Gene

KWMTBOMO01312  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009010

Annotation

26S_proteasome_non-ATPase_regulatory_subunit_14_[Bombyx_mori]

Location

Bomo_Chr3(-):7913496-7915524      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 14      

Alternative Name

26S proteasome regulatory complex subunit p37B
26S proteasome regulatory subunit rpn11
Yippee-interacting protein 5

Location in the cell

Cytoplasmic   Reliability : 2.273

CDS

ATGGATCGTCTTCTTCGTCTTGGTGGTGGAATGGCGGGCTTATCACAGGCGCCACCTCCTACCGATGCTCCAGCAGTGGACACCGCGGAGCAAGTGTACATCTCTTCCCTAGCACTCCTTAAAATGCTGAAACATGGACGTGCTGGCGTTCCTATGGAGGTTATGGGTCTCATGCTCGGAGAGTTTGTAGATGACTATACAGTTCGAGTTATTGATGTATTTGCTATGCCACAAACCGGGACTGGAGTATCTGTAGAGGCTGTTGATCCAGTCTTCCAAGCTAAGATGTTGGACATGTTGAAACAAACAGGACGACCCGAAATGGTTGTTGGATGGTATCATTCACATCCTGGCTTTGGTTGTTGGTTATCTGGTGTGGATATCAACACTCAACAGTCATTTGAAGCATTATCGGAACGTGCAGTAGCTGTTGTGGTTGATCCCATCCAGTCGGTAAAGGGTAAAGTTGTGATAGACGCGTTCCGCCTTATCAACTCAAATATGATGGTACTTGGACAAGAGCCCAGACAAACCACCTCAAATCTCGGGCACCTCCAGAAACCATCTGTACAAGCTCTTATACATGGATTAAATCGTCACTACTATTCAATTAGTATAAATTATAGAAAGAACGAGTTGGAACAAAAAATGTTGTTGAATTTACATAAGAAGTCCTGGATGGATGGACTAACTTTATCTGACTACAAAGAGCATTGTTCTGTTAATGAGTCCACAGTTACCGACATGCTGGAATTAGCTAAAAACTATAATAAGGCTTTAGAAGATGAGGAGAAGATGACTCCAGAACAATTAGCCATTAAGAATGTAGGCAAACAAGATCCTAAAAGACATTTAGAGGAGAAAGTGGATGTGCTCATGGCCAACAACATAGTCCAGTGTCTAGGAGCTATGCTTGACACTTTGGTATTCAAATGA

Protein

MDRLLRLGGGMAGLSQAPPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQTGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINSNMMVLGQEPRQTTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSWMDGLTLSDYKEHCSVNESTVTDMLELAKNYNKALEDEEKMTPEQLAIKNVGKQDPKRHLEEKVDVLMANNIVQCLGAMLDTLVFK

Description

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

Subunit

Component of the 19S regulatory cap of the 26S proteasome.

Similarity

Belongs to the peptidase M67A family. PSMD14 subfamily.

Keywords

Complete proteome   Direct protein sequencing   Hydrolase   Metal-binding   Metalloprotease   Protease   Proteasome   Reference proteome   Ubl conjugation pathway   Zinc  

Feature

chain  26S proteasome non-ATPase regulatory subunit 14

Uniprot

Q2F5N7   A0A212EQ66   A0A2H1VXS1   A0A2W1B852   A0A2A4J7I3   S4NU49   + More
I4DMY6   J3JVK4   I4DKB2   A0A194RML5   A0A1Q3FEL7   B0WLK2   Q1HQQ2   A0A023EPA8   A0A1J1IW37   U5EXX8   A0A2D1QUF2   A0A0T6AYI3   A0A1B6CSD0   A0A0A9Z932   T1D4F2   T1DQF6   A0A2M3Z9H2   A0A2M4AE55   A0A2M4BV04   W5J7L3   A0A182F6B3   A0A1B0DN76   A0A2J7Q9C6   A0A067RLY5   A0A1Y1KM44   U4UXV9   A0A1A9Z0C9   A0A1B6I1S0   D3TMM1   A0A224XUA1   A0A1L8DST8   A0A0P4VT87   B3MP98   R4G5H6   A0A1A9WK85   A0A0L0C8T7   A0A1B0FFC1   A0A0K8W8U2   A0A1A9VHE6   A0A034WRD2   A0A0A1WT77   A0A1A9Z983   A0A1W4UVX8   W8C923   A0A3B0K8G1   B4P3T4   A0A0M4E6M4   B4I1C7   B3N4S4   B4Q3I6   Q9V3H2   A0A182LVF8   A0A2R7WGC1   A0A182J2V2   A0A182P4A6   A0A084WFX5   A0A182RK71   A0A182NTE0   A0A182YN49   B4MTP8   A0A182WFI1   A0A182Q4C5   A0A182UWX1   A0A182JRC1   A0A182TYU0   E0VE95   A0A182KN91   A0A182X5Y1   Q7Q8I2   A0A182IBL3   B4LTW4   B4KGS8   A0A1A9XSD4   A0A0C9QXN5   B4JAT1   A0A1A9UTC1   Q29L00   D6WVU4   A0A0V0G4B4   E2BD78   A0A154PSI5   A0A1B0BIK2   B4GSJ6   A0A1I8QE54   A0A1L8EDG7   A0A195D163   A0A151J272   E9IJN8   F4WSS4   A0A195B771   A0A0J7L4A1   A0A158NH06   E2AS02   A0A151XD85  

