Gene

KWMTBOMO01149  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007459

Annotation

diphosphomevalonate_decarboxylase_[Bombyx_mori]

Location

Bomo_Chr3(-):3357375-3358751      View in EpiBrowser

Full name

Diphosphomevalonate decarboxylase      

Alternative Name

Mevalonate (diphospho)decarboxylase
Mevalonate pyrophosphate decarboxylase

Location in the cell

Cytoplasmic   Reliability : 0.965

CDS

ATGAGCAACATAGTTACAGTTATTGCTCCAGTAAATATTGCAGTAATAAAATACTGGGGAAAACGTGACGAGAAATTAATTTTACCGTTAAATGATTCCGTTAGTGCTACTTTCGATACAAGTGTTATGTGTGCTAAAACATCGGTATCTACTCATCCGGATTTCGTAGAAGATCAGATTTGGTTAAATGGAAAAGAAGAGTCATTTTCGAATCCAAGATTACAAAACTGCCTCAGGGAGATAAAATCACGAGCTGTTGCAGAGAAAACGATTGCTGAAGATGTACTATCATGGAAAGTTCATGTTTCTTCAGAGAACAATTTTCCAACCGCTGCTGGTTTAGCATCCTCGGCTGCAGGATATGCTTGCTTGGTGTCAGCTTTAGCAAAATTGTATAAAATTAAATCAGATGTCAGTTCAATTGCAAGATTAGGCTCAGGCAGTGCATGTAGAAGTGTTTACGGAGGTTTTGTAAGGTGGCATGCTGGCTCAAAACCTGATGGTAGCGATTCTATAGCCACACAAATTGCAGATTCGAATCATTGGCCTGAAATGCGTGTTTTAGTACTTGTAGTTGGTAATACTCAAAAGAAAGTCAGTTCAACTGTAGGAATGAAAATATCTTCAGAAACATCTGAATTATTAAAACACCGAATACAACACTGTGTTCCCCAAAGAACTGAAGAAATTATAGAAGCTATAAAGAACAAAGACTTTTCTAAATTTGCAGAGATAACAATGAAAGACAGTAATCAGTTTCATGCAATTTGCTTAGATTCATATCCTCCTATTGTGTACATGACAGACATTTCTCATTCAATTGTAGATTTGATTCATAAATATAATGACTTTAGTGGGGTGACAAAAGTAGCATACACATTCGATGCTGGATCGAATGCTTGTTTGTACTTGTTAAAGCATGATGTCCCTAAAGTAATTTCATTAATAAAATATGCATTCCCTTCAACGTCACCAGAAAAATTCATAACAGGTTTAAGTGTTGCCAAAGAAGAAATAAATACTGATATTTTATCAAAGTTGTGTATTGAACCAATGGGAATGGATATGATTAAATACATTATACACACTAAAATAGGTGAAGGACCTACAGAAATAGATTCACATTTGCTGGACAGTAACGGGCTGCCTATTTCAAAGATAAACAAGATATAA

Protein

MSNIVTVIAPVNIAVIKYWGKRDEKLILPLNDSVSATFDTSVMCAKTSVSTHPDFVEDQIWLNGKEESFSNPRLQNCLREIKSRAVAEKTIAEDVLSWKVHVSSENNFPTAAGLASSAAGYACLVSALAKLYKIKSDVSSIARLGSGSACRSVYGGFVRWHAGSKPDGSDSIATQIADSNHWPEMRVLVLVVGNTQKKVSSTVGMKISSETSELLKHRIQHCVPQRTEEIIEAIKNKDFSKFAEITMKDSNQFHAICLDSYPPIVYMTDISHSIVDLIHKYNDFSGVTKVAYTFDAGSNACLYLLKHDVPKVISLIKYAFPSTSPEKFITGLSVAKEEINTDILSKLCIEPMGMDMIKYIIHTKIGEGPTEIDSHLLDSNGLPISKINKI

Description

Performs the first committed step in the biosynthesis of isoprenes.

