Gene

KWMTBOMO01232  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008848

Annotation

putative_ly-6/neurotoxin_superfamily_member_1_[Operophtera_brumata]

Location

Bomo_Chr3(+):5709588-5727064      View in EpiBrowser

Full name

Protein quiver      

Alternative Name

Protein sleepless

Location in the cell

Extracellular   Reliability : 4.448

CDS

ATGGCAAAACTATCGTTTCTTGTGCCCGTTTTGCTTCTTGCGCTATTCGTGAAGGACAGTGAACCAGTGAATTGTTGGGCGTGTTCGTCTAACGTGAATCCGCTGTGCAACGATCCTTTTAATATCCGTATCGACACCGGGAATTCTTATTTGTTCCGCCTCGAAAACTGCGACAAGAATGCTGGAGCTACCTTTCCTTATTTGACAGCTTCGAAGTCTGTATGCAAGAAAGAAAAGAAATACATTGATGGTGAATTAGTTGTGAGTCGTGGTTGCACCTGGAAACGCCAGGATGACTTCGAAGTCGGTTGCCCTACTTCCAGAAACGAAGCAAACGAAGTGAATCTCTTCTGTCAGACCTGTGACTACGACGGATGCAACGGAGCCGCTACCATCGGCAGGACGATCGCTCTATTGCTCGCACCTCTCAGCCTCCTCTTGTTGAAGTAA

Protein

MAKLSFLVPVLLLALFVKDSEPVNCWACSSNVNPLCNDPFNIRIDTGNSYLFRLENCDKNAGATFPYLTASKSVCKKEKKYIDGELVVSRGCTWKRQDDFEVGCPTSRNEANEVNLFCQTCDYDGCNGAATIGRTIALLLAPLSLLLLK

Description

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

Similarity

Belongs to the quiver family.

Feature

chain  Protein quiver

Uniprot

H9JH51   A0A2W1BY38   A0A2H1X2D0   A0A0L7L7W8   I4DJK1   A0A194QIQ9   + More
A0A212F7X5   S4P8V1   A0A1E1W9R6   A0A069DPK0   A0A224XN13   A0A0P4VKI5   A0A0V0G953   Q1HQZ0   A0A2S2NT63   U5EDB7   A0A023EFU8   A0A182G4H2   C4WW54   B0X7N2   A0A2S2Q6L0   A0A0A9X2S6   A0A1Q3FZI3   A0A1Q3FZJ7   A0A146MCS9   A0A1B0CML5   A0A336K8A4   A0A1L8DNZ8   A0A1J1IL94   T1D554   A0A084W7P2   A0A1B6DS46   B3NKY0   R4UNF8   C5IWP3   B4IFH2   B4Q3V6   Q9VII5   B4P724   A0A0K8VK42   A0A034VLL4   A0A1I8MED2   A0A067R4K6   W8B283   A0A182U3Y2   A0A2M4A5I1   A0A2M4A553   A0A1S4GYT8   A0A2C9GS45   A0A182UND5   A0A158NNF8   Q7Q8G7   A0A2M4DN25   A0A2M4A497   A0A0L0CG35   A0A3L8DS81   E1ZV82   A0A151WUG8   A0A182QTB6   A0A2M3YXU6   A0A2M3ZE83   A0A0A1WPV7   A0A1W4XP76   A0A2M3YWC5   A0A0C5AYN4   A0A182F362   A0A336KJT5   A0A3B0K1X1   T1E9L8   A0A1Y9IWC7   A0A2M4C2D0   A0A2M4C2A7   B5DIR0   B4G725   A0A2M4C2B6   A0A2M4C1V1   V9ILT4   A0A088AHD2   A0A195CCW9   A0A1W4UW05   E9IIU0   E0VVY9   A0A182RK49   B4MV59   A0A2A3E573   A0A0M4E781   A0A0L7R443   A0A1I8PHK9   B3MU82   A0A182PVG4   A0A0M8ZZ44   B4LUN4   B4JD94   A0A182JZ17   B4KL10   A0A0Q9XII0   A0A1B0GAJ1   A0A154PAQ1  

