Gene

KWMTBOMO01234

Annotation

Uncharacterized_protein_OBRU01_14001_[Operophtera_brumata]

Location

Bomo_Chr3(+):5734098-5735283      View in EpiBrowser

Full name

Protein quiver      

Alternative Name

Protein sleepless

Location in the cell

Extracellular   Reliability : 3.814

CDS

ATGTATGTAAAACTAATGTTTGTTTCCCTTTTATGTACCTTTCAAACAGTTGTTTCGATAAAATGCTACCAATGCGCGTCTTCTCAAGATCACAAAGGGGAAGATACATGCGGAGCATACAGGAAATTCGATAGAGAAAGTCACATAGCTGTAGACTGTGGTAGCGATGAATCTCACATGCCAGGAGCATTTTGTATGAAGTTAACTCAACAAGGACCCAAAGGGTTCATTTGGGATGGCAGATGGCGTCAAGTTATAAGACGATGCGCATCTGTAGCTGAGACTGGAGTGACCGGTGTCTGTAACTGGGGTGTCTATGACAACGGTGTGTACTGGGAAGAATGTTACTGTACCTCAGATGAATGCAATGGTTCTACGAGTGTATCTCTCTCAATTGCATTATTCATGGGCTCATTGAGCATATTGTTTGGCTTGTATAAGGTCTAG

Protein

MYVKLMFVSLLCTFQTVVSIKCYQCASSQDHKGEDTCGAYRKFDRESHIAVDCGSDESHMPGAFCMKLTQQGPKGFIWDGRWRQVIRRCASVAETGVTGVCNWGVYDNGVYWEECYCTSDECNGSTSVSLSIALFMGSLSILFGLYKV

Description

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

Similarity

Belongs to the quiver family.
Belongs to the AAA ATPase family.

Feature

chain  Protein quiver

Uniprot

A0A2A4JKV3   A0A0L7L7B0   A0A2H1WRX4   A0A212EVR2   S4NXK5   A0A067RGD8   + More
A0A1W4WK12   A0A0L0BT11   D6WXS0   A0A0A1WWD6   A0A0A1XHA5   A0A1B0CB01   A0A0T6B460   B3MNV4   A0A1Y1LY69   W8BKT3   B4KG96   A0A0K8WHA7   A0A2J7QW61   A0A1I8N3Q3   A0A1B6HNU8   A0A1L8DNY4   B3N3W0   B4LTR7   A0A0M4E7V2   Q9VKA1   B4IE77   A0A1B6L8F0   A0A1W4V309   B4P1Z9   Q8SZ82   Q29M71   B4G9N1   B4Q3R6   A0A3B0K6U2   A0A1J1HDY4   A0A1B0D4T5   Q71D51   A0A3B0JZU9   B4MVF1   B4JDG0   A0A1L8DNU6   A0A336LCK0   A0A182G4H0   A0A182YN73   A0A336LVK1   A0A1B6F5U8   A0A1A9VA77   A0A034WKB7   A0A182SY11   A0A023EH01   A0A1A9WZL2   Q17CL1   U5ESH5   A0A023EFJ7   A0A023EFB9   K7J3F8   A0A182IBJ2   A0A182VF76   A0A182NGP9   A0A1I8PYI1   A0A182RK47   A0A1S4GZK7   A0A1B0B2B4   A0A182WFF6   A0A1A9Y495   A0A182PVG5   E2B2C5   A0A1B0FHH4   E9FYS0   A0A1B0AAM8   A0A182KN54   E0VU09   A0A182JZ18   A0A182QCR2   W5JF11   A0A2M4C2G4   A0A182X5V9   A0A0A9XZ32   A0A087ZQE3   A0A2M4AVJ8   A0A182F363   A0A0C9QAZ2   A0A2A3E5P6   Q7Q8G5   A0A1D2MG56   A0A2M4C2D1   A0A1B6C834   A0A2M3ZED3   A0A182TXA0   A0A164Y888   A0A0P6ALF7   A0A0N8BIC2   A0A2M4C366   A0A182ILI7   A0A0P5VCG8   A0A1Q3F8D5   A0A2M4AYW3   A0A3L8DM28   A0A026W1W7  

