Gene

KWMTBOMO01332

Pre Gene Modal

BGIBMGA008885

Annotation

PREDICTED:_protein_smoothened_isoform_X1_[Papilio_machaon]

Location

Bomo_Chr3(+):8077265-8088249      View in EpiBrowser

Full name

Protein smoothened      

Alternative Name

SMOH
Smooth
dSMO

Location in the cell

PlasmaMembrane   Reliability : 4.914

CDS

ATGATCTTGACGTGGACGCGGTGGCTGCTCGTCTTGTCATCATGTCGCGGGAGTCATTTCGATTCTGGCAGCGACAAAAACTTATTAGTGGACTTAAAGGAAAACGTCACCGTTCACCTTGAAGCGATTAACGGGACCCCAATTTACAGATTAATAAGACCAGACGAAAGTACACAATGGTTTCCGGAACGAGAAACGAAAATGAATAGTTGTGTGATGAGGGCCCGCTGTGAACCGCTTTTTAATTCCACGTGCCTCGGGTCGATACTTCCATATAGTAAAACAAGCGTGCACTTGACGTTCTACAATAGTCAGCGGCAAATACAGAACCAACTAGAGTTTTATAAAAATTTAATCAATGTACCCAATTGTTGGGCCGTTATCCAACCCTTGCTTTGTGCGACTTTCATGCCGAAATGTGAGAAAATACTAGATCACGATATGGTATATATGCCTTCGTTCGAGATGTGCAAAATAACAATGGAACCGTGCGCTATCCTCTATAACACTTCGTATTTTCCTTCTTTTCTCAAATGCAACACAACATTGTTTCCGCCGAATTGTGATAATGCCATGAGAGAGGTTAAATTTAATACAACCGGAAAATGTTTACCGCCCCTAATACACACGGACAAGTCCTTGCGCGTCTACGAAGGTATTACCGGTTGCGGGTTGCCGTGTCGTGACCCGTTGTATACTGAAGATGAACATCAACAAATACATAAACTGGTAGCCTGGGGCGCCGGTGTGTGTCTGGCCTTAAACCTGTTGACCGTAGCCACGTTCCTCATAGACTGGCGGAGTGCTAACAAATATCCCGCATTAGTTATATTTTATATCAACGTGTGTTTCGCTGTTGCATCAATGGGTTGGCTTGTTCAATTCGGTGTCGGCTCAAGAGACGATATAGTTTGCTCCAAAGATGGCACTAGACGACAAGGGGAGCCATCGGCCGAAGAAAATTTATTTTGCGTTGTCGTATTCGTTTTGGTTTATTATTTTATGATGGCAGCCTGCGTCTGGTTCGTTATATTCACGTACGCTTGGCACATGTGTAGTTTTCGAGCTTTGGGTAAAATACAAGATCGTATTGACAAGAAAGCTGCGTATTTCCACCTGGTGGCGTGGTCTCTCCCTTTGATATTAACGATAACAACAATGGCGTTCGGAGAAGTGGACGGGAGCAGCGTCACGGGCGTGTGCTTCGTCGGCTACGTGAACCATCCCATGCGCGCCGCCTTGTTGCTCGCGCCGCTGGCTGTCGTGCTTACTTTAGGCGGATATTTTCTTTTAAGAGGCGTATTTTCCCTTGTCGTGGTCCGAGTGTCGAGTAAAGACGTGATATCTCCGCGAGCCTCAAACAAGATCCGCCGTACGATCACGCGGTGCTCCATCACGGCGGCGCTGGTGGCCGTCTTCATCTGCGTCACGTTCGCTTGTCACATCTACGAGTTCAGGAATGCAGACCTTTGGAAAGACTCATTCAAGAGGAATATCATCTGTCGACTAGAAGCTGGTCAAGAAAGGCAGAAGGAATGTTTGACGGGCTCTCGTCCCTCGATATCTGTGCTGCAGCTGCGACTGCTGTGTTGCTTCGCTGCCGGTGCACTCATGTCCTCGTGGACCTGGACGCCGGCTGCCCTCGCCGCCTGGAGACGATATCTGGCCAGGAAATGTGGATGCTCCGTTGATGAGGAAATAACTCGTCGCGCACAAAAGCACGAGTTGATACGTCGAGCCTACAGACGCCGCGCGGAGTTCGCGGCCCGCGGACGGCTCTCCATATCTCTGGGCGGCTCCAGACAAGATCCCGTTGGGCTGTGTCTGGATCACACCTCTCCGATCGATTACCCGGAAGATGCGAAACATGAAAGCGGTGAATTGTCGTCGTCGTGGGCGGCCAACCTGCCGCGGTTCGTGCGGCGCCGCGACGCGCTCGTGTTGCCCGCGCACGCGCACCCGCACCACTCGCTCAGCTCCACGCCGGACCGACGCAACTCGCAGGACTCTCAGATCAGCATCAGCCTACGACACGTGTCCGTAGAATCTCGCCGCAACTCACTCGACAGTCAGCTCTCGGTGAAGATCGCCGAGATGAAAACCAAAGTCGGTCGCCGCCGAACCAAACATACCAAAGCGAAACGTAAACGGGCCACCGGGCCCCGCAAGGAGAGCACGCCTTCCATCGAGAGTCAAATAAGCCGCTATTGGCTGCAGGCCGTCGCGGCTAACAACGATCGCTCCAGAGAAGAAGTCAAATTCAGCTTTGAATGA

