Silkworm Genome Informatics Database

Gene

KWMTBOMO01167

Pre Gene Modal

BGIBMGA007455

Annotation

PREDICTED:_kinesin-like_protein_unc-104_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr3(-):3723987-3749025 View in EpiBrowser

Full name

Kinesin-like protein unc-104

Alternative Name

Protein immaculate connections

Location in the cell

Cytoplasmic Reliability : 2.429

CDS

ATGGTGTACAAAGACATCGGTGAAGAGATGTTACAACACGCTTTCGACGGTTACAATATATGCATATTCGCTTACGGTCAGACCGGGGCTGGTAAATCTTATACGATGATGGGCCGCGGTGAGGATGGTCAGGAGGGCATCATTCCTCAGATCTGCAAGGATCTGTTCAGGCGCATCAGACAGACTACGTCCGATGATCTCAAATATTCGGTTGAAGTGTCGTACATGGAAATTTATTGCGAACGGGTTCGTGACTTACTGAACCCTAAGAATAAGGGAAATCTTCGGGTCCGTGAGCACCCCGCCCTCGGACCGTACGTGGAGGATCTCAGCAAACTGGCGGTCACCTCCTACCAAGACATTTACGATCTCATCGACGAGGGTAACAAAGCTAGGACCGTGGCGGCTACGAACATGAACGAGACGTCGTCTCGCTCTCACGCCGTCTTCACCATATTCTTCACGCAGCAACGTCATGACGTCACTACGAATTTGATGTCCGAAAAGGTCTCGAAAATATCGCTTGTCGATCTGGCCGGCTCGGAGCGTGCCGATTCTACCGGAGCCAAAGGAACTCGTCTCAAGGAAGGAGCTAACATCAACAAATCTCTGACCACACTCGGAAAAGTGATTTCCGCTCTAGCCGAAATTGCCTCTAAGAGCAAGAAGTCCAAGAAGGCGGACTTCATACCGTACCGTGACTCGGTGCTGACGTGGCTGCTTCGCGAGAACCTCGGCGGTAACTCGAAGACCGCCATGATAGCCGCCATCTCGCCGGCCGACATCAACTTCGACGAGACGCTCAGTACACTTAGATACGCGGATCGAGCCAAACAGATCGTATGCAAGGCGATCGTGAACGAGGACGCGAACGCTAAACTCATTCGCGAACTCAAAGAGGAGATCCTGAAGCTTCGCGAACTGCTCAAGGCTGAAGGGATCGACGTGGAAGAAGGCGAACAAAATTCGTCGCCGCAACGCAAAAAGAGCGAAGCAGAGGTTCTGTCGCCGAAGCTGTCCCGAGCCGCCACCACCATCGCCGAGGAGGCAGTGGATCAGCTCCAAGCCTCCGAGAAGCTTATCGCTGAACTCAACGAAACTTGGGAGGAAAAACTCAAGCGGACAGAACAGATCCGCGTCCAGCGCGAAGCGGTCTTCGCGGAAATGGGTCTTGCTGTCAAGGAGGGCATCACCGTCGGCATATACTCGCCGAAGAAAACGCCACACCTCGTCAACTTGAACGAAGACCCGAACCTGTCCGAATGCCTGCTTTACTATATAAAAGACGGTGTGACTCGCGTGGGCACATCTGAAGCGAAAGTCCCACAAGACATCCAGCTGTCCGGCTCGCACATACTGAGCGAGCACTGCATCTTCGAGAACGCGGACGGCGTGATCTGCCTCATTCCGCACCGCGGGGCACTGGTCTACGTCAACGGACGGGAGCTGGAAGAGCCCGTGATACTGAAGAGCGGTTCCCGCGTGATCCTGGGCAAGAACCACGTGTTCCGGTTCACCCACCCCGGGCAGCCGCGCGAGCTGCCGCCCGTCAACAAGGCGCTCACAGACTCCACCGAGTCGGCAGCTGAAGTCGCTACCGAGAGCAGCAGCGATACAGAAAATCAGAACGTCGACTGGGACTTCGCTCAGTGCGAGCTGCTAGAGAAACAGGGCATCGACTTGAAGGCGGAGATGCAGAAGCGTCTGATGGCCCTCGAGGAACAGTTCCGTAGGGAGAAGGAGCACGCCGACCAGCAGTTTGAGGAGCAGCGTAAGAACTACGAGGCTCGCATCGATGCTCTCCAGCGTCAGGTGGAGGAGCAGAGCGTAACGATGTCCATGTACAGCTCCTACACGCCCGAAGACTTCCATAACGATGAAGATATATTCGTGAACCCGTTGTTCGAGACGGAGTGCTGGTCGGCTCGCGAGGTGGGGCTGGCGGCCTGGGCCTTCCGCAAGTGGAAGTACCATCAGTTCACGTCGCTCCGAGACGACCTCTGGGGAAATGCGATCTTCCTCAAGGAAGCGAACGCGATCTCTGTGGAGCTGCGCAAGAAAGTTCAGTTTCAGTTCACTCTGCTAACGGACACGCCGTACTCCCCCCTCCCCGCGGAGCTGGCCCCCCGCGACGACGCCGACGACGAGTACCGGCCCAGCGCGCCCACGGTGGTCGCCGTCGAGGTCACCGACACCAAGAACGGCGCCACGCACTACTGGACCCTAGAGAAGCTACGCCATCGTCTGGAGCTAATGCGTCAGATATACAACATGAACGAGAGCTCGTGCGTAGAGGACGAGGAGACCACGCCCCTAGGTGCTCCGCCCTCGATCGGGGCGCCGCCCCCGCCCGCCGACATCCTACAATGTATATCGGCCTGCGCGCAACAAACCCGCCTCTCCCTAGCCAACTTGCTACCATCGAGACAACGGCTCGAGTTAATGCGCGAGATGTATCACAACGAGGCCGAGCTGTCGCCTACTTCGCCCGACCACAACATCGAGTCGGTAACCGGCGGCGATCCTTTCTACGATAGGTTCCCGTGGTTCCGTCTTGTTGGACGGAGCTTTGTATACTTGTCGAACCTCCTGTACCCGGTTCCTCTCATTCACAAGGTCGCTATAGTGAACGAGAAAGGAGACGTGAAGGGCTACCTCCGGGTCGCCGTGCAGGCCGTTATCGACGCCGAGAAGAACAACGCGGAATTCGCAGCTGGCGTGAAGCAGTCAGCCAAGATATGCTTCGACGACGATGTAGTGCCGCGCGCCCGGGTCCGCGCCGCCAACAGCGTCGACAAGAACAACGCCATCAACCTGGACGAACGCGCCGTCGAGGTCCAGGACTCGAACATCAAAATTGAGGAATTGGCTGGAGGAGAGTGCGATGCGGATAGCGGCCGCGGGGACAGCTCTCTCGCTTCTGAACTGAAAGAGGAAGACTTGCCTGAACACTTGACCCTCGGCAAGGAGTTCACCTTCCGCGTCACCGTGCTCCAAGCTCACAGCGTCGCCACCGACTATGCTGATGTCTTCTGTCAGTTCAACTTCCTTCACCGCAACGAGGACGCCTTCTCCACCGAACCCGTCAAGAACGCAGGAAAAAATACACCACTCGGATTCTACCACGTGCAGAATATAACTGTACCGATTACAAAATCATTTGTGGAATACATTAAAACTCAACCGATCGTGTTTGAAGTCTTCGGTCATTATCAGCAGCATCCGTTACATAAGGATGCGAAACAAGATGGCCCTGTGGGAGGCCGCACGCCCCCGCGCCGCATGCTGCCGCCCTCCATCCCCATCTCGGCCCCCGTGCGGAGCCCCAAGTGGGGGGCCGCCAGTGTGGCGCCGCCCTGCTGCTCCTCGCACCTGCACTCCAAGCATGACCTGCTCGTCTGGTTCGAGATCTGCGAGCTCGCACCCAATGGAGAATACGTACCTGCCGTGGTGGAGCACAGTGACGAGCTCCCCTGCCGCGGGCTCTTCCTTCTGCACCAGGGAATCCAGCGCCGCATCCGCATCACCATCCTGCACGAGCCCTCCGCTGACCTGCAGTGGACCGATGTCAGGGAGCTCGTTGTCGGTCGCATCCGCAACACGCCCGAAGCCAATGAGGATACCACTGACGGGGACGAGGATGGCGCCCTCTCACTCGGCCTGTTCCCCGGGGAGAGACCCGCGCTCGACGATCGGGCCGTCTTCCGGTTCGAAGCGGCCTGGGACAGCAGCCTGCACGGCTCGCCGCTACTGAACCGAGTGAGCGCTAACGGGGAAGTGGTCTACATCACGCTCAGCGCTTACCTCGAGATGGAGAACTGCGGGCGGCCGGCGATCGTGACGAAGGACCTGTCGGTGGTGGTGGTAGGTCGCGAGGCGCGCACGGGCCGTTCGCTGCGCCGCGCACTGTTTGGGTCCCGCGCCGCCCGCGCCGACCACATCACCGGCGTCTACGAGCTCAGCCTGCACCGCGCGCTCGAACCCGGAGTCCAGCGCCGGCAGCGTCGCGTGCTGGACACGAGCGGCACGTACGTGCGCGGGGAAGAGAACCTACACGGGTGGAGGCCGCGCGGGGACTCGCTCATATTCGACCACCAGGTAATTACGCAAATTATCATTTTTCATGTTTGA

