Gene

KWMTBOMO01185

Pre Gene Modal

BGIBMGA007492

Annotation

PREDICTED:_frizzled-4_[Bombyx_mori]

Location

Bomo_Chr3(+):4057750-4068280      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 3.773

CDS

ATGGCGAGAAACGACCGCCACTCATCCCTGCTTCAGCTGGCGGCGTGGGGCGTGCCGGCAGCCCTAGCAGCAGCCGTTCTCGTCACCAGAGACGTAGATGCCGATGAACTTACAGGTACGTGCTTCGTCGGCAATCAATCGACCAAGTCCCTCCTTGCGCTCGTAATCGTACCTGAAGCAATATGTCTGCTACTCGGCTGCGTGTTCCTTTCGTCCGGACTACGCGCTGTTCTTCGCAAACCAGTTCCCGTGCACACACCAGCCCTATTATTAAACGCTCCACAGCCGCACACAGATCAAAGCGTTTTGCGTTTAGGTGCTTTCGCAGCTCTATACGCTGTTCCGTCGGCGTGTATTCTCGCTACTTGGGTTTATGAATACGCGTGGAGAGACGAATGGCTGGCTTCACCGGTTCCGTCTTCGGAGCCATCGACACACGCCCACCCAGCATTCTGGGTGTTCCTATTTAGAATATTCGCTATTCAAATACTCGGTGTGATGGTGGCCGTTTGGATAGCAACGCCCCGCCTTAAAGCTCTGTGGAGAAGGGTGACGGGACCTAGAAAGCCAGTGCCTCCCAAATGTCCGACGGGGCCGACACAAGCGCCCCTAACTCTTCATTGTTACGCAACACATCCTCATACGATAGCGCGACATCCTTATAATCCAACAAAGTACGCAACATACCGACCTCCGCAGCAGCATTCGTACAGGAAACCTAGGCATTATCATTATTCAGCGGGTGAAACTATACTATGA

Protein

MARNDRHSSLLQLAAWGVPAALAAAVLVTRDVDADELTGTCFVGNQSTKSLLALVIVPEAICLLLGCVFLSSGLRAVLRKPVPVHTPALLLNAPQPHTDQSVLRLGAFAALYAVPSACILATWVYEYAWRDEWLASPVPSSEPSTHAHPAFWVFLFRIFAIQILGVMVAVWIATPRLKALWRRVTGPRKPVPPKCPTGPTQAPLTLHCYATHPHTIARHPYNPTKYATYRPPQQHSYRKPRHYHYSAGETIL

Similarity

Belongs to the G-protein coupled receptor Fz/Smo family.

Uniprot

H9JD95   A0A0L7LSB0   A0A2H1WHI8   A0A0N1II58   A0A2W1BUH4   A0A194QGY9   + More
A0A2A4ISU3   E0VTY7   A0A067QI70   A0A2P8ZKJ3   A0A2J7PDI9   D6WXE3   A0A3L8DBE7   A0A2M4BIR5   A0A2M4ACJ2   A0A2M4AB01   A0A2M4BI20   A0A2M4BHQ9   A0A0P6K0R9   A0A1S4FJE8   A0A182F5Q8   A0A2M4DM48   A0A2M4DMA2   A0A2M4DM18   A0A1W4XS35   A0A0U2WR83   W5JI88   A0A0C9RMH7   A0A026W7Q1   A0A182R0Y2   A0A182ML64   A0A0C9Q5Y9   U5EVX7   T1D110   T1J7J7   A0A182Y946   A0A1L8DJY3   A0A1L8DK55   A0A0R3T3S4   A0A2Y9D338   A0A2Y9D3G4   A0A1S4GZH6   A0A2Y9D1A0   A0A2Y9D0X8   Q7PWS3  

Pubmed

19121390    26227816    26354079    28756777    20566863    24845553    + More
29403074    18362917    19820115    30249741    26999592    26640641    20920257    23761445    24508170    28171748    25244985    12364791    20966253   