Catalytic Activity

(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate

Subunit

Homodimer.

Similarity

Belongs to the diphosphomevalonate decarboxylase family.

Keywords

3D-structure   Acetylation   ATP-binding   Cholesterol biosynthesis   Cholesterol metabolism   Complete proteome   Lipid biosynthesis   Lipid metabolism   Lyase   Nucleotide-binding   Reference proteome   Steroid biosynthesis   Steroid metabolism   Sterol biosynthesis   Sterol metabolism  

Feature

chain  Diphosphomevalonate decarboxylase

Uniprot

A5A7A2   H9JD62   A0A2A4JDV1   A0A2H1W8I6   A0A2W1BJS3   A0A0C5LBM1   + More
A0A0L7LJ17   A0A0N0PDF4   A0A194QBH9   A0A212F8V0   S4PE89   A0A2J7RDE7   A0A0A9XIY2   A0A1W4XSS6   A0A1Y1MYD1   I1VX04   A0A023F341   A0A0G3F646   A0A088A0J4   A0A0L7QWY1   A0A1S3JKE6   A0A1B6MMD3   A0A0P4VUR6   R7U748   A0A1S3I4D9   U4TXP9   I1VJ71   A0A224XHX9   J3JYG3   N6TD62   A0A154PAK3   A0A1D2NHI4   A0A1L8DZ38   U5ETY9   A0A1S4F6T1   Q17DS1   A0A1J1J527   T1I721   A0A1L8DZH7   B0W7P4   D6WE42   A0A226DMJ1   A0A087T943   A0A1B0CBF5   E2AFE1   A0A2L2YMZ7   A0A158NDC2   A0A3L8DRS7   A0A3B3Q6V1   A0A131YNJ8   A0A067RMX6   K7ISQ8   A0A131X9U7   A0A224YL36   A0A0H4J596   A0A218USD9   A0A2A3EQS7   A0A3M0K8C1   B4NPC5   A0A336MPX2   C3ZGP5   G3MND8   A0A2U9BCM1   A0A336KUU7   A0A3B3Q5H6   H2VB93   A0A1V4K1D9   A0A3B4Y9W2   A0A3B4VBU7   V9KP19   L7M8G4   A0A1I8NM45   A0A232F494   A0A0C9S2U5   A0A3P8T653   W5K7U2   W5UCK4   W8BAX3   B3NTG5   A0A210PNE5   A0A1I8NCY0   Q3UYC1   Q99JF5   A0A1S3KUY7   A0A060Y7M2   A0A1A6HGM4   G3GRT8   A0A0D2WTJ3   B4KSJ4   F6Y9W8   A0A1W5B150   A0A3B4Z576   H3ABU7   A0A1W4V3D2   B4J7I0   A0A340Y7V9   Q0P570   A0A1S3AAS8   A0A293MV42   A0A1E1X7R0  

EC Number

4.1.1.33

Pubmed

17628279    19121390    28756777    26227816    26354079    22118469    + More
23622113    25401762    26823975    28004739    25474469    27129103    23254933    23537049    22516182    27289101    17510324    18362917    19820115    20798317    26561354    21347285    30249741    29240929    26830274    24845553    20075255    28049606    28797301    26899871    17994087    18563158    22216098    21551351    24402279    25576852    28648823    26131772    25329095    23127152    24495485    28812685    25315136    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    16141072    15489334    24755649    21804562    29704459    17495919    9215903    28503490   

