Gene

KWMTBOMO01229  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008847

Annotation

PREDICTED:_uncharacterized_protein_LOC101743420_[Bombyx_mori]

Location

Bomo_Chr3(+):5645038-5658217      View in EpiBrowser

Full name

Protein quiver      

Alternative Name

Protein sleepless

Location in the cell

Extracellular   Reliability : 4.474

CDS

ATGGCAAAAAGTGTAGCATTCGCCTTCGCTGTTCTACTAGCGCTATTCGAAACAGGCTATTGCATCAAGTGCTACCAATGTAACAGTGAACAGGATAAGAACTGCGGGGACCCGTTCAAGAGCGCCAAACCCCCAGTAGAATGCAACACCCAGGATTCGATTAACTTCAATACGCTCTACCTGCGCAACATTCTGCCTGTCGAAGTCTTGAACAGCGTTACGGGAGCTCCTAGATACTGTCACAAGATCGTCATGAAGAGCGGAACTGTTGTCCGTACTTGCTTGGATGTCAACCCCAACGATTCCCAGCACACCTGCCGAGTTGTCGAGCTCGCCTCCAACACCGCGATCGCTGACAGCGCGAAGGTCAAGTCCTGCGCTGTGTGCAACAAGGACAACTGTAACGGAGCTGGATCTATTTCCTTCTCTCTCCCACTGGCCACATTCGCTCTGATCGCTACGTATTTCGTTTTCAAACAATAA

Protein

MAKSVAFAFAVLLALFETGYCIKCYQCNSEQDKNCGDPFKSAKPPVECNTQDSINFNTLYLRNILPVEVLNSVTGAPRYCHKIVMKSGTVVRTCLDVNPNDSQHTCRVVELASNTAIADSAKVKSCAVCNKDNCNGAGSISFSLPLATFALIATYFVFKQ

Description

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability.

Similarity

Belongs to the quiver family.

Feature

chain  Protein quiver

Uniprot

H9JH50   A0A2A4J434   A0A2W1BWX5   I4DL69   I4DMY3   A0A194QK48   + More
A0A0N1IH29   A0A1E1W402   S4P3Z0   A0A0V0G953   R4G540   A0A069DPK0   A0A224XN13   A0A0J9R4N1   A0A1I8M3Z3   B4MV65   B4IFH8   B4Q3W2   B5DIQ8   B4G719   A0A224XUK9   B4P719   A0A0V0G2Y8   A0A286P0W6   B4LUN1   T1IFT4   C5IWP3   A0A0P4VKI5   Q9VIH9   A0A1W4UVF0   A0A151JBA9   A0A023FD89   B4JD91   R4G7Y0   B3PAG6   A0A3B0K3I3   B3NKX1   A0A2P8YVI6   T1I2D3   E2J782   A0A1W4WPE1   E0VVY9   A0A0M4EEB1   A0A195EWX4   A0A067R4V8   B3MU77   R4UWG9   A0A067R6Z0   A0A182K0L5   A0A0L7R443   B3NKW9   A0A2J7QW69   A0A1S3D977   S4PL98   Q0MTF2   A0A195C5M5   B3NKX5   A0A182PPI2   B3PAG8   A0A182L1H1   A0NF51   A0A182HUP4   F4WTA6   A0A1B6DS46   A0A1B6M6Z4   A0A0K2TAN0   Q7YSZ1   W8BKT3   V5GFQ0   A0A2P8ZJ36   T1HRF9   A0A0P4VQE4   B4KL07   B4Q3W0   Q9VII1   B4P720   A0A1I8MA47   Q71D96   A0A2P8ZDE0   B4HDE4   B4LUN2   A0A2J7QW68   A0A034WQS1   A0FD26   A0A1B6FV14   A0A067RDS9   A0A1E1WWY4   A0FD27   A0A1W4VFG9   A0A0M8ZZ44   B4JD92   A0FD25   A0A0A1XHA5   B4LSX1   B4LKT4   B4IFH6   W5J3F7  

Pubmed

19121390    28756777    22651552    26354079    23622113    26334808    + More
22936249    25315136    17994087    15632085    17550304    27129103    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25474469    29403074    20566863    24845553    20966253    12364791    14747013    17210077    21719571    14976983    24495485    14525923    25348373    17071113    28503490    25830018    20920257    23761445   