Protein

MILTWTRWLLVLSSCRGSHFDSGSDKNLLVDLKENVTVHLEAINGTPIYRLIRPDESTQWFPERETKMNSCVMRARCEPLFNSTCLGSILPYSKTSVHLTFYNSQRQIQNQLEFYKNLINVPNCWAVIQPLLCATFMPKCEKILDHDMVYMPSFEMCKITMEPCAILYNTSYFPSFLKCNTTLFPPNCDNAMREVKFNTTGKCLPPLIHTDKSLRVYEGITGCGLPCRDPLYTEDEHQQIHKLVAWGAGVCLALNLLTVATFLIDWRSANKYPALVIFYINVCFAVASMGWLVQFGVGSRDDIVCSKDGTRRQGEPSAEENLFCVVVFVLVYYFMMAACVWFVIFTYAWHMCSFRALGKIQDRIDKKAAYFHLVAWSLPLILTITTMAFGEVDGSSVTGVCFVGYVNHPMRAALLLAPLAVVLTLGGYFLLRGVFSLVVVRVSSKDVISPRASNKIRRTITRCSITAALVAVFICVTFACHIYEFRNADLWKDSFKRNIICRLEAGQERQKECLTGSRPSISVLQLRLLCCFAAGALMSSWTWTPAALAAWRRYLARKCGCSVDEEITRRAQKHELIRRAYRRRAEFAARGRLSISLGGSRQDPVGLCLDHTSPIDYPEDAKHESGELSSSWAANLPRFVRRRDALVLPAHAHPHHSLSSTPDRRNSQDSQISISLRHVSVESRRNSLDSQLSVKIAEMKTKVGRRRTKHTKAKRKRATGPRKESTPSIESQISRYWLQAVAANNDRSREEVKFSFE

Subunit

Interacts with cos.

Similarity

Belongs to the G-protein coupled receptor Fz/Smo family.

Keywords

3D-structure   Cell membrane   Complete proteome   Developmental protein   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Phosphoprotein   Receptor   Reference proteome   Signal   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Protein smoothened

Uniprot

A0A2W1BX54   A0A2A4JX22   A0A2A4JY61   A0A437AUY0   A0A212EQ67   A0A194RLP0   + More
A0A194PVF9   A0A0L7LBB5   S4PKF0   A0A182YN57   Q175G5   A0A182RK65   A0A182TC12   A0A182MEB3   A0A182ILD3   A0A182GWI8   A0A182WFH4   A0A182HAH8   A0A182Q336   A0A084WFW9   A0A182P4A0   B0W046   A0A182F3D6   A0A182JRB6   A0A182MZ95   W5JQ90   A0A182VLW4   A0A1W4UQJ6   E5LCE7   A0A2Y9D159   A0A182X5X6   Q86PA9   D0QWD4   P91682   Q29NW6   B4GJP7   A0A182UA20   B4Q616   B4P2B8   B3N7N0   A0A0R1DIH5   B4ICU6   A0A0A1WQ87   B4MWJ5   A0A182KN72   A0A336K3M0   A0A3B0K8N5   A0A3B0JIG0   B4LU52   A0A1B0C9F1   B4JBG2   B3MUK2   A0A0K8UBW1   B4KHG7   A0A1I8PGR5   A0A1I8MLM7   A0A1S4GZI7   A0A0M4E766   Q7PPM7   A0A1A9WK74   A0A1I8MLM6   A0A1B0FJK7   A0A1B0AUL6   A0A1A9XQH4   A0A1A9UTD6   A0A1J1IML9   A0A2J7Q946   A0A2A3EJV5   A0A088APW7   A0A0L7R8D6   A0A154NZZ6   A0A0N0U309   T1HLP2   A0A224X7Q2   A0A023F248   A0A0K8TV70   E2B9T9   A0A158NQM4   A0A195D3P5   U5EP59   A0A195ERS4   A0A195BQZ3   A0A195DI48   F4WKG2   A0A151XB26   E2AN13   A0A0K8S5C7   A0A0A9ZEX8   A0A2R7WCF9   A0A034VSR5   A0A1Y1LLJ7   A0A1Y1LJ79   A0A232EKC5   K7IPU4   A0A026WDQ6   A0A067RTB7   A0A1B6DDX7   D6WXL7  