EMBL

AB274993    BAF62111.1    BABH01036249    BABH01036250    NWSH01001901    PCG69734.1    + More
PCG69735.1    ODYU01007030    SOQ49415.1    KZ150100    PZC73517.1    KJ951986    AJP70489.1    JTDY01000888    KOB75553.1    KQ460366    KPJ15582.1    KQ459249    KPJ02345.1    AGBW02013108    AGBW02009673    OWR43971.1    OWR50157.1    GAIX01003271    JAA89289.1    NEVH01005291    PNF38856.1    GBHO01024826    GDHC01010516    JAG18778.1    JAQ08113.1    GEZM01017487    JAV90649.1    JQ413986    AFI55102.1    GBBI01003166    JAC15546.1    KP420148    AKJ80168.1    KQ414705    KOC63133.1    GEBQ01002905    JAT37072.1    GDKW01000294    JAI56301.1    AMQN01009085    KB304553    ELU01936.1    KB631811    ERL86359.1    JQ855692    AFI45055.1    GFTR01005772    JAW10654.1    BT128291    AEE63249.1    APGK01042724    KB741007    ENN75638.1    KQ434846    KZC08258.1    LJIJ01000037    ODN04721.1    GFDF01002395    JAV11689.1    GANO01002564    JAB57307.1    CH477291    EAT44593.1    CVRI01000072    CRL07495.1    ACPB03000766    GFDF01002399    JAV11685.1    DS231855    EDS38188.1    KQ971318    EFA00378.2    LNIX01000014    OXA46752.1    KK114061    KFM61632.1    AJWK01005106    AJWK01005107    GL439108    EFN67834.1    IAAA01033033    LAA09486.1    ADTU01012588    QOIP01000005    RLU22873.1    GEDV01009096    JAP79461.1    KK852528    KDR21975.1    AAZX01002897    GEFH01004187    JAP64394.1    GFPF01007212    MAA18358.1    KP689340    AKO63322.1    MUZQ01000150    OWK56674.1    KZ288201    PBC33576.1    QRBI01000116    RMC09342.1    CH964291    EDW86365.1    UFQT01001498    SSX30823.1    GG666620    EEN48271.1    JO843389    AEO35006.1    CP026247    AWP01654.1    UFQS01001020    UFQT01001020    SSX08599.1    SSX28515.1    LSYS01005191    OPJ78246.1    JW867432    AFO99949.1    GACK01004699    JAA60335.1    NNAY01001047    OXU25349.1    GBZX01001376    JAG91364.1    JT411031    AHH39284.1    GAMC01016284    JAB90271.1    CH954180    EDV46969.1    NEDP02005575    OWF37946.1    AK134803    CH466525    BAE22291.1    EDL11681.1    AJ309922    AK089354    AK154883    AK170773    BC008526    FR907970    CDQ87522.1    LZPO01034768    OBS77110.1    JH000004    RAZU01000146    EGV94082.1    RLQ69307.1    KE346368    KJE94983.1    CH933808    EDW09499.2    AFYH01193560    CH916367    EDW01104.1    BC120432    GFWV01019080    MAA43808.1    GFAC01003896    JAT95292.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007151    + More
UP000235965    UP000192223    UP000005203    UP000053825    UP000085678    UP000014760    UP000030742    UP000019118    UP000076502    UP000094527    UP000008820    UP000183832    UP000015103    UP000002320    UP000007266    UP000198287    UP000054359    UP000092461    UP000000311    UP000005205    UP000279307    UP000261540    UP000027135    UP000002358    UP000197619    UP000242457    UP000269221    UP000007798    UP000001554    UP000246464    UP000005226    UP000190648    UP000261360    UP000261420    UP000095300    UP000215335    UP000265080    UP000018467    UP000221080    UP000008711    UP000242188    UP000095301    UP000000589    UP000087266    UP000193380    UP000092124    UP000001075    UP000273346    UP000008743    UP000009192    UP000002280    UP000192224    UP000261400    UP000008672    UP000192221    UP000001070    UP000265300    UP000009136    UP000079721   

PRIDE

A5A7A2    H9JD62    Q99JF5    G3GRT8    Q0P570   

Pfam

PF18376   MDD_C        + More
PF00288   GHMP_kinases_N
PF01180   DHO_dh
PF00071   Ras