Protein

MVYKDIGEEMLQHAFDGYNICIFAYGQTGAGKSYTMMGRGEDGQEGIIPQICKDLFRRIRQTTSDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPALGPYVEDLSKLAVTSYQDIYDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQQRHDVTTNLMSEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEIASKSKKSKKADFIPYRDSVLTWLLRENLGGNSKTAMIAAISPADINFDETLSTLRYADRAKQIVCKAIVNEDANAKLIRELKEEILKLRELLKAEGIDVEEGEQNSSPQRKKSEAEVLSPKLSRAATTIAEEAVDQLQASEKLIAELNETWEEKLKRTEQIRVQREAVFAEMGLAVKEGITVGIYSPKKTPHLVNLNEDPNLSECLLYYIKDGVTRVGTSEAKVPQDIQLSGSHILSEHCIFENADGVICLIPHRGALVYVNGRELEEPVILKSGSRVILGKNHVFRFTHPGQPRELPPVNKALTDSTESAAEVATESSSDTENQNVDWDFAQCELLEKQGIDLKAEMQKRLMALEEQFRREKEHADQQFEEQRKNYEARIDALQRQVEEQSVTMSMYSSYTPEDFHNDEDIFVNPLFETECWSAREVGLAAWAFRKWKYHQFTSLRDDLWGNAIFLKEANAISVELRKKVQFQFTLLTDTPYSPLPAELAPRDDADDEYRPSAPTVVAVEVTDTKNGATHYWTLEKLRHRLELMRQIYNMNESSCVEDEETTPLGAPPSIGAPPPPADILQCISACAQQTRLSLANLLPSRQRLELMREMYHNEAELSPTSPDHNIESVTGGDPFYDRFPWFRLVGRSFVYLSNLLYPVPLIHKVAIVNEKGDVKGYLRVAVQAVIDAEKNNAEFAAGVKQSAKICFDDDVVPRARVRAANSVDKNNAINLDERAVEVQDSNIKIEELAGGECDADSGRGDSSLASELKEEDLPEHLTLGKEFTFRVTVLQAHSVATDYADVFCQFNFLHRNEDAFSTEPVKNAGKNTPLGFYHVQNITVPITKSFVEYIKTQPIVFEVFGHYQQHPLHKDAKQDGPVGGRTPPRRMLPPSIPISAPVRSPKWGAASVAPPCCSSHLHSKHDLLVWFEICELAPNGEYVPAVVEHSDELPCRGLFLLHQGIQRRIRITILHEPSADLQWTDVRELVVGRIRNTPEANEDTTDGDEDGALSLGLFPGERPALDDRAVFRFEAAWDSSLHGSPLLNRVSANGEVVYITLSAYLEMENCGRPAIVTKDLSVVVVGREARTGRSLRRALFGSRAARADHITGVYELSLHRALEPGVQRRQRRVLDTSGTYVRGEENLHGWRPRGDSLIFDHQVITQIIIFHV

Description

Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.

