494.1    GFDL01002549    JAV32496.1    AAAB01008849    EAA07202.4    AXCM01000168    APCN01005154    ATLV01016449    KE525091    KFB41348.1    KM098145    AIS22434.1    GGFJ01003028    MBW52169.1    AXCN02001756    GGFM01006662    MBW27413.1    ADMH02000002    ETN68137.1    GGFK01002760    MBW36081.1    GBHO01021610    GBRD01008830    GDHC01008054    JAG21994.1    JAG56991.1    JAQ10575.1    GGFK01002780    MBW36101.1    NEVH01016943    PNF25089.1    JXUM01099388    KQ564488    KXJ72205.1    GECU01003842    JAT03865.1    GANO01001255    JAB58616.1    AK417890    BAN21105.1    AJWK01017478    AJWK01017479    AJWK01017480    AJWK01017481    AJWK01017482    AJWK01017483    DS231921    EDS26512.1    GFDF01001754    JAV12330.1    HACA01024595    CDW41956.1    CH963894    EDW77148.1    KRF98587.1    CP012524    ALC41853.1    GALA01001749    JAA93103.1    KY027056    ATP16742.1    CH479181    EDW31689.1    GL440811    EFN65418.1    CM000071    EAL24918.1    KRT01692.1    LBMM01000341    KMR00218.1    LJIJ01000544    ODM96389.1    GEDC01003948    JAS33350.1    CH477675    EAT37381.1    OUUW01000001    SPP75142.1    KA645063    AFP59692.1    CM002911    KMY95086.1    CH954179    EDV55204.1    CM000158    EDW91502.1    AE013599    AY051472    BT099627    Y09064    GDIQ01184056    JAK67669.1    GAPW01000570    JAC13028.1    CH940648    EDW60557.1    KRF79479.1    GDIP01165779    JAJ57623.1    UFQS01000020    UFQT01000020    SSW97497.1    SSX17883.1    GDIP01198727    JAJ24675.1    GDIP01200173    JAJ23229.1    GDIP01128530    GDIP01100377    GDIP01076396    GDIP01051749    GDIP01049839    GDIP01043236    LRGB01000626    JAM51966.1    KZS17456.1    CH916375    EDV98182.1    KQ971358    EFA09226.1    GL445574    EFN89374.1    GDIP01253170    JAI70231.1    CH933808    EDW10605.1    GDIP01196730    JAJ26672.1    GBBI01000219    JAC18493.1    MTYJ01000013    OQV23244.1    GDIP01253413    JAI69988.1    JRES01001422    KNC23038.1    GDIP01110780    JAL92934.1    GDIP01137932    JAL65782.1    GDIP01253314    JAI70087.1    GDIP01139137    GDIP01131546    JAL64577.1    ACPB03004429    GDIP01194428    JAJ28974.1    KK107566    QOIP01000006    EZA48877.1    RLU21947.1    GDIP01015918    JAM87797.1    GDIP01136425    JAL67289.1    GL888493    EGI60151.1    AKCR02000001    PKK34158.1    GDIP01130188    JAL73526.1    CH902619    EDV35711.1    KPU75792.1    LSYS01008581    OPJ68407.1    GDIP01210021    JAJ13381.1    KL891806    KGL79173.1    KL672903    KFW87390.1    MUZQ01000018    OWK62965.1    ABQF01022872   

Proteomes

UP000005204    UP000007151    UP000075881    UP000075882    UP000007062    UP000076407    + More
UP000075883    UP000075884    UP000075903    UP000075840    UP000030765    UP000076408    UP000075920    UP000075885    UP000075886    UP000000673    UP000075900    UP000069272    UP000075880    UP000235965    UP000069940    UP000249989    UP000092461    UP000002320    UP000007798    UP000092553    UP000008744    UP000000311    UP000075902    UP000001819    UP000036403    UP000094527    UP000008820    UP000268350    UP000095300    UP000095301    UP000008711    UP000002282    UP000000803    UP000192223    UP000008792    UP000192221    UP000076858    UP000001070    UP000007266    UP000008237    UP000079169    UP000009192    UP000037069    UP000002358    UP000015103    UP000053097    UP000279307    UP000007755    UP000053872    UP000007801    UP000190648    UP000053641    UP000053258    UP000197619    UP000007754   