Pubmed

26227816    22118469    23622113    24845553    26108605    18362917    + More
19820115    25830018    17994087    28004739    24495485    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    15632085    22936249    14525923    26483478    25244985    25348373    24945155    17510324    20075255    12364791    20798317    21292972    20966253    20566863    20920257    23761445    25401762    27289101    30249741    24508170   

EMBL

NWSH01001143    PCG72416.1    JTDY01002449    KOB71392.1    ODYU01010604    SOQ55825.1    + More
AGBW02012162    OWR45551.1    GAIX01012122    JAA80438.1    KK852699    KDR18169.1    JRES01001399    KNC23182.1    KQ971362    EFA07943.2    GBXI01011497    GBXI01011306    JAD02795.1    JAD02986.1    GBXI01003523    JAD10769.1    AJWK01004691    LJIG01016081    KRT81671.1    CH902620    EDV32141.2    GEZM01046792    GEZM01046791    JAV77005.1    GAMC01007173    JAB99382.1    CH933807    EDW11083.2    GDHF01001865    JAI50449.1    NEVH01009767    PNF32828.1    GECU01031349    JAS76357.1    GFDF01005925    JAV08159.1    CH954177    EDV58812.1    CH940649    EDW63968.1    CP012525    ALC42854.1    AE014134    BT056238    KX531468    AAF53177.1    ACL68685.1    ANY27278.1    CH480831    EDW45904.1    GEBQ01019985    JAT19992.1    CM000157    EDW88170.1    AY071055    AAL48677.1    CH379060    EAL33823.2    CH479180    EDW29061.1    CM000361    CM002910    EDX04791.1    KMY89894.1    OUUW01000004    SPP79218.1    CVRI01000001    CRK86176.1    AJVK01024863    AF532019    AAQ09918.1    SPP79219.1    CH963857    EDW76496.1    CH916368    EDW03330.1    GFDF01005955    JAV08129.1    UFQS01003100    UFQT01003100    SSX15199.1    SSX34574.1    JXUM01042352    KQ561321    KXJ78985.1    UFQT01000223    SSX21984.1    GECZ01024133    GECZ01022626    GECZ01012570    JAS45636.1    JAS47143.1    JAS57199.1    GAKP01004165    JAC54787.1    GAPW01005494    JAC08104.1    CH477307    EAT44086.1    GANO01002351    JAB57520.1    GAPW01005496    JAC08102.1    GAPW01005495    JAC08103.1    APCN01000707    AAAB01008944    JXJN01007544    GL445130    EFN90162.1    CCAG010008329    GL732527    EFX87583.1    DS235777    EEB16865.1    AXCN02002080    ADMH02001597    ETN61913.1    GGFJ01010308    MBW59449.1    GBHO01018430    GBRD01012933    JAG25174.1    JAG52893.1    GGFK01011492    MBW44813.1    GBYB01000399    JAG70166.1    KZ288389    PBC26391.1    EAA10154.4    LJIJ01001394    ODM91862.1    GGFJ01010303    MBW59444.1    GEDC01027704    JAS09594.1    GGFM01006121    MBW26872.1    LRGB01000930    KZS14980.1    GDIP01029307    JAM74408.1    GDIQ01174883    JAK76842.1    GGFJ01010307    MBW59448.1    GDIP01117065    JAL86649.1    GFDL01011214    JAV23831.1    GGFK01012658    MBW45979.1    QOIP01000006    RLU21484.1    KK107487    EZA50060.1   

