Gene

KWMTBOMO01189

Pre Gene Modal

BGIBMGA007324

Annotation

PREDICTED:_homogentisate_1?2-dioxygenase_[Amyelois_transitella]

Location

Bomo_Chr3(-):4095651-4111779      View in EpiBrowser

Full name

Homogentisate 1,2-dioxygenase      

Alternative Name

Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Location in the cell

Cytoplasmic   Reliability : 1.28

CDS

ATGACCGAATTAAAGTATCTATCGGGCTTTGGTTCGGAGTTTTCTTCAGAGGACCCGCGGAAGCCGGGATCGCTTCCGATCGGTCAGAACAGCCCACAGAAATGCCCCTATGGTCTCTATGCCGAACAATTATCAGGTACAGCTTTCACCGCTCCAAGGCACGAGAACAAAAGATCCTGGTTGTATAGAATACGTCCCTCCGTTGTACATAAGCCGTTCAAGAAATTAGACATTGCCAAACATCTCACGCACAACTGGGATGAACAAGAGCCGGATCCTAATCAATCTCGCTGGCTTCCCTTCGACATTCCATCAGACGAGTCTGTGGACTTTGTGACCGGACTCCATACGGTGTGTGGTGCTGGCGATCCTCGCTCTAGACATGGAATAGCCATCCACGTGTACTTGTGCAACGCTTCCATGGATAAAAGCGCATTTTACAGCAGCGACGGAGACTTTCTAATCGTGCCACAGCAAGGCAAATTGAAGATCACCACTGAATTTGGTCTAATGGAGGTGGCCCCGAATGAAATTGCCGTTATTCAACTTGGAATGAGATTCGCTGTATTTGTTGAGGGTCCTACCAGGGGGTACATATTAGAAGTTTTCGACGGTCATTTTAAGCTGCCTGATCTTGGACCTATCGGAGCTAATGGACTGGCGAATCCGAGGGATTTTCTAACACCGGTAGCTCACTATGTTGATGAAGAAACTCCTGGTTTCCAGATCTTCAACAAGTACCAAGGGTTTCTATTTGTTGCCGAACAAAATCACAATCCGTTCGACGTAGTTGCTTGGCACGGAAACTATGTGCCTTACAAATACGATCTAAACAACTTTATGGTTATCAACGCTGTTTTGTACGATCATTGTGACCCTTCAATATTTACGGTGTTGACGTGTCCTTCTGCAAAACCTGGGATCGCCATCGCTGATTTCGTAATATTCCCACCCAGATGGTCTGTGCAGGAGCACACTTTCAGACCTCCTTATTACCACAGAAACTGTATGAGCGAGTTCATGGGGTTGATTCTTGGTTCTTACGAGGCGAAAGAAGGCGGTTTCCTTCCCGGCGGTGCGTCTCTGCATTCCATGATGACACCTCACGGGCCTGACGACAAATGTTTCAACGCTGCATCCAATGGAGCACTAGTGCCGCAGAAAATTGCAGTAGGAACTCAGGCTTTTATGTTTGAATCTTCTTTGAGTCTGGCCATCACCAAGTGGGGCGCGGAAACCTGTCAAAAATTGGACCCCAAATATTACGAATGTTGGCAAAACCTGCCAAAGCATTTCTCGGATAAAGCAAAAGTCTAA

Protein

MTELKYLSGFGSEFSSEDPRKPGSLPIGQNSPQKCPYGLYAEQLSGTAFTAPRHENKRSWLYRIRPSVVHKPFKKLDIAKHLTHNWDEQEPDPNQSRWLPFDIPSDESVDFVTGLHTVCGAGDPRSRHGIAIHVYLCNASMDKSAFYSSDGDFLIVPQQGKLKITTEFGLMEVAPNEIAVIQLGMRFAVFVEGPTRGYILEVFDGHFKLPDLGPIGANGLANPRDFLTPVAHYVDEETPGFQIFNKYQGFLFVAEQNHNPFDVVAWHGNYVPYKYDLNNFMVINAVLYDHCDPSIFTVLTCPSAKPGIAIADFVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLILGSYEAKEGGFLPGGASLHSMMTPHGPDDKCFNAASNGALVPQKIAVGTQAFMFESSLSLAITKWGAETCQKLDPKYYECWQNLPKHFSDKAKV

Catalytic Activity

homogentisate + O2 = 4-maleylacetoacetate + H(+)

Cofactor

Fe cation

Similarity

Belongs to the homogentisate dioxygenase family.

