Gene

KWMTBOMO01124

Annotation

atypical_protein_kinase_C_[Bombyx_mori]

Location

Bomo_Chr3(-):2654402-2667061      View in EpiBrowser

Full name

Protein kinase C       + More
Atypical protein kinase C      

Location in the cell

Cytoplasmic   Reliability : 2.899

CDS

ATGGCACTTGGGACTTTATTGATCGATTGCGAAAGTGAAGACCCGACAAGGGTATTCGGAGTTTATTTGGGGAGCATATACAGGAGAGGAGCACGGCGGTGGCGTAAACTGTACCGCGTCAATGGACACATCTTTCAAGCTAAAAGATTTAATAGACGCGCTTTCTGTGCCTTCTGCCAAGACCGCATCTGGGGCCTCGGAAGACAGGGCTTCAAATGCATCCAGTGTAAGCTGCTCGTTCACAAGAAGTGTCACAAGCTCGTGCAGAAGCCGTGCTCGAATGAGCATGTCGATCCCATTGAGGTCAAAGACGACGCGAACGGAGAGGCCACTTTGGGCCGGGCTTCTTCTGTCAGGTCTCGTGCGGAGGAACAGCCCCCTCTGCCGGAGACGCCGCCGGCGCCGGCGCCCCCCGCCCGCCCCGAGGAGCTGGAGCCGGGCTCGCAGCGGCAGTACTCGCTCGACGACTTTGAGCTCATCAGGGTCATCGGACGTGGCTCTTATGCCAAGGTGCTGATGGTAGAATTAAAACGCACGAAGCGCATATACGCTATGAAGGTGATAAAGAAGGCGCTCGTCACCGACGACGAGGACATCGACTGGGTTCAGACTGAGAAACACGTGTTCGAGACCGCCTCGAACCACCCATTCCTGGTCGGCCTGCACTCCTGCTTCCAAACACCGAGCAGATTGTTCTTCGTGATCGAGTTCGTCAGGGGAGGGGATCTGATGTTCCACATGCAGCGTCAGCGGCGGCTGCCGGAGGAGCACGCGCGGTTCTACGCGGCCGAGATCTCGCTGGCGCTGCACTTCCTGCACGAGCGCGGCGTCATCTACCGCGACCTCAAGCTGGACAACGTGCTGCTCGACCACGAGGGACACATCAAGCTCACCGATTACGGAATGTGCAAGGAGGGAGTGCGTCCGGGCGACACGACCTCTACGTTCTGCGGCACTCCCAACTACATCGCGCCGGAGATCCTCCGCGGCGAGGAGTACGGCTTCTCCGTGGACTGGTGGGCGCTCGGGGTCCTCACGTACGAGATGTTGGCTGGCAGATCGCCCTTCGACATCGCCCAAGCTGCTGACAACCCCGACCAGAATACAGAAGACTATCTCTTCCAGGTGATATTGGAGAAGACGATCCGTATCCCGCGCTCGCTGTCCGTGAAGGCGGCCTCGGTGCTGAAGGGCTTCCTCAACAAGAACCCGGTGGAGCGGCTCGGCTGCGGCGAGAACGGCTTCCTCGACATCGTCAACCATCCCTTCTTCAAGAGCATCGAGTGGGAGATGTTGGAGCAGAAACAAGTGGTGCCTCCGTTCAAGCCCCGTCTGGAAGGCGAACGGGACCTCGCCAACTTCCCGCCGGAGTTCACTGACGAGCCCGTGCATCTCACGCCCGATAACGAGAGCGTGATCGCCGACATCGACCAGTCGGAGTTCGAAGGGTTCGAGTACGTGAACCCGCTGCTGATGTCCCTGGAGGACTGCGTGTGA

Protein

MALGTLLIDCESEDPTRVFGVYLGSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAFCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKPCSNEHVDPIEVKDDANGEATLGRASSVRSRAEEQPPLPETPPAPAPPARPEELEPGSQRQYSLDDFELIRVIGRGSYAKVLMVELKRTKRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALHFLHERGVIYRDLKLDNVLLDHEGHIKLTDYGMCKEGVRPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLTYEMLAGRSPFDIAQAADNPDQNTEDYLFQVILEKTIRIPRSLSVKAASVLKGFLNKNPVERLGCGENGFLDIVNHPFFKSIEWEMLEQKQVVPPFKPRLEGERDLANFPPEFTDEPVHLTPDNESVIADIDQSEFEGFEYVNPLLMSLEDCV

Description

Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with baz; the interaction is required for apical localization of aPKC in neuroblasts and epithelial cells. Interacts with Dap160; the interaction promotes aPKC apical localization and kinase activity. Interacts with and phosphorylates l(2)gl and yrt. Interacts with crb and ref(2)P. Forms a complex with baz, fz and Patj.