Pubmed

19121390    28756777    26227816    22651552    26354079    22118469    + More
23622113    26334808    27129103    17204158    17510324    24945155    26483478    25401762    26823975    24330624    24438588    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25348373    25315136    24845553    24495485    12364791    21347285    26108605    30249741    20798317    25830018    15632085    21282665    20566863    18057021   

EMBL

BABH01012984    KZ149910    PZC78147.1    ODYU01012936    SOQ59481.1    JTDY01002449    + More
KOB71391.1    AK401469    BAM18091.1    KQ458756    KPJ05284.1    AGBW02009823    OWR49844.1    GAIX01007117    JAA85443.1    GDQN01007304    JAT83750.1    GBGD01003342    JAC85547.1    GFTR01002540    JAW13886.1    GDKW01003584    JAI53011.1    GECL01001598    JAP04526.1    DQ440304    CH477307    ABF18337.1    EAT44084.1    GGMR01007726    MBY20345.1    GANO01004834    JAB55037.1    GAPW01005310    JAC08288.1    JXUM01042357    JXUM01042358    JXUM01042359    JXUM01042360    KQ561321    KXJ78987.1    ABLF02036169    AK341857    BAH72124.1    DS232456    EDS42044.1    GGMS01004038    MBY73241.1    GBHO01029638    GBHO01029637    GBHO01029636    GBHO01029635    GBHO01029634    GBHO01029633    GBRD01013774    GBRD01013773    GBRD01013772    GBRD01013770    JAG13966.1    JAG13967.1    JAG13968.1    JAG13969.1    JAG13970.1    JAG13971.1    JAG52052.1    GFDL01002092    JAV32953.1    GFDL01002067    JAV32978.1    GDHC01002289    JAQ16340.1    AJWK01018884    AJWK01018885    AJWK01018886    AJWK01018887    UFQS01000114    UFQT01000114    SSW99848.1    SSX20228.1    GFDF01005886    JAV08198.1    CVRI01000055    CRL01013.1    GALA01000678    JAA94174.1    ATLV01021269    KE525315    KFB46236.1    GEDC01008796    JAS28502.1    CH954179    EDV54503.1    KC740871    AGM32695.1    FJ968776    ACR56003.1    CH480833    EDW46394.1    CM000361    CM002910    EDX05672.1    KMY91231.1    AE014134    AY075543    KX531351    AAF53934.3    AAL68350.1    AHN54627.1    ANY27161.1    CM000158    EDW89993.1    GDHF01033478    GDHF01013082    JAI18836.1    JAI39232.1    GAKP01014771    JAC44181.1    KK852699    KDR18171.1    GAMC01019179    JAB87376.1    GGFK01002669    MBW35990.1    GGFK01002616    MBW35937.1    AAAB01008944    APCN01000707    ADTU01021428    ADTU01021429    ADTU01021430    ADTU01021431    ADTU01021432    ADTU01021433    ADTU01021434    ADTU01021435    ADTU01021436    ADTU01021437    EAA10065.4    GGFL01014792    MBW78970.1    GGFK01002313    MBW35634.1    JRES01000438    KNC31210.1    QOIP01000004    RLU23290.1    GL434441    EFN74941.1    KQ982730    KYQ51486.1    AXCN02002080    GGFM01000336    MBW21087.1    GGFM01006095    MBW26846.1    GBXI01013596    JAD00696.1    GGFF01000090    MBW20557.1    KM974262    AJL35192.1    UFQS01000518    UFQT01000518    SSX04541.1    SSX24904.1    OUUW01000004    SPP79596.1    GAMD01001227    JAB00364.1    GGFJ01010302    MBW59443.1    GGFJ01010301    MBW59442.1    CH379060    EDY70202.1    CH479180    EDW29224.1    GGFJ01010170    MBW59311.1    GGFJ01010169    MBW59310.1    JR050453    AEY61284.1    KQ977935    KYM98565.1    GL763529    EFZ19513.1    DS235816    EEB17545.1    CH963857    EDW76404.1    KZ288365    PBC26840.1    CP012523    ALC39566.1    ALC40334.1    KQ414659    KOC65618.1    CH902624    EDV33411.1    KPU74465.1    KQ435819    KOX72519.1    CH940649    EDW64220.1    CH916368    EDW03267.1    CH933807    EDW12760.2    KRG03411.1    CCAG010013001    CCAG010013002    CCAG010013003    KQ434860    KZC08922.1   

