Gene

KWMTBOMO01315  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000596

Annotation

vacuolar_ATP_synthase_subunit_H_[Bombyx_mori]

Location

Bomo_Chr3(+):7923005-7929620      View in EpiBrowser

Full name

V-type proton ATPase subunit H      

Alternative Name

Vacuolar proton pump subunit H
Vacuolar proton pump subunit SFD

Location in the cell

Cytoplasmic   Reliability : 2.03

CDS

ATGGCTAATGTTAGCGAGGAAAATGTTAGTCAGTTAATTCCAACGCTAGGTGACGAAAAAATCGACATGATTGCGGCCACCAGCGTCCTACAGATCCGGGCAAGTGAGATACGCCAAACTCGGATTAACTGGCAGTCATATCTGCAGTCGCAGATGATCACTCAGCGCGATCACGATTTTATCGTGAACTTAGACCAGCGCGGCCAAAAAGATCTGCCTGACAAGAATCCTGATGCCTGTGCCGAAGTCTTTCTCAACCTCCTGACGCATATCAGCAAGGACCACACCATTCAATACATTCTTGTGCTCATTGATGACATTCTTTCTGAAGATAAATCGAGGGTGAAGATATTTCGTGAGACGAAATTCTCTGGCAACGTTTGGCAGCCCTTCCTGAATTTGCTGAACCGTCAGGATGAATTTGTCCAGCACATGACTGCTCGCATCATTGCCAAGCTAGCTTGCTGGCATCCGCAGCTGATGGACAAAAGTGATTTGCACTTCTATCTCTCCTGGCTTAAAGATCAACTCAAGACCAATAACAACGACTATATCCAGTCTGTGGCCCGGTGTCTGCAGATGATGCTGCGTATCGATGAATACCGCTTTGCTTTCCTCTCTGTCGATGGTATATCCACCTTACTGTCGATTCTGGCCTCCAGAGTGAACTTCCAGGTTCAATACCAACTTGTATTTTGTCTCTGGGTTTTGACATTCAATCCCCTATTGGCTGAAAAAATGAACAAGTTCAATGTTATTCCAATCTTAGCTGATATCCTTAGCGACTCCGTTAAAGAGAAGGTCACGCGTATTGTGCTCGCAGTGTTCAGGAATTTAATTGAAAAACCTGAAGATCAACAGGTTGCCAAAGAGCACTGCATTGCCATGGTACAGTGCAAGGTACTCAAGCAACTGTCAATCCTTGAACAGAAGCGTTCTGATGATGAGGATATTATGAATGATGTGGAATATTTGAATGAACGTCTACAAGCTTCCGTACAGGATCTTAGTTCTTTTGATCAATATGCTACTGAAGTAAAGAGTGGCCGCCTGGAATGGTCGCCGGTACACAAATCGGCCAAGTTCTGGCGCGAAAACGCGGCTCGTTTGAACGAACGTGGCCAAGAACTGCTCCGCACCCTGGTGCACTTGCTGGAGAAGAGCCGCGACCCTGTCGTACTCGCCGTCGCTTGCTATGACATCGGAGAATATGTGCGCCACTATCCGCGCGGCAAACACATCATCGAACAACTTGGTGGTAAACAACGTGTCATGTACCTCCTGAGTCACGACGATCCGAATGTACGTTACGAAGCCTTGCTCGCCGTGCAGAAACTTATGGTTCACAACTGGGAATATCTCGGCAAGCAACTGGAGAAGGAACAAATCGACAAACAGGCTGGCACTGTGGTTGGAGCTAAGGCATAA