EMBL

BABH01036314    JTDY01000193    KOB78363.1    ODYU01008711    SOQ52528.1    KQ460366    + More
KPJ15618.1    KZ149958    PZC76430.1    KQ458860    KPJ04808.1    NWSH01008663    PCG62458.1    DS235777    EEB16843.1    KK853353    KDR08218.1    PYGN01000028    PSN57015.1    NEVH01026386    PNF14399.1    KQ971361    EFA09255.1    QOIP01000010    RLU17433.1    GGFJ01003753    MBW52894.1    GGFK01005194    MBW38515.1    GGFK01004636    MBW37957.1    GGFJ01003568    MBW52709.1    GGFJ01003448    MBW52589.1    GDUN01000892    JAN95027.1    GGFL01014462    MBW78640.1    GGFL01014509    MBW78687.1    GGFL01014438    MBW78616.1    KT989649    KT266541    ALS30888.1    ANS60432.1    ADMH02001100    ETN64107.1    GBYB01009540    JAG79307.1    KK107356    EZA52028.1    AXCN02002086    AXCM01001391    GBYB01009538    JAG79305.1    GANO01003211    JAB56660.1    KY348660    GAKV01000004    AQT19765.1    JAA92564.1    JH431934    GFDF01007328    JAV06756.1    GFDF01007327    JAV06757.1    UZAE01000684    VDN97531.1    AAAB01008984    APCN01003367    EAA14897.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000053268    UP000218220    UP000009046    + More
UP000027135    UP000245037    UP000235965    UP000007266    UP000279307    UP000069272    UP000192223    UP000000673    UP000053097    UP000075886    UP000075883    UP000076408    UP000046398    UP000278807    UP000075903    UP000076407    UP000075882    UP000075840    UP000007062   

PRIDE

H9JD95   

Pfam

PF01534   Frizzled        + More
PF01392   Fz

Interpro

IPR000539   Frizzled/Smoothened_TM        + More
IPR017981   GPCR_2-like       
IPR015526   Frizzled/SFRP       
IPR020067   Frizzled_dom       
IPR026551   FZD4       
IPR036790   Frizzled_dom_sf       
IPR041765   FZ4_CRD       

SUPFAM

SSF63501   SSF63501       

Gene 3D

1.10.2000.10    

CDD

cd07448  CRD_FZ4

ProteinModelPortal

H9JD95   A0A0L7LSB0   A0A2H1WHI8   A0A0N1II58   A0A2W1BUH4   A0A194QGY9   + More
A0A2A4ISU3   E0VTY7   A0A067QI70   A0A2P8ZKJ3   A0A2J7PDI9   D6WXE3   A0A3L8DBE7   A0A2M4BIR5   A0A2M4ACJ2   A0A2M4AB01   A0A2M4BI20   A0A2M4BHQ9   A0A0P6K0R9   A0A1S4FJE8   A0A182F5Q8   A0A2M4DM48   A0A2M4DMA2   A0A2M4DM18   A0A1W4XS35   A0A0U2WR83   W5JI88   A0A0C9RMH7   A0A026W7Q1   A0A182R0Y2   A0A182ML64   A0A0C9Q5Y9   U5EVX7   T1D110   T1J7J7   A0A182Y946   A0A1L8DJY3   A0A1L8DK55   A0A0R3T3S4   A0A2Y9D338   A0A2Y9D3G4   A0A1S4GZH6   A0A2Y9D1A0   A0A2Y9D0X8   Q7PWS3  

PDB

6BD4     E-value=4.6484e-07,     Score=126

KEGG

101742593    K02354 frizzled 4 | (RefSeq) frizzled-4

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0042813   GO:0016021   GO:0007275   GO:0004888   GO:0007166   GO:0005886   GO:0017147   GO:0035567   GO:0060070   GO:0016055   GO:0016020   GO:0051287   GO:0006000   GO:0004553   GO:0005634   GO:0006334   GO:0003779  

PANTHER

PTHR11309   PTHR11309:SF23  

Length:

252

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

88.0697000000001

Exp number, first 60 AAs:

30.46988

Total prob of N-in:

0.98481

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  51

TMhelix

52  -  74

inside

75  -  101

TMhelix

102  -  124

outside

125  -  150

TMhelix

151  -  173

inside

174  -  252

 

 

Pi

177.636653

Theta

142.32568

Tajima's D

0.837958

CLR

0.009738

CSRT

0.613219339033048

Interpretation

Uncertain