Gene

KWMTBOMO01329

Pre Gene Modal

BGIBMGA008883

Annotation

PREDICTED:_uncharacterized_protein_LOC101736819_[Bombyx_mori]

Location

Bomo_Chr3(+):8037315-8040609      View in EpiBrowser

Full name

Glandular kallikrein, prostatic       + More
Mast cell protease 4      

Alternative Name

Prostate esterase
Tissue kallikrein
MSMCP
Myonase
Serosal mast cell protease

Location in the cell

Extracellular   Reliability : 2.453

CDS

ATGATGTTCTGCATAGGGTCTCTTATTGAAACAAACGTCGTTCTCACTCCAGCGAGCTGTGTCTTTGGTGAAAGATACAAATTCGACGTTCATGCTGGTACTCATAATTTTATTGAAAACACTGGAATAAGCAGAGAAGCAGAGCACGTGTGCTTACATAAAGGATACAATCACACTTCTCGCTGGGTGCAATGTTCCACAGATAATTTGGCAATTTTGGTATTGAATGAACACTTTTCCTTTCAAAAACGTGAGACTGGTTCCGATTATGTCGTCAACAGGGTTCGATATGGAACATCAGCACCGAGAGATCAGAGTCGAATAGGAGATACTACCTGTCGCTATTACGGATGGGGTAGTAGAAGAAATGGTTATATGCTACCATTGCTCCTAAAACTTCGACGTATGGATGTTGAAATATTGCCGCCCGAAAAATGTTATCAAATATGGAACTACAAAGAAAAGTATTTGTGTCTTCGACAGCCGGCGTGTAAGGATGACTTGGGTTCATTGATTGAGTGCTCGGGCTTCGCGCAAGGAATGATGACGTCACGTCTAATAGACCGCCCCTGTGGAGTTGGTTTTATTGACCTCAGTTTGTATAACAAGTTCCTGACTTGTGCCGTGGATGACTCAAGAGACGTGATCAACCACGACGTTTCTATGGCCTTCGAATACACCACTAATACGAGGGTCACTCCGTCTATTGCAACAGCATCGGTCACAAATAGAACTAATAAATTCTGA

Protein

MMFCIGSLIETNVVLTPASCVFGERYKFDVHAGTHNFIENTGISREAEHVCLHKGYNHTSRWVQCSTDNLAILVLNEHFSFQKRETGSDYVVNRVRYGTSAPRDQSRIGDTTCRYYGWGSRRNGYMLPLLLKLRRMDVEILPPEKCYQIWNYKEKYLCLRQPACKDDLGSLIECSGFAQGMMTSRLIDRPCGVGFIDLSLYNKFLTCAVDDSRDVINHDVSMAFEYTTNTRVTPSIATASVTNRTNKF

Description

Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing.

Catalytic Activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Subunit

Monomer.

Similarity

Belongs to the peptidase S1 family.
Belongs to the peptidase S1 family. Kallikrein subfamily.
Belongs to the peptidase S1 family. Granzyme subfamily.

Keywords

Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Protease   Reference proteome   Serine protease   Polymorphism   Signal   Zymogen  

Feature

chain  Glandular kallikrein, prostatic
propeptide  Activation peptide

Uniprot

H9JH86   A0A2W1BZ86   A0A2H1V6J1   A0A212EQ93   A0A194RN47   A0A3S2LQU9   + More
A0A194PU95   A0A0N1I374   A0A0L7LAS9   A0A154P6Q3   E9IG41   E2C0U9   A0A232F3Q0   E2B8J9   A0A026WKV8   A0A3L8E2E3   H2MWI2   A0A1A9V6D9   A0A2A3E858   F7ENA0   A0A1L8ERH2   A0A158NW80   Q1HG82   A0A088AGZ8   A0A3S2NVW1   K7IRN0   A1KXG4   A0A232FHI8   A0A1A9ZHE1   C8CGF3   P12323   Q16IK2   A0A3N1DRQ8   A0A088SCQ8   Q58E07   A0A2S6XCE5   L7NL57   A0A1B0G220   B4JVV3   A0A0A1WET5   B3M1T5   A0A154PQ05   A0A3Q2WT02   Q16ZR3   A0A195BE72   A0A1A9X3Z7   A0A1A9ZHE3   A0A0L0CBJ8   A0A088AKU3   A0A1B0BRV2   A0A210PLZ8   A0A1A9Y652   H0V5Y0   E1ZWT5   A0A194QJW1   A0A0D9NM96   A0A1B0CTP0   T1IT27   E2BZ94   B4LDU3   A0A2A6E9E3   A0A0K8W2W2   A0A1I8PE12   K7J5P6   A0A232FJD4   A0A091NPJ4   A0A3B3X3U7   B0W666   B6Z1X1   A0A0A9ZFZ3   A0A1A9Y654   A0A195BD63   A8CW36   A0A1I8MUS5   G9D4D7   W8C9S0   A0A3B5Q883   F4WBT1   B0WZE4   P21812   D0EL76   Q3UN88   A0A0M9A9Z8   Q16IK3   H9GDA9   A0A1A9Z6S9   A0A1S4FZI6   C8CGF4   A0A1I8N1Z8   A0A0B6VSQ6  