Protein

MANVSEENVSQLIPTLGDEKIDMIAATSVLQIRASEIRQTRINWQSYLQSQMITQRDHDFIVNLDQRGQKDLPDKNPDACAEVFLNLLTHISKDHTIQYILVLIDDILSEDKSRVKIFRETKFSGNVWQPFLNLLNRQDEFVQHMTARIIAKLACWHPQLMDKSDLHFYLSWLKDQLKTNNNDYIQSVARCLQMMLRIDEYRFAFLSVDGISTLLSILASRVNFQVQYQLVFCLWVLTFNPLLAEKMNKFNVIPILADILSDSVKEKVTRIVLAVFRNLIEKPEDQQVAKEHCIAMVQCKVLKQLSILEQKRSDDEDIMNDVEYLNERLQASVQDLSSFDQYATEVKSGRLEWSPVHKSAKFWRENAARLNERGQELLRTLVHLLEKSRDPVVLAVACYDIGEYVRHYPRGKHIIEQLGGKQRVMYLLSHDDPNVRYEALLAVQKLMVHNWEYLGKQLEKEQIDKQAGTVVGAKA

Description

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).

Subunit

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Similarity

Belongs to the V-ATPase H subunit family.

Keywords

Hydrogen ion transport   Ion transport   Transport   Alternative splicing   Complete proteome   Reference proteome  

Feature

chain  V-type proton ATPase subunit H
splice variant  In isoform B.

Uniprot

Q1HPJ9   Q9U5N0   H9ITL6   A0A2A4J7U6   I4DJP3   S4PX42   + More
A0A1E1WF42   A0A0D3L6K4   A0A0D3L6K9   A0A194RLQ0   A0A194PW52   A0A0C9RCZ0   A0A2J7RRL5   A0A023ZZ51   V5I8V7   A0A2D1QUD7   A0A026WVU6   K7IWJ4   A0A084VPJ7   Q0IF50   A0A023ETY0   A0A1Y1LRC7   A0A1L8DF92   A0A2M4CTQ0   A0A2M3Z0F2   A0A1W4WVG5   U5EWK6   A0A2J7RRL0   A0A2M4BM69   A0A1L8DFF0   A0A158P3I8   B0W5Q3   A0A1L8DFK7   A0A2M4A477   A0A182RGC9   A0A1Q3FJ75   A0A182PA86   V9IK54   A0A2C9H1C2   T1DQR3   A0A0J7KQU2   A0A069DV46   A0A1B6K9Z3   A0A1B6FZX2   A0A161M902   R4G5L0   A0A224XBP5   J3JVP9   A0A1I8PQW3   A0A151HYZ3   A0A0V0G4Q3   A0A023F9H7   E0VQC4   A0A2R7WGG3   A0A0P4VM08   A0A2A3EB40   A0A1L8EER0   A0A0A9XMX6   A0A0K8U503   A0A034W025   R4WIU5   A0A0C9RPY1   A0A0A1WQ73   T1PB95   A0A1W4VXR0   A0A1I8MD39   A0A0N8NZJ1   A0A0R3NSM8   A0A0Q9W948   U4UPV4   M9PDK5   Q9V3J1   A0A0J9TPK3   A0A0Q9XH85   A0A0Q9WQ72   A0A1B6DSM1   A0A3B0KB61   A0A151JXJ8   A0A0A9YKV4   A0A0Q5W2M8   A0A0R1DRB4   D3TS59   A0A2S2R3U4   A0A1I9WLJ4   A0A2H8TY66   A0A1S3CTK5   A0A1B6BXI2   X2F5F3   Q9V3J1-3   A0A0J9R3A5   J9JPW6   T1JCY2   A0A0R1DQ25   A0A0Q5VN59   A0A2S2PDQ8   A0A2R5L869   A0A293N2U5   A0A1L8DF87   A0A162CNC8   A0A0P6B3U8  

Pubmed

11030595    19121390    22651552    23622113    26354079    25863352    + More
24508170    20075255    24438588    17510324    24945155    28004739    21347285    12364791    26334808    22516182    25474469    20566863    27129103    25401762    26823975    25348373    23691247    25830018    25315136    17994087    15632085    23537049    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    22936249    17550304    20353571    27538518   

