Gene

KWMTBOMO01344  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008892

Annotation

PREDICTED:_iron-sulfur_cluster_assembly_2_homolog?_mitochondrial_[Amyelois_transitella]

Location

Bomo_Chr3(+):8366897-8369642      View in EpiBrowser

Full name

Iron-sulfur cluster assembly 2 homolog, mitochondrial      

Alternative Name

HESB-like domain-containing protein 1

Location in the cell

Nuclear   Reliability : 2.266

CDS

ATGTTTTTACGTTTTAGAAATTTACACCAGTTAAAAAAGTTTGTTAATGTAAACACATTAAACAAAAGATTCTCCCAAGAACCAGCAACTTCTGTTTCAAGTACAGATATCAGTATTAGTGACAATTGTGTACAAAAATTAAAAGAATTATGTAAAGAAAACGATACCTTTCTGAGGCTTTGTGTAGAAAGTGGTGGATGCTCTGGATTCCAGTATAAATTCAACTTAGACAATGTTGTTGATAGTGATGACAGGATATTTGAAAAAAATGGTGTCAAAGTGGTGGTTGATGAGACGTCACTTGAGTATATTAAAGGTTCAACAATAGATTATCACACTGAACTTATTAGGTCTGCTTTCCGAGTGCAACAGAACCCAAATGCAGATATAGGTTGCTCTTGCGGTGCTAGTTTTTCTATAAAAATTGATTGA

Protein

MFLRFRNLHQLKKFVNVNTLNKRFSQEPATSVSSTDISISDNCVQKLKELCKENDTFLRLCVESGGCSGFQYKFNLDNVVDSDDRIFEKNGVKVVVDETSLEYIKGSTIDYHTELIRSAFRVQQNPNADIGCSCGASFSIKID

Description

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.

Similarity

Belongs to the HesB/IscA family.

Keywords

Alternative splicing   Complete proteome   Disease mutation   Iron   Iron-sulfur   Metal-binding   Mitochondrion   Primary mitochondrial disease   Reference proteome   Transit peptide  

Feature

chain  Iron-sulfur cluster assembly 2 homolog, mitochondrial
splice variant  In isoform 2.
sequence variant  In MMDS4; dbSNP:rs730882246.

Uniprot

H9JH95   A0A212FEH2   A0A2W1C053   A0A2H1WQ37   A0A0P4WKA7   A0A232EWM8   + More
K7J3W4   A0A0N0U766   A0A0L7R7F6   A0A2T7NYK1   A0A151HZX2   E1ZVH5   A0A2A3ECD0   A0A088AFN0   A0A3M6TF45   A0A195CGG2   F4WYY5   A0A195EBE9   A0A151WFJ3   A0A195F964   A0A2J7PR06   E2BPH3   V4BFF7   A0A026WZ53   J9KAR5   A0A067RJ57   U4UL75   W4ZE95   A0A0J7L919   A0A2H8TF64   A0A2B4SKM6   A0A0C9QV68   J3JYI5   N6T541   A0A139WEV1   A0A1S4EDR9   A0A1X7VN15   A0A2R7W9J4   A0A1S4EDZ6   A0A182HR10   A0A182W8H7   A0A182XH88   Q7Q0Y4   A0A182U397   Q175J2   A0A1S4MWS8   A0A182R1Q2   A0A2S2PFF4   A0A0B6ZSG6   A0A182YQN7   A0A023EG68   A0A182PZS8   B0XLT2   A0A1B6JJ07   A0A182PVP5   A0A182NNS1   A0A0P4VWC1   R4G7R2   A0A1I7Z332   A0A1Y1N8M1   A0A034WQ22   A0A182G0U2   A0A2L1K407   A0A1B6KVV3   A0A2M4C349   A0A1B6EKB2   A0A1D1UI87   A0A1Q3FK48   D4A4L5   A0A1I8MJR8   T1F9C1   A0A0K8UYV4   W5JGC6   F1RBD9   A0A0K8UB87   A0A1J1III5   A0A1I8QBK6   X1WF43   G1KSM7   G3I937   A0A2R8ZSR6   H2R991   A0A2K6CN30   A0A2K6M2I5   A0A2K5U1X3   A0A2K5YIN1   A0A2K6P5Q3   H9EW17   G3SGX5   J9P4R1   Q86U28   A0A2M4AR78   A0A2K5K4R1   A0A096NUJ9   A0A0V0GC83  