Interpro

IPR036554   GHMP_kinase_C_sf        + More
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR006204   GHMP_kinase_N_dom       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR005935   Mev_decarb       
IPR029765   Mev_diP_decarb       
IPR041431   Mvd1_C       
IPR005720   Dihydroorotate_DH       
IPR027417   P-loop_NTPase       
IPR001295   Dihydroorotate_DH_CS       
IPR005225   Small_GTP-bd_dom       
IPR013785   Aldolase_TIM       
IPR001806   Small_GTPase       
IPR018935   RIO_kinase_CS       
IPR011009   Kinase-like_dom_sf       
IPR000687   RIO_kinase       

SUPFAM

SSF54211   SSF54211        + More
SSF55060   SSF55060       
SSF52540   SSF52540       
SSF56112   SSF56112       

Gene 3D

3.30.230.10     3.30.70.890     3.20.20.70    

ProteinModelPortal

A5A7A2   H9JD62   A0A2A4JDV1   A0A2H1W8I6   A0A2W1BJS3   A0A0C5LBM1   + More
A0A0L7LJ17   A0A0N0PDF4   A0A194QBH9   A0A212F8V0   S4PE89   A0A2J7RDE7   A0A0A9XIY2   A0A1W4XSS6   A0A1Y1MYD1   I1VX04   A0A023F341   A0A0G3F646   A0A088A0J4   A0A0L7QWY1   A0A1S3JKE6   A0A1B6MMD3   A0A0P4VUR6   R7U748   A0A1S3I4D9   U4TXP9   I1VJ71   A0A224XHX9   J3JYG3   N6TD62   A0A154PAK3   A0A1D2NHI4   A0A1L8DZ38   U5ETY9   A0A1S4F6T1   Q17DS1   A0A1J1J527   T1I721   A0A1L8DZH7   B0W7P4   D6WE42   A0A226DMJ1   A0A087T943   A0A1B0CBF5   E2AFE1   A0A2L2YMZ7   A0A158NDC2   A0A3L8DRS7   A0A3B3Q6V1   A0A131YNJ8   A0A067RMX6   K7ISQ8   A0A131X9U7   A0A224YL36   A0A0H4J596   A0A218USD9   A0A2A3EQS7   A0A3M0K8C1   B4NPC5   A0A336MPX2   C3ZGP5   G3MND8   A0A2U9BCM1   A0A336KUU7   A0A3B3Q5H6   H2VB93   A0A1V4K1D9   A0A3B4Y9W2   A0A3B4VBU7   V9KP19   L7M8G4   A0A1I8NM45   A0A232F494   A0A0C9S2U5   A0A3P8T653   W5K7U2   W5UCK4   W8BAX3   B3NTG5   A0A210PNE5   A0A1I8NCY0   Q3UYC1   Q99JF5   A0A1S3KUY7   A0A060Y7M2   A0A1A6HGM4   G3GRT8   A0A0D2WTJ3   B4KSJ4   F6Y9W8   A0A1W5B150   A0A3B4Z576   H3ABU7   A0A1W4V3D2   B4J7I0   A0A340Y7V9   Q0P570   A0A1S3AAS8   A0A293MV42   A0A1E1X7R0  

PDB

3F0N     E-value=3.06761e-108,     Score=1001

KEGG

100101206    K01597 diphosphomevalonate decarboxylase [EC:4.1.1.33] | (RefSeq) Mppd, Mppd_bm; diphosphomevalonate

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0006695   GO:0004163   GO:0019287   GO:0005829   GO:0004152   GO:0005525   GO:0003924   GO:0006207   GO:0016021   GO:0004674   GO:0042803   GO:0030544   GO:0008284   GO:0005777   GO:0005782   GO:0008299   GO:0016831   GO:0005634   GO:0006334   GO:0003779  

Length:

390

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.28738

Exp number, first 60 AAs:

0.12063

Total prob of N-in:

0.01714

outside

1  -  390

 

 

Pi

307.015168

Theta

242.556715

Tajima's D

0.838543

CLR

0.207299

CSRT

0.607669616519174

Interpretation

Uncertain