Subunit

Monomer (By similarity). Interacts with Arl8 (PubMed:30174114).

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.

Keywords

Alternative splicing ATP-binding Cell projection Coiled coil Complete proteome Cytoplasm Cytoskeleton Microtubule Motor protein Nucleotide-binding Phosphoprotein Protein transport Reference proteome Transport

Feature

chain Kinesin-like protein unc-104
splice variant In isoform E.

Uniprot

A0A2H1WUC8 A0A194QBJ1 A0A2J7Q5K3 A0A2J7Q5K0 A0A0C9RLS1 A0A088A1K2 + More
E1ZX90 A0A2J7Q5K2 F4WBT9 A0A139WDX9 A0A2A3EHV1 A0A195C3P2 A0A151WN78 A0A195FU85 A0A3L8E154 A0A158NW85 A0A195BD68 D6WVN9 A0A0L7QNY7 A0A195DI52 E2B9W7 A0A336LU78 A0A336LUI3 A0A0M8ZQ99 B4MIT1 A0A0R1DSR7 B3NP74 A0A0R1DUM0 A0A0R1DSJ0 A0A084WAX1 A1ZAJ2-2 A0A0R1DY12 A0A0Q5W0R5 U4U2Y2 A0A0Q5VLD5 A0A0R1DSK4 A0A0R1DY25 A0A0Q5VL17 A0A0Q5VZM5 A0A0Q5VLV6 B3MDI4 B4QIF3 A0A0J9U3T7 A0A0J9RFJ1 N6W6Y3 A0A0M4EVV7 A0A182JSX9 A0A0J9RE31 A0A0J9RFJ7 N6SZ40 A0A0J9U3U8 A0A0R3NQ16 A0A0R3NV63 A0A1A9UHE4 A0A0R3NQ74 A0A0R3NWD4 A0A0R3NQT2 A0A0R3NVL4 A0A1A9Z4G3 A0A1A9WWP0 X1WXH4 A0A1B0BZT0 B0WDG3 A0A1B0CG12 T1IJB9 B4H744 A0A2C9M9P4 A0A2C9M9S1 A0A2C9M9R5 A0A2C9M9R1 A0A2C9M9R2 A0A2C9MA25 A0A2C9M9R0 A0A2C9MA21 A0A2C9M9S0 K1RN38 A0A087URW9 A0A0V1MPD1 A0A0V1MPB9 A0A0V1H0V9 A0A0V1H0T9 A0A0V1EG07 A0A0V1IIL9 A0A0V1ABV8 A0A0V1CHM6 A0A0V0RHW1 A0A0V0RHP6 A0A0V0V2J5 A0A0V1BA73 A0A0V0RHH0 A0A0V0TF06 A0A0V1BAF1 A0A0V0TG64 A0A0V1BAH8 A0A0V1PG02 A0A0V1PFS2 A0A0V1H109 A0A0V1BA88

Pubmed

26354079 20798317 21719571 18362917 19820115 30249741 + More
21347285 17994087 17550304 24438588 10731132 12537572 17643120 18327897 30174114 23537049 18057021 22936249 15632085 23185243 15562597 22992520