Proteomes

UP000218220    UP000037510    UP000007151    UP000027135    UP000192223    UP000037069    + More
UP000007266    UP000092461    UP000007801    UP000009192    UP000235965    UP000095301    UP000008711    UP000008792    UP000092553    UP000000803    UP000001292    UP000192221    UP000002282    UP000001819    UP000008744    UP000000304    UP000268350    UP000183832    UP000092462    UP000007798    UP000001070    UP000069940    UP000249989    UP000076408    UP000078200    UP000075901    UP000091820    UP000008820    UP000002358    UP000075840    UP000075903    UP000075884    UP000095300    UP000075900    UP000092460    UP000075920    UP000092443    UP000075885    UP000008237    UP000092444    UP000000305    UP000092445    UP000075882    UP000009046    UP000075881    UP000075886    UP000000673    UP000076407    UP000005203    UP000069272    UP000242457    UP000007062    UP000094527    UP000075902    UP000076858    UP000075880    UP000279307    UP000053097   

PRIDE

Q9VKA1    Q8SZ82   

Pfam

PF17064   QVR        + More
PF00004   AAA
PF17862   AAA_lid_3

Interpro

IPR031424   QVR        + More
IPR041569   AAA_lid_3       
IPR003593   AAA+_ATPase       
IPR027417   P-loop_NTPase       
IPR003960   ATPase_AAA_CS       
IPR003959   ATPase_AAA_core       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

A0A2A4JKV3   A0A0L7L7B0   A0A2H1WRX4   A0A212EVR2   S4NXK5   A0A067RGD8   + More
A0A1W4WK12   A0A0L0BT11   D6WXS0   A0A0A1WWD6   A0A0A1XHA5   A0A1B0CB01   A0A0T6B460   B3MNV4   A0A1Y1LY69   W8BKT3   B4KG96   A0A0K8WHA7   A0A2J7QW61   A0A1I8N3Q3   A0A1B6HNU8   A0A1L8DNY4   B3N3W0   B4LTR7   A0A0M4E7V2   Q9VKA1   B4IE77   A0A1B6L8F0   A0A1W4V309   B4P1Z9   Q8SZ82   Q29M71   B4G9N1   B4Q3R6   A0A3B0K6U2   A0A1J1HDY4   A0A1B0D4T5   Q71D51   A0A3B0JZU9   B4MVF1   B4JDG0   A0A1L8DNU6   A0A336LCK0   A0A182G4H0   A0A182YN73   A0A336LVK1   A0A1B6F5U8   A0A1A9VA77   A0A034WKB7   A0A182SY11   A0A023EH01   A0A1A9WZL2   Q17CL1   U5ESH5   A0A023EFJ7   A0A023EFB9   K7J3F8   A0A182IBJ2   A0A182VF76   A0A182NGP9   A0A1I8PYI1   A0A182RK47   A0A1S4GZK7   A0A1B0B2B4   A0A182WFF6   A0A1A9Y495   A0A182PVG5   E2B2C5   A0A1B0FHH4   E9FYS0   A0A1B0AAM8   A0A182KN54   E0VU09   A0A182JZ18   A0A182QCR2   W5JF11   A0A2M4C2G4   A0A182X5V9   A0A0A9XZ32   A0A087ZQE3   A0A2M4AVJ8   A0A182F363   A0A0C9QAZ2   A0A2A3E5P6   Q7Q8G5   A0A1D2MG56   A0A2M4C2D1   A0A1B6C834   A0A2M3ZED3   A0A182TXA0   A0A164Y888   A0A0P6ALF7   A0A0N8BIC2   A0A2M4C366   A0A182ILI7   A0A0P5VCG8   A0A1Q3F8D5   A0A2M4AYW3   A0A3L8DM28   A0A026W1W7  

KEGG

101742852    no KO assigned | (RefSeq) uncharacterized LOC101742852

GO

GO:0016021   GO:0045187   GO:0005886   GO:0048511   GO:0034235   GO:1903818   GO:0030431   GO:0032222   GO:0031225   GO:0005829   GO:0005524  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.995057

 

 

Length:

148

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.8193

Exp number, first 60 AAs:

0.74635

Total prob of N-in:

0.33948

outside

1  -  148

 

 

Pi

183.638976

Theta

183.862612

Tajima's D

-0.53259

CLR

0.681756

CSRT

0.23638818059097

Interpretation

Uncertain