EC Number

3.4.21.35
3.4.21.-

Pubmed

19121390    28756777    22118469    26354079    26227816    21282665    + More
20798317    28648823    24508170    30249741    17554307    18464734    27762356    21347285    20075255    20100490    3307909    17510324    17994087    25830018    26108605    28812685    21993624    25102932    19294452    25401762    18194529    25315136    21967427    24495485    23542700    21719571    1988455    11141502    2060576    9538257    2326280    8363563    12900518    20017753    10349636    11042159    11076861    11217851    12466851    12040188    16141073    19468303    21881562    21183079    28224083   

EMBL

BABH01012760    KZ149894    PZC78904.1    ODYU01000688    SOQ35884.1    AGBW02013301    + More
OWR43637.1    KQ459989    KPJ18755.1    RSAL01000400    RVE41926.1    KQ459591    KPI96981.1    KQ459273    KPJ02054.1    JTDY01001898    KOB72588.1    KQ434827    KZC07503.1    GL762910    EFZ20472.1    GL451850    EFN78385.1    NNAY01001042    OXU25381.1    GL446337    EFN87985.1    KK107159    EZA56682.1    QOIP01000001    RLU26369.1    KZ288328    PBC27937.1    CM004483    OCT61944.1    ADTU01027838    DQ489308    DQ489309    ABF39002.1    ABF39003.1    RSAL01000052    RVE50139.1    AY283282    AAP35067.2    NNAY01000219    OXU29928.1    GQ398045    ACV07662.1    CH478072    EAT34105.1    RJKF01000001    ROO96227.1    KM010013    AIO08869.1    BC092122    AAH92122.1    MULI01000009    PPS89336.1    JN215469    AEX33291.1    CCAG010020624    CH916375    EDV98091.1    GBXI01017369    JAC96922.1    CH902617    EDV42195.1    KQ435030    KZC13981.1    GQ398047    CH477485    ACV07664.1    EAT40158.1    KQ976511    KYM82509.1    JRES01000648    KNC29607.1    JXJN01019325    NEDP02005588    OWF37522.1    AAKN02046385    AAKN02046386    GL434905    EFN74332.1    KQ458761    KPJ05200.1    KE384781    KJK73735.1    AJWK01027790    AJWK01027791    AJWK01027792    AFFK01019063    GL451577    EFN79000.1    CH940647    EDW68966.2    NSLJ01000009    PDP44225.1    GDHF01006915    JAI45399.1    NNAY01000131    OXU30693.1    KL389859    KFP91256.1    DS231847    EDS36413.1    EU790594    ACJ22640.1    GBHO01000663    JAG42941.1    KYM82511.1    EU124576    ABV60294.1    JF777190    AEU11535.1    GAMC01001914    JAC04642.1    GL888066    EGI68359.1    DS232206    EDS37458.1    M55617    M55616    AY007569    X68804    AB051900    GQ851941    ACX31149.1    AC163646    AK144385    CH466535    BAE25859.1    EDL36217.1    KQ435706    KOX80247.1    EAT34104.1    AAWZ02029209    GQ398046    ACV07663.1    AB981036    LT631597    BAQ21981.1    SFW93244.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000283053    UP000053268    UP000037510    + More
UP000076502    UP000008237    UP000215335    UP000053097    UP000279307    UP000001038    UP000078200    UP000242457    UP000002279    UP000186698    UP000005205    UP000005203    UP000002358    UP000092445    UP000005447    UP000008820    UP000277273    UP000239339    UP000092444    UP000001070    UP000007801    UP000264840    UP000078540    UP000091820    UP000037069    UP000092460    UP000242188    UP000092443    UP000000311    UP000054544    UP000092461    UP000008792    UP000219259    UP000095300    UP000261480    UP000002320    UP000095301    UP000002852    UP000007755    UP000000589    UP000053105    UP000001646   