EC Number

3.4.19.-

Pubmed

22118469    28756777    23622113    22651552    22516182    26354079    + More
17204158    17510324    24945155    26483478    25401762    26823975    24330624    20920257    23761445    24845553    28004739    23537049    20353571    27129103    17994087    26108605    25348373    25830018    24495485    17550304    22936249    10893261    10731132    12537572    12537569    24438588    25244985    20566863    20966253    12364791    14747013    17210077    15632085    18362917    19820115    20798317    21282665    21719571    21347285   

EMBL

DQ311386    ABD36330.1    AGBW02013301    OWR43626.1    ODYU01005035    SOQ45526.1    + More
KZ150370    PZC71151.1    NWSH01002535    PCG68045.1    GAIX01011951    JAA80609.1    AK402654    BAM19276.1    BT127272    AEE62234.1    AK401730    KQ459591    BAM18352.1    KPI96992.1    KQ459989    KPJ18767.1    GFDL01009073    JAV25972.1    DS231987    EDS30532.1    DQ440392    CH477313    ABF18425.1    EAT43850.1    JXUM01097755    GAPW01002772    KQ564368    JAC10826.1    KXJ72376.1    CVRI01000058    CRL02753.1    GANO01000715    JAB59156.1    KY285045    ATP16148.1    LJIG01022525    KRT80122.1    GEDC01020954    JAS16344.1    GBHO01005289    GDHC01019488    JAG38315.1    JAP99140.1    GALA01000988    JAA93864.1    GAMD01002534    JAA99056.1    GGFM01004422    MBW25173.1    GGFK01005709    MBW39030.1    GGFJ01007640    MBW56781.1    ADMH02002020    GGFL01004299    ETN59956.1    MBW68477.1    AJVK01017343    NEVH01016943    PNF25183.1    KK852428    KDR24038.1    GEZM01079585    JAV62394.1    KB632408    ERL95140.1    GECU01026833    JAS80873.1    CCAG010021960    EZ422673    ADD18949.1    GFTR01004895    JAW11531.1    GFDF01004542    JAV09542.1    GDKW01000879    JAI55716.1    CH902620    EDV32217.1    ACPB03017385    GAHY01000565    JAA76945.1    JRES01000753    KNC28686.1    CCAG010019941    GDHF01005064    JAI47250.1    GAKP01002040    JAC56912.1    GBXI01012230    JAD02062.1    GAMC01002539    JAC04017.1    OUUW01000006    SPP81916.1    CM000157    EDW88385.1    CP012523    ALC38240.1    CH480820    EDW54334.1    CH954177    EDV57826.1    CM000361    CM002910    EDX03790.1    KMY88235.1    AF145313    AE014134    AY070977    AF195189    AXCM01003294    KK854773    PTY18588.1    ATLV01023407    KE525343    KFB49119.1    CH963852    EDW75487.1    AXCN02000709    DS235088    EEB11701.1    AAAB01008944    EAA10169.2    APCN01000708    CH940649    EDW64015.1    CH933807    EDW11128.1    GBYB01000445    JAG70212.1    CH916368    EDW03889.1    CH379061    EAL33024.1    KQ971358    EFA08241.1    GECL01003235    JAP02889.1    GL447585    EFN86306.1    KQ435134    KZC14876.1    JXJN01014982    CH479189    EDW25355.1    GFDG01002105    JAV16694.1    KQ976973    KYN06650.1    KQ980447    KYN15999.1    GL763877    EFZ19212.1    GL888327    EGI62731.1    KQ976574    KYM80105.1    LBMM01000855    KMQ97368.1    ADTU01015424    GL442209    EFN63776.1    KQ982294    KYQ58336.1   