EMBL

ODYU01011089 SOQ56607.1 KQ459249 KPJ02360.1 NEVH01017557 PNF23861.1 + More
PNF23862.1 GBYB01007926 JAG77693.1 GL435030 EFN74180.1 PNF23863.1 GL888066 EGI68367.1 KQ971357 KYB26178.1 KZ288241 PBC31278.1 KQ978317 KYM95220.1 KQ982911 KYQ49316.1 KQ981280 KYN43449.1 QOIP01000001 RLU26397.1 ADTU01027849 ADTU01027850 KQ976511 KYM82516.1 EFA08595.1 KQ414851 KOC60216.1 KQ980824 KYN12573.1 GL446605 EFN87554.1 UFQT01000198 SSX21596.1 SSX21595.1 KQ435971 KOX67776.1 CH963719 EDW72020.2 CM000158 KRK00173.1 CH954179 EDV55713.1 KRK00171.1 KRK00174.1 KRK00176.1 ATLV01022273 KE525331 KFB47365.1 AF247761 AE013599 AAF74192.1 KRK00162.1 KQS62424.1 KB631948 ERL87402.1 KQS62416.1 KRK00168.1 KRK00172.1 KRK00177.1 KQS62413.1 KQS62418.1 KQS62420.1 KQS62423.1 CH902619 EDV37447.2 KPU76827.1 CM000362 CM002911 EDX07400.1 KMY94336.1 KMY94340.1 KMY94339.1 CM000071 ENO01988.1 CP012524 ALC42087.1 KMY94338.1 KMY94342.1 KMY94343.1 KMY94344.1 APGK01058543 KB741291 ENN70508.1 KMY94350.1 KRT03230.1 KRT03231.1 KRT03223.1 KRT03232.1 KRT03228.1 KRT03224.1 KRT03229.1 ABLF02019510 JXJN01023289 DS231897 EDS44534.1 AJWK01010636 AJWK01010637 AJWK01010638 AJWK01010639 JH430253 CH479216 EDW33577.1 JH818911 EKC43000.1 KK121271 KFM80108.1 JYDO01000060 KRZ73655.1 KRZ73652.1 JYDP01000171 KRZ04176.1 KRZ04178.1 JYDR01000043 KRY72570.1 JYDS01000186 JYDV01000073 KRZ22037.1 KRZ36424.1 JYDQ01000010 KRY22309.1 JYDI01000197 KRY48757.1 JYDL01000176 KRX13967.1 KRX13970.1 JYDN01000096 KRX57737.1 JYDH01000075 KRY33908.1 KRX13966.1 JYDJ01000305 KRX37537.1 KRY33906.1 KRX37539.1 KRY33905.1 JYDM01000014 KRZ95084.1 KRZ95085.1 KRZ04177.1 KRY33904.1

Proteomes

UP000053268 UP000235965 UP000005203 UP000000311 UP000007755 UP000007266 + More
UP000242457 UP000078542 UP000075809 UP000078541 UP000279307 UP000005205 UP000078540 UP000053825 UP000078492 UP000008237 UP000053105 UP000007798 UP000002282 UP000008711 UP000030765 UP000000803 UP000030742 UP000007801 UP000000304 UP000001819 UP000092553 UP000075881 UP000019118 UP000078200 UP000092445 UP000091820 UP000007819 UP000092460 UP000002320 UP000092461 UP000008744 UP000076420 UP000005408 UP000054359 UP000054843 UP000055024 UP000054632 UP000054805 UP000054826 UP000054783 UP000054653 UP000054630 UP000054681 UP000054776 UP000055048 UP000054924

PRIDE

A1ZAJ2

Pfam

PF12423   KIF1B        + More
PF00498   FHA
PF12473   DUF3694
PF16183   Kinesin_assoc
PF00169   PH
PF00225   Kinesin
PF02338   OTU

Interpro

IPR008984   SMAD_FHA_dom_sf        + More
IPR000253   FHA_dom
IPR022164   Kinesin-like
IPR019821   Kinesin_motor_CS
IPR027417   P-loop_NTPase
IPR001849   PH_domain
IPR011993   PH-like_dom_sf
IPR036961   Kinesin_motor_dom_sf
IPR032405   Kinesin_assoc
IPR001752   Kinesin_motor_dom
IPR027640   Kinesin-like_fam
IPR022140   Kinesin-like_KIF1-typ
IPR038765   Papain-like_cys_pep_sf
IPR003323   OTU_dom