PRIDE

H9JH86    A0A088AGZ8    A0A088AKU3    P21812   

Pfam

PF00089   Trypsin        + More
PF18322   CLIP_1
PF01391   Collagen

Interpro

IPR009003   Peptidase_S1_PA        + More
IPR001254   Trypsin_dom       
IPR033116   TRYPSIN_SER       
IPR018114   TRYPSIN_HIS       
IPR001314   Peptidase_S1A       
IPR012224   Pept_S1A_FX       
IPR006311   TAT_signal       
IPR041515   PPAF-2_Clip       
IPR000884   TSP1_rpt       
IPR008160   Collagen       
IPR026444   Secre_tail       
IPR008964   Invasin/intimin_cell_adhesion       

SUPFAM

SSF50494   SSF50494        + More
SSF49373   SSF49373       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

H9JH86   A0A2W1BZ86   A0A2H1V6J1   A0A212EQ93   A0A194RN47   A0A3S2LQU9   + More
A0A194PU95   A0A0N1I374   A0A0L7LAS9   A0A154P6Q3   E9IG41   E2C0U9   A0A232F3Q0   E2B8J9   A0A026WKV8   A0A3L8E2E3   H2MWI2   A0A1A9V6D9   A0A2A3E858   F7ENA0   A0A1L8ERH2   A0A158NW80   Q1HG82   A0A088AGZ8   A0A3S2NVW1   K7IRN0   A1KXG4   A0A232FHI8   A0A1A9ZHE1   C8CGF3   P12323   Q16IK2   A0A3N1DRQ8   A0A088SCQ8   Q58E07   A0A2S6XCE5   L7NL57   A0A1B0G220   B4JVV3   A0A0A1WET5   B3M1T5   A0A154PQ05   A0A3Q2WT02   Q16ZR3   A0A195BE72   A0A1A9X3Z7   A0A1A9ZHE3   A0A0L0CBJ8   A0A088AKU3   A0A1B0BRV2   A0A210PLZ8   A0A1A9Y652   H0V5Y0   E1ZWT5   A0A194QJW1   A0A0D9NM96   A0A1B0CTP0   T1IT27   E2BZ94   B4LDU3   A0A2A6E9E3   A0A0K8W2W2   A0A1I8PE12   K7J5P6   A0A232FJD4   A0A091NPJ4   A0A3B3X3U7   B0W666   B6Z1X1   A0A0A9ZFZ3   A0A1A9Y654   A0A195BD63   A8CW36   A0A1I8MUS5   G9D4D7   W8C9S0   A0A3B5Q883   F4WBT1   B0WZE4   P21812   D0EL76   Q3UN88   A0A0M9A9Z8   Q16IK3   H9GDA9   A0A1A9Z6S9   A0A1S4FZI6   C8CGF4   A0A1I8N1Z8   A0A0B6VSQ6  

PDB

3BSQ     E-value=1.4303e-05,     Score=113

KEGG

101736819    no KO assigned | (RefSeq) uncharacterized LOC101736819

GO

GO:0004252   GO:0016021   GO:0005509   GO:0007596   GO:0008236   GO:0019897   GO:0046658   GO:0002002   GO:0005615   GO:0008233   GO:0006508   GO:0005737   GO:0006412   GO:0005622   GO:0016820   GO:0016042   GO:0005634   GO:0006334   GO:0003779  

Length:

248

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0158

Exp number, first 60 AAs:

0.01312

Total prob of N-in:

0.01609

outside

1  -  248

 

 

Pi

163.614204

Theta

154.881275

Tajima's D

0.119888

CLR

0.810744

CSRT

0.403729813509325

Interpretation

Possibly Positive selection