Pubmed

19121390    22118469    28756777    28648823    20075255    20798317    + More
30382153    21719571    23254933    24508170    30249741    24845553    23537049    22516182    18362917    19820115    12364791    14747013    17210077    17510324    20566863    25244985    24945155    27129103    26392177    28004739    25348373    26483478    27649274    15057822    15632090    25315136    20920257    23761445    23594743    21804562    22722832    16136131    25362486    17431167    25319552    22398555    16341006    14702039    12508121    15489334    21269460    22323289    23186163    24275569    25539947    25944712   

EMBL

BABH01012718    AGBW02008935    OWR52134.1    KZ149894    PZC78887.1    ODYU01010210    + More
SOQ55173.1    GDRN01030148    JAI67572.1    NNAY01001838    OXU22754.1    AAZX01005146    KQ435710    KOX79828.1    KQ414642    KOC66774.1    PZQS01000008    PVD26257.1    KQ976642    KYM78691.1    GL434534    EFN74812.1    KZ288301    PBC28859.1    RCHS01003769    RMX39844.1    KQ977873    KYM99173.1    GL888463    EGI60639.1    KQ979236    KYN22164.1    KQ983211    KYQ46597.1    KQ981727    KYN37145.1    NEVH01022633    PNF18771.1    GL449633    EFN82377.1    KB202849    ESO87649.1    KK107061    QOIP01000014    EZA61340.1    RLU14744.1    ABLF02035565    KK852653    KDR19361.1    KDR19363.1    KB632263    ERL90911.1    AAGJ04060801    LBMM01000164    KMR04676.1    GFXV01000914    MBW12719.1    LSMT01000066    PFX29420.1    GBYB01007644    JAG77411.1    BT128313    AEE63271.1    APGK01052223    KB741211    ENN72778.1    KQ971354    KYB26466.1    KK854495    PTY16356.1    APCN01001630    AAAB01008980    EAA14541.4    CH477400    EAT41726.1    EAT41727.1    EAT41728.1    AAZO01006252    GGMR01015551    MBY28170.1    HACG01023835    CEK70700.1    GAPW01005742    JAC07856.1    AXCN02001979    DS234730    EDS34908.1    GECU01008532    JAS99174.1    GDKW01002694    JAI53901.1    ACPB03011086    GAHY01002277    JAA75233.1    GEZM01009840    JAV94272.1    GAKP01003094    JAC55858.1    JXUM01135268    KQ568246    KXJ69085.1    KY827231    AVE16220.1    GEBQ01024404    JAT15573.1    GGFJ01010538    MBW59679.1    GECZ01031405    JAS38364.1    BDGG01000001    GAU89429.1    GFDL01007054    JAV27991.1    AC113727    CH473982    EDL81531.1    AMQM01005305    KB096900    ESO00543.1    GDHF01020543    JAI31771.1    ADMH02001289    ETN63141.1    CR759765    GDHF01028410    JAI23904.1    CVRI01000051    CRK99578.1    JH001565    EGW12998.1    AJFE02085031    AACZ04008420    GABC01010506    GABF01008229    GABE01009231    NBAG03000214    JAA00832.1    JAA13916.1    JAA35508.1    PNI84250.1    AQIA01065493    JSUE03040072    JU322820    JU474273    AFE66576.1    AFH31077.1    CABD030093219    AAEX03005849    BX248252    AK290728    AC005479    CH471061    BC015771    BC032893    GGFK01009901    MBW43222.1    AHZZ02032425    GECL01000458    JAP05666.1   

