Gene

KWMTBOMO01131  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007469

Annotation

translation_initiation_factor_5A_[Bombyx_mori]

Location

Bomo_Chr3(-):2890414-2897786      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 5A      

Location in the cell

Cytoplasmic   Reliability : 2.87

CDS

ATGGGTGACATCGAAGACACACACTTTGAGACCGGAGACTCCGGGGCCTCAGCCACCTTCCCCATGCAATGTTCGGCCCTGCGTAAAAATGGTTTCGTTATGCTGAAGGGTCGTCCATGCAAGATTGTTGAAATGTCCACATCCAAAACCGGAAAGCACGGCCACGCTAAAGTTCACTTGGTTGGGATTGATATCTTCAATGGTAAAAAGTATGAAGATATCTGTCCCTCCACACACAACATGGACGTACCTCACGTGAAGCGCGAAGACTACCAACTGACTGATATCTCGGATGATGGCTACCTGACCCTGATGGCTGACAACGGTGACCTGCGTGAGGACCTCAAAATCCCGGATGGTGACCTCGGCACACAGTTGCGTACTGACTTCGACAGCGGCAAGGAATTGTTGTGCACCGTGCTGAAATCCTGCGGTGAGGAGTGCGTCATCGCCGTCAAAGCAAACACAGCTCTCGACAAATAA

Protein

MGDIEDTHFETGDSGASATFPMQCSALRKNGFVMLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFNGKKYEDICPSTHNMDVPHVKREDYQLTDISDDGYLTLMADNGDLREDLKIPDGDLGTQLRTDFDSGKELLCTVLKSCGEECVIAVKANTALDK

Description

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity).

Similarity

Belongs to the eIF-5A family.

Keywords

3D-structure   Cytoplasm   Elongation factor   Hypusine   Protein biosynthesis   RNA-binding  

Feature

chain  Eukaryotic translation initiation factor 5A

Uniprot

Q4F863   I4DMW9   A0A194R5L3   A0A3G1T1A0   B2DBM0   A0A1C8CJF5   + More
A0A2W1BBW7   A0A2H1VLR9   A0A2A4JE50   P62925   P62924   A0A212ESF1   A0A0L7KT76   S4PA57   A0A0K8TQ69   A0A1D1Y2Z3   A0A2P8XBV1   J3JU48   N6TFL6   A0A0T6B2I4   A0A1I9WLD9   V5G8K7   A0A224XYR2   A6YPI2   A0A069DP22   R4G8K4   A0A1B6KB52   A0A1B6GK56   A0A0L0CB82   A0A0A9WR93   E9IJD5   A0A3L8DBG7   A0A232F0B6   K7IUS7   A0A0P4VUG7   A0A0J7NGD7   E2AEJ2   A0A1L8DRR4   A0A1B6EEW5   T1P7N0   A0A1I8PW16   A0A1L8EF92   A0A023FD48   F4WRT8   A0A158NEM2   E0VDY5   A0A1L8EGX5   A2I404   A0A1Y1KHI5   C4WSD9   A0A1S3D1W7   A0A310SD46   A0A336M0Q5   A0A0C9QXD3   A0A0A1XP59   A0A0K8VTI6   A0A034VRW1   A0A154PHD0   U5EXD7   A0A2H8TL60   A0A0L7RGT1   T1E2I6   W8C1R5   A0A0P6IGR1   A0A2A3ET02   V9IJK5   A0A088ALS2   A0A1A9XAC9   A0A1A9VKL8   A0A1B0C1I4   A0A1A9ZVI8   A0A1A9W2I2   D3TMH0   C6ZJP8   Q1HRN6   A0A1Q3F5W0   B0W2N9   A0A161TE13   A0A1J1IDS5   A0A0P5BDP7   A0A0P5FW23   A0A0P5GKE0   A0A0N8B886   A0A164RJF6   W5JUW2   A0A2M3YXV1   A0A2M4A0C4   A0A182FLL9   A0A0N8DAV9   A0A1D2N039   A0A0P5YVD9   A0A0P6JX55   A0A0P6AZ56   A0A0P5GXZ8   A0A182WYS9   Q7PSR5   E9GL78   A0A084VD29   A0A182NT18   A0A182JQZ6  