SUPFAM

SSF49879   SSF49879        + More
SSF52540   SSF52540
SSF54001   SSF54001

Gene 3D

2.30.29.30 3.40.850.10

CDD

cd00060 FHA

ProteinModelPortal

A0A2H1WUC8 A0A194QBJ1 A0A2J7Q5K3 A0A2J7Q5K0 A0A0C9RLS1 A0A088A1K2 + More
E1ZX90 A0A2J7Q5K2 F4WBT9 A0A139WDX9 A0A2A3EHV1 A0A195C3P2 A0A151WN78 A0A195FU85 A0A3L8E154 A0A158NW85 A0A195BD68 D6WVN9 A0A0L7QNY7 A0A195DI52 E2B9W7 A0A336LU78 A0A336LUI3 A0A0M8ZQ99 B4MIT1 A0A0R1DSR7 B3NP74 A0A0R1DUM0 A0A0R1DSJ0 A0A084WAX1 A1ZAJ2-2 A0A0R1DY12 A0A0Q5W0R5 U4U2Y2 A0A0Q5VLD5 A0A0R1DSK4 A0A0R1DY25 A0A0Q5VL17 A0A0Q5VZM5 A0A0Q5VLV6 B3MDI4 B4QIF3 A0A0J9U3T7 A0A0J9RFJ1 N6W6Y3 A0A0M4EVV7 A0A182JSX9 A0A0J9RE31 A0A0J9RFJ7 N6SZ40 A0A0J9U3U8 A0A0R3NQ16 A0A0R3NV63 A0A1A9UHE4 A0A0R3NQ74 A0A0R3NWD4 A0A0R3NQT2 A0A0R3NVL4 A0A1A9Z4G3 A0A1A9WWP0 X1WXH4 A0A1B0BZT0 B0WDG3 A0A1B0CG12 T1IJB9 B4H744 A0A2C9M9P4 A0A2C9M9S1 A0A2C9M9R5 A0A2C9M9R1 A0A2C9M9R2 A0A2C9MA25 A0A2C9M9R0 A0A2C9MA21 A0A2C9M9S0 K1RN38 A0A087URW9 A0A0V1MPD1 A0A0V1MPB9 A0A0V1H0V9 A0A0V1H0T9 A0A0V1EG07 A0A0V1IIL9 A0A0V1ABV8 A0A0V1CHM6 A0A0V0RHW1 A0A0V0RHP6 A0A0V0V2J5 A0A0V1BA73 A0A0V0RHH0 A0A0V0TF06 A0A0V1BAF1 A0A0V0TG64 A0A0V1BAH8 A0A0V1PG02 A0A0V1PFS2 A0A0V1H109 A0A0V1BA88

PDB

4UXS E-value=1.44897e-136, Score=1251

KEGG

101742157 K10392 kinesin family member 1 | (RefSeq) kinesin-like protein unc-104

GO

GO:0008017 GO:0005524 GO:0003777 GO:0007018 GO:0005871 GO:0016192 GO:0016887 GO:0008574 GO:0005874 GO:0030705 GO:0003774 GO:0051963 GO:0047496 GO:0007528 GO:0046847 GO:0040012 GO:0032024 GO:0045886 GO:0016188 GO:0030742 GO:0008089 GO:0030424 GO:0030425 GO:0048490 GO:0048814 GO:0015031 GO:1904115 GO:0048489 GO:0045202 GO:0008345 GO:0007411 GO:0008088 GO:0005875 GO:0005515 GO:0019287 GO:0005634 GO:0006334 GO:0003779 GO:0016021

PANTHER

PTHR24115

Subcellular location

Cytoplasm   Microtubule-associated.   With evidence from 5 publications.
Cytoskeleton   Microtubule-associated.   With evidence from 5 publications.
Cell projection   Microtubule-associated.   With evidence from 5 publications.
Axon   Microtubule-associated.   With evidence from 5 publications.

Length:

1376

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0824099999999999

Exp number, first 60 AAs:

0.08002

Total prob of N-in:

0.00430

outside

1 - 1376

Pi

196.121142

Theta

172.163871

Tajima's D

0.712173

CLR

1.224044

CSRT

0.580020998950053

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics