Gene

KWMTBOMO01243

Pre Gene Modal

BGIBMGA008851

Annotation

PREDICTED:_dual_3'?5'-cyclic-AMP_and_-GMP_phosphodiesterase_11_isoform_X5_[Bombyx_mori]

Location

Bomo_Chr3(+):6105095-6116679      View in EpiBrowser

Full name

Phosphodiesterase       + More
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11      

Alternative Name

cAMP and cGMP phosphodiesterase 11

Location in the cell

Cytoplasmic   Reliability : 1.425 Nuclear   Reliability : 1.011 PlasmaMembrane   Reliability : 1.45

CDS

ATGACTGTGAACATCGCGGATGCTTATTTGGATGCCCGTTTTGATCCCGCCGTCGATGAAGGAACCGGCTTCAAGCACAATACGATCCTCTGCATGGCCATTAAGAATTCAGAGGGGAGGATAATCGGTGTTATTCAGTTGATCAACAAGTTTGATGACTTGTTGTTCACGAAGAACGATGAGAACTTCGTCGAAGCTTTTGCCATTTTTTGCGGAATGGGCATCCACAATACGCACATGTACGAGAAGGCGATCACGGCTATGGCGAAGCAAAGCGTCACGCTTGACGTGTTGAGCTACCACGCATCAGCTTCGTTGGACGATGCTCAGCGATTACGGTCCTTGTTCCAGTCGTTGAGGATACCGTCATCGGCTCACTTCAGCCTCCACGAGCTGGCGTTCGACGACATCAATATGACGGACGACGACACGTTGAGAGCGTGCCTCCGGATGTTTCTGGACATGGACTTTGTCGAGAGATTTCACATAGACTACGCGGTCTTGTGCCGGTGGCTGCTGAGCGTGAAGAAAAACTATCGGAACGTCACTTACCACAATTGGAGGCACGCTTTCAATGTGGCCCAAATGATGTTCGCAATATTGACGGAGACTCAGTGGTGGAAGATATTCGGCGAGCTGGAATGCTTAGCTTTAATTATTGGCTGTCTGTGTCACGACCTTGATCACCGAGGGACCAATAACTCTTTCCAAATAAAGGCGTCGTCGCCATTAGCGCAGCTGTATTCGACATCCACAATGGAGCATCATCACTTCGATCAGTGTCTGATGATCTTGAACTCTCCCGGGAACCAAATCCTGCTGAATCTGTCTTCAGACGATTACGAGAAGGTCGTCAAGGTACTCGAGGACGCTATACTCTCCACCGACTTGGCTGTTTATTTCAGCAAAAGGAAAGCCTTCATAGAGCTGGTGAACTCTGATCGGACGGTGACTCCGTTGTGGGGCGAGTGCGTGGAGAGGCGTGGGCTGCTACGCGCCATGCTCATGACGGCCTGTGACCTCGCCGCCATCACCAAGCCCTGGCCAATAGAGCGGCGCGTGGCAGGACTGGTCGCTGGAGAGTTCTTCAGACAGGGCGACCTGGAGAGACAGAACCTGAACTTGACCCCTATTGACATAATGAATAGAGACAAAGAGGACCAGCTTCCGGCCATGCAAGTCAAGTTCATTGATACGATCTGCCTTCCGATATACGAGGCATTCGCGCGTCTATCGCCGGCCCTGCAGCCGATGCTCGATCGCGTCGAGAGCAATCGCGCGCACTGGATCGAGATGTCGAACAACGACGAGAAAATCGATTACGGACTCGAACGGGAAGCGATCGATAAAAACGACAAGTCCAGCGTCAGCTCGCAGAATGTCGACGACACCGAGAATACGTACGAAGGGGACAGCAGCGGCGCCGTCAGTCTGTCCTCCGAGACTAACTCGAAGTATGAGAACCTCGAGAATCCGGTCGTGGGGCTGTTGTGTAACAACGCGCTCGCCATCCCGAGAGACGCGACCAAGTTCTGTCACATTAACGACGTCAACTAG