Keywords

Complete proteome   Dioxygenase   Iron   Metal-binding   Oxidoreductase   Phenylalanine catabolism   Reference proteome   Tyrosine catabolism  

Feature

chain  Homogentisate 1,2-dioxygenase

Uniprot

H9JCS7   A0A2A4JDY4   A0A2W1BS28   A0A0N0PDG6   A0A194QH24   A0A212F454   + More
A0A182GKZ4   A0A1S4FZN3   Q16IJ1   A0A0L0BZ99   A0A182GL47   A0A182GKZ3   A0A1B0CFN5   B0W013   A0A336L0W1   A0A182Q5Q8   A0A1Q3FL82   A0A1B0DIC8   A0A1L8E2V1   A0A182J453   A0A182LZZ2   A0A067QV44   A0A084VNK3   A0A182F2P2   T1PEH7   A0A182NB22   A0A182KD08   A0A182VTS1   W5JFE6   A0A1B0BWW5   A0A182Y8F0   B4MWE2   A0A182L606   A0A182UIA8   A0A1A9Y364   A0A0M4EAB4   A0A336MJ12   Q7PMI7   A0A182ICN4   A0A182XCG8   A0A1A9VTU6   B4HX25   A0A1A9W0S3   B4QAB9   D3TM25   A0A1I8NSW9   A0A1B0A0U1   A0A2J7PDI4   Q9VKJ0   B4LQH1   A0A1W4W4A5   B3N4K4   B3MMW5   B4KHA9   B4P179   Q29M34   A0A0T6AVE1   A0A3B0K391   T1H6W3   A0A0R1DRK4   B4JBD2   A0A182PAS7   K7IVV2   A0A232EGW2   A0A1B6CQL8   D6WUS5   U4U9T0   N6T133   J3JX58   A0A026W1V7   A0A1B6HYV4   V4ADS8   A0A1B6FUV5   A0A158NG87   A0A023ETQ6   A0A151J5E3   E2B2D1   E9IMP4   A0A195B748   A0A1W4XRL9   A7RPG9   A0A195FG69   A0A131Y425   E2AA15   E0VXD2   A0A0K8RJ82   A0A224Z0R5   A0A131YMZ8   A0A195CIZ6   A0A2T7P3I8   A0A1E1X3L6   T1IUP4   A0A1Y1K8H2   W4XH57   A0A0P5INM3   A0A0U2MWR7   A0A1J1I361   A0A293N349   W5M1I1   A0A1S3H295  

EC Number

1.13.11.5

Pubmed

19121390    28756777    26354079    22118469    26483478    17510324    + More
26108605    24845553    24438588    20920257    23761445    25244985    17994087    20966253    12364791    14747013    17210077    22936249    20353571    10731132    12537572    12537569    17550304    15632085    20075255    28648823    18362917    19820115    23537049    22516182    24508170    30249741    23254933    21347285    24945155    20798317    21282665    17615350    20566863    28797301    26830274    28503490    28004739   

EMBL

BABH01040851    BABH01040852    BABH01040853    NWSH01001823    PCG69996.1    KZ149958    + More
PZC76425.1    KQ460366    KPJ15622.1    KQ458860    KPJ04812.1    AGBW02010442    OWR48511.1    JXUM01070968    JXUM01070969    KQ562637    KXJ75443.1    CH478073    EAT34091.1    JRES01001119    KNC25382.1    JXUM01071238    JXUM01071239    KQ562651    KXJ75400.1    KXJ75442.1    AJWK01010200    AJWK01010201    DS231816    EDS37585.1    UFQS01000775    UFQT01000775    SSX06800.1    SSX27145.1    AXCN02000647    GFDL01006750    JAV28295.1    AJVK01062333    GFDF01001125    JAV12959.1    AXCM01000962    KK853353    KDR08225.1    ATLV01014759    KE524984    KFB39547.1    KA646530    AFP61159.1    ADMH02001646    ETN61605.1    JXJN01021989    CH963857    EDW76012.1    CP012523    ALC39301.1    UFQT01001406    SSX30412.1    AAAB01008980    EAA13786.5    APCN01005735    CH480818    EDW52570.1    CM000361    CM002910    EDX04674.1    KMY89708.1    CCAG010004953    EZ422477    ADD18753.1    NEVH01026386    PNF14388.1    AF131124    AE014134    BT003496    CH940649    EDW63421.1    CH954177    EDV58916.1    CH902620    EDV30990.1    CH933807    EDW13326.1    CM000157    EDW88054.1    CH379060    EAL33861.2    LJIG01022720    KRT79065.1    OUUW01000004    SPP79481.1    KRJ97539.1    CH916368    EDW02937.1    NNAY01004662    OXU17585.1    GEDC01021587    JAS15711.1    KQ971363    EFA07806.1    KB631850    ERL86700.1    APGK01056999    KB741277    ENN71238.1    BT127826    AEE62788.1    KK107487    QOIP01000006    EZA50050.1    RLU21846.1    GECU01027864    JAS79842.1    KB201931    ESO93280.1    GECZ01015801    JAS53968.1    ADTU01015054    GAPW01001799    JAC11799.1    KQ980017    KYN18225.1    GL445130    EFN90168.1    GL764255    EFZ18133.1    KQ976574    KYM80343.1    DS469525    EDO46736.1    KQ981625    KYN39019.1    GEFM01003000    JAP72796.1    GL438001    EFN69714.1    DS235830    EEB18038.1    GADI01002850    JAA70958.1    GFPF01008464    MAA19610.1    GEDV01007928    JAP80629.1    KQ977721    KYN00407.1    PZQS01000006    PVD27992.1    GFAC01005354    JAT93834.1    JH431551    GEZM01094000    JAV56015.1    AAGJ04158164    AAGJ04158165    AAGJ04158166    GDIQ01210121    JAK41604.1    KR181951    ALJ76675.1    CVRI01000040    CRK94775.1    GFWV01022489    MAA47216.1    AHAT01003326    AHAT01003327    AHAT01003328   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000069940    + More
UP000249989    UP000008820    UP000037069    UP000092461    UP000002320    UP000075886    UP000092462    UP000075880    UP000075883    UP000027135    UP000030765    UP000069272    UP000075884    UP000075881    UP000075920    UP000000673    UP000092460    UP000076408    UP000007798    UP000075882    UP000075902    UP000092443    UP000092553    UP000007062    UP000075840    UP000076407    UP000078200    UP000001292    UP000091820    UP000000304    UP000092444    UP000095300    UP000092445    UP000235965    UP000000803    UP000008792    UP000192221    UP000008711    UP000007801    UP000009192    UP000002282    UP000001819    UP000268350    UP000015102    UP000001070    UP000075885    UP000002358    UP000215335    UP000007266    UP000030742    UP000019118    UP000053097    UP000279307    UP000030746    UP000005205    UP000078492    UP000008237    UP000078540    UP000192223    UP000001593    UP000078541    UP000000311    UP000009046    UP000078542    UP000245119    UP000007110    UP000183832    UP000018468    UP000085678   