EMBL

DQ443403    ABF51492.1    AJ249389    BABH01006739    NWSH01002535    PCG68041.1    + More
AK401511    BAM18133.1    GAIX01005693    JAA86867.1    GDQN01005446    JAT85608.1    KC683729    AHF70968.1    KC683730    AHF70969.1    KQ459989    KPJ18763.1    KQ459591    KPI96989.1    GBYB01014454    JAG84221.1    NEVH01000599    PNF43479.1    KJ476830    AHY84718.1    GALX01004015    JAB64451.1    KY285046    ATP16149.1    KK107088    EZA59801.1    ATLV01015007    KE524999    KFB39891.1    CH477394    EAT41889.1    GAPW01001247    JAC12351.1    GEZM01054530    JAV73577.1    GFDF01008968    JAV05116.1    GGFL01004471    MBW68649.1    GGFM01001256    MBW22007.1    GANO01001374    JAB58497.1    PNF43478.1    GGFJ01004991    MBW54132.1    GFDF01008969    JAV05115.1    ADTU01008088    ADTU01008089    DS231844    EDS35706.1    GFDF01008970    JAV05114.1    GGFK01002293    MBW35614.1    GFDL01007471    JAV27574.1    JR049161    AEY60881.1    AAAB01008839    GAMD01001010    JAB00581.1    LBMM01004251    KMQ92661.1    GBGD01001312    JAC87577.1    GEBQ01031711    JAT08266.1    GECZ01014030    JAS55739.1    GEMB01004302    JAR98970.1    ACPB03017385    GAHY01000440    JAA77070.1    GFTR01006579    JAW09847.1    BT127317    AEE62279.1    KQ976710    KYM77039.1    GECL01003460    JAP02664.1    GBBI01000672    JAC18040.1    DS235418    EEB15580.1    KK854773    PTY18589.1    GDKW01001054    JAI55541.1    KZ288311    PBC28512.1    GFDG01001665    JAV17134.1    GBHO01025134    GDHC01007726    JAG18470.1    JAQ10903.1    GDHF01030859    JAI21455.1    GAKP01011809    JAC47143.1    AK417400    BAN20615.1    GBYB01009241    JAG79008.1    GBXI01013290    JAD01002.1    KA645997    AFP60626.1    CH902624    KPU74468.1    CH379060    KRT04025.1    CH940649    KRF81293.1    KB632408    ERL95137.1    AE014134    AGB93045.1    AF159457    AY052122    CM002910    KMY90555.1    CH933807    KRG03601.1    CH963857    KRF98314.1    GEDC01008627    JAS28671.1    OUUW01000006    SPP82291.1    KQ981604    KYN39720.1    GBHO01011871    GDHC01000236    JAG31733.1    JAQ18393.1    CH954179    KQS62959.1    CM000158    KRJ99069.1    CCAG010018508    EZ424261    ADD20537.1    GGMS01015466    MBY84669.1    KU932378    APA34014.1    GFXV01006936    MBW18741.1    GEDC01031306    JAS05992.1    KJ018752    AHM92104.1    KMY90553.1    ABLF02006768    JH432085    KRJ99070.1    KQS62957.1    GGMR01014971    MBY27590.1    GGLE01001534    MBY05660.1    GFWV01022666    MAA47393.1    GFDF01008986    JAV05098.1    LRGB01000930    KZS14926.1    GDIP01034194    JAM69521.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000235965    UP000053097    + More
UP000002358    UP000030765    UP000008820    UP000192223    UP000005205    UP000002320    UP000075900    UP000075885    UP000036403    UP000015103    UP000095300    UP000078540    UP000009046    UP000242457    UP000192221    UP000095301    UP000007801    UP000001819    UP000008792    UP000030742    UP000000803    UP000009192    UP000007798    UP000268350    UP000078541    UP000008711    UP000002282    UP000092444    UP000079169    UP000007819    UP000076858   

