Gene

KWMTBOMO01274  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009021

Annotation

PREDICTED:_calcyclin-binding_protein_[Amyelois_transitella]

Location

Bomo_Chr3(-):7231729-7234538      View in EpiBrowser

Full name

Calcyclin-binding protein      

Location in the cell

Nuclear   Reliability : 3.504

CDS

ATGTCAGAAGCAAAAATACAAGAGATAAGAAGCGATATCGAAGAGATCAATGATCTGTTAAAGCAAGCTAAACGTAAGAAAGTACAGGATTTACTCTCCTTGGAGATCAGAAAACTTGAGACAGAACTAATAACATTAAAAGAAAAGGAAACTTTGACGCCCATGGAAGTATCACCAATACCCACAACAAGTACATCAGCTCCAGTGCAAAAGAAGTATCAAGTCAAATTGAATGTATATGGTTGGGACCAGTCGGATAAATTTGTTAAGGTATTTGTTGAACTAAAGAATGTTCATACACTACCAAAGGAACAGGTATATTGTAAATTGACAGATAAATCAATGGAGCTGCATGTGGACAATCTGGAAAATAAAGATTACTTGCTTGTTATTAACAAGTTATTGGAACCTATAAATGTGGCAGACAGTCATTGGAAACAAAAAACAGATAAGGTAGTCATATTCCTTGCAAAATCTAATCCAAACACAACATGGTCTCATATGACTGAAATTGAAAAAAAATTTGAAGACCAACGTAATAACCGCTTGAAACCTGCCGAAACTGACAAGAAAGATCCACAAGATTCCATAATGAGTCTCATGAAGAATATGTATGAAACTGGTGATGATGAAATGAAGAGAATGATCTCCAAGGCTTGGTATGAAGGACAGCAGCGTAAGAAAACTGATATAATGGATTTATAA

Protein

MSEAKIQEIRSDIEEINDLLKQAKRKKVQDLLSLEIRKLETELITLKEKETLTPMEVSPIPTTSTSAPVQKKYQVKLNVYGWDQSDKFVKVFVELKNVHTLPKEQVYCKLTDKSMELHVDNLENKDYLLVINKLLEPINVADSHWKQKTDKVVIFLAKSNPNTTWSHMTEIEKKFEDQRNNRLKPAETDKKDPQDSIMSLMKNMYETGDDEMKRMISKAWYEGQQRKKTDIMDL

Description

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).

Subunit

Monomer or homodimer. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity).

Keywords

Acetylation   Complete proteome   Cytoplasm   Nucleus   Phosphoprotein   Reference proteome   Ubl conjugation pathway  

Feature

chain  Calcyclin-binding protein

Uniprot

H9JHM3   A0A194PUM2   A0A194R8N4   A0A2H1X061   A0A2W1BMA2   A0A2A4IV95   + More
A0A212EHF9   S4PE51   A0A1B6MMV3   A0A1B6H7D3   A0A1W4WIL7   A0A2J7QUK2   A0A067R418   A0A2P8YCA2   D7GXT5   A0A0J7MRE2   A0A1B6CCB6   E2BSE3   K7IRE0   V5H2G8   A0A232F303   A0A158NH28   E2AA03   A0A195D1F5   A0A088AK08   I6LNT1   A0A154PPW2   A0A069DR20   A0A0V0G4V8   A0A151XDB4   A0A0P4VL48   R4G3G8   A0A0L7R511   F4WSV6   A0A023F876   A0A0P5A3G8   A0A2R7W062   A0A0P5XMP6   A0A0P4ZI35   A0A1Y1M5A7   A0A182F7Z1   A0A3L8DN99   A0A1L8DLP9   A0A0P5R797   A0A023EKU1   A0A1L8DLZ4   W5JAT2   U5ENM9   A0A310SQ90   Q16JJ2   N6TWA1   A0A0P5BSU5   E9IMS7   A0A182G1Q6   T1E7K4   A0A084W9U3   A0A182XW24   B0XGQ8   A0A0P5XQB8   A0A1A9Z3X0   A0A0L0C1U4   A0A1Q3F5T1   K9IZ15   A0A0M9AA74   A0A1B0D1S2   A0A1B0FNW9   A0A182XGG9   A0A182Q7R6   A0A182N6A4   A0A250YCT2   L5KYI4   A0A182LYA8   A0A2M4AR34   A0A182PNB7   E9GDE7   A0A2C9GRK4   Q7PYU2   A0A1A9VWX7   H2ZZ02   A0A182UY46   A0A1A9XYJ1   A0A3B3QP14   C1BVY9   A0A2K6MEQ0   A0A182LQY2   S7MVZ0   A0A182UAE3   A0A1B0ASR9   A0A1B0CX15   G3TH46   Q7ZWU4   A0A1U7USE1   M3W9V3   A0A2Y9GLN5   A0A2U3XP45   A0A2U3X389   Q3T168   A0A182IN24   A0A182K5T1   A0A2U3V766  