Protein

MTVNIADAYLDARFDPAVDEGTGFKHNTILCMAIKNSEGRIIGVIQLINKFDDLLFTKNDENFVEAFAIFCGMGIHNTHMYEKAITAMAKQSVTLDVLSYHASASLDDAQRLRSLFQSLRIPSSAHFSLHELAFDDINMTDDDTLRACLRMFLDMDFVERFHIDYAVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTETQWWKIFGELECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILLNLSSDDYEKVVKVLEDAILSTDLAVYFSKRKAFIELVNSDRTVTPLWGECVERRGLLRAMLMTACDLAAITKPWPIERRVAGLVAGEFFRQGDLERQNLNLTPIDIMNRDKEDQLPAMQVKFIDTICLPIYEAFARLSPALQPMLDRVESNRAHWIEMSNNDEKIDYGLEREAIDKNDKSSVSSQNVDDTENTYEGDSSGAVSLSSETNSKYENLENPVVGLLCNNALAIPRDATKFCHINDVN

Description

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Catalytic Activity

3',5'-cyclic GMP + H2O = GMP + H(+)
3',5'-cyclic AMP + H2O = AMP + H(+)

Cofactor

a divalent metal cation

Biophysicochemical Properties

18.5 uM for cAMP KM=6 uM for cGMP

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

Alternative splicing   cAMP   cGMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome   Repeat  

Feature

chain  Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
splice variant  In isoform C.

Uniprot

A0A2W1BX00   A0A2A4JRT0   A0A2H1X2K2   H9JH54   A0A194R7T1   A0A1S4F7V7   + More
Q17CK8   B0X978   A0A0L7RKM4   A0A1I8P1H4   A0A182G306   A0A195CCX4   A0A1B0FN80   A0A182GNV7   B4P9V0   A0A1A9VXM8   A0A1A9ZIV5   A0A0Q9WCQ4   B4LTJ1   B4KK28   B4JDM2   E1ZV78   A0A0Q9XE74   Q9VJ79-2   A0A1B0B4N4   E0VX88   B3MM25   A0A0Q5VZ46   A0A0J9R482   A0A026W6P7   Q9VJ79-3   A0A1Q3EX09   A0A195BFM4   X2J6P6   X2J8Z1   A0A0Q5VUH7   A0A0J9R528   Q9VJ79   T1PGJ0   A0A1Q3EW90   A0A1W4V9M4   A0A0Q9WBB0   A0A0Q9X413   A0A1A9XDR6   A0A1I8P1C0   A0A151WUW1   A0A1W4VMQ0   A0A088AHD5   A0A1B6F748   A0A0C9QUJ7   A0A154PAQ7   B4MZG4   A0A0A1XNM9   A0A0J7KKA5   A0A151JB35   M9MSJ0   A0A195FAQ6   A0A0R3NSE6   A0A1B6KEA3   A0A182KA65   A0A0Q5VKF0   A0A0J9R475   A0A084W7Q4   A0A1W4VM14   M9MRK1   W8AMK1   A0A0J9R3I8   A0A182J222   B4Q8U9   A0A0K8WEA3   B5DHZ2   B4I5H6   A0A0K8VLT8   A0A1I8MJ33   A0A0C9RZA0   E2BX21   A0A182NGQ3   A0A3B0J9Q2   A0A3B0JFK7   A0A0M4EE19   A0A067R4U9   A0A0L0CC81   A0A182TAU6   A0A0N0BHH4   A0A0R3NSI8   A0A1J1IHZ2   W8B7A9   D6WXS4   T1I6M0   A0A2M3Z0Y2   A0A2M4A1J8   U4U9I9   N6U5Q9   A0A2R7VRY1   A0A2M3Z0V7   A0A069DZL1   A0A2M3YYZ9   A0A1Y1MHF0   A0A182P1L3   A0A2M4BBA8  