Proteomes

UP000005204    UP000037510    UP000053268    UP000007151    UP000008820    UP000069940    + More
UP000249989    UP000007819    UP000002320    UP000092461    UP000183832    UP000030765    UP000008711    UP000001292    UP000000304    UP000000803    UP000002282    UP000095301    UP000027135    UP000075902    UP000075840    UP000075903    UP000005205    UP000007062    UP000037069    UP000279307    UP000000311    UP000075809    UP000075886    UP000192223    UP000069272    UP000268350    UP000075920    UP000001819    UP000008744    UP000005203    UP000078542    UP000192221    UP000009046    UP000075900    UP000007798    UP000242457    UP000092553    UP000053825    UP000095300    UP000007801    UP000075885    UP000053105    UP000008792    UP000001070    UP000075881    UP000009192    UP000092444    UP000076502   

PRIDE

H9JH51    Q9VII5   

Pfam

PF17064   QVR

Interpro

IPR031424   QVR       

ProteinModelPortal

H9JH51   A0A2W1BY38   A0A2H1X2D0   A0A0L7L7W8   I4DJK1   A0A194QIQ9   + More
A0A212F7X5   S4P8V1   A0A1E1W9R6   A0A069DPK0   A0A224XN13   A0A0P4VKI5   A0A0V0G953   Q1HQZ0   A0A2S2NT63   U5EDB7   A0A023EFU8   A0A182G4H2   C4WW54   B0X7N2   A0A2S2Q6L0   A0A0A9X2S6   A0A1Q3FZI3   A0A1Q3FZJ7   A0A146MCS9   A0A1B0CML5   A0A336K8A4   A0A1L8DNZ8   A0A1J1IL94   T1D554   A0A084W7P2   A0A1B6DS46   B3NKY0   R4UNF8   C5IWP3   B4IFH2   B4Q3V6   Q9VII5   B4P724   A0A0K8VK42   A0A034VLL4   A0A1I8MED2   A0A067R4K6   W8B283   A0A182U3Y2   A0A2M4A5I1   A0A2M4A553   A0A1S4GYT8   A0A2C9GS45   A0A182UND5   A0A158NNF8   Q7Q8G7   A0A2M4DN25   A0A2M4A497   A0A0L0CG35   A0A3L8DS81   E1ZV82   A0A151WUG8   A0A182QTB6   A0A2M3YXU6   A0A2M3ZE83   A0A0A1WPV7   A0A1W4XP76   A0A2M3YWC5   A0A0C5AYN4   A0A182F362   A0A336KJT5   A0A3B0K1X1   T1E9L8   A0A1Y9IWC7   A0A2M4C2D0   A0A2M4C2A7   B5DIR0   B4G725   A0A2M4C2B6   A0A2M4C1V1   V9ILT4   A0A088AHD2   A0A195CCW9   A0A1W4UW05   E9IIU0   E0VVY9   A0A182RK49   B4MV59   A0A2A3E573   A0A0M4E781   A0A0L7R443   A0A1I8PHK9   B3MU82   A0A182PVG4   A0A0M8ZZ44   B4LUN4   B4JD94   A0A182JZ17   B4KL10   A0A0Q9XII0   A0A1B0GAJ1   A0A154PAQ1  

KEGG

101743136    no KO assigned | (RefSeq) uncharacterized LOC101743136

GO

GO:0016021   GO:0045187   GO:0034235   GO:0048511   GO:0005886   GO:1903818   GO:0030431   GO:0032222   GO:0031225  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 22,         Likelihood:  0.998219

 

 

Length:

149

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.88286

Exp number, first 60 AAs:

0.01573

Total prob of N-in:

0.04256

outside

1  -  149

 

 

Pi

219.772865

Theta

171.207314

Tajima's D

0.54875

CLR

0.432339

CSRT

0.527273636318184

Interpretation

Uncertain