Pubmed

28756777    22118469    26354079    26227816    23622113    25244985    + More
17510324    26483478    24438588    20920257    23761445    19859648    8706127    8700230    10731132    12537572    15616566    15691767    18327897    24351982    25639794    15632085    17994087    22936249    17550304    25830018    20966253    25315136    12364791    25474469    20798317    21347285    21719571    25401762    26823975    25348373    28004739    28648823    20075255    24508170    24845553    18362917    19820115   

EMBL

KZ149894    PZC78901.1    NWSH01000444    PCG76359.1    PCG76360.1    RSAL01000400    + More
RVE41928.1    AGBW02013301    OWR43640.1    KQ459989    KPJ18753.1    KQ459591    KPI96978.1    JTDY01001866    KOB72690.1    GAIX01004535    JAA88025.1    CH477401    EAT41704.2    AXCM01003295    JXUM01093223    JXUM01093224    KQ564042    KXJ72879.1    JXUM01031223    KQ560913    KXJ80372.1    AXCN02002069    ATLV01023407    KE525343    KFB49113.1    DS231816    EDS37618.1    ADMH02000838    ETN64904.1    HQ406725    ADQ00194.1    APCN01000708    BT003246    AAO25003.1    FJ821025    ACN94640.1    U87613    AF030334    AE014134    BT053691    CH379058    EAL34527.1    CH479184    EDW36863.1    CM000361    CM002910    EDX03200.1    KMY87280.1    CM000157    EDW87114.1    CH954177    EDV57206.1    KRJ97029.1    CH480829    EDW45372.1    GBXI01013270    JAD01022.1    CH963857    EDW76136.1    UFQS01000093    UFQT01000093    SSW99249.1    SSX19629.1    OUUW01000006    SPP81986.1    SPP81985.1    CH940649    EDW64039.2    AJWK01002277    AJWK01002278    CH916368    EDW03985.1    CH902624    EDV33531.2    GDHF01028253    JAI24061.1    CH933807    EDW11231.1    AAAB01008944    CP012523    ALC38552.1    EAA10160.2    CCAG010023359    JXJN01003674    CVRI01000055    CRL01467.1    NEVH01016943    PNF25083.1    KZ288232    PBC31542.1    KQ414632    KOC67135.1    KQ434782    KZC04568.1    KQ435922    KOX68621.1    ACPB03014790    GFTR01008050    JAW08376.1    GBBI01003708    JAC15004.1    GDHF01033940    JAI18374.1    GL446605    EFN87526.1    ADTU01023408    KQ976885    KYN07517.1    GANO01000299    JAB59572.1    KQ982021    KYN30579.1    KQ976419    KYM89276.1    KQ980824    KYN12516.1    GL888199    EGI65300.1    KQ982335    KYQ57539.1    GL441034    EFN65171.1    GBRD01017448    JAG48379.1    GBHO01001656    GDHC01005105    JAG41948.1    JAQ13524.1    KK854542    PTY16700.1    GAKP01014359    JAC44593.1    GEZM01054378    JAV73708.1    GEZM01054377    JAV73709.1    NNAY01003824    OXU18795.1    KK107260    EZA54187.1    KK852428    KDR24055.1    GEDC01013404    JAS23894.1    KQ971362    EFA09161.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000076408    UP000008820    UP000075900    UP000075901    UP000075883    UP000075880    UP000069940    UP000249989    UP000075920    UP000075886    UP000030765    UP000075885    UP000002320    UP000069272    UP000075881    UP000075884    UP000000673    UP000075903    UP000192221    UP000075840    UP000076407    UP000000803    UP000001819    UP000008744    UP000075902    UP000000304    UP000002282    UP000008711    UP000001292    UP000007798    UP000075882    UP000268350    UP000008792    UP000092461    UP000001070    UP000007801    UP000009192    UP000095300    UP000095301    UP000092553    UP000007062    UP000091820    UP000092444    UP000092460    UP000092443    UP000078200    UP000183832    UP000235965    UP000242457    UP000005203    UP000053825    UP000076502    UP000053105    UP000015103    UP000008237    UP000005205    UP000078542    UP000078541    UP000078540    UP000078492    UP000007755    UP000075809    UP000000311    UP000215335    UP000002358    UP000053097    UP000027135    UP000007266   