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily.

Keywords

Alternative splicing   ATP-binding   Cell membrane   Complete proteome   Cytoplasm   Kinase   Membrane   Metal-binding   Nucleotide-binding   Reference proteome   Transferase   Zinc   Zinc-finger  

Feature

chain  Protein kinase C
splice variant  In isoform F.

Uniprot

A0A2R8G5Z7   Q4AED5   A0A2A4JY12   A0A2A4JZT3   A0A1L8DMH1   A0A1L8DMD5   + More
A0A1Q3G2J3   A0A1Q3G2D1   A0A067R2P7   A0A1W4XKZ1   A0A1B6DB11   A0A1W4XL00   A0A023F5R6   A0A224X9U0   A0A182QX87   Q17GR4   A0A1W4XJV6   A0A182IQT2   A0A0P6IYY5   A0A2M4CTW5   A0A2M4AHK3   A0A2M3Z5G1   A0A1B6KEU6   A0A1B6KX77   A0A1Y1MDI0   A0A1Y1MBV0   A0A0A9ZEF0   A0A0A9ZC39   V5GWH4   A0A034VKR0   A0A1I8M1P2   V5GSK4   A0A0K8WKF8   A0A0M3TCH4   A0A1A9Y727   A0A1A9Z5B8   B4KP34   A0A1A9WV58   A0A310S6P5   A0A0J9RD44   A0A088A8P9   A0A0J9RCU8   A0A0L7REQ1   A0A0B4JD78   A0A0B4KG15   A0A0Q9WFW4   B4HRS5   V9I8D2   A0A0Q5W036   A0A0Q5VLS2   A0A0J9RD09   A0A0B4KEQ8   A0A0B4KEV2   A0A0R1DRI0   A0A1I8PAU2   V9IAN8   A1Z9X0   A0A2A3EGP3   A0A154P8H9   A0A2S2PS44   A0A1W4U9P8   A0A1W4ULK7   A1Z9X0-4   A0A0J9RCV4   N6WCA0   A0A0B4KFQ6   A0A0P8ZLZ9   B4J5Z1   A1Z9X0-5   A0A182UEM5   A0A1W4U9Q2   Q28YC5   A0A3B0J2S6   B3MH03   A0A1W4ULS4   X1WYI0   N6VFF2   A0A1W4UAB5   A0A2S2QHV1   K7J023   A0A182KLK6   A0A182FVS2   B4MQ00   E0VZB9   A0A194R4Q6   A0A158NZJ5   A0A182HHR7   A0A195FDA6   A0A182M485   A0A195EK64   A0A2J7R615   E2BWJ8   A0A0P4W3P1   E9GL76   A0A1S4H907   T1J7C8   A0A2H4IAU8   A0A0K2TS93   A0A0J9RD05   A0A3L8D787  

EC Number

2.7.11.13

Pubmed

24845553    25474469    17510324    26999592    28004739    25401762    + More
26823975    25348373    25315136    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    10995441    12537569    11734648    12446795    11914720    14657233    15302858    15907474    17488624    18094021    18614576    19472188    20434988    22223679    24515345    24830287    15632085    18057021    20075255    20966253    20566863    26354079    21347285    20798317    21292972    30249741   