Pubmed

16610134    19121390    22651552    26354079    18712529    28756777    + More
10620048    22118469    26227816    23622113    26369729    29403074    22516182    23537049    27538518    18207082    26334808    26108605    25401762    26823975    21282665    30249741    28648823    20075255    27129103    20798317    25315136    25474469    21719571    21347285    20566863    28004739    25830018    25348373    24330624    24495485    20353571    20819232    24945155    17204158    17510324    20920257    23761445    27289101    12364791    14747013    17210077    21292972    24438588   

EMBL

BABH01036213    DQ104412    DQ150251    DQ201182    DQ202521    HQ638205    + More
AAZ15319.1    AAZ80490.1    ABA54172.1    ABA54998.1    AEH16568.1    AK402637    BAM19259.1    KQ460685    KPJ12804.1    MG846906    AXY94758.1    AB264704    AK401187    KQ459249    BAG30779.1    BAM17809.1    KPJ02318.1    KM979431    AKN79609.1    KZ150241    PZC71911.1    ODYU01003256    SOQ41771.1    NWSH01001909    PCG69720.1    AF109731    AF109730    AGBW02012799    OWR44422.1    JTDY01006176    KOB66219.1    GAIX01003394    JAA89166.1    GDAI01001317    JAI16286.1    GDJX01018921    JAT49015.1    PYGN01003543    PSN29485.1    BT126760    AEE61722.1    APGK01040100    KB740975    KB632267    ENN76543.1    ERL90988.1    LJIG01016107    KRT81594.1    KU932323    APA33959.1    GALX01002036    JAB66430.1    GFTR01002676    JAW13750.1    EF638993    ABR27878.1    GBGD01003289    JAC85600.1    ACPB03009649    GAHY01000817    JAA76693.1    GEBQ01031296    JAT08681.1    GECZ01022231    GECZ01006937    JAS47538.1    JAS62832.1    JRES01000655    KNC29511.1    GBHO01033295    GBRD01014755    GDHC01002387    JAG10309.1    JAG51071.1    JAQ16242.1    GL763764    EFZ19316.1    QOIP01000010    RLU17453.1    NNAY01001398    OXU24114.1    GDKW01000921    JAI55674.1    LBMM01005335    KMQ91600.1    GL438862    EFN68149.1    GFDF01004942    JAV09142.1    GEDC01000815    JAS36483.1    KA644497    AFP59126.1    GFDG01001441    JAV17358.1    GBBI01000078    JAC18634.1    GL888292    EGI63095.1    ADTU01013499    ADTU01013500    ADTU01013501    DS235088    EEB11591.1    GFDG01000940    JAV17859.1    EF070507    ABM55573.1    GEZM01083933    JAV60932.1    ABLF02017872    AK340152    BAH70809.1    KQ761155    OAD58133.1    UFQT01000292    SSX22901.1    GBYB01000340    JAG70107.1    GBXI01001143    JAD13149.1    GDHF01019370    GDHF01010146    JAI32944.1    JAI42168.1    GAKP01014109    GAKP01014108    GAKP01014107    GAKP01014105    GAKP01014103    GAKP01014101    GAKP01014100    JAC44852.1    KQ434905    KZC11259.1    GANO01001003    JAB58868.1    GFXV01003082    MBW14887.1    KQ414592    KOC70187.1    GALA01000679    JAA94173.1    GAMC01000798    JAC05758.1    GDIQ01004641    JAN90096.1    KZ288191    PBC34432.1    JR049029    AEY60837.1    JXJN01024053    CCAG010017210    EZ422622    ADD18898.1    EU910137    GAPW01005273    ACJ76424.1    JAC08325.1    DQ440058    CH477283    ABF18091.1    EAT44852.1    GFDL01012099    JAV22946.1    DS231827    EDS29347.1    GEMB01001374    JAS01782.1    CVRI01000047    CRK97150.1    GDIP01186653    JAJ36749.1    GDIQ01253161    JAJ98563.1    GDIQ01239314    JAK12411.1    GDIQ01203171    JAK48554.1    LRGB01002190    KZS08712.1    ADMH02000297    ETN67073.1    GGFM01000315    MBW21066.1    GGFK01000878    MBW34199.1    GDIP01051775    JAM51940.1    LJIJ01000337    ODM98656.1    GDIP01052923    JAM50792.1    GDIQ01004939    JAN89798.1    GDIP01022282    JAM81433.1    GDIQ01240966    JAK10759.1    AAAB01008816    EAA05154.4    GL732550    EFX79841.1    ATLV01011135    KE524643    KFB35873.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000037510    + More
UP000245037    UP000019118    UP000030742    UP000015103    UP000037069    UP000279307    UP000215335    UP000002358    UP000036403    UP000000311    UP000095301    UP000095300    UP000007755    UP000005205    UP000009046    UP000007819    UP000079169    UP000076502    UP000053825    UP000242457    UP000005203    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000092444    UP000008820    UP000002320    UP000183832    UP000076858    UP000000673    UP000069272    UP000094527    UP000076407    UP000007062    UP000000305    UP000030765    UP000075884    UP000075881   