PRIDE

Q86PA9    P91682   

Pfam

PF01392   Fz        + More
PF01534   Frizzled
PF00400   WD40
PF05253   zf-U11-48K

Interpro

IPR017981   GPCR_2-like        + More
IPR036790   Frizzled_dom_sf       
IPR000539   Frizzled/Smoothened_TM       
IPR035683   SMO_7TM       
IPR026544   SMO       
IPR020067   Frizzled_dom       
IPR015526   Frizzled/SFRP       
IPR036322   WD40_repeat_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR041771   SMO_CRD       
IPR022776   TRM13/UPF0224_CHHC_Znf_dom       
IPR036236   Znf_C2H2_sf       

SUPFAM

SSF63501   SSF63501        + More
SSF50978   SSF50978       
SSF57667   SSF57667       

Gene 3D

1.10.2000.10     2.130.10.10    

CDD

cd15030  7tmF_SMO_homolog
cd07451  CRD_SMO

ProteinModelPortal

A0A2W1BX54   A0A2A4JX22   A0A2A4JY61   A0A437AUY0   A0A212EQ67   A0A194RLP0   + More
A0A194PVF9   A0A0L7LBB5   S4PKF0   A0A182YN57   Q175G5   A0A182RK65   A0A182TC12   A0A182MEB3   A0A182ILD3   A0A182GWI8   A0A182WFH4   A0A182HAH8   A0A182Q336   A0A084WFW9   A0A182P4A0   B0W046   A0A182F3D6   A0A182JRB6   A0A182MZ95   W5JQ90   A0A182VLW4   A0A1W4UQJ6   E5LCE7   A0A2Y9D159   A0A182X5X6   Q86PA9   D0QWD4   P91682   Q29NW6   B4GJP7   A0A182UA20   B4Q616   B4P2B8   B3N7N0   A0A0R1DIH5   B4ICU6   A0A0A1WQ87   B4MWJ5   A0A182KN72   A0A336K3M0   A0A3B0K8N5   A0A3B0JIG0   B4LU52   A0A1B0C9F1   B4JBG2   B3MUK2   A0A0K8UBW1   B4KHG7   A0A1I8PGR5   A0A1I8MLM7   A0A1S4GZI7   A0A0M4E766   Q7PPM7   A0A1A9WK74   A0A1I8MLM6   A0A1B0FJK7   A0A1B0AUL6   A0A1A9XQH4   A0A1A9UTD6   A0A1J1IML9   A0A2J7Q946   A0A2A3EJV5   A0A088APW7   A0A0L7R8D6   A0A154NZZ6   A0A0N0U309   T1HLP2   A0A224X7Q2   A0A023F248   A0A0K8TV70   E2B9T9   A0A158NQM4   A0A195D3P5   U5EP59   A0A195ERS4   A0A195BQZ3   A0A195DI48   F4WKG2   A0A151XB26   E2AN13   A0A0K8S5C7   A0A0A9ZEX8   A0A2R7WCF9   A0A034VSR5   A0A1Y1LLJ7   A0A1Y1LJ79   A0A232EKC5   K7IPU4   A0A026WDQ6   A0A067RTB7   A0A1B6DDX7   D6WXL7  

PDB

5V56     E-value=1.40453e-99,     Score=930

KEGG

NA   

GO

GO:0016021   GO:0004888   GO:0007275   GO:0007224   GO:0007166   GO:0070273   GO:0035019   GO:0007193   GO:0007346   GO:0048592   GO:0005929   GO:0048099   GO:1904263   GO:0043025   GO:0042803   GO:0001746   GO:2000134   GO:0030707   GO:0005887   GO:0007455   GO:0042802   GO:0042981   GO:0002385   GO:0007350   GO:0007476   GO:0007367   GO:0030425   GO:0004930   GO:1903078   GO:0048100   GO:0005886   GO:0030424   GO:0007417   GO:0071679   GO:0005113   GO:0045880   GO:0005515   GO:0016020   GO:0016820   GO:0016042   GO:0005634   GO:0006334   GO:0003779  

PANTHER

PTHR11309   PTHR11309:SF35  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 17,         Likelihood:  0.794792

 

 

Length:

757

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

145.33112

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.01753

outside

1  -  243

TMhelix

244  -  266

inside

267  -  272

TMhelix

273  -  295

outside

296  -  324

TMhelix

325  -  347

inside

348  -  367

TMhelix

368  -  390

outside

391  -  412

TMhelix

413  -  435

inside

436  -  462

TMhelix

463  -  485

outside

486  -  757

 

 

Pi

237.07767

Theta

194.183068

Tajima's D

0.834964

CLR

12.112843

CSRT

0.609519524023799

Interpretation

Uncertain