Gene

KWMTBOMO01251

Pre Gene Modal

BGIBMGA008855

Annotation

cGMP-dependent_protein_kinase?_isozyme_2_forms_cD4/T1/T3A/T3B_[Papilio_xuthus]

Location

Bomo_Chr3(+):6321511-6324233      View in EpiBrowser

Full name

cGMP-dependent protein kinase       + More
Mediator of RNA polymerase II transcription subunit 4      

Alternative Name

Mediator complex subunit 4

Location in the cell

Nuclear   Reliability : 3.507

CDS

ATGTCGCACACGCACACGAAACAGTCCCAAATGGAGCACAATTACAAATTGGAGAAGAAATATTTGGAAATGAAGCGAATGGTTTACGAACGTACCGAAGAACTAAAACGGAGGGATAAAATTATTACACTATTGGAAAACGAGATTGACGAGAAAGACGCTCAAATAAGATATCTCAAGAACGAGATTGACAAATATAGGCAAGTCGTGAAACCATTGACGCGTCAGATTATTGACAGCCACAAAAACGGAATCGATACCGACGAGGAATGCTTCACGATGAAGACTCCGGGCGTCGAGAATACGCGAGTTTATTCATTAAATGAACCACGACTGAAAAGGACTGCGATATCAGCGGAGCCCCTATCGTCGCTGACTCAAGAGCATGAGTTGAAGTTATTGAAAATACCGAAAAGCCACAGATCTCGCGAGCTGATTAAGACTGCGATCCTCGACAACGACTTCATGAAGAATCTAGAAATGACACAGATCAGAGAAATAGTGGATTGCATGTATCCCGTCGAATATGCAGCCGGCAGCATTATTATCAAAGAAGGCGACGTTGGAAGCATAGTTTATGTTATGGAAGATGGCGCTTTAGCAGAAATTTAA

Protein

MSHTHTKQSQMEHNYKLEKKYLEMKRMVYERTEELKRRDKIITLLENEIDEKDAQIRYLKNEIDKYRQVVKPLTRQIIDSHKNGIDTDEECFTMKTPGVENTRVYSLNEPRLKRTAISAEPLSSLTQEHELKLLKIPKSHRSRELIKTAILDNDFMKNLEMTQIREIVDCMYPVEYAAGSIIIKEGDVGSIVYVMEDGALAEI

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Belongs to the Mediator complex subunit 4 family.

Uniprot

H9JH58   A0A2H1W9V6   A0A194QIC8   A0A194R7S6   A0A2A4ITY4   A0A212EK53   + More
A0A0L7LCS9   A0A182RUS6   A0A182LN13   A0A182NPY3   A0A182Y953   Q5TNQ0   A0A182I751   A0A1B0CTA2   A0A182Q6A5   A0A182VU81   A0A182XDF2   A0A182LWB4   A0A182K2C8   A0A182V0F5   A0A1S4GZF7   A0A182TVI1   W5JAF4   A0A182F5P8   A0A182JMX8   A0A182P699   A0A1B6MN91   B0WEA0   A0A1B6H3B7   V5GAA9   E0VGN9   A0A084VYK8   A0A182HFC5   A0A195BR46   Q170R4   F4W6N2   E9J3W6   A0A088AEL9   C3PUN5   A0A195CLN6   U4U839   A0A2J7QHI8   A0A2J7QHL2   A0A1I8M0W3   A0A0L0BX72   A0A067QRI0   A0A1J1IK64   A0A195DIV3   A0A1J1II54   A0A286NL54   A0A2A3EII9   A0A154PSC4   C3PUN4   A0A034VA88   A0A0A1XJT6   A0A139WDC9   A0A232F2K2   A0A1S3KIL0   A0A2K5MRU0   A0A3Q0IQ78   A0A2Y9RTP1   A0A2Y9RLI9   Q32KM5   A0A2U3WLJ6   A0A3Q0CEB2   A0A1U8C3D8   F6YCF0   A0A1B0FRC2   A0A2R8YE50   A0A2R8YH74   A0A1U7U448   A0A1B0A618   A0A3B3QXZ2   B1ALS0   A0A2K6QTG9   A0A2R8Y507   L8I106   S7PYU2   D2GZ26   A0A161MSN1   A0A2U3YC82   A0A060VTS8   A0A2K6N0U1   A0A091CXW1   A0A1A9YSE5   A0A3B5KDT0   A0A1A9V0Y8   A0A151NZZ3   A0A151P0K9   A0A060W1F2   A0A1B0BC86   G1RMZ8   A0A3B3Z234   A0A3P9PHF9   A0A287D7T9   G7PDG2   A0A2K5D639   A0A2K5RSD6   A0A2R8P3E2  