Proteomes

UP000007151    UP000218220    UP000053268    UP000053240    UP000002320    UP000008820    + More
UP000069940    UP000249989    UP000183832    UP000000673    UP000069272    UP000092462    UP000235965    UP000027135    UP000030742    UP000092445    UP000092444    UP000007801    UP000015103    UP000091820    UP000037069    UP000078200    UP000192221    UP000268350    UP000002282    UP000092553    UP000001292    UP000008711    UP000000304    UP000000803    UP000075883    UP000075880    UP000075885    UP000030765    UP000075900    UP000075884    UP000076408    UP000007798    UP000075920    UP000075886    UP000075903    UP000075881    UP000075902    UP000009046    UP000075882    UP000076407    UP000007062    UP000075840    UP000008792    UP000009192    UP000092443    UP000001070    UP000001819    UP000007266    UP000008237    UP000076502    UP000092460    UP000008744    UP000095300    UP000078542    UP000078492    UP000007755    UP000078540    UP000036403    UP000005205    UP000000311    UP000075809   

PRIDE

Q2F5N7    Q9V3H2   

Pfam

PF01398   JAB        + More
PF13012   MitMem_reg
PF10252   PP28

Interpro

IPR024969   Rpn11/EIF3F_C        + More
IPR000555   JAMM/MPN+_dom       
IPR037518   MPN       
IPR035299   PSMD14       
IPR019380   Casein_kinase_sb_PP28       

ProteinModelPortal

Q2F5N7   A0A212EQ66   A0A2H1VXS1   A0A2W1B852   A0A2A4J7I3   S4NU49   + More
I4DMY6   J3JVK4   I4DKB2   A0A194RML5   A0A1Q3FEL7   B0WLK2   Q1HQQ2   A0A023EPA8   A0A1J1IW37   U5EXX8   A0A2D1QUF2   A0A0T6AYI3   A0A1B6CSD0   A0A0A9Z932   T1D4F2   T1DQF6   A0A2M3Z9H2   A0A2M4AE55   A0A2M4BV04   W5J7L3   A0A182F6B3   A0A1B0DN76   A0A2J7Q9C6   A0A067RLY5   A0A1Y1KM44   U4UXV9   A0A1A9Z0C9   A0A1B6I1S0   D3TMM1   A0A224XUA1   A0A1L8DST8   A0A0P4VT87   B3MP98   R4G5H6   A0A1A9WK85   A0A0L0C8T7   A0A1B0FFC1   A0A0K8W8U2   A0A1A9VHE6   A0A034WRD2   A0A0A1WT77   A0A1A9Z983   A0A1W4UVX8   W8C923   A0A3B0K8G1   B4P3T4   A0A0M4E6M4   B4I1C7   B3N4S4   B4Q3I6   Q9V3H2   A0A182LVF8   A0A2R7WGC1   A0A182J2V2   A0A182P4A6   A0A084WFX5   A0A182RK71   A0A182NTE0   A0A182YN49   B4MTP8   A0A182WFI1   A0A182Q4C5   A0A182UWX1   A0A182JRC1   A0A182TYU0   E0VE95   A0A182KN91   A0A182X5Y1   Q7Q8I2   A0A182IBL3   B4LTW4   B4KGS8   A0A1A9XSD4   A0A0C9QXN5   B4JAT1   A0A1A9UTC1   Q29L00   D6WVU4   A0A0V0G4B4   E2BD78   A0A154PSI5   A0A1B0BIK2   B4GSJ6   A0A1I8QE54   A0A1L8EDG7   A0A195D163   A0A151J272   E9IJN8   F4WSS4   A0A195B771   A0A0J7L4A1   A0A158NH06   E2AS02   A0A151XD85  

PDB

6MSK     E-value=8.05376e-150,     Score=1359

KEGG

692958    K03030 26S proteasome regulatory subunit N11 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0000502   GO:0061578   GO:0005838   GO:0043161   GO:0007623   GO:0046872   GO:0005829   GO:0005654   GO:0016579   GO:0004843   GO:0008063   GO:0008237   GO:0008541   GO:0070628   GO:0005515   GO:0020037   GO:0000287   GO:0015934   GO:0005576   GO:0016042   GO:0005634   GO:0006334   GO:0003779   GO:0016021  

PANTHER

PTHR10410:SF22  

Length:

311

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02641

Exp number, first 60 AAs:

0.00104

Total prob of N-in:

0.00647

outside

1  -  311

 

 

Pi

242.992076

Theta

172.448901

Tajima's D

0.936736

CLR

0.003402

CSRT

0.64136793160342

Interpretation

Uncertain