EMBL

BABH01012989    NWSH01003451    PCG66274.1    KZ149910    PZC78145.1    AK402037    + More
BAM18659.1    AK402651    BAM19273.1    KQ458756    KPJ05285.1    KQ460317    KPJ16013.1    GDQN01009348    JAT81706.1    GAIX01007881    JAA84679.1    GECL01001598    JAP04526.1    ACPB03025722    GAHY01000820    JAA76690.1    GBGD01003342    JAC85547.1    GFTR01002540    JAW13886.1    CM002910    KMY91237.1    CH963857    EDW76410.1    CH480833    EDW46400.1    CM000361    EDX05678.1    CH379060    EDY70200.1    CH479180    EDW29218.1    GFTR01002928    JAW13498.1    CM000158    EDW89988.1    GECL01003781    JAP02343.1    AB999705    BBA30659.1    CH940649    EDW64217.1    ACPB03001161    FJ968776    ACR56003.1    GDKW01003584    JAI53011.1    AE014134    AY119487    KX531372    AAF53940.1    AAM50141.1    AGB93181.1    ANY27182.1    KQ979147    KYN22441.1    GBBI01000023    JAC18689.1    CH916368    EDW03264.1    GAHY01001937    JAA75573.1    CH954451    EDV45278.2    OUUW01000004    SPP79591.1    CH954179    EDV54494.1    PYGN01000337    PSN48245.1    HP429300    ADN29800.1    DS235816    EEB17545.1    CP012523    ALC40325.1    ALC40335.1    KQ981940    KYN32728.1    KK852699    KDR18172.1    CH902624    EDV33406.1    KC740812    AGM32636.1    KDR18173.1    KQ414659    KOC65618.1    EDV54492.2    NEVH01009767    PNF32830.1    GAIX01004140    JAA88420.1    DQ846783    ABH09417.1    KQ978231    KYM96147.1    EDV54498.1    EDV45280.1    AAAB01008964    EAU76347.1    APCN01002469    GL888334    EGI62569.1    GEDC01008796    JAS28502.1    GEBQ01008282    JAT31695.1    HACA01005788    CDW23149.1    ACPB03009472    ACPB03009473    ACPB03009474    AY340271    GAHY01000792    AAQ20836.1    JAA76718.1    GAMC01007173    JAB99382.1    GALX01005657    JAB62809.1    PYGN01000040    PSN56518.1    ACPB03031755    GDKW01002540    JAI54055.1    CH933807    EDW12757.1    EDX05676.1    KMY91236.1    BT032654    AAF53938.1    ACD81668.1    EDW89989.1    AF531973    AAQ09872.1    PYGN01000090    PSN54515.1    CH480180    EDW26664.1    EDW64218.1    PNF32829.1    GAKP01002854    JAC56098.1    DQ907921    ABJ97669.1    GECZ01015723    JAS54046.1    KDR18170.1    GFAC01007653    JAT91535.1    DQ907922    ABJ97670.1    KQ435819    KOX72519.1    EDW03265.1    DQ907920    ABJ97668.1    GBXI01003523    JAD10769.1    EDW64882.1    CH940648    EDW60738.1    EDW46398.1    ADMH02002111    ETN58882.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000015103    UP000095301    + More
UP000007798    UP000001292    UP000000304    UP000001819    UP000008744    UP000002282    UP000008792    UP000000803    UP000192221    UP000078492    UP000001070    UP000008711    UP000268350    UP000245037    UP000192223    UP000009046    UP000092553    UP000078541    UP000027135    UP000007801    UP000075881    UP000053825    UP000235965    UP000079169    UP000078542    UP000075885    UP000075882    UP000007062    UP000075840    UP000007755    UP000009192    UP000053105    UP000000673   

PRIDE

H9JH50    Q9VIH9    Q9VII1   

Pfam

PF17064   QVR

Interpro

IPR031424   QVR       

ProteinModelPortal

H9JH50   A0A2A4J434   A0A2W1BWX5   I4DL69   I4DMY3   A0A194QK48   + More
A0A0N1IH29   A0A1E1W402   S4P3Z0   A0A0V0G953   R4G540   A0A069DPK0   A0A224XN13   A0A0J9R4N1   A0A1I8M3Z3   B4MV65   B4IFH8   B4Q3W2   B5DIQ8   B4G719   A0A224XUK9   B4P719   A0A0V0G2Y8   A0A286P0W6   B4LUN1   T1IFT4   C5IWP3   A0A0P4VKI5   Q9VIH9   A0A1W4UVF0   A0A151JBA9   A0A023FD89   B4JD91   R4G7Y0   B3PAG6   A0A3B0K3I3   B3NKX1   A0A2P8YVI6   T1I2D3   E2J782   A0A1W4WPE1   E0VVY9   A0A0M4EEB1   A0A195EWX4   A0A067R4V8   B3MU77   R4UWG9   A0A067R6Z0   A0A182K0L5   A0A0L7R443   B3NKW9   A0A2J7QW69   A0A1S3D977   S4PL98   Q0MTF2   A0A195C5M5   B3NKX5   A0A182PPI2   B3PAG8   A0A182L1H1   A0NF51   A0A182HUP4   F4WTA6   A0A1B6DS46   A0A1B6M6Z4   A0A0K2TAN0   Q7YSZ1   W8BKT3   V5GFQ0   A0A2P8ZJ36   T1HRF9   A0A0P4VQE4   B4KL07   B4Q3W0   Q9VII1   B4P720   A0A1I8MA47   Q71D96   A0A2P8ZDE0   B4HDE4   B4LUN2   A0A2J7QW68   A0A034WQS1   A0FD26   A0A1B6FV14   A0A067RDS9   A0A1E1WWY4   A0FD27   A0A1W4VFG9   A0A0M8ZZ44   B4JD92   A0FD25   A0A0A1XHA5   B4LSX1   B4LKT4   B4IFH6   W5J3F7  

KEGG

101743420    no KO assigned | (RefSeq) uncharacterized LOC101743420

GO

GO:0016021   GO:0005886   GO:0048511   GO:0034235   GO:0045187   GO:0031225   GO:0032222   GO:1903818   GO:0030431   GO:0005737   GO:0019991   GO:0035151  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 21,         Likelihood:  0.998686

 

 

Length:

160

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

37.49227

Exp number, first 60 AAs:

15.84516

Total prob of N-in:

0.15759

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  22

inside

23  -  135

TMhelix

136  -  158

outside

159  -  160

 

 

Pi

311.614393

Theta

182.148178

Tajima's D

1.472253

CLR

0.537927

CSRT

0.781510924453777

Interpretation

Uncertain