Pubmed

19121390    26354079    28756777    22118469    23622113    24845553    + More
29403074    18362917    19820115    20798317    20075255    28648823    21347285    22539186    26334808    27129103    21719571    25474469    28004739    30249741    24945155    20920257    23761445    17510324    23537049    21282665    26483478    24438588    25244985    26108605    28087693    23258410    21292972    12364791    14747013    17210077    9215903    29240929    20433749    25069045    20966253    27762356    17975172   

EMBL

BABH01012835    KQ459591    KPI97022.1    KQ460597    KPJ13864.1    ODYU01012404    + More
SOQ58693.1    KZ150082    PZC73840.1    NWSH01006459    PCG63416.1    AGBW02014900    OWR40912.1    GAIX01003316    JAA89244.1    GEBQ01002782    JAT37195.1    GECU01037182    JAS70524.1    NEVH01010537    PNF32263.1    KK852771    KDR16863.1    PYGN01000706    PSN41902.1    GG694600    EFA13571.1    LBMM01021456    KMQ83075.1    GEDC01026194    JAS11104.1    GL450203    EFN81395.1    GALX01001438    JAB67028.1    NNAY01001120    OXU25065.1    ADTU01015494    GL437990    EFN69732.1    KQ976973    KYN06681.1    GU722329    GU722333    KZ288256    ADT65129.1    ADT65133.1    PBC30559.1    KQ434998    KZC13288.1    GBGD01002792    JAC86097.1    GECL01003057    JAP03067.1    KQ982294    KYQ58361.1    GDKW01000758    JAI55837.1    ACPB03007281    GAHY01001691    JAA75819.1    KQ414654    KOC65975.1    GL888327    EGI62763.1    GBBI01001245    JAC17467.1    GDIP01216846    GDIP01216844    JAJ06556.1    KK854210    PTY13133.1    GDIP01082166    JAM21549.1    GDIP01216845    JAJ06557.1    GEZM01040269    JAV80913.1    QOIP01000006    RLU21915.1    GFDF01006698    JAV07386.1    GDIQ01104658    LRGB01000687    JAL47068.1    KZS16746.1    GAPW01003785    JAC09813.1    GFDF01006697    JAV07387.1    ADMH02002023    ETN59945.1    GANO01000529    JAB59342.1    KQ760357    OAD60752.1    CH478006    EAT34449.1    APGK01052695    KB741213    ENN72666.1    GDIP01184854    JAJ38548.1    GL764255    EFZ18148.1    JXUM01038854    KQ561182    KXJ79452.1    GAMD01002957    JAA98633.1    ATLV01021913    KE525325    KFB46987.1    DS233057    EDS27781.1    GDIP01070214    JAM33501.1    JRES01001001    KNC26227.1    GFDL01012217    JAV22828.1    GABZ01007736    JAA45789.1    KQ435715    KOX79113.1    AJVK01010364    CCAG010014421    AXCN02000278    GFFW01003326    JAV41462.1    KB030474    ELK16250.1    AXCM01000395    GGFK01009912    MBW43233.1    GL732540    EFX82491.1    APCN01002014    AAAB01008987    EAA01517.4    AFYH01230726    BT078768    ACO13192.1    KE162497    EPQ08679.1    JXJN01002966    AJWK01033103    BC046706    CM004473    AAH46706.1    OCT82782.1    AANG04001043    BC102091   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000192223    + More
UP000235965    UP000027135    UP000245037    UP000007266    UP000036403    UP000008237    UP000002358    UP000215335    UP000005205    UP000000311    UP000078542    UP000005203    UP000242457    UP000076502    UP000075809    UP000015103    UP000053825    UP000007755    UP000069272    UP000279307    UP000076858    UP000000673    UP000008820    UP000019118    UP000069940    UP000249989    UP000030765    UP000076408    UP000002320    UP000092445    UP000037069    UP000053105    UP000092462    UP000092444    UP000076407    UP000075886    UP000075884    UP000010552    UP000075883    UP000075885    UP000000305    UP000075840    UP000007062    UP000078200    UP000008672    UP000075903    UP000092443    UP000261540    UP000265140    UP000233180    UP000075882    UP000075902    UP000092460    UP000092461    UP000007646    UP000186698    UP000189704    UP000011712    UP000248481    UP000245341    UP000245340    UP000009136    UP000075880    UP000075881    UP000245320   