EC Number

3.1.4.-

Pubmed

28756777    19121390    26354079    17510324    26483478    17994087    + More
17550304    18057021    20798317    10731132    12537572    12537569    15673286    20566863    22936249    24508170    30249741    12537568    12537573    12537574    16110336    17569856    17569867    25830018    15632085    24438588    24495485    25315136    24845553    26108605    18362917    19820115    23537049    26334808    28004739   

EMBL

KZ149910    PZC78154.1    NWSH01000794    PCG74173.1    ODYU01012511    SOQ58864.1    + More
BABH01012950    KQ460597    KPJ13893.1    CH477307    EAT44089.1    DS232522    EDS43010.1    KQ414568    KOC71369.1    JXUM01006736    JXUM01006737    JXUM01006738    JXUM01006739    JXUM01006740    JXUM01006741    JXUM01006742    JXUM01006743    JXUM01006744    KQ560221    KXJ83750.1    KQ977935    KYM98570.1    CCAG010022043    JXUM01014948    JXUM01014949    JXUM01014950    KQ560417    KXJ82517.1    CM000158    EDW90291.2    CH940649    KRF81958.1    EDW64964.2    KRF81959.1    CH933807    EDW11546.2    CH916368    EDW03392.1    GL434441    EFN74937.1    KRG02750.1    AE014134    AY122262    JXJN01008376    DS235829    EEB17994.1    CH902620    EDV30840.2    CH954179    KQS61928.1    CM002910    KMY90831.1    KK107373    QOIP01000004    EZA51643.1    RLU23841.1    GFDL01015196    JAV19849.1    KQ976502    KYM82982.1    AHN54558.1    AHN54559.1    KQS61929.1    KMY90824.1    KA646973    AFP61602.1    GFDL01015471    JAV19574.1    KRF81960.1    KRG02752.1    KQ982730    KYQ51491.1    GECZ01023784    JAS45985.1    GBYB01004307    JAG74074.1    KQ434860    KZC08932.1    CH963920    EDW77749.2    GBXI01001735    JAD12557.1    LBMM01006380    KMQ90654.1    KQ979181    KYN22352.1    ADV37086.1    KQ981700    KYN37518.1    CH379060    KRT04088.1    GEBQ01030218    JAT09759.1    KQS61927.1    KMY90826.1    ATLV01021272    KE525315    KFB46248.1    ADV37087.1    GAMC01020837    GAMC01020834    JAB85718.1    KMY90827.1    CM000361    EDX05381.1    GDHF01003134    JAI49180.1    EDY70048.2    CH480822    EDW55632.1    GDHF01012467    GDHF01011566    JAI39847.1    JAI40748.1    GBYB01013436    JAG83203.1    GL451202    EFN79740.1    OUUW01000004    SPP79004.1    SPP79002.1    CP012523    ALC40197.1    KK852699    KDR18162.1    JRES01000613    KNC29856.1    KQ435754    KOX76072.1    KRT04087.1    CVRI01000054    CRK99879.1    GAMC01020831    JAB85724.1    KQ971362    EFA07940.2    ACPB03010138    GGFM01001422    MBW22173.1    GGFK01001365    MBW34686.1    KB632186    ERL89722.1    APGK01039019    APGK01039020    APGK01039021    APGK01039022    APGK01039023    KB740966    ENN76950.1    KK854049    PTY10277.1    GGFM01001416    MBW22167.1    GBGD01000450    JAC88439.1    GGFM01000734    MBW21485.1    GEZM01030960    JAV85134.1    GGFJ01001169    MBW50310.1   

Proteomes

UP000218220    UP000005204    UP000053240    UP000008820    UP000002320    UP000053825    + More
UP000095300    UP000069940    UP000249989    UP000078542    UP000092444    UP000002282    UP000078200    UP000092445    UP000008792    UP000009192    UP000001070    UP000000311    UP000000803    UP000092460    UP000009046    UP000007801    UP000008711    UP000053097    UP000279307    UP000078540    UP000192221    UP000092443    UP000075809    UP000005203    UP000076502    UP000007798    UP000036403    UP000078492    UP000078541    UP000001819    UP000075881    UP000030765    UP000075880    UP000000304    UP000001292    UP000095301    UP000008237    UP000075884    UP000268350    UP000092553    UP000027135    UP000037069    UP000075901    UP000053105    UP000183832    UP000007266    UP000015103    UP000030742    UP000019118    UP000075885   

PRIDE

H9JH54    Q9VJ79    X2J6P6    X2J8Z1   

Pfam

PF01590   GAF        + More
PF00233   PDEase_I

Interpro

IPR003607   HD/PDEase_dom        + More
IPR036971   PDEase_catalytic_dom_sf       
IPR029016   GAF-like_dom_sf       
IPR002073   PDEase_catalytic_dom       
IPR003018   GAF       
IPR023088   PDEase       
IPR023174   PDEase_CS       

Gene 3D

1.10.1300.10     3.30.450.40    

CDD

cd00077  HDc

ProteinModelPortal

A0A2W1BX00   A0A2A4JRT0   A0A2H1X2K2   H9JH54   A0A194R7T1   A0A1S4F7V7   + More
Q17CK8   B0X978   A0A0L7RKM4   A0A1I8P1H4   A0A182G306   A0A195CCX4   A0A1B0FN80   A0A182GNV7   B4P9V0   A0A1A9VXM8   A0A1A9ZIV5   A0A0Q9WCQ4   B4LTJ1   B4KK28   B4JDM2   E1ZV78   A0A0Q9XE74   Q9VJ79-2   A0A1B0B4N4   E0VX88   B3MM25   A0A0Q5VZ46   A0A0J9R482   A0A026W6P7   Q9VJ79-3   A0A1Q3EX09   A0A195BFM4   X2J6P6   X2J8Z1   A0A0Q5VUH7   A0A0J9R528   Q9VJ79   T1PGJ0   A0A1Q3EW90   A0A1W4V9M4   A0A0Q9WBB0   A0A0Q9X413   A0A1A9XDR6   A0A1I8P1C0   A0A151WUW1   A0A1W4VMQ0   A0A088AHD5   A0A1B6F748   A0A0C9QUJ7   A0A154PAQ7   B4MZG4   A0A0A1XNM9   A0A0J7KKA5   A0A151JB35   M9MSJ0   A0A195FAQ6   A0A0R3NSE6   A0A1B6KEA3   A0A182KA65   A0A0Q5VKF0   A0A0J9R475   A0A084W7Q4   A0A1W4VM14   M9MRK1   W8AMK1   A0A0J9R3I8   A0A182J222   B4Q8U9   A0A0K8WEA3   B5DHZ2   B4I5H6   A0A0K8VLT8   A0A1I8MJ33   A0A0C9RZA0   E2BX21   A0A182NGQ3   A0A3B0J9Q2   A0A3B0JFK7   A0A0M4EE19   A0A067R4U9   A0A0L0CC81   A0A182TAU6   A0A0N0BHH4   A0A0R3NSI8   A0A1J1IHZ2   W8B7A9   D6WXS4   T1I6M0   A0A2M3Z0Y2   A0A2M4A1J8   U4U9I9   N6U5Q9   A0A2R7VRY1   A0A2M3Z0V7   A0A069DZL1   A0A2M3YYZ9   A0A1Y1MHF0   A0A182P1L3   A0A2M4BBA8  

PDB

3BJC     E-value=1.77073e-123,     Score=1134

KEGG

101738997    K13298 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [EC:3.1.4.17 3.1.4.35] | (RefSeq) dual 3'

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004114   GO:0007165   GO:0046872   GO:0004115   GO:0046058   GO:0046068   GO:0047555   GO:0005829   GO:0016021   GO:0008081   GO:0005515   GO:0006000   GO:0004553   GO:0005634   GO:0006334   GO:0003779  

Length:

518

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.18852

Exp number, first 60 AAs:

0.0011

Total prob of N-in:

0.01054

outside

1  -  518

 

 

Pi

148.138446

Theta

179.863721

Tajima's D

-1.022427

CLR

1487.627695

CSRT

0.133793310334483

Interpretation

Uncertain