EC Number

2.7.11.12

Pubmed

19121390    26354079    22118469    26227816    20966253    25244985    + More
12364791    20920257    23761445    20566863    24438588    26483478    17510324    21719571    21282665    19332792    23537049    25315136    26108605    24845553    25348373    25830018    18362917    19820115    28648823    26383154    20431018    15164054    29240929    21269460    25362486    22751099    20010809    24755649    21551351    22293439    22002653   

EMBL

BABH01012935    ODYU01007254    SOQ49869.1    KQ458756    KPJ05272.1    KQ460597    + More
KPJ13888.1    NWSH01006819    PCG63225.1    AGBW02014320    OWR41861.1    JTDY01001633    KOB73292.1    AAAB01008984    EAL38953.3    APCN01003364    APCN01003365    AJWK01027341    AJWK01027342    AJWK01027343    AJWK01027344    AXCN02002088    AXCM01001316    ADMH02002048    ETN59764.1    GEBQ01028033    GEBQ01027389    GEBQ01026875    GEBQ01002605    JAT11944.1    JAT12588.1    JAT13102.1    JAT37372.1    DS231906    EDS45394.1    GECZ01000603    JAS69166.1    GALX01001406    JAB67060.1    AAZO01002204    DS235150    EEB12545.1    ATLV01018376    KE525231    KFB43052.1    JXUM01037095    JXUM01037096    JXUM01037097    KQ561117    KXJ79656.1    KQ976419    KYM89358.1    CH477469    EAT40455.1    GL887707    EGI70108.1    GL768069    EFZ12418.1    EF999976    ABW22624.1    KQ977595    KYN01615.1    KB632064    ERL88498.1    NEVH01013973    PNF28055.1    PNF28056.1    JRES01001205    KNC24596.1    KK853043    KDR12116.1    CVRI01000054    CRK99932.1    KQ980824    KYN12439.1    CRK99933.1    KX809576    ASZ69797.1    KZ288230    PBC31613.1    KQ435124    KZC14773.1    EF999975    ABW22623.1    GAKP01020474    JAC38478.1    GBXI01013756    GBXI01003142    JAD00536.1    JAD11150.1    KQ971361    KYB25936.1    NNAY01001164    OXU24925.1    BC110022    AAI10023.1    AAMC01046206    AAMC01046207    AAMC01046208    AAMC01046209    AAMC01046210    AAMC01046211    AAMC01046212    CCAG010005704    AC022537    AC068062    AC069079    AC073584    AL157399    AL596105    AL607031    AL731537    KF455236    JH882335    ELR49868.1    KE163776    EPQ13767.1    GL192388    EFB20288.1    GEMB01000717    JAS02419.1    FR904300    CDQ58257.1    KN123966    KFO22695.1    AKHW03001467    KYO42378.1    KYO42379.1    FR904360    CDQ60846.1    JXJN01011892    ADFV01114579    ADFV01114580    ADFV01114581    ADFV01114582    ADFV01114583    ADFV01114584    ADFV01114585    ADFV01114586    ADFV01114587    ADFV01114588    AGTP01107148    AGTP01107149    AGTP01107150    AGTP01107151    AGTP01107152    AGTP01107153    AGTP01107154    AGTP01107155    AGTP01107156    AGTP01107157    CM001284    EHH64844.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000037510    + More
UP000075900    UP000075882    UP000075884    UP000076408    UP000007062    UP000075840    UP000092461    UP000075886    UP000075920    UP000076407    UP000075883    UP000075881    UP000075903    UP000075902    UP000000673    UP000069272    UP000075880    UP000075885    UP000002320    UP000009046    UP000030765    UP000069940    UP000249989    UP000078540    UP000008820    UP000007755    UP000005203    UP000078542    UP000030742    UP000235965    UP000095301    UP000037069    UP000027135    UP000183832    UP000078492    UP000242457    UP000076502    UP000007266    UP000215335    UP000085678    UP000233060    UP000079169    UP000248480    UP000245340    UP000189706    UP000008143    UP000092444    UP000005640    UP000189704    UP000092445    UP000261540    UP000233200    UP000245341    UP000193380    UP000233180    UP000028990    UP000092443    UP000005226    UP000078200    UP000050525    UP000092460    UP000001073    UP000261480    UP000242638    UP000005215    UP000009130    UP000233020    UP000233040    UP000008225   