PRIDE

Q1HPJ9    Q9U5N0    H9ITL6    M9PDK5    Q9V3J1   

Pfam

PF11698   V-ATPase_H_C        + More
PF03224   V-ATPase_H_N
PF08583   Cmc1

Interpro

IPR011987   ATPase_V1-cplx_hsu_C        + More
IPR011989   ARM-like       
IPR016024   ARM-type_fold       
IPR038497   ATPase_V1-cplx_hsu_C_sf       
IPR004908   ATPase_V1-cplx_hsu       
IPR000225   Armadillo       
IPR013892   Cyt_c_biogenesis_Cmc1-like       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10     1.25.40.150    

ProteinModelPortal

Q1HPJ9   Q9U5N0   H9ITL6   A0A2A4J7U6   I4DJP3   S4PX42   + More
A0A1E1WF42   A0A0D3L6K4   A0A0D3L6K9   A0A194RLQ0   A0A194PW52   A0A0C9RCZ0   A0A2J7RRL5   A0A023ZZ51   V5I8V7   A0A2D1QUD7   A0A026WVU6   K7IWJ4   A0A084VPJ7   Q0IF50   A0A023ETY0   A0A1Y1LRC7   A0A1L8DF92   A0A2M4CTQ0   A0A2M3Z0F2   A0A1W4WVG5   U5EWK6   A0A2J7RRL0   A0A2M4BM69   A0A1L8DFF0   A0A158P3I8   B0W5Q3   A0A1L8DFK7   A0A2M4A477   A0A182RGC9   A0A1Q3FJ75   A0A182PA86   V9IK54   A0A2C9H1C2   T1DQR3   A0A0J7KQU2   A0A069DV46   A0A1B6K9Z3   A0A1B6FZX2   A0A161M902   R4G5L0   A0A224XBP5   J3JVP9   A0A1I8PQW3   A0A151HYZ3   A0A0V0G4Q3   A0A023F9H7   E0VQC4   A0A2R7WGG3   A0A0P4VM08   A0A2A3EB40   A0A1L8EER0   A0A0A9XMX6   A0A0K8U503   A0A034W025   R4WIU5   A0A0C9RPY1   A0A0A1WQ73   T1PB95   A0A1W4VXR0   A0A1I8MD39   A0A0N8NZJ1   A0A0R3NSM8   A0A0Q9W948   U4UPV4   M9PDK5   Q9V3J1   A0A0J9TPK3   A0A0Q9XH85   A0A0Q9WQ72   A0A1B6DSM1   A0A3B0KB61   A0A151JXJ8   A0A0A9YKV4   A0A0Q5W2M8   A0A0R1DRB4   D3TS59   A0A2S2R3U4   A0A1I9WLJ4   A0A2H8TY66   A0A1S3CTK5   A0A1B6BXI2   X2F5F3   Q9V3J1-3   A0A0J9R3A5   J9JPW6   T1JCY2   A0A0R1DQ25   A0A0Q5VN59   A0A2S2PDQ8   A0A2R5L869   A0A293N2U5   A0A1L8DF87   A0A162CNC8   A0A0P6B3U8  

PDB

1HO8     E-value=5.47021e-24,     Score=276

KEGG

733031    K02144 V-type H+-transporting ATPase subunit H | (RefSeq) vacuolar ATP synthase subunit H

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0015991   GO:0000221   GO:0046961   GO:0008340   GO:0033181   GO:0033227   GO:0005488   GO:0016820   GO:0016042   GO:0005634   GO:0006334   GO:0003779   GO:0016021  

PANTHER

PTHR10698  

Length:

475

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.83499

Exp number, first 60 AAs:

0.00108

Total prob of N-in:

0.07901

outside

1  -  475

 

 

Pi

297.924289

Theta

215.377214

Tajima's D

0.774624

CLR

0.018961

CSRT

0.593520323983801

Interpretation

Uncertain