EMBL

MF040614    AVZ23636.1    AB184962    BAE17023.1    NWSH01000370    PCG76911.1    + More
PCG76912.1    GFDF01006473    JAV07611.1    GFDF01006472    JAV07612.1    GFDL01001086    JAV33959.1    GFDL01001085    JAV33960.1    KK853053    KDR12017.1    GEDC01014425    GEDC01003682    JAS22873.1    JAS33616.1    GBBI01002193    JAC16519.1    GFTR01007299    JAW09127.1    AXCN02001803    CH477256    EAT45873.1    GDUN01000867    JAN95052.1    GGFL01004614    MBW68792.1    GGFK01006881    MBW40202.1    GGFM01003001    MBW23752.1    GEBQ01029985    GEBQ01025291    JAT09992.1    JAT14686.1    GEBQ01023924    GEBQ01010216    JAT16053.1    JAT29761.1    GEZM01035984    JAV83058.1    GEZM01035982    JAV83061.1    GBHO01000783    GBHO01000780    JAG42821.1    JAG42824.1    GBHO01005115    GBHO01000777    GBHO01000775    GDHC01017225    GDHC01002558    JAG38489.1    JAG42827.1    JAG42829.1    JAQ01404.1    JAQ16071.1    GALX01003878    JAB64588.1    GAKP01016547    GAKP01016545    GAKP01016544    JAC42405.1    GALX01003879    JAB64587.1    GDHF01023493    GDHF01000974    JAI28821.1    JAI51340.1    KR075828    ALE20547.1    CH933808    EDW10100.2    KQ767320    OAD53404.1    CM002911    KMY93886.1    KMY93883.1    KQ414609    KOC69318.1    AE013599    ADV37185.1    AGB93516.1    CH940648    KRF79653.1    CH480816    EDW47939.1    JR036779    AEY57393.1    CH954179    KQS62586.1    KQS62589.1    KMY93887.1    AGB93519.1    AGB93518.1    CM000158    KRJ99614.1    JR036780    AEY57394.1    AF288482    AY118402    BT056247    AAF58177.2    AAG01528.1    AAM48431.1    ACL68694.1    KZ288254    PBC30897.1    KQ434844    KZC08172.1    GGMR01019673    MBY32292.1    KMY93888.1    CM000071    ENO01779.1    AGB93517.1    CH902619    KPU75811.1    CH916367    EDW00834.1    EAL26040.1    OUUW01000001    SPP75537.1    EDV35762.1    KPU75812.1    ABLF02028965    ABLF02028966    ENO01780.2    GGMS01007887    MBY77090.1    CH963849    EDW74189.1    DS235851    EEB18725.1    KQ460685    KPJ12798.1    ADTU01004650    APCN01002436    KQ981685    KYN38024.1    AXCM01002439    KQ978747    KYN28655.1    NEVH01006983    PNF36270.1    GL451131    EFN79954.1    GDRN01074945    JAI63151.1    GL732550    EFX79842.1    JH431917    KX100579    ARV85772.1    HACA01011543    CDW28904.1    KMY93882.1    QOIP01000012    RLU16106.1   

Proteomes

UP000218220    UP000027135    UP000192223    UP000075886    UP000008820    UP000075880    + More
UP000095301    UP000092443    UP000092445    UP000009192    UP000091820    UP000005203    UP000053825    UP000000803    UP000008792    UP000001292    UP000008711    UP000002282    UP000095300    UP000242457    UP000076502    UP000192221    UP000001819    UP000007801    UP000001070    UP000075902    UP000268350    UP000007819    UP000002358    UP000075882    UP000069272    UP000007798    UP000009046    UP000053240    UP000005205    UP000075840    UP000078541    UP000075883    UP000078492    UP000235965    UP000008237    UP000000305    UP000279307   

PRIDE

Q4AED5    A1Z9X0   

Pfam

PF00069   Pkinase        + More
PF00433   Pkinase_C
PF00130   C1_1
PF00564   PB1
PF00083   Sugar_tr
PF00076   RRM_1

Interpro

IPR000961   AGC-kinase_C        + More
IPR020454   DAG/PE-bd       
IPR017892   Pkinase_C       
IPR000719   Prot_kinase_dom       
IPR034659   Atypical_PKC       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR002219   PE/DAG-bd       
IPR034877   PB1_aPKC       
IPR012233   PKC       
IPR000270   PB1_dom       
IPR007110   Ig-like_dom       
IPR036179   Ig-like_dom_sf       
IPR013783   Ig-like_fold       
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR005828   MFS_sugar_transport-like       
IPR000504   RRM_dom       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR035979   RBD_domain_sf       
IPR014375   Protein_kinase_C_a/b/g       