Proteomes

UP000005204    UP000007151    UP000215335    UP000002358    UP000053105    UP000053825    + More
UP000245119    UP000078540    UP000000311    UP000242457    UP000005203    UP000275408    UP000078542    UP000007755    UP000078492    UP000075809    UP000078541    UP000235965    UP000008237    UP000030746    UP000053097    UP000279307    UP000007819    UP000027135    UP000030742    UP000007110    UP000036403    UP000225706    UP000019118    UP000007266    UP000079169    UP000007879    UP000075840    UP000075920    UP000076407    UP000007062    UP000075902    UP000008820    UP000075900    UP000076408    UP000075886    UP000002320    UP000075885    UP000075884    UP000015103    UP000095287    UP000069940    UP000249989    UP000186922    UP000002494    UP000095301    UP000015101    UP000000673    UP000000437    UP000183832    UP000095300    UP000001646    UP000001075    UP000240080    UP000002277    UP000233120    UP000233180    UP000233100    UP000233140    UP000233200    UP000006718    UP000001519    UP000002254    UP000005640    UP000233080    UP000028761   

PRIDE

H9JH95    D4A4L5    Q86U28   

Pfam

PF01521   Fe-S_biosyn

Interpro

IPR000361   FeS_biogenesis        + More
IPR035903   HesB-like_dom_sf       
IPR016092   FeS_cluster_insertion       
IPR017870   FeS_cluster_insertion_CS       

SUPFAM

SSF89360   SSF89360       

Gene 3D

2.60.300.12    

ProteinModelPortal

H9JH95   A0A212FEH2   A0A2W1C053   A0A2H1WQ37   A0A0P4WKA7   A0A232EWM8   + More
K7J3W4   A0A0N0U766   A0A0L7R7F6   A0A2T7NYK1   A0A151HZX2   E1ZVH5   A0A2A3ECD0   A0A088AFN0   A0A3M6TF45   A0A195CGG2   F4WYY5   A0A195EBE9   A0A151WFJ3   A0A195F964   A0A2J7PR06   E2BPH3   V4BFF7   A0A026WZ53   J9KAR5   A0A067RJ57   U4UL75   W4ZE95   A0A0J7L919   A0A2H8TF64   A0A2B4SKM6   A0A0C9QV68   J3JYI5   N6T541   A0A139WEV1   A0A1S4EDR9   A0A1X7VN15   A0A2R7W9J4   A0A1S4EDZ6   A0A182HR10   A0A182W8H7   A0A182XH88   Q7Q0Y4   A0A182U397   Q175J2   A0A1S4MWS8   A0A182R1Q2   A0A2S2PFF4   A0A0B6ZSG6   A0A182YQN7   A0A023EG68   A0A182PZS8   B0XLT2   A0A1B6JJ07   A0A182PVP5   A0A182NNS1   A0A0P4VWC1   R4G7R2   A0A1I7Z332   A0A1Y1N8M1   A0A034WQ22   A0A182G0U2   A0A2L1K407   A0A1B6KVV3   A0A2M4C349   A0A1B6EKB2   A0A1D1UI87   A0A1Q3FK48   D4A4L5   A0A1I8MJR8   T1F9C1   A0A0K8UYV4   W5JGC6   F1RBD9   A0A0K8UB87   A0A1J1III5   A0A1I8QBK6   X1WF43   G1KSM7   G3I937   A0A2R8ZSR6   H2R991   A0A2K6CN30   A0A2K6M2I5   A0A2K5U1X3   A0A2K5YIN1   A0A2K6P5Q3   H9EW17   G3SGX5   J9P4R1   Q86U28   A0A2M4AR78   A0A2K5K4R1   A0A096NUJ9   A0A0V0GC83  

PDB

1NWB     E-value=7.86232e-18,     Score=215

KEGG

101736064    K22072 iron-sulfur cluster assembly 2 | (RefSeq) iron-sulfur assembly protein IscA-like 2, mitochond

GO

GO:0051536   GO:0005198   GO:0097428   GO:0016226   GO:0106035   GO:0051604   GO:0051539   GO:0051537   GO:0005739   GO:0005506   GO:0005759   GO:0044281   GO:0016020   GO:0016820   GO:0016042   GO:0005634   GO:0006334   GO:0003779   GO:0016021  

Subcellular location

Mitochondrion  

Length:

143

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10992

outside

1  -  143

 

 

Pi

198.350245

Theta

187.137756

Tajima's D

0.35125

CLR

0.323666

CSRT

0.464726763661817

Interpretation

Uncertain