PRIDE

H9JH58    B1ALS0   

Pfam

PF00027   cNMP_binding        + More
PF00069   Pkinase
PF16808   PKcGMP_CC
PF10018   Med4

Interpro

IPR018488   cNMP-bd_CS        + More
IPR000595   cNMP-bd_dom       
IPR018490   cNMP-bd-like       
IPR014710   RmlC-like_jellyroll       
IPR012198   cAMP_dep_PK_reg_su       
IPR002374   cGMP_dep_kinase       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR035014   STKc_cGK       
IPR011009   Kinase-like_dom_sf       
IPR000961   AGC-kinase_C       
IPR000719   Prot_kinase_dom       
IPR031831   PKcGMP_CC       
IPR019258   Mediator_Med4       

SUPFAM

SSF51206   SSF51206        + More
SSF56112   SSF56112       

Gene 3D

2.60.120.10    

CDD

cd00038  CAP_ED
cd05572  STKc_cGK

ProteinModelPortal

H9JH58   A0A2H1W9V6   A0A194QIC8   A0A194R7S6   A0A2A4ITY4   A0A212EK53   + More
A0A0L7LCS9   A0A182RUS6   A0A182LN13   A0A182NPY3   A0A182Y953   Q5TNQ0   A0A182I751   A0A1B0CTA2   A0A182Q6A5   A0A182VU81   A0A182XDF2   A0A182LWB4   A0A182K2C8   A0A182V0F5   A0A1S4GZF7   A0A182TVI1   W5JAF4   A0A182F5P8   A0A182JMX8   A0A182P699   A0A1B6MN91   B0WEA0   A0A1B6H3B7   V5GAA9   E0VGN9   A0A084VYK8   A0A182HFC5   A0A195BR46   Q170R4   F4W6N2   E9J3W6   A0A088AEL9   C3PUN5   A0A195CLN6   U4U839   A0A2J7QHI8   A0A2J7QHL2   A0A1I8M0W3   A0A0L0BX72   A0A067QRI0   A0A1J1IK64   A0A195DIV3   A0A1J1II54   A0A286NL54   A0A2A3EII9   A0A154PSC4   C3PUN4   A0A034VA88   A0A0A1XJT6   A0A139WDC9   A0A232F2K2   A0A1S3KIL0   A0A2K5MRU0   A0A3Q0IQ78   A0A2Y9RTP1   A0A2Y9RLI9   Q32KM5   A0A2U3WLJ6   A0A3Q0CEB2   A0A1U8C3D8   F6YCF0   A0A1B0FRC2   A0A2R8YE50   A0A2R8YH74   A0A1U7U448   A0A1B0A618   A0A3B3QXZ2   B1ALS0   A0A2K6QTG9   A0A2R8Y507   L8I106   S7PYU2   D2GZ26   A0A161MSN1   A0A2U3YC82   A0A060VTS8   A0A2K6N0U1   A0A091CXW1   A0A1A9YSE5   A0A3B5KDT0   A0A1A9V0Y8   A0A151NZZ3   A0A151P0K9   A0A060W1F2   A0A1B0BC86   G1RMZ8   A0A3B3Z234   A0A3P9PHF9   A0A287D7T9   G7PDG2   A0A2K5D639   A0A2K5RSD6   A0A2R8P3E2  

PDB

3SHR     E-value=1.45236e-22,     Score=259

KEGG

692605    K07376 cGMP-dependent protein kinase 1 [EC:2.7.11.12] | (RefSeq) PKG-I, PKG-II; protein kinase, cGMP

GO

GO:0016301   GO:0005829   GO:0019934   GO:0047555   GO:0030552   GO:0004692   GO:0005524   GO:0005952   GO:0008603   GO:0030553   GO:0016592   GO:0006357   GO:0003712   GO:0016021   GO:0043087   GO:0016358   GO:0030900   GO:0005794   GO:0005246   GO:0001764   GO:0005886   GO:0060087   GO:0090331   GO:1904753   GO:1904706  

Subcellular location

Nucleus  

Length:

203

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01747

Exp number, first 60 AAs:

0

Total prob of N-in:

0.30690

outside

1  -  203

 

 

Pi

144.756832

Theta

155.819621

Tajima's D

0.682891

CLR

0

CSRT

0.568071596420179

Interpretation

Uncertain