SUPFAM

SSF56112   SSF56112        + More
SSF48726   SSF48726       
SSF103473   SSF103473       
SSF54928   SSF54928       

Gene 3D

2.60.40.10     3.30.70.330    

CDD

cd00029  C1
cd05588  STKc_aPKC
cd06404  PB1_aPKC
cd06174  MFS

ProteinModelPortal

A0A2R8G5Z7   Q4AED5   A0A2A4JY12   A0A2A4JZT3   A0A1L8DMH1   A0A1L8DMD5   + More
A0A1Q3G2J3   A0A1Q3G2D1   A0A067R2P7   A0A1W4XKZ1   A0A1B6DB11   A0A1W4XL00   A0A023F5R6   A0A224X9U0   A0A182QX87   Q17GR4   A0A1W4XJV6   A0A182IQT2   A0A0P6IYY5   A0A2M4CTW5   A0A2M4AHK3   A0A2M3Z5G1   A0A1B6KEU6   A0A1B6KX77   A0A1Y1MDI0   A0A1Y1MBV0   A0A0A9ZEF0   A0A0A9ZC39   V5GWH4   A0A034VKR0   A0A1I8M1P2   V5GSK4   A0A0K8WKF8   A0A0M3TCH4   A0A1A9Y727   A0A1A9Z5B8   B4KP34   A0A1A9WV58   A0A310S6P5   A0A0J9RD44   A0A088A8P9   A0A0J9RCU8   A0A0L7REQ1   A0A0B4JD78   A0A0B4KG15   A0A0Q9WFW4   B4HRS5   V9I8D2   A0A0Q5W036   A0A0Q5VLS2   A0A0J9RD09   A0A0B4KEQ8   A0A0B4KEV2   A0A0R1DRI0   A0A1I8PAU2   V9IAN8   A1Z9X0   A0A2A3EGP3   A0A154P8H9   A0A2S2PS44   A0A1W4U9P8   A0A1W4ULK7   A1Z9X0-4   A0A0J9RCV4   N6WCA0   A0A0B4KFQ6   A0A0P8ZLZ9   B4J5Z1   A1Z9X0-5   A0A182UEM5   A0A1W4U9Q2   Q28YC5   A0A3B0J2S6   B3MH03   A0A1W4ULS4   X1WYI0   N6VFF2   A0A1W4UAB5   A0A2S2QHV1   K7J023   A0A182KLK6   A0A182FVS2   B4MQ00   E0VZB9   A0A194R4Q6   A0A158NZJ5   A0A182HHR7   A0A195FDA6   A0A182M485   A0A195EK64   A0A2J7R615   E2BWJ8   A0A0P4W3P1   E9GL76   A0A1S4H907   T1J7C8   A0A2H4IAU8   A0A0K2TS93   A0A0J9RD05   A0A3L8D787  

PDB

5LIH     E-value=1.27215e-173,     Score=1566

KEGG

692468    K06069 atypical protein kinase C iota type [EC:2.7.11.13] | (RefSeq) Apkc; atypical protein kinase C

GO

GO:0005524   GO:0046872   GO:0007163   GO:0004697   GO:0035556   GO:0004674   GO:0022857   GO:0016021   GO:1904580   GO:0016324   GO:0030011   GO:0007613   GO:0045179   GO:0000132   GO:0045167   GO:0003382   GO:0045198   GO:0016332   GO:0051601   GO:0005938   GO:0001738   GO:0007314   GO:0002052   GO:0060446   GO:0017022   GO:0055059   GO:0030860   GO:0006468   GO:0035003   GO:0016334   GO:0035011   GO:0034332   GO:0010592   GO:0007423   GO:0045196   GO:0007416   GO:0016327   GO:0007294   GO:0045197   GO:0007043   GO:0045176   GO:0072659   GO:0045186   GO:0046667   GO:0007430   GO:0090163   GO:0007283   GO:0051491   GO:0003723   GO:0008270   GO:0018105   GO:0004672   GO:0005634   GO:0006334   GO:0003779  

Subcellular location

Cytoplasm   Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis.   With evidence from 6 publications.
Cell cortex   Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis.   With evidence from 6 publications.
Apicolateral cell membrane   Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis.   With evidence from 6 publications.

Length:

498

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00348

Exp number, first 60 AAs:

0.00051

Total prob of N-in:

0.00059

outside

1  -  498

 

 

Pi

164.737163

Theta

145.419239

Tajima's D

1.052443

CLR

0.722159

CSRT

0.681565921703915

Interpretation

Uncertain