PRIDE

H9JHM3    A0A088AK08    Q3T168   

Pfam

PF04969   CS        + More
PF09032   Siah-Interact_N
PF05002   SGS
PF03835   Rad4
PF10403   BHD_1
PF10404   BHD_2
PF10405   BHD_3

Interpro

IPR007699   SGS_dom        + More
IPR037893   CS_CacyBP       
IPR015120   Siah-Interact_N       
IPR008978   HSP20-like_chaperone       
IPR007052   CS_dom       
IPR037201   CacyBP_N       
IPR018326   Rad4_beta-hairpin_dom1       
IPR036985   Transglutaminase-like_sf       
IPR004583   DNA_repair_Rad4       
IPR018325   Rad4/PNGase_transGLS-fold       
IPR018328   Rad4_beta-hairpin_dom3       
IPR018327   BHD_2       
IPR038765   Papain-like_cys_pep_sf       

SUPFAM

SSF49764   SSF49764        + More
SSF140106   SSF140106       
SSF54001   SSF54001       

Gene 3D

2.60.40.790     3.90.260.10    

CDD

cd06468  p23_CacyBP

ProteinModelPortal

H9JHM3   A0A194PUM2   A0A194R8N4   A0A2H1X061   A0A2W1BMA2   A0A2A4IV95   + More
A0A212EHF9   S4PE51   A0A1B6MMV3   A0A1B6H7D3   A0A1W4WIL7   A0A2J7QUK2   A0A067R418   A0A2P8YCA2   D7GXT5   A0A0J7MRE2   A0A1B6CCB6   E2BSE3   K7IRE0   V5H2G8   A0A232F303   A0A158NH28   E2AA03   A0A195D1F5   A0A088AK08   I6LNT1   A0A154PPW2   A0A069DR20   A0A0V0G4V8   A0A151XDB4   A0A0P4VL48   R4G3G8   A0A0L7R511   F4WSV6   A0A023F876   A0A0P5A3G8   A0A2R7W062   A0A0P5XMP6   A0A0P4ZI35   A0A1Y1M5A7   A0A182F7Z1   A0A3L8DN99   A0A1L8DLP9   A0A0P5R797   A0A023EKU1   A0A1L8DLZ4   W5JAT2   U5ENM9   A0A310SQ90   Q16JJ2   N6TWA1   A0A0P5BSU5   E9IMS7   A0A182G1Q6   T1E7K4   A0A084W9U3   A0A182XW24   B0XGQ8   A0A0P5XQB8   A0A1A9Z3X0   A0A0L0C1U4   A0A1Q3F5T1   K9IZ15   A0A0M9AA74   A0A1B0D1S2   A0A1B0FNW9   A0A182XGG9   A0A182Q7R6   A0A182N6A4   A0A250YCT2   L5KYI4   A0A182LYA8   A0A2M4AR34   A0A182PNB7   E9GDE7   A0A2C9GRK4   Q7PYU2   A0A1A9VWX7   H2ZZ02   A0A182UY46   A0A1A9XYJ1   A0A3B3QP14   C1BVY9   A0A2K6MEQ0   A0A182LQY2   S7MVZ0   A0A182UAE3   A0A1B0ASR9   A0A1B0CX15   G3TH46   Q7ZWU4   A0A1U7USE1   M3W9V3   A0A2Y9GLN5   A0A2U3XP45   A0A2U3X389   Q3T168   A0A182IN24   A0A182K5T1   A0A2U3V766  

PDB

1X5M     E-value=1.55119e-22,     Score=259

KEGG

101741265    K04507 calcyclin binding protein | (RefSeq) calcyclin-binding protein

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0031625   GO:0015631   GO:0044548   GO:0007507   GO:0005634   GO:0016021   GO:1990830   GO:0005641   GO:0042803   GO:0019005   GO:0030877   GO:0019904   GO:0005654   GO:0005829   GO:0006289   GO:0003684  

PANTHER

PTHR12135  

Subcellular location

Nucleus  
Cytoplasm  

Length:

234

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00018

Exp number, first 60 AAs:

0

Total prob of N-in:

0.16410

outside

1  -  234

 

 

Pi

169.626629

Theta

142.623585

Tajima's D

0.595008

CLR

0.902919

CSRT

0.544522773861307

Interpretation

Uncertain