PRIDE

Q4F863   

Pfam

PF01287   eIF-5a        + More
PF08207   EFP_N

Interpro

IPR008991   Translation_prot_SH3-like_sf        + More
IPR020189   Transl_elong_IF5A_C       
IPR012340   NA-bd_OB-fold       
IPR014722   Rib_L2_dom2       
IPR019769   Trans_elong_IF5A_hypusine_site       
IPR001884   IF5A-like       
IPR013185   Transl_elong_KOW-like       

SUPFAM

SSF50104   SSF50104        + More
SSF50249   SSF50249       

Gene 3D

2.30.30.30    

ProteinModelPortal

Q4F863   I4DMW9   A0A194R5L3   A0A3G1T1A0   B2DBM0   A0A1C8CJF5   + More
A0A2W1BBW7   A0A2H1VLR9   A0A2A4JE50   P62925   P62924   A0A212ESF1   A0A0L7KT76   S4PA57   A0A0K8TQ69   A0A1D1Y2Z3   A0A2P8XBV1   J3JU48   N6TFL6   A0A0T6B2I4   A0A1I9WLD9   V5G8K7   A0A224XYR2   A6YPI2   A0A069DP22   R4G8K4   A0A1B6KB52   A0A1B6GK56   A0A0L0CB82   A0A0A9WR93   E9IJD5   A0A3L8DBG7   A0A232F0B6   K7IUS7   A0A0P4VUG7   A0A0J7NGD7   E2AEJ2   A0A1L8DRR4   A0A1B6EEW5   T1P7N0   A0A1I8PW16   A0A1L8EF92   A0A023FD48   F4WRT8   A0A158NEM2   E0VDY5   A0A1L8EGX5   A2I404   A0A1Y1KHI5   C4WSD9   A0A1S3D1W7   A0A310SD46   A0A336M0Q5   A0A0C9QXD3   A0A0A1XP59   A0A0K8VTI6   A0A034VRW1   A0A154PHD0   U5EXD7   A0A2H8TL60   A0A0L7RGT1   T1E2I6   W8C1R5   A0A0P6IGR1   A0A2A3ET02   V9IJK5   A0A088ALS2   A0A1A9XAC9   A0A1A9VKL8   A0A1B0C1I4   A0A1A9ZVI8   A0A1A9W2I2   D3TMH0   C6ZJP8   Q1HRN6   A0A1Q3F5W0   B0W2N9   A0A161TE13   A0A1J1IDS5   A0A0P5BDP7   A0A0P5FW23   A0A0P5GKE0   A0A0N8B886   A0A164RJF6   W5JUW2   A0A2M3YXV1   A0A2M4A0C4   A0A182FLL9   A0A0N8DAV9   A0A1D2N039   A0A0P5YVD9   A0A0P6JX55   A0A0P6AZ56   A0A0P5GXZ8   A0A182WYS9   Q7PSR5   E9GL78   A0A084VD29   A0A182NT18   A0A182JQZ6  

PDB

5HY6     E-value=7.20738e-85,     Score=794

KEGG

693075    K03263 translation initiation factor 5A | (RefSeq) translation initiation factor 5A

GO

GO:0006452   GO:0045901   GO:0043022   GO:0045905   GO:0003743   GO:0003746   GO:0005737   GO:0003723   GO:0005634   GO:0006334   GO:0003779   GO:0016021  

PANTHER

PTHR11673  

Subcellular location

Cytoplasm  

Length:

160

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00304

Exp number, first 60 AAs:

0.00304

Total prob of N-in:

0.08307

outside

1  -  160

 

 

Pi

135.893541

Theta

197.086084

Tajima's D

-0.912108

CLR

2402.897266

CSRT

0.152042397880106

Interpretation

Uncertain