PRIDE

H9JCS7    Q9VKJ0   

Pfam

PF04209   HgmA        + More
PF05199   GMC_oxred_C
PF00732   GMC_oxred_N

Interpro

IPR005708   Homogentis_dOase        + More
IPR011051   RmlC_Cupin_sf       
IPR014710   RmlC-like_jellyroll       
IPR036188   FAD/NAD-bd_sf       
IPR007867   GMC_OxRtase_C       
IPR000172   GMC_OxRdtase_N       

SUPFAM

SSF51182   SSF51182        + More
SSF51905   SSF51905       

Gene 3D

2.60.120.10    

ProteinModelPortal

H9JCS7   A0A2A4JDY4   A0A2W1BS28   A0A0N0PDG6   A0A194QH24   A0A212F454   + More
A0A182GKZ4   A0A1S4FZN3   Q16IJ1   A0A0L0BZ99   A0A182GL47   A0A182GKZ3   A0A1B0CFN5   B0W013   A0A336L0W1   A0A182Q5Q8   A0A1Q3FL82   A0A1B0DIC8   A0A1L8E2V1   A0A182J453   A0A182LZZ2   A0A067QV44   A0A084VNK3   A0A182F2P2   T1PEH7   A0A182NB22   A0A182KD08   A0A182VTS1   W5JFE6   A0A1B0BWW5   A0A182Y8F0   B4MWE2   A0A182L606   A0A182UIA8   A0A1A9Y364   A0A0M4EAB4   A0A336MJ12   Q7PMI7   A0A182ICN4   A0A182XCG8   A0A1A9VTU6   B4HX25   A0A1A9W0S3   B4QAB9   D3TM25   A0A1I8NSW9   A0A1B0A0U1   A0A2J7PDI4   Q9VKJ0   B4LQH1   A0A1W4W4A5   B3N4K4   B3MMW5   B4KHA9   B4P179   Q29M34   A0A0T6AVE1   A0A3B0K391   T1H6W3   A0A0R1DRK4   B4JBD2   A0A182PAS7   K7IVV2   A0A232EGW2   A0A1B6CQL8   D6WUS5   U4U9T0   N6T133   J3JX58   A0A026W1V7   A0A1B6HYV4   V4ADS8   A0A1B6FUV5   A0A158NG87   A0A023ETQ6   A0A151J5E3   E2B2D1   E9IMP4   A0A195B748   A0A1W4XRL9   A7RPG9   A0A195FG69   A0A131Y425   E2AA15   E0VXD2   A0A0K8RJ82   A0A224Z0R5   A0A131YMZ8   A0A195CIZ6   A0A2T7P3I8   A0A1E1X3L6   T1IUP4   A0A1Y1K8H2   W4XH57   A0A0P5INM3   A0A0U2MWR7   A0A1J1I361   A0A293N349   W5M1I1   A0A1S3H295  

PDB

1EYB     E-value=0,     Score=1643

KEGG

101747176    K00451 homogentisate 1,2-dioxygenase [EC:1.13.11.5] | (RefSeq) homogentisate 1,2-dioxygenase

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006570   GO:0006559   GO:0004411   GO:0006520   GO:0046872   GO:0006572   GO:0016614   GO:0050660   GO:0051287   GO:0006000   GO:0004553   GO:0005634   GO:0006334   GO:0003779   GO:0016021   GO:0055114  

PANTHER

PTHR11056  

Length:

438

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01379

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00185

outside

1  -  438

 

 

Pi

252.313993

Theta

173.92188

Tajima's D

1.096838

CLR

0.180043

CSRT

0.684765761711914

Interpretation

Uncertain