PRIDE

H9JHK2    Q94523   

Pfam

PF00890   FAD_binding_2        + More
PF02910   Succ_DH_flav_C

Interpro

IPR003953   FAD-binding_2        + More
IPR015939   Fum_Rdtase/Succ_DH_flav-like_C       
IPR014006   Succ_Dhase_FrdA_Gneg       
IPR027477   Succ_DH/fumarate_Rdtase_cat_sf       
IPR037099   Fum_R/Succ_DH_flav-like_C_sf       
IPR011281   Succ_DH_flav_su_fwd       
IPR036188   FAD/NAD-bd_sf       
IPR003952   FRD_SDH_FAD_BS       

SUPFAM

SSF51905   SSF51905        + More
SSF46977   SSF46977       
SSF56425   SSF56425       

Gene 3D

3.50.50.60     3.90.700.10    

ProteinModelPortal

H9JHK2   A0A2W1BZK9   A0A212FEF5   M9VDW9   A0A1Q3FY45   A0A182KAN5   + More
A0A1Q3FY46   A0A1Q3FY53   A0A1Q3FY78   A0A182LN92   Q7QDV0   A0A182WR96   A0A182MA54   A0A182NDK7   A0A182ULS7   A0A182HX90   A0A084VTQ4   A0A182YLX1   A0A096ZN66   A0A182W3S5   A0A2M4BGH8   A0A182PVF3   A0A182Q1E1   A0A2M3ZFY9   W5JUV9   A0A182RBD4   A0A182FM31   A0A2M4A5Q6   A0A0A9XPU2   A0A182J2T0   A0A2M4A5S3   A0A2J7Q925   A0A182GZD1   A0A1B6JXD6   U5ELV7   R4WJV3   A0A1B0CLP4   B0WFX7   A0A1L8E0S2   A0A0K2UW91   B4MYF9   A0A0M3QV67   T1E1E5   A0A2D1QW02   B4GDN2   E2AMC7   A0A182TQ59   Q292E4   A0A0J7L7M0   A0A1D2MTD8   A0A1B6E5X9   Q16SE4   A0A3B0J5Z3   A0A1I8Q5A7   T1PAV8   A0A0J9RGM7   B3NJU5   B4PBL8   Q94523   A0A0P5KK93   A0A023EV92   A0A1W4WNT7   B4LJP8   A0A0P5D600   A0A1W4VHE0   A0A336LMK4   A0A0P5AIL3   A0A0P5AEN9   A0A0P5Z0V4   B4JW44   D6WVS3   E2B4M1   A0A3Q0IHL7   A0A0P4WYF9   B4KT93   A0A0P5AMF6   A0A023FCI3   A0A1W0X758   A0A0P4WTD1   A0A0L0BSS9   A0A0P5UMW0   A0A0P5SMH2   A0A0P4WMI9   A0A0P5T1B1   K7ITI9   T1IC04   A0A0P5BVR8   A0A026VYM8   A0A0P6BER3   A0A0P5SY40   F4X086   A0A2I0MWU9   A0A0P5T6T1   B3MGG8   A0A1V4J9E3   A0A0P4ZXE5   A0A099ZDT3   A0A093QLW7   A0A218VA71   H0ZD78  

PDB

2WQY     E-value=0,     Score=2377

KEGG

101735811    K00234 succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] | (RefSeq) succinate d

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005743   GO:0008177   GO:0022900   GO:0050660   GO:0006099   GO:0006121   GO:0000104   GO:0009055   GO:0005749   GO:0045282   GO:0016020   GO:0005739   GO:0016491   GO:0016627   GO:0016820   GO:0016042   GO:0005634   GO:0006334   GO:0003779   GO:0016021   GO:0055114  

Subcellular location

Mitochondrion inner membrane  

Length:

655

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0871899999999999

Exp number, first 60 AAs:

0.03039

Total prob of N-in:

0.00472

outside

1  -  655

 

 

Pi

206.887721

Theta

172.53391

Tajima's D

1.180786

CLR

0.095668

CSRT

0.713064346